KR101841989B1 - 칼륨 채널 조절제로서 4-(ｎ-아자사이클로알킬)아닐리드 유도체 - Google Patents

칼륨 채널 조절제로서 4-(ｎ-아자사이클로알킬)아닐리드 유도체 Download PDF

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KR101841989B1
KR101841989B1 KR1020127022876A KR20127022876A KR101841989B1 KR 101841989 B1 KR101841989 B1 KR 101841989B1 KR 1020127022876 A KR1020127022876 A KR 1020127022876A KR 20127022876 A KR20127022876 A KR 20127022876A KR 101841989 B1 KR101841989 B1 KR 101841989B1
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compound
chr
alkyl
cycloalkyl
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KR20120123695A (ko
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잔-미켈 베르니에르
마르다 데라로사
후안밍 첸
짐 젠 우
개리 리 라슨
란 웨인 체니
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제논 파마슈티칼스 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR1020127022876A 2010-02-01 2011-01-25 칼륨 채널 조절제로서 4-(ｎ-아자사이클로알킬)아닐리드 유도체 Active KR101841989B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/698,070 2010-02-01
US12/698,070 US8993593B2 (en) 2006-08-23 2010-02-01 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
PCT/US2011/022345 WO2011094186A1 (en) 2010-02-01 2011-01-25 Derivatives of 4-(n-azacycloalkyl) aniilides as potassium channel modulators

Publications (2)

Publication Number Publication Date
KR20120123695A KR20120123695A (ko) 2012-11-09
KR101841989B1 true KR101841989B1 (ko) 2018-03-26

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KR1020127022876A Active KR101841989B1 (ko) 2010-02-01 2011-01-25 칼륨 채널 조절제로서 4-(ｎ-아자사이클로알킬)아닐리드 유도체

Country Status (12)

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US (1) US8993593B2 (enExample)
EP (1) EP2531024A4 (enExample)
JP (1) JP5844285B2 (enExample)
KR (1) KR101841989B1 (enExample)
CN (1) CN102869250A (enExample)
AU (1) AU2011209731A1 (enExample)
BR (1) BR112012019199A2 (enExample)
CA (1) CA2788712C (enExample)
EA (1) EA201290748A1 (enExample)
MX (1) MX2012008969A (enExample)
SG (1) SG182799A1 (enExample)
WO (1) WO2011094186A1 (enExample)

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US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
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KR20190008411A (ko) 2016-06-10 2019-01-23 사이플루어 라이프 사이언시즈, 인크 플로오르화 2-아미노-4-(치환된 아미노)페닐 카르밤산염 유도체
UA127229C2 (uk) * 2018-05-11 2023-06-14 Ксенон Фармасьютікалз Інк. Спосіб збільшення біологічної доступності й ступеня впливу активатора потенціалзалежних калієвих каналів
CN110511220B (zh) 2018-05-22 2022-04-01 上海挚盟医药科技有限公司 作为钾通道调节剂的对二氨基苯衍生物、其制备方法及其在医药上的应用
TWI886158B (zh) * 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
KR20220098746A (ko) 2019-11-08 2022-07-12 제논 파마슈티칼스 인크. 우울 장애 치료 방법
CN114786658A (zh) * 2019-12-06 2022-07-22 泽农医药公司 Kv7钾离子通道开放剂治疗疼痛的用途
US20210213009A1 (en) * 2019-12-13 2021-07-15 Xenon Pharmaceuticals Inc. Methods of treating pain
PE20231856A1 (es) 2021-02-09 2023-11-21 Xenon Pharmaceuticals Inc Terapia conjunta para el tratamiento de trastornos convulsivos
IL304920A (en) 2021-02-09 2023-10-01 Xenon Pharmaceuticals Inc A voltage-gated potassium channel opener for use in the treatment of anhedonia
CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
IL291332B2 (en) * 2021-10-27 2025-10-01 Shanghai Zhimeng Biopharma Inc Potassium channel blocker, method of preparation and uses
WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
CN116535353A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
EP4536356A1 (en) 2022-06-08 2025-04-16 Xenon Pharmaceuticals Inc. Pyridinamine derivatives and their use as potassium channel modulators
WO2025167886A1 (zh) * 2024-02-08 2025-08-14 上海挚盟医药科技有限公司 四氢异喹啉基化合物的晶型及其应用
WO2025179128A1 (en) 2024-02-22 2025-08-28 Xenon Pharmaceuticals Inc. Azetukalner for use in the treatment of depression, anhedonia or a seizure disorder such as epilepsy in pediatric subjects

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WO2008024398A2 (en) * 2006-08-23 2008-02-28 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators

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AU2011209731A1 (en) 2012-08-23
MX2012008969A (es) 2012-09-07
KR20120123695A (ko) 2012-11-09
CA2788712A1 (en) 2011-08-04
JP2013518815A (ja) 2013-05-23
US8993593B2 (en) 2015-03-31
BR112012019199A2 (pt) 2017-01-17
SG182799A1 (en) 2012-09-27
EA201290748A1 (ru) 2013-04-30
WO2011094186A1 (en) 2011-08-04
EP2531024A4 (en) 2013-06-19
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US20110003850A1 (en) 2011-01-06
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