CN102863428B - 作为丙型肝炎病毒抑制剂的螺环化合物 - Google Patents
作为丙型肝炎病毒抑制剂的螺环化合物 Download PDFInfo
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- CN102863428B CN102863428B CN201210239748.8A CN201210239748A CN102863428B CN 102863428 B CN102863428 B CN 102863428B CN 201210239748 A CN201210239748 A CN 201210239748A CN 102863428 B CN102863428 B CN 102863428B
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- 0 CC*(*)=C(CCI=C)Nc(*1c2NC(C)C(*)(CCC(*)C*)*1)ccc2NC1*(*)C*C1 Chemical compound CC*(*)=C(CCI=C)Nc(*1c2NC(C)C(*)(CCC(*)C*)*1)ccc2NC1*(*)C*C1 0.000 description 23
- TZGQDLUKXXHZLM-UHFFFAOYSA-N C(C1)CNC1c1ncc(-c(cc2)ccc2-c(c(C2)c3CC22CCCCC2)ccc3-c2cnc(C3NCCC3)[nH]2)[nH]1 Chemical compound C(C1)CNC1c1ncc(-c(cc2)ccc2-c(c(C2)c3CC22CCCCC2)ccc3-c2cnc(C3NCCC3)[nH]2)[nH]1 TZGQDLUKXXHZLM-UHFFFAOYSA-N 0.000 description 1
- BKQXDGIRKKLXPD-FCUFFLNPSA-N CC(C)C(C(N(CCC1)[C@@H]1c1ncc(-c(cc2)ccc2-c(cc2)c(CC3(CCCC3)C3)c3c2-c(cc2)nc3c2nc([C@H](CCC2)N2C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[nH]1)=O)NC(OC)=O Chemical compound CC(C)C(C(N(CCC1)[C@@H]1c1ncc(-c(cc2)ccc2-c(cc2)c(CC3(CCCC3)C3)c3c2-c(cc2)nc3c2nc([C@H](CCC2)N2C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[nH]1)=O)NC(OC)=O BKQXDGIRKKLXPD-FCUFFLNPSA-N 0.000 description 1
- LNLSIXKNYQWOSP-UHFFFAOYSA-N CC(C)C(C(N1CCCC1)=O)NC(OC)=O Chemical compound CC(C)C(C(N1CCCC1)=O)NC(OC)=O LNLSIXKNYQWOSP-UHFFFAOYSA-N 0.000 description 1
- ZZTQFDYTFSLDIW-SWEGCAAESA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(ccc(-c(cc2)c(CC3(CCCC3)C3)c3c2-c2ccc(-c3cnc(C(CCC4)N4C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[s]2)c2)c2[nH]1)=O)NC(O)OC Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(ccc(-c(cc2)c(CC3(CCCC3)C3)c3c2-c2ccc(-c3cnc(C(CCC4)N4C([C@H](C(C)C)NC(OC)=O)=O)[nH]3)[s]2)c2)c2[nH]1)=O)NC(O)OC ZZTQFDYTFSLDIW-SWEGCAAESA-N 0.000 description 1
- GAEXLMLKMSWIHP-SXWICGLRSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(-c(cc2)ccc2-c(c2c3CC4(CCCC4)C2)ccc3-c2cnc(C(CCC3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1ncc(-c(cc2)ccc2-c(c2c3CC4(CCCC4)C2)ccc3-c2cnc(C(CCC3)N3C([C@H](C(C)C)NC(OC)=O)=O)[nH]2)[nH]1)=O)NC(OC)=O GAEXLMLKMSWIHP-SXWICGLRSA-N 0.000 description 1
- UMBLZBRILIAXJS-QXSHOWHUSA-N CC(C)[C@@H](C(N(C[C@@H](C1)F)[C@@H]1C(OCC(c(cc1)ccc1-c(cc1)c(CC2(CCCC2)C2)c2c1C(COC(C(C[C@H](C1)F)N1C([C@H](C(C)C)NC(OC)=O)=O)=O)=O)=O)=O)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(C[C@@H](C1)F)[C@@H]1C(OCC(c(cc1)ccc1-c(cc1)c(CC2(CCCC2)C2)c2c1C(COC(C(C[C@H](C1)F)N1C([C@H](C(C)C)NC(OC)=O)=O)=O)=O)=O)=O)=O)NC(OC)=O UMBLZBRILIAXJS-QXSHOWHUSA-N 0.000 description 1
- UBVLNROZKCSHAX-HRDYMLBCSA-N CC(C)[C@H](C(N(C[C@@H](C1)F)[C@@H]1C(O)=O)=O)NC(OC)=O Chemical compound CC(C)[C@H](C(N(C[C@@H](C1)F)[C@@H]1C(O)=O)=O)NC(OC)=O UBVLNROZKCSHAX-HRDYMLBCSA-N 0.000 description 1
- BEVCCTNFEGQILN-UHFFFAOYSA-N CC(CC1)CCC1(Cc1c(C)ccc(C)c11)C1=O Chemical compound CC(CC1)CCC1(Cc1c(C)ccc(C)c11)C1=O BEVCCTNFEGQILN-UHFFFAOYSA-N 0.000 description 1
- BSRPVFPQWOQTIW-UHFFFAOYSA-N CN(CCC1)C1I Chemical compound CN(CCC1)C1I BSRPVFPQWOQTIW-UHFFFAOYSA-N 0.000 description 1
- NCPLSOPWOCTMOU-UHFFFAOYSA-N Cc1nc(CCOc2c-3ccc(C)c2)c-3[nH]1 Chemical compound Cc1nc(CCOc2c-3ccc(C)c2)c-3[nH]1 NCPLSOPWOCTMOU-UHFFFAOYSA-N 0.000 description 1
- FAGLOQMYSBDWGF-UHFFFAOYSA-N O=C(CBr)c(cc1)ccc1-c(cc1)c(CC2(C3)CCCCC2)c3c1C(CBr)=O Chemical compound O=C(CBr)c(cc1)ccc1-c(cc1)c(CC2(C3)CCCCC2)c3c1C(CBr)=O FAGLOQMYSBDWGF-UHFFFAOYSA-N 0.000 description 1
- GIIDWCACMFAQJR-UHFFFAOYSA-N O=C(CBr)c(cc1)ccc1-c(cc1)c(CC2(CCCC2)C2)c2c1C(CBr)=O Chemical compound O=C(CBr)c(cc1)ccc1-c(cc1)c(CC2(CCCC2)C2)c2c1C(CBr)=O GIIDWCACMFAQJR-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210239748.8A CN102863428B (zh) | 2011-07-09 | 2012-07-09 | 作为丙型肝炎病毒抑制剂的螺环化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110195113 | 2011-07-09 | ||
| CN201110195113.8 | 2011-07-09 | ||
| CN201210239748.8A CN102863428B (zh) | 2011-07-09 | 2012-07-09 | 作为丙型肝炎病毒抑制剂的螺环化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102863428A CN102863428A (zh) | 2013-01-09 |
| CN102863428B true CN102863428B (zh) | 2014-12-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210239748.8A Active CN102863428B (zh) | 2011-07-09 | 2012-07-09 | 作为丙型肝炎病毒抑制剂的螺环化合物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9303061B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2730572B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2014520822A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140053166A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102863428B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012283609B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014000563A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2841095A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI482766B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013007106A1 (cg-RX-API-DMAC7.html) |
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| US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| EP3495366A1 (en) * | 2011-07-15 | 2019-06-12 | Shionogi & Co., Ltd | Azabenzimidazole derivative having ampk-activating activity |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| TWI610916B (zh) * | 2012-08-03 | 2018-01-11 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的橋環化合物及其在藥物中的應用 |
| TW201412709A (zh) * | 2012-09-28 | 2014-04-01 | Sunshine Lake Pharma Co Ltd | 作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用 |
| TWI585082B (zh) * | 2012-11-29 | 2017-06-01 | 廣東東陽光藥業有限公司 | 作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們的用途 |
| TW201439060A (zh) * | 2013-02-27 | 2014-10-16 | Sunshine Lake Pharma Co Ltd | 作爲丙型肝炎抑制劑的橋環化合物及其藥物組合物和用途 |
| CN105837561B (zh) * | 2013-06-06 | 2019-06-28 | 上海爱博医药科技有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| CN105530933B (zh) | 2013-07-17 | 2018-12-11 | 百时美施贵宝公司 | 用于治疗hcv的包含联苯衍生物的组合产品 |
| US9738629B2 (en) | 2014-01-23 | 2017-08-22 | Sunshine Lake Pharma Co., Ltd. | Bridged ring compounds as Hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof |
| CN104860931A (zh) * | 2014-02-21 | 2015-08-26 | 常州寅盛药业有限公司 | 丙肝病毒抑制剂及其制药用途 |
| CN105085493A (zh) * | 2014-04-15 | 2015-11-25 | 广东东阳光药业有限公司 | 作为丙型肝炎抑制剂的螺环化合物及其在药物中的应用 |
| WO2015184644A1 (zh) * | 2014-06-06 | 2015-12-10 | 爱博新药研发(上海)有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
| US10100027B2 (en) | 2014-09-26 | 2018-10-16 | Changzhou Yinsheng Pharmaceutical Co., Ltd. | Benzofuran analogue as NS4B inhibitor |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN106432195B (zh) * | 2015-08-12 | 2020-01-14 | 杭州民生药物研究院有限公司 | 一种制备(r)-2-(2-甲基吡咯烷-2-基)-1h-苯并咪唑-4-甲酰胺的方法 |
| CN105461701A (zh) * | 2015-12-14 | 2016-04-06 | 上海步越化工科技有限公司 | 一种抗丙肝新药达卡他韦新的合成方法 |
| CN105622583A (zh) * | 2015-12-22 | 2016-06-01 | 苏州步跃医药科技有限公司 | 一种抗丙肝新药达卡他韦新的制备方法 |
| CN112225778A (zh) * | 2020-10-26 | 2021-01-15 | 辰欣药业股份有限公司 | 一种马来酸依那普利的制备方法 |
| CN116120272A (zh) * | 2022-12-31 | 2023-05-16 | 淮北师范大学 | 一种合成咯菌腈中间体2,2-二氟-1,3-苯并二噁茂-4-甲醛的方法 |
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| BR112013007696A2 (pt) | 2010-09-29 | 2019-09-24 | Merck Sharp & Dohme | composto, composição farmacêutica, usos do referido composto e da referida composição |
| JP2013540122A (ja) | 2010-09-29 | 2013-10-31 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合四環式化合物誘導体およびウィルス疾患治療のためのそれの使用方法 |
| WO2012040924A1 (en) | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Fused tetracyclic heterocycle compounds and methods of use thereof for treatment of viral diseases |
| WO2012050918A2 (en) | 2010-09-29 | 2012-04-19 | Presidio Pharmaceutical, Inc. | Tricyclic fused ring inhibitors of hepatitis c |
| EP2621932A4 (en) | 2010-09-29 | 2014-03-26 | Merck Sharp & Dohme | TETRACYCLIC HETEROCYCLUS COMPOUNDS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS |
| US8841275B2 (en) * | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
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| EP2651926A4 (en) | 2010-12-15 | 2014-07-09 | Abbvie Inc | ANTI-VIRAL COMPOUNDS |
| CA2821973A1 (en) | 2010-12-16 | 2012-06-21 | Abbvie Inc. | Anti-viral compounds |
| WO2012122716A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
| WO2013022810A1 (en) | 2011-08-08 | 2013-02-14 | Glaxosmithkline Llc | Chemical compounds |
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| KR20210043734A (ko) | 2011-11-16 | 2021-04-21 | 길리애드 파마셋 엘엘씨 | 항바이러스성 화합물로서의 축합된 이미다졸릴이미다졸 |
| AU2012360905B2 (en) | 2011-12-28 | 2017-04-27 | Janssen Sciences Ireland Uc | Hetero-bicyclic derivatives as HCV inhibitors |
| NZ628515A (en) | 2012-02-10 | 2016-06-24 | Lupin Ltd | Antiviral compounds with a dibenzooxaheterocycle moiety |
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2012
- 2012-07-09 CN CN201210239748.8A patent/CN102863428B/zh active Active
- 2012-07-09 JP JP2014519378A patent/JP2014520822A/ja active Pending
- 2012-07-09 WO PCT/CN2012/000945 patent/WO2013007106A1/zh not_active Ceased
- 2012-07-09 TW TW101124685A patent/TWI482766B/zh not_active IP Right Cessation
- 2012-07-09 US US14/130,320 patent/US9303061B2/en not_active Expired - Fee Related
- 2012-07-09 CA CA2841095A patent/CA2841095A1/en not_active Abandoned
- 2012-07-09 BR BR112014000563-0A patent/BR112014000563A2/pt not_active Application Discontinuation
- 2012-07-09 KR KR1020147002974A patent/KR20140053166A/ko not_active Withdrawn
- 2012-07-09 EP EP12811420.4A patent/EP2730572B1/en not_active Not-in-force
- 2012-07-09 AU AU2012283609A patent/AU2012283609B2/en not_active Ceased
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| US20140147412A1 (en) | 2014-05-29 |
| CA2841095A1 (en) | 2013-01-17 |
| AU2012283609B2 (en) | 2016-09-29 |
| KR20140053166A (ko) | 2014-05-07 |
| JP2014520822A (ja) | 2014-08-25 |
| EP2730572A1 (en) | 2014-05-14 |
| US9303061B2 (en) | 2016-04-05 |
| AU2012283609A1 (en) | 2014-02-20 |
| TWI482766B (zh) | 2015-05-01 |
| EP2730572B1 (en) | 2015-09-16 |
| TW201302731A (zh) | 2013-01-16 |
| WO2013007106A1 (zh) | 2013-01-17 |
| HK1191935A1 (en) | 2014-08-08 |
| EP2730572A4 (en) | 2014-12-10 |
| CN102863428A (zh) | 2013-01-09 |
| BR112014000563A2 (pt) | 2019-12-10 |
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Application publication date: 20130109 Assignee: Ru Yuan Dongyang light pharmaceutcal corporation, Ltd Assignor: Dongyangguang Pharmaceutical Co., Ltd., Guangdong Contract record no.: 2015440000197 Denomination of invention: Spiro-compounds taken as hepatitis c virus (HCV) inhibitor Granted publication date: 20141224 License type: Exclusive License Record date: 20150604 |
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