CN102834108A - 用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物 - Google Patents

用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物 Download PDF

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CN102834108A
CN102834108A CN2011800170897A CN201180017089A CN102834108A CN 102834108 A CN102834108 A CN 102834108A CN 2011800170897 A CN2011800170897 A CN 2011800170897A CN 201180017089 A CN201180017089 A CN 201180017089A CN 102834108 A CN102834108 A CN 102834108A
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aminoacid
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R.D.迪马基
马涛
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Indiana University Research and Technology Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Genetics & Genomics (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
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  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2011800170897A 2010-01-27 2011-01-26 用于治疗代谢紊乱和肥胖症的胰高血糖素拮抗剂-gip激动剂偶联物和组合物 Pending CN102834108A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29881210P 2010-01-27 2010-01-27
US61/298,812 2010-01-27
PCT/US2011/022608 WO2011094337A1 (en) 2010-01-27 2011-01-26 Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity

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CN102834108A true CN102834108A (zh) 2012-12-19

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EP (1) EP2528618A4 (US07919591-20110405-C00054.png)
JP (2) JP2013518115A (US07919591-20110405-C00054.png)
KR (1) KR20120123443A (US07919591-20110405-C00054.png)
CN (1) CN102834108A (US07919591-20110405-C00054.png)
BR (1) BR112012018585A2 (US07919591-20110405-C00054.png)
CA (1) CA2788304A1 (US07919591-20110405-C00054.png)
IN (1) IN2012DN06437A (US07919591-20110405-C00054.png)
MX (1) MX2012008603A (US07919591-20110405-C00054.png)
RU (1) RU2012136450A (US07919591-20110405-C00054.png)
WO (1) WO2011094337A1 (US07919591-20110405-C00054.png)

Cited By (8)

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CN104902919A (zh) * 2012-12-21 2015-09-09 赛诺菲 Glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂
CN105440102A (zh) * 2014-09-24 2016-03-30 中国科学院大连化学物理研究所 一种源于鹿皮的具有dpp-iv抑制活性的多肽及其应用
CN105504009A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种源于鹿筋的具有dpp-iv抑制活性的多肽及其应用
CN105504011A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的多肽及其在降血糖药物中的应用
CN105504010A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的多肽及其应用
CN105504008A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的鹿肽及其应用
US9339482B2 (en) 2013-11-22 2016-05-17 Regents Of The University Of Minnesota Methods to treat dysregulated blood glucose disorders
CN108210988A (zh) * 2018-03-08 2018-06-29 武汉职业技术学院 一种鱼皮胶原制备医用止血海绵的新工艺

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CN105504011A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的多肽及其在降血糖药物中的应用
CN105504010A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的多肽及其应用
CN105504008A (zh) * 2014-09-24 2016-04-20 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的鹿肽及其应用
CN105504008B (zh) * 2014-09-24 2018-09-21 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的鹿肽及其应用
CN105504011B (zh) * 2014-09-24 2018-09-25 中国科学院大连化学物理研究所 一种具有dpp-iv抑制活性的多肽及其在制备降血糖药物中的应用
CN105504009B (zh) * 2014-09-24 2018-10-09 中国科学院大连化学物理研究所 一种源于鹿筋的具有dpp-iv抑制活性的多肽及其应用
CN108210988A (zh) * 2018-03-08 2018-06-29 武汉职业技术学院 一种鱼皮胶原制备医用止血海绵的新工艺

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