CN102793866B - Preparation method for traditional Chinese medicine used for treatment of feet oedema type acute glomerulonephritis - Google Patents

Abstract

A preparation method for a traditional Chinese medicine used for the treatment of feet oedema type acute glomerulus nephritis, belongs to the technical field of traditional Chinese medicine preparation methods. Currently, carbenicillin is commonly used for the treatment of the kidney and yin deficient type acute glomerulonephritis, which may cause various types of allergic reactions. The technical scheme of the method is that: soaking the following 29 kinds of Chinese medicine herbs: poria cocos, polyporus, shuan-tsao root, polygonum aviculare, mole cricket, carp, crucian, cricket, Chinese pink herb, coffee senna, common alstonia, lophatherum gracile, mung bean, dandelion, stonecrop, shortstalk slimtop meadowrue root, fruticose breynia juvenile branchlet and leaf, smallleaf desmodium herb, franchet groundcherry calyx and fruit, Chinese twinleaf rhizome, radix rhapontici seu radix echinopsis, olive, drymoglossum subcordatum fee, justicia, gamboges, potentilla discolor, corn silk and licorice in water, and then decocting with slow fire. The decoction is the traditional Chinese medicine used for the treatment of feet oedema type acute glomerulus nephritis. The traditional Chinese medicine has the advantage of short treatment course and high cure rate and sovereign, minister, assistant and courier are just right. By using the traditional Chinese medicine, the adverse reaction, anaphylactic reaction and toxic response caused by using western medicine can be prevented.

Description

A kind of Chinese medicinal preparation method for the treatment of pedal edema type acute glomerulonephritis

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, more specifically a kind of Chinese medicinal preparation method for the treatment of pedal edema type acute glomerulonephritis.

Background technology

Treatment pedal edema type acute glomerulonephritis generally adopts: 1, carbenicillin: various types of allergy can occur at present.May cause neural poison reaction, pulmonary edema after heavy dose of administration, may occur the transience transaminase during the medication and raise and granulocytopenia.2, amoxicillin: accidental erythra, oral can have nauseating, epigastric discomfort, diarrhoea etc. after a large amount of; Pseudomembranous colitis.3, captopril: important side effect is Toxicity of Kidney and granulocytopenia, is erythra, dysgeusia and cough secondly.Heavy dose can cause hemodynamic change, symptomatic hypotension etc.4, penicillin: allergy easily occurs in this product, anaphylactic shock (the most dangerous anaphylactic shock particularly, can occur in and do tuerculoderma at that time, only a few can occur in the continuous use process, Delayed Hypersensitivity shock), such as untimely rescue, can critical life, so all will improve protection before, during and after the medication, so as to avoid an accident.Attention: before the application, must ask to have or not clearly anaphylactic disease, with having or not the allergy such as erythra, heating to occur behind the penicillin, must do first penicillin skin test.5, hydrochlorothiazide: the low blood chlorine of 1. hypokalemia, and normal companion, hypomagnesemia, hypokalemia can bring out hepatic coma and Folium Digitalis Purpureae institute proarrhythmia, needs timely kalium replenishment or add to stay the potassium diuretic; 2. hyperglycemia reduces carbohydrate tolerance; 3. symptom can be brought out or increase the weight of to hyperuricemia to the goat image; 4. azotemia because reducing glomerular filtration rate, increases the weight of azotemia and renal function is further worsened the renal insufficiency patient, and this product diuretic effect is poor, so the careful usefulness of renal failure patient or forbidding; 5. ammonirrhea reduces, and may the H+ secretion be reduced because suppressing carbonic anhydrase, and the ammonia secretion also reduces.During hepatic disfunction, can bring out hepatic coma; 6. parathyroid gland effect: long-term taking can cause hypercalcemia, low serum p disease and parathyroid hyperplasia; 7. other: skin erythema, photoallergic dermatitis, pancreatitis, intrahepatic cholestasis, bone marrow depression, especially thrombocytopenia can cause the announcements that all appear in the newspapers such as purpura, neutrophilic granulocyte minimizing, hemolytic anemia of newborn, the serum antinuclear antibody positive.6, reserpine: nasal obstruction, gastric acid secretion increase, times of defecation increases and aroused in interest slack-off etc., even apathetic expression can appear in long-term extensive application, drowsiness, spirit depressing causes extrapyramidal symptoms, the performance muscular tremor.1. to activeness Peptic Ulcers and dysthymia person's forbidding; 2. reserpine can enter fetal tissue by Placenta Hominis, if the antenatal application of anemia of pregnant woman can cause neonate nasal obstruction, respiratory tract obstruction, should need not as far as possible.

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of pedal edema type acute glomerulonephritis.Acute glomerulonephritis is called for short acute nephritis, is one group of common glomerule illness.Onset is anxious, take hematuria, oliguria, albuminuria, edema and hypertension etc. as its Clinical symptoms.Acute nephritis can be because of due to the Different types of etiopathogenises, and wherein modal is post-streptococcal infection nephritis, and other causes of disease still have antibacterial (such as staphylococcus), virus (such as hepatitis B virus), protozoon (such as plasmodium) etc.Primary disease belongs to " edema due to wind pathogen ", the category of " YANG edema " and " hematuria " in the Chinese medicine " edema ".

Etiology and pathogenesis:Acute glomerulonephritis is take hematuria, edema,proteinuria,hypertension as main clinical manifestation.Human liquid's metabolism relies on the logical of lung qi to transfer, the transferring of temper, and opening of kidney qi is entire, thereby makes three warmers bring into play the duty that it is certainly shown disrespect on.Ailment said due to cold or exposure, water are wet in order to experience for the primary disease cause of disease, noxious dampness, damp and hot heresy, invasion and attack flesh table, and internal injury is in lung, impairment of dispersing and descending function of the lung; Or in be attributed to spleen, spleen loses transporting; Under injure kidney, kidney loses folding, disturbance in water passage then, and be edema.In the acute nephritis edema stage, the main diseases position is at lung, spleen, take inhibited pulmonary QI as main.If hematuria is obvious, how by the damp-heat accumulation bladder, injury of blood collaterals by heat is due to venation is impaired.If the intenseness of heat wind symptom is disturbed clearly sun on the wind-fire, dizziness headache then appears, even the evil cards of violating conscience such as convulsions, coma.Spleen-QI failing to rise up, deficiency of kidney-QI, smart closing admittedly, albuminuria then appears in the separating clear and excreting turbid dereliction of duty.So the sick position of primary disease is dirty at lung, spleen, kidney three, syndrome develop be from table and in, reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels by the part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, develop to simulataneous insufficiency and excessive from real.Because spleen, lung, renal dysfunction, the heresy that water is wet is made a bet and is sent out primary disease.

Clinical manifestation:Pedal edema is main.Onset is more anxious, and state of an illness weight does not wait.Most of patients has clear and definite streptococcal infection history, such as upper respiratory tract infection, pharyngitis, tonsillitis and skin infection etc.Sudden onset, onset symptoms mostly are edema and hematuria.1, edema: the lighter only plays blepharoedema morning, and complexion is paler, is " nephritis face ".Severe one is prolonged and whole body, and finger pressure skin can be without significant depressions, and body weight also increases thereupon.2, hypertension: see 80% case, mostly be light moderate hypertension, diastolic pressure is less than 14kpa.The hypertension of acute nephritis mostly is a property crossed, and the generation reason is mainly water, sodium retention makes due to the blood volume expansion.3, urine is unusual: 1. oliguria: the most of patients onset has oliguria often, as every day the urine amount be less than 500ml person, slight azotemia can appear.2. hematuria: see all acute nephritis patients, can be gross hematuria, or muddy coffee-like, general persistence is not long, namely transfers microscopic hematuria to.3. albuminuria: most of patients all has in various degree 4. whole body performance of albuminuria: tired, lumbago, anorexia, feel sick, vomiting, the person of being in a bad way can have headache, dizziness, drowsiness, blurred vision etc.Red tongue, yellow fur, rapid pulse.

Its technical scheme is:Get Poria 6 grams, Caulis et Folium Brassicae junceae 6 grams, Polyporus 3 grams, Radix Hemerocallis 1 gram Herba Polygoni Avicularis 6 grams, Gryllotalpa 1 gram, Cyprinus carpio 9 grams, Carassius auratus 9 grams, Gryllus Chinensis 1 gram, Herba Dianthi 6 grams, Herba cassiae occidentalis 6 grams, Cortex Alstoniae scholaris 6 grams, Herba Lophatheri 9 grams, Semen phaseoli radiati 15 grams, Herba Taraxaci 12 grams, Herba hylotelephii erythrosticti 3 grams, Radix Thalictri brevipedis 9 grams, Folium et cacumen Breyniae Fruticosae 6 grams, Herba desmodii microphylli 6 grams, Calyx seu fructus physalis 3 grams, Rhizoma jeffersoniae dubiae 6 grams, Radix Rhapontici 9 grams, Fructus Canarii albi 9 grams, Lemmaphyllum microphullum Presl 6 grams, Herba Rostellulariae 9 grams, Resina garciniae 1 gram, Herba Potentillae Discoloris 6 grams, Stigma Maydis 9 grams and Radix Glycyrrhizae 9 grams, above 29 flavor Chinese medicines are put into 1800 ml waters, soaked 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine for the treatment of pedal edema type acute glomerulonephritis.

The advantage of this invention is:We's 29 flavor Chinese medicines all can have been bought in pharmacy, make simply, and the herb liquid toxic and side effects of making is little, short treating period, and cure rate is high.Monarch, just right.When using Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine to cause.Poria, Caulis et Folium Brassicae junceae, Polyporus, Radix Hemerocallis, Herba Polygoni Avicularis, Gryllotalpa, Cyprinus carpio, Carassius auratus, Gryllus Chinensis, Herba Dianthi, more than 10 flavor medical instruments the burst effect of carbuncle, inducing diuresis to remove edema of eliminating dampness and diuresis, clearing away heat-damp and promoting diuresis, eliminating stagnation is arranged.In the process for the treatment of pedal edema type acute glomerulonephritis, play the primary treatment effect, so be monarch drug.Herba cassiae occidentalis, Cortex Alstoniae scholaris, Herba Lophatheri, Semen phaseoli radiati, Herba Taraxaci, Herba hylotelephii erythrosticti, Radix Thalictri brevipedis, Folium et cacumen Breyniae Fruticosae, Herba desmodii microphylli, Calyx seu fructus physalis, Rhizoma jeffersoniae dubiae, Radix Rhapontici, Fructus Canarii albi, Lemmaphyllum microphullum Presl, Herba Rostellulariae, Resina garciniae, Herba Potentillae Discoloris, more than 17 flavor medical instruments the effect of heat clearing and damp drying, eliminating fire and detoxication, reducing swelling and alleviating pain, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain is arranged.In the process for the treatment of pedal edema type acute glomerulonephritis, can assist principal agent performance therapeutical effect, so be ministerial drug.Stigma Maydis: sweet, light, flat; Nontoxic.Enter liver, kidney, small intestinal three warps.Inducing diuresis to remove edema, promoting the function of the gallbladder to alleviate jaundice, dredging collateral for promoting lactation.The all medicines of the energy rate focus of going directly is so be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate again the toxicity of all medicines, so for making medicine.Poria, Caulis et Folium Brassicae junceae, Polyporus, Radix Hemerocallis, Herba Polygoni Avicularis, Gryllotalpa, Cyprinus carpio, Carassius auratus, Gryllus Chinensis, Herba Dianthi, Herba cassiae occidentalis, Cortex Alstoniae scholaris, Herba Lophatheri, Semen phaseoli radiati, Herba Taraxaci, Herba hylotelephii erythrosticti, Radix Thalictri brevipedis, Folium et cacumen Breyniae Fruticosae, Herba desmodii microphylli, Calyx seu fructus physalis, Rhizoma jeffersoniae dubiae, Radix Rhapontici, Fructus Canarii albi, Lemmaphyllum microphullum Presl, Herba Rostellulariae, Resina garciniae, Herba Potentillae Discoloris, Stigma Maydis, Radix Glycyrrhizae, more than 29 flavor medical instruments the burst effect of carbuncle, inducing diuresis to remove edema, heat clearing and damp drying, eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain of eliminating dampness and diuresis, clearing away heat-damp and promoting diuresis, eliminating stagnation is arranged.Poria: sweet, light, flat.Enter the heart, spleen, lung, bladder, three warmers, stomach the six channels.Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, strong lean marrow.Herba Capsellae: sweet, flat.Enter liver, the heart, lung three warps.Invigorate blood circulation with spleen stomach reinforcing, inducing diuresis to remove edema, hemostasis, removing heat in the liver for improving eyesight.Polyporus: sweet, light, flat.Enter spleen, kidney, bladder three warps.Promoting diuresis to eliminate damp pathogen, expel the heat-evil quench the thirst, treating malaria antidiarrheal.Radix Hemerocallis: sweet, cool, poisonous.Enter the heart, spleen, liver three warps.Inducing diuresis to remove edema, cooling blood for hemostasis, heat-clearing and toxic substances removing, heat-clearing and dampness-resolving, treatment gas fire scrofula.Herba Polygoni Avicularis: bitter, puckery, cold.Enter spleen, stomach, kidney, bladder four warps.Diuresis, clearing away heat-damp and promoting diuresis, parasite killing.Gryllotalpa: salty, cold, slightly poisonous.Enter stomach, bladder, large intestine, small intestinal four warps.Inducing diuresis to remove edema, the routed carbuncle of eliminating stagnation, clearing away stomach-heat.Cyprinus carpio: sweet, flat, nontoxic.Enter spleen, lung, liver, kidney four warps.Inducing diuresis to remove edema, the treatment QI rising in reverse order and cough, the watery diarrhea of dysentery relieving disease, lactogenesis, antiabortive, subduing inflammation.Carassius auratus: sweet, warm, nontoxic.Enter spleen, stomach, large intestine three warps.Warming middle-JIAO and strengthening the spleen, inducing diuresis to remove edema, stimulating milk secretion, promoting blood circulation and hemostasis, treatment deficiency and coldness dysentery, puerperal knot, Xiao Snore breathes heavily, the eliminating carbuncle eliminating stagnation.Gryllus Chinensis: hot, salty, temperature, poisonous.Enter bladder, large intestine, small intestinal three warps.Inducing diuresis to remove edema is treated impotence due to deficiency of the kidney, the enuresis, is expedited the emergence of.Herba Dianthi: bitter, cold.Enter the heart, small intestinal, bladder three warps.Clearing away heat and promoting diuresis, removing blood stasis stimulate the menstrual flow, reducing swelling and alleviating pain.Herba cassiae occidentalis: hardship, cold.Enter lung, liver, stomach warp.Relieving cough and asthma, liver heat removing and eyesight improving, stomach function regulating help digestion, subduing swelling and detoxicating, inducing diuresis for treating stranguria syndrome, relieving constipation by purgation.Cortex Alstoniae scholaris: bitter, light, cold.Enter lung, Liver Channel.Heat-clearing and toxic substances removing, hemostasia and detumescence.Herba Lophatheri: sweet, light, cold.Enter the heart, stomach, kidney, small intestine meridian.Relieving restlessness, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, Qinghua heat-phlegm clear away heart-fire.Semen phaseoli radiati: sweet, cold.Enter the heart, spleen, stomach, lung meridian.Heat-clearing and toxic substances removing, relieve heat and thirst, inducing diuresis to remove edema, QI invigorating skin moistening, the thick intestinal of clearing stomach.Herba Taraxaci: bitter, sweet, cold.Enter liver, stomach warp.Heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, tonneau urine.Herba hylotelephii erythrosticti: bitter, sour, cold.Enter the heart, liver, kidney, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Radix Thalictri brevipedis: hardship, cold, nontoxic.Enter lung, the heart, spleen, large intestine channel.Clearing away damp-heat, heat-clearing and toxic substances removing, lowering the adverse-rising QI to subdue asthma.Folium et cacumen Breyniae Fruticosae: hardship, cold.Enter large intestine, Liver Channel.Heat-clearing and toxic substances removing, removing stasis to stop bleeding.Herba desmodii microphylli: sweet, bitter, cold.Enter spleen, stomach, the heart, kidney channel.Heat-clearing and toxic substances removing, invigorating spleen to remove dampness, clearing away heat-damp and promoting diuresis.Calyx seu fructus physalis: sour, bitter, cold.Enter lung, spleen channel.Clearing heat, eliminating phlegm, relieving cough, heat-clearing and toxic substances removing, treatment edema.Rhizoma jeffersoniae dubiae: hardship, cold.Enter the heart, liver, stomach, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis, the treatment diarrhea due to damp-heat.Radix Rhapontici: bitter, salty, cold.Enter stomach, large intestine two warps.Heat-clearing and toxic substances removing, detumescence and apocenosis, treatment galactozemia, logical muscle arteries and veins, cooling blood for hemostasis.Fructus Canarii albi: sweet, puckery, sour, flat.Enter lung, stomach two warps.Clearing away lung-heat to relieve cough, heat-clearing and toxic substances removing sore-throat relieving, promoting the production of body fluid to quench thirst, detoxifcation dysentery relieving, checking hyperfunction of the liver for relieving convulsion, solution Trionyx sinensis Wiegmann poison.Lemmaphyllum microphullum Presl: hot, sweet, little hardship, cold.Enter lung, spleen, stomach, kidney four warps.Heat-clearing and toxic substances removing, cooling blood for hemostasis, nourishing the lung to arrest cough, expelling wind and dampness, clearing away heat-damp and promoting diuresis, treatment lithangiuria, acute toothache, fulminant dysentery.Herba Rostellulariae: salty, little suffering, little hardship, cold.Enter liver, gallbladder, spleen three warps.Heat-clearing and toxic substances removing, dampness removing stagnant, the promoting blood circulation and stopping pain that disappears.Resina garciniae: sour, puckery, cold.Very toxic.Enter spleen, stomach, large intestine three warps.Removing toxic substances and promoting subsidence of swelling, astringing to arrest bleeding, parasite killing are treated skin ulcer.Herba Potentillae Discoloris: sweet, little hardship, flat (cooler).Enter liver, stomach, large intestine three warps.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Stigma Maydis: sweet, light, flat; Nontoxic.Enter liver, kidney, small intestinal three warps.Inducing diuresis to remove edema, promoting the function of the gallbladder to alleviate jaundice, dredging collateral for promoting lactation.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.

The specific embodiment

Get Poria 6g, Caulis et Folium Brassicae junceae 6g, Polyporus 3g, Radix Hemerocallis 1g Herba Polygoni Avicularis 6g, Gryllotalpa 1g, Cyprinus carpio 9g, Carassius auratus 9g, Gryllus Chinensis 1g, Herba Dianthi 6g, Herba cassiae occidentalis 6g, Cortex Alstoniae scholaris 6g, Herba Lophatheri 9g, Semen phaseoli radiati 15g, Herba Taraxaci 12g, Herba hylotelephii erythrosticti 3g, Radix Thalictri brevipedis 9g, Folium et cacumen Breyniae Fruticosae 6g, Herba desmodii microphylli 6g, Calyx seu fructus physalis 3g, Rhizoma jeffersoniae dubiae 6g, Radix Rhapontici 9g, Fructus Canarii albi 9g, Lemmaphyllum microphullum Presl 6g, Herba Rostellulariae 9g, Resina garciniae 1g, Herba Potentillae Discoloris 6g, Stigma Maydis 9g and Radix Glycyrrhizae 9g, more than 29 the flavor medicines put into together 1800 ml waters, soaked 35 minutes, then slow fire is fried 30 minutes, filter and remove residue, fried medicinal liquid are the Chinese medicine for the treatment of pedal edema type acute glomerulonephritis.Boil medicine altogether 390 milliliters of liquid, when the client need treatment of pedal edema type acute glomerulonephritis, making fluid temperature is 36 ℃, each 130 milliliters, oral, every day three times, two is a course for the treatment of, if symptom is still deposited, takes for second course for the treatment of again, so that recovery from illness.

Among the 391 routine pedal edema type acute glomerulonephritis patients, male's 216 examples account for 55.24%; Women's 175 examples account for 44.76%.The male is more than the women.

The range of age of table one, 391 routine pedal edema type acute glomerulonephritis patients

Age (year)	18～26	27～36	37～46	47～56
					The example number	7	241	138	5
Percentage ratio	1.79%	61.64%	35.29%	1.28%

Table two, 391 routine pedal edema type acute glomerulonephritis patient curative effect tables

Curative effect	Cure	Take a turn for the better	Invalid
				The example number	389	2	Nothing
Percentage ratio	99.49%	0.51%	Nothing

Table three, 391 routine pedal edema type acute glomerulonephritis patients show the course for the treatment of

The treatment natural law	3～5	6～10	11～15	16～25
					The example number	9	261	116	5
Percentage ratio	2.3%	66.75%	29.67%	1.28%

Information slip before and after table four, the 391 routine pedal edema type acute glomerulonephritis patient treatments

Claims (1)

1. Chinese medicinal preparation method for the treatment of pedal edema type acute glomerulonephritis, it is characterized in that: get Poria 6 grams, Caulis et Folium Brassicae junceae 6 grams, Polyporus 3 grams, Radix Hemerocallis 1 gram Herba Polygoni Avicularis 6 grams, Gryllotalpa 1 gram, Cyprinus carpio 9 grams, Carassius auratus 9 grams, Gryllus Chinensis 1 gram, Herba Dianthi 6 grams, Herba cassiae occidentalis 6 grams, Cortex Alstoniae scholaris 6 grams, Herba Lophatheri 9 grams, Semen phaseoli radiati 15 grams, Herba Taraxaci 12 grams, Herba hylotelephii erythrosticti 3 grams, Radix Thalictri brevipedis 9 grams, Folium et cacumen Breyniae Fruticosae 6 grams, Herba desmodii microphylli 6 grams, Calyx seu fructus physalis 3 grams, Rhizoma jeffersoniae dubiae 6 grams, Radix Rhapontici 9 grams, Fructus Canarii albi 9 grams, Lemmaphyllum microphullum Presl 6 grams, Herba Rostellulariae 9 grams, Resina garciniae 1 gram, Herba Potentillae Discoloris 6 grams, Stigma Maydis 9 grams and Radix Glycyrrhizae 9 grams, above 29 flavor Chinese medicines are put into 1800 ml waters, soaked 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine for the treatment of pedal edema type acute glomerulonephritis.