CN102813771A - Preparation method of traditional Chinese medicine for treating hydroncus type acute glomerulonephritis - Google Patents

Abstract

The invention relates to a preparation method of a traditional Chinese medicine for treating hydroncus type acute glomerulonephritis, belonging to the technical field of preparation methods of traditional Chinese medicines. At present, penicillin is generally adopted for treating hydroncus type acute glomerulonephritis, but penicillin can easily cause allergic reaction, especially allergic shock, and if rescue is not performed in time, life may be threatened. The technical scheme adopted in the invention is as follows: taking pericarpium arecae, muskroot-like semiaquilegia root, akebiaquinata, pyrrosia lingua, spirifer, scincid, waxgourd peel, cluster mallow fruit, fructus kochiae, cerealose, holly leaves, lotus seed, codonopsis pilosula, mulberry, astragalus mongholicus, black soybean and liquorice, soaking the 28 kinds of traditional Chinese medicines in water, and decocting with slow fire, wherein the decocted liquid medicine is the traditional Chinese medicine for treating hydroncus type acute glomerulonephritis. The traditional Chinese medicine for treating hydroncus type acute glomerulonephritis has the advantages of short course of treatment and high cure rate. Assistant and guide are achieved so that the function is just right. When the traditional Chinese medicine is applied, adverse reaction, allergic reaction and toxic reaction caused by Western medicine are avoided.

Description

A kind of Chinese medicinal preparation method of treating the edema type acute glomerulonephritis

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, is a kind of Chinese medicinal preparation method of treating the edema type acute glomerulonephritis more specifically.

Background technology

Treatment edema type acute glomerulonephritis generally adopts: 1, penicillin: easy allergy, particularly anaphylactic shock (the most dangerous anaphylactic shock that takes place of these article at present; Can occur in and do tuerculoderma at that time, only a few can occur in the continuous use process, the Delayed Hypersensitivity shock); Like untimely rescue; Can critical life, thus all to improve protection before, during and after the medication, so as to avoid an accident.Attention: before the application, must ask to have or not anaphylactic disease clearly,, must do the penicillin skin test earlier with having or not allergy such as erythra, heating to occur behind the penicillin.2, amoxicillin: accidental erythra, oral can have nauseating, epigastric discomfort, diarrhoea etc. after a large amount of; Pseudomembranous colitis.3, captopril: important side effect is Toxicity of Kidney and granulocytopenia, is erythra, dysgeusia and cough secondly.Heavy dose can cause hemodynamic change, symptomatic hypotension etc.4, hydrochlorothiazide: the low blood chlorine of 1. hypokalemia, and normal companion, hypomagnesemia, hypokalemia can bring out hepatic coma and Folium Digitalis Purpureae institute proarrhythmia, needs timely kalium replenishment or add to stay the potassium diuretic; 2. hyperglycemia reduces carbohydrate tolerance; 3. symptom can brought out or increase the weight of to hyperuricemia to the goat image; 4. azotemia because of reducing glomerular filtration rate, increases the weight of azotemia and renal function is further worsened the renal insufficiency patient, and these article diuretic effect is poor, so careful usefulness of renal failure patient or forbidding; 5. ammonirrhea reduces, and possibly the H+ secretion reduced because of suppressing carbonic anhydrase, and the ammonia secretion also reduces.During hepatic disfunction, can bring out hepatic coma; 6. parathyroid gland effect: take for a long time and can cause hypercalcemia, low serum p disease and parathyroid hyperplasia; 7. other: skin erythema, photoallergic dermatitis, pancreatitis, intrahepatic cholestasis, bone marrow depression, especially thrombocytopenia can cause the announcements that all appear in the newspapers such as purpura, neutrophilic granulocyte minimizing, hemolytic anemia of newborn, the serum anti antinuclear antibodies positive.5, reserpine: nasal obstruction, gastric acid secretion increase, times of defecation increases and aroused in interest slack-off etc., even apathetic expression can appear in long-term extensive application, drowsiness, spirit depressing causes EPS, the performance muscular tremor.1. to activeness Peptic Ulcers and dysthymia person's forbidding; 2. reserpine can get into fetal tissue through Placenta Hominis, if the antenatal application of anemia of pregnant woman can cause neonate nasal obstruction, respiratory tract obstruction, should try one's best need not.6, carbenicillin: various types of allergy can occur.Possibly cause neural poison reaction, pulmonary edema after heavy dose of administration, possibly occur the transience transaminase during the medication and raise and granulocytopenia.

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method of treating the edema type acute glomerulonephritis.Acute glomerulonephritis is called for short acute nephritis, is one group of common glomerule illness.Onset is anxious, is its Clinical symptoms with hematuria, oliguria, albuminuria, edema and hypertension etc.Acute nephritis can be because of due to the Different types of etiopathogenises, and wherein modal is post-streptococcal infection nephritis, and other causes of disease still have antibacterial (like staphylococcus), virus (like hepatitis B virus), protozoon (like plasmodium) etc.Primary disease belongs to " edema due to wind pathogen ", the category of " YANG edema " and " hematuria " in the Chinese medicine " edema ".

Etiology and pathogenesis:Acute glomerulonephritis is a main clinical manifestation with hematuria, edema,proteinuria,hypertension.Human liquid's metabolism relies on the logical of lung qi to transfer, the transferring of temper, and opening of kidney qi is entire, thereby makes its duty of certainly showing disrespect on of three warmers performance.Ailment said due to cold or exposure, water are wet in order to experience for the primary disease cause of disease, noxious dampness, damp and hot heresy, invasion and attack flesh table, and internal injury is in lung, impairment of dispersing and descending function of the lung; Or in belong to spleen, spleen loses fortuneization; Under injure kidney, kidney loses folding, disturbance in water passage then, and be edema.In the acute nephritis edema stage, the main diseases position is main at lung, spleen with inhibited pulmonary QI.If hematuria is obvious, how by the damp-heat accumulation bladder, injury of blood collaterals by heat is due to venation is impaired.If the intenseness of heat wind symptom, disturb sun clearly on the wind-fire, dizziness headache then appears, even the evil cards of violating conscience such as convulsions, coma.Spleen-QI failing to rise up, deficiency of kidney-QI, smart closing admittedly, albuminuria then appears in the separating clear and excreting turbid dereliction of duty.So the sick position of primary disease is dirty at lung, spleen, kidney three, syndrome develop be from table and in, reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels by the part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, develop to simulataneous insufficiency and excessive from real.Owing to occupying wetland for a long time or paddling in spite of the rain, to invade in the gas that water wets, the spleen being blocked by dampness loses in strong fortune, and sends out primary disease.

Clinical manifestation:The puffiness of the eyes, extremity are all swollen to be main.Onset is more anxious, and state of an illness weight does not wait.Most of patients has clear and definite streptococcal infection history, like upper respiratory tract infection, pharyngitis, tonsillitis and skin infection etc.Sudden onset, mostly first symptom is edema and hematuria.1, edema: the lighter only plays blepharoedema morning, and complexion is paler, is " nephritis face ".Weight person prolongs and whole body, and finger pressure skin can not have significant depressions, and body weight also increases thereupon.2, hypertension: be shown in 80% case, be mostly light moderate hypertension, diastolic pressure is less than 14kpa.Mostly the hypertension of acute nephritis is a property crossed, and the generation reason is mainly water, sodium retention makes due to the blood volume expansion.3, urine is unusual: 1. oliguria: the most of patients onset has oliguria often, as every day the urine amount be less than 500ml person, but the had slight azotemia.2. hematuria: be shown in all acute nephritis patients, can be gross hematuria, or muddy coffee-like, general persistence is not long, promptly transfers microscopic hematuria to.3. albuminuria: most of patients all has 4. whole body performance of albuminuria in various degree: tired, lumbago, anorexia, feel sick, vomiting, the person of being in a bad way can have headache, dizziness, drowsiness, blurred vision etc.Red tongue, yellow fur, rapid pulse.

Its technical scheme is:Get Pericarpium Arecae 9 weight portions, Radix Semiaquilegiae 1 weight portion, Caulis Akebiae 6 weight portions, Folium Pyrrosiae 1 weight portion, Fossilia Spiriferis 1 weight portion, Eumeces Chinensis 1 weight portion, Exocarpium Benincasae 6 weight portions, Semen Abutili 1 weight portion, the Fructus Kochiae 1 weight portion, Folium seu Cortex Nerii 0.5 weight portion, Herba Polygoni Perfoliati 6 weight portions, Medulla Junci 6 weight portions, Herba Hydrocotylis 3 weight portions, Caulis Aristolochiae Manshuriensis 3 weight portions, Semen Phaseoli 6 weight portions, Herba Lysimachiae 6 weight portions, Rhizoma Alismatis 6 weight portions, Poria 6 weight portions, Ganoderma lucidum seu Japonicum 6 weight portions, Ovum Gallus domesticus Flavus 3 weight portions, maltose 3 weight portions, Folium Ilicis Cornutae 3 weight portions, Semen Nelumbinis 6 weight portions, Radix Codonopsis 9 weight portions, Fructus Mori 6 weight portions, the Radix Astragali 6 weight portions, Semen sojae atricolor 6 weight portions and Radix Glycyrrhizae 9 weight portions; Above 28 flavor Chinese medicines are put into 1800 ml waters; Soaked 35 minutes; Slow fire is fried 30 minutes then; Boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of treatment edema type acute glomerulonephritis.

The advantage of this invention is:We's 28 flavor Chinese medicines all can have been bought in pharmacy, make simply, and the herb liquid toxic and side effects of processing is little, short treating period, and cure rate is high.Monarch, just right.When using Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine to cause.Pericarpium Arecae, Radix Semiaquilegiae, Caulis Akebiae, Folium Pyrrosiae, Fossilia Spiriferis, Eumeces Chinensis, Exocarpium Benincasae, Semen Abutili, the Fructus Kochiae, Folium seu Cortex Nerii, Herba Polygoni Perfoliati, Medulla Junci, Herba Hydrocotylis, Caulis Aristolochiae Manshuriensis, Semen Phaseoli, Herba Lysimachiae, Rhizoma Alismatis, Poria; More than 18 flavor medical instruments the effect of therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, inducing diuresis to remove edema, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, warming YANG to promote diuresis, relieving stranguria by diuresis, eliminating dampness and diuresis, mind tranquilizing and the heart calming, strong lean marrow is arranged; In the process of treatment edema type acute glomerulonephritis; Play main therapeutical effect, so be monarch drug.Ganoderma lucidum seu Japonicum, Ovum Gallus domesticus Flavus, maltose, Folium Ilicis Cornutae, Semen Nelumbinis, Radix Codonopsis, Fructus Mori, the Radix Astragali, more than 8 flavor medical instruments the effect of kidney tonifying complement, strengthening body resistance and dispelling evil, the strengthening the spleen that nourishes heart, replenishing QI to invigorate the spleen, liver and kidney tonifying, life lengthening is arranged.In the process of treatment edema type acute glomerulonephritis, can assist principal agent performance therapeutical effect, so be ministerial drug.Semen sojae atricolor: sweet, flat.Go into kidney, spleen two warps.The diuretic therapeutic method to keep the adverse QI flowing downwards, the kidney invigorating is moisturized in the detoxifcation of dispeling the wind.The through focus of all medicines of energy rate is so be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.The bias of all medicines can be entangled, the toxicity of all medicines can be alleviated again, so be messenger drug.Pericarpium Arecae, Radix Semiaquilegiae, Caulis Akebiae, Folium Pyrrosiae, Fossilia Spiriferis, Eumeces Chinensis, Exocarpium Benincasae, Semen Abutili, the Fructus Kochiae, Folium seu Cortex Nerii, Herba Polygoni Perfoliati, Medulla Junci, Herba Hydrocotylis, Caulis Aristolochiae Manshuriensis, Semen Phaseoli, Herba Lysimachiae, Rhizoma Alismatis, Poria, Ganoderma lucidum seu Japonicum, Ovum Gallus domesticus Flavus, maltose, Folium Ilicis Cornutae, Semen Nelumbinis, Radix Codonopsis, Fructus Mori, the Radix Astragali, Semen sojae atricolor, Radix Glycyrrhizae, more than 28 flavor medical instruments therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, inducing diuresis to remove edema, clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, relieving cough and asthma, strong lean marrow, kidney tonifying complement, the strengthening the spleen that nourishes heart, replenishing QI to invigorate the spleen, supplementing QI for promoting the production of body fluid, liver and kidney tonifying are arranged, increase the effect that liquid promotes the production of body fluid.Monarch, compatibility is proper, is the optimum formula of treatment edema type acute glomerulonephritis.Pericarpium Arecae: suffering, tepor.Go into spleen, stomach, large and small intestinal warp.Therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, inducing diuresis to remove edema.Radix Semiaquilegiae: sweet, bitter, cold.Go into spleen, small intestinal, urinary bladder channel.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, relieving cough and asthma, eliminating stagnation lactogenesis, clearing away heat and relieving the wind syndrome.Caulis Akebiae: bitter, cold.Go into the heart, lung, small intestinal, urinary bladder channel.Pathogenic fire reducing diuresis, the stimulating milk secretion of stimulating the menstrual flow, inducing diuresis to remove edema, activating blood circulation and unblocking obstruction, heat-clearing and toxic substances removing.Folium Pyrrosiae: bitter, sweet, cool.Go into lung, urinary bladder channel.Relieving stranguria by diuresis, removing heat from the lung and dissipating phlegm, clearing away heat to stop bleeding.Fossilia Spiriferis: salty, sweet, cold; Nontoxic.Go into kidney, Liver Channel.Treating stranguria, the nebula removing of drying disappear barrier, leukorrhagia stopping stimulates the menstrual flow.Eumeces Chinensis: salty, cold, poisonous.Go into kidney, spleen channel.Broken knot row water, removing toxic substances and promoting subsidence of swelling, kidney invigorating and YANG supporting.Exocarpium Benincasae: sweet, light, cool.Go into lung, kidney, urinary bladder channel.Inducing diuresis to remove edema, clearing and antitussive.Semen Abutili: sweet, cold.Go into large intestine, small intestinal, urinary bladder channel.Row neatly intestinal, lactogenesis, clearing away heat and discharging pus.The Fructus Kochiae: sweet, bitter, cold, nontoxic.Go into kidney, urinary bladder channel.Dehumidifying diuresis, heat-clearing and toxic substances removing, beneficial smart reinforcing YIN-essence.Folium seu Cortex Nerii: hot, warm, poisonous.Go into the heart, lung, kidney channel.Warming YANG to promote diuresis, eliminating phlegm and relieving asthma, eliminating stasis to stop pain, spasmolytic relieve dizziness, high fever, infantile convulsions, epilepsy, etc.Herba Polygoni Perfoliati: sour, bitter, cold, flat.Go into kidney, large intestine, bladder, lung, Liver Channel.Inducing diuresis to remove edema, heat-clearing and toxic substances removing, dampness removing jaundice eliminating.Medulla Junci: sweet, light, be slightly cold.Go into the heart, lung, small intestine meridian.Inducing diuresis for treating stranguria syndrome, clearing heat and relieving fidgetness.Herba Hydrocotylis: salty, sweet, cold.Go into liver, kidney, urinary bladder channel.Relieving stranguria by diuresis, damp eliminating heat and jaundice eliminating.Caulis Aristolochiae Manshuriensis: bitter, cold.Go into the heart, small intestinal, urinary bladder channel.Clearing away heat and promoting diuresis, promoting blood circulation.Semen Phaseoli: sweet, sour, flat.Go into the heart, small intestine meridian.Drying damp and strengthening spleen, treatment carbuncle, galactostasis, the tired pain in joint.Herba Lysimachiae: bitter, hot, cold.Go into liver, gallbladder, kidney, bladder, lung meridian.Clearing away heat and promoting diuresis, dampness removing jaundice eliminating, treating stranguria and eliminating stone, relieving cough and resolving phlegm, relaxing muscles and tendons and activating QI and blood in the collateral, subduing swelling and detoxicating.Rhizoma Alismatis: sweet, light, cold.Go into kidney, urinary bladder channel.Promoting diuresis to eliminate damp pathogen, expel the heat-evil, clever knowledge.Poria: sweet, light, flat.Go into the heart, spleen, lung, bladder, three warmers, stomach the six channels.Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, strong lean marrow.Ganoderma lucidum seu Japonicum: sweet, flat.Go into kidney, liver, the heart, lung four warps.Ear is filled in refreshing, the hard muscle profit of the smart guarantor of benefit face, the kidney invigorating, eliminating impediment dispels the wind.Ovum Gallus domesticus Flavus: sweet, flat.Go into the heart, kidney channel.Nourshing Yin and drynsessmoistening prescription, nourishing blood for calming endogenous wind, clearing away heat to cure dysentery, removing heat from blood leak-stopping, clearing heat for detumescence.Maltose: sweet, temperature.Go into spleen, stomach, lung meridian.Pain relieving, QI invigorating tonify deficiency in slow, promote the production of body fluid moisturize, main tonify deficiency lacks, disappears ossified thorn.Folium Ilicis Cornutae: hardship, flat.Go into liver, kidney channel.Nourishing the liver and kidney, benefiting vital QI and blood, expelling wind and removing dampness, nourishing YIN and stopping bleeding, blood circulation promoting and blood stasis dispelling.Semen Nelumbinis: sweet, puckery, flat.Go into the heart, spleen, kidney channel.Spleen reinforcing antidiarrheal, kidney tonifying end something lost, tranquilizing by nourishing the heart.Radix Codonopsis: sweet, flat.Go into lung, spleen channel.Replenishing QI to invigorate the spleen, supplementing QI for promoting the production of body fluid, QI invigorating heat extraction.Fructus Mori: sweet, cold.Go into liver, kidney, heart channel.Liver and kidney tonifying, increase that liquid promotes the production of body fluid, nourishing YIN and benefiting blood, life lengthening.The Radix Astragali: sweet, tepor, nontoxic.Go into lung, spleen channel.Tonifying Qi and lifting yang, hemostasis by invigorating QI, QI invigorating row stagnate, blood stasis removing eliminating stagnation, benefiting QI for strengthening the superficies, QI invigorating tonifying YIN, inducing diuresis to remove edema, warming the interior cold expelling, pus expelling by strengthening vital QI granulation promoting, strong body constitution, life lengthening.Semen sojae atricolor: sweet, flat.Go into kidney, spleen two warps.The diuretic therapeutic method to keep the adverse QI flowing downwards, the kidney invigorating is moisturized in the detoxifcation of dispeling the wind.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.

The specific embodiment

Get Pericarpium Arecae 9g, Radix Semiaquilegiae 1g, Caulis Akebiae 6g, Folium Pyrrosiae 1g, Fossilia Spiriferis 1g, Eumeces Chinensis 1g, Exocarpium Benincasae 6g, Semen Abutili 1g, Fructus Kochiae 1g, Folium seu Cortex Nerii 0.5g, Herba Polygoni Perfoliati 6g, Medulla Junci 6g, Herba Hydrocotylis 3g, Caulis Aristolochiae Manshuriensis 3g, Semen Phaseoli 6g, Herba Lysimachiae 6g, Rhizoma Alismatis 6g, Poria 6g, Ganoderma lucidum seu Japonicum 6g, Ovum Gallus domesticus Flavus 3g, maltose 3g, Folium Ilicis Cornutae 3g, Semen Nelumbinis 6g, Radix Codonopsis 9g, Fructus Mori 6g, Radix Astragali 6g, Semen sojae atricolor 6g and Radix Glycyrrhizae 9g; More than 28 the flavor medicines put into 1800 ml waters together; Soaked 35 minutes; Slow fire is fried 30 minutes then; Filter and remove residue, fried medicinal liquid are the Chinese medicine of treatment edema type acute glomerulonephritis.Boil medicine altogether 390 milliliters of liquid, when the patient of edema type acute glomerulonephritis need treat, making fluid temperature was 36 ℃, each 130 milliliters, oral, every day three times, two is a course of treatment, if symptom is still deposited, obeys for second course of treatment again, so that recovery from illness.

Among the 395 routine edema type acute glomerulonephritis patients, male's 255 examples account for 64.56%; Women's 140 examples account for 35.44%.The male is more than the women.

Table one, 395 routine edema type acute glomerulonephritis patient's age scopes

Age (year)	18～20	21～30	31～50	51～60
					The example number	12	249	131	3
Percentage ratio	3.04%	63.04%	33.16%	0.76%

Table two, 395 routine edema type acute glomerulonephritis patient curative effect tables

Curative effect	Cure	Take a turn for the better	Invalid
				The example number	392	3	Do not have
Percentage ratio	99.24%	0.76%	Do not have

Table three, 395 routine edema type acute glomerulonephritis patients show the course of treatment

The treatment natural law	3～5	6～9	10～15	16～26
					The example number	15	285	92	3
Percentage ratio	3.8%	72.15%	23.29%	0.76%

Information slip before and after table four, the 395 routine edema type acute glomerulonephritis patient treatments

Claims (1)

1. Chinese medicinal preparation method of treating the edema type acute glomerulonephritis; It is characterized in that: get Pericarpium Arecae 9 gram, Radix Semiaquilegiae 1 gram, Caulis Akebiae 6 grams, Folium Pyrrosiae 1 gram, Fossilia Spiriferis 1 gram, Eumeces Chinensis 1 gram, Exocarpium Benincasae 6 grams, Semen Abutili 1 gram, the Fructus Kochiae 1 gram, Folium seu Cortex Nerii 0.5 gram, Herba Polygoni Perfoliati 6 grams, Medulla Junci 6 grams, Herba Hydrocotylis 3 grams, Caulis Aristolochiae Manshuriensis 3 grams, Semen Phaseoli 6 grams, Herba Lysimachiae 6 grams, Rhizoma Alismatis 6 grams, Poria 6 grams, Ganoderma lucidum seu Japonicum 6 grams, Ovum Gallus domesticus Flavus 3 grams, maltose 3 grams, Folium Ilicis Cornutae 3 grams, Semen Nelumbinis 6 grams, Radix Codonopsis 9 grams, Fructus Mori 6 grams, the Radix Astragali 6 gram, Semen sojae atricolor 6 gram and Radix Glycyrrhizae 9 gram; Above 28 flavor Chinese medicines are put into 1800 ml waters; Soaked 35 minutes; Slow fire is fried 30 minutes then; Boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of treatment edema type acute glomerulonephritis.