JP5844285B2 - カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体 - Google Patents

カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体 Download PDF

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JP5844285B2
JP5844285B2 JP2012551221A JP2012551221A JP5844285B2 JP 5844285 B2 JP5844285 B2 JP 5844285B2 JP 2012551221 A JP2012551221 A JP 2012551221A JP 2012551221 A JP2012551221 A JP 2012551221A JP 5844285 B2 JP5844285 B2 JP 5844285B2
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compound
formula
provides
chr
alkyl
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JP2013518815A (ja
JP2013518815A5 (enExample
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ジャン−ミシェル ベルニエ，
ジャン−ミシェル ベルニエ，
マーサ デラローサ，
マーサ デラローサ，
ホアンミン チェン，
ホアンミン チェン，
チム チェン ウー，
チム チェン ウー，
ゲイリー リー ラーソン，
ゲイリー リー ラーソン，
イアン ウェイン チェイニー，
イアン ウェイン チェイニー，
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バレアント ファーマシューティカルズ インターナショナル
バレアント ファーマシューティカルズ インターナショナル
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP2012551221A 2010-02-01 2011-01-25 カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体 Active JP5844285B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/698,070 2010-02-01
US12/698,070 US8993593B2 (en) 2006-08-23 2010-02-01 N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
PCT/US2011/022345 WO2011094186A1 (en) 2010-02-01 2011-01-25 Derivatives of 4-(n-azacycloalkyl) aniilides as potassium channel modulators

Publications (3)

Publication Number Publication Date
JP2013518815A JP2013518815A (ja) 2013-05-23
JP2013518815A5 JP2013518815A5 (enExample) 2014-02-27
JP5844285B2 true JP5844285B2 (ja) 2016-01-13

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JP2012551221A Active JP5844285B2 (ja) 2010-02-01 2011-01-25 カリウムチャネルモジュレーターとしての４−（ｎ−アザシクロアルキル）アニリドの誘導体

Country Status (12)

Country Link
US (1) US8993593B2 (enExample)
EP (1) EP2531024A4 (enExample)
JP (1) JP5844285B2 (enExample)
KR (1) KR101841989B1 (enExample)
CN (1) CN102869250A (enExample)
AU (1) AU2011209731A1 (enExample)
BR (1) BR112012019199A2 (enExample)
CA (1) CA2788712C (enExample)
EA (1) EA201290748A1 (enExample)
MX (1) MX2012008969A (enExample)
SG (1) SG182799A1 (enExample)
WO (1) WO2011094186A1 (enExample)

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CN113698345B (zh) * 2021-10-27 2022-02-01 上海挚盟医药科技有限公司 作为钾通道调节剂的化合物及其制备和应用
JP7294734B2 (ja) * 2021-10-27 2023-06-20 シャンハイ ジムン バイオファーマ，インコーポレーテッド カリウムチャネル調節剤としての化合物ならびにその調製および応用
WO2023125935A1 (zh) * 2021-12-31 2023-07-06 上海翰森生物医药科技有限公司 苯并哌啶衍生物调节剂、其制备方法和应用
CN116535353A (zh) * 2022-01-25 2023-08-04 上海挚盟医药科技有限公司 作为钾通道调节剂的酰胺类化合物及其制备和应用
TW202404583A (zh) 2022-06-08 2024-02-01 加拿大商再諾製藥公司 吡啶胺衍生物及其作為鉀通道調節劑之用途
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WO2011094186A1 (en) 2011-08-04
EP2531024A1 (en) 2012-12-12
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US20110003850A1 (en) 2011-01-06
CN102869250A (zh) 2013-01-09
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KR20120123695A (ko) 2012-11-09
AU2011209731A1 (en) 2012-08-23
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US8993593B2 (en) 2015-03-31
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