CN102813798B - Preparation method of traditional Chinese medicine for treating heat toxicity-type acute glomerulonephritis - Google Patents
Preparation method of traditional Chinese medicine for treating heat toxicity-type acute glomerulonephritis Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine for treating heat toxicity-type acute glomerulonephritis and belongs to the technical field of traditional Chinese medicine preparation. Dihydrochlorothiazide used for treating heat toxicity-type acute glomerulonephritis at present may cause hypokalemia, hypochloremia and hypomagnesemia, and hypokalemia may cause hepatic coma and digitalis-resulted arrhythmia. The preparation method comprises the following steps of immersing 23 traditional Chinese medicines of China ixeris, medicinal changium root, loveyly hemsleyaroot, common anemarrhena rhizome, tinospora root, trollflower, honeysuckle, bidens biternata, heartleaf houttuynia herb, crneate lespedeza, hyperforin perforatum, stringy stonecrop herb, underleaf pearl, calabash, dayflower herb, polygonum aviculare, lilac pink herb, akebia stem, ricepaperplant pith, common rush, dysosma versipellis, dyer woad leaf and liquorice root in water, and carrying out decoction by a slow fire to obtain a decoction, wherein the decoction is the traditional Chinese medicine for treating heat toxicity-type acute glomerulonephritis. The traditional Chinese medicine for treating heat toxicity-type acute glomerulonephritis has a short treatment course and a high cure rate, and realizes just right utilization of the monarch drugs, the minister drugs, the assistant drugsand the guide drugs. The traditional Chinese medicine for treating heat toxicity-type acute glomerulonephritis utilizes traditional Chinese medicines as raw materials, and prevents adverse reactions,anaphylactic reactions and toxic reactions caused by western medicines.
Description
Technical field
The present invention relates to the Chinese medicinal preparation method technical field, is the brightic Chinese medicinal preparation method of a kind of treatment heat and noxious type acute more specifically.
Background technology
Treat the heat and noxious type acute glomerulonephritis at present, the general employing: 1, hydrochlorothiazide: 1. hypokalemia, and normal companion hangs down blood chlorine, hypomagnesemia, and hypokalemia can bring out hepatic coma and Folium Digitalis Purpureae institute proarrhythmia, needs timely kalium replenishment or add to stay the potassium diuretic; 2. hyperglycemia reduces carbohydrate tolerance; 3. symptom can be brought out or increase the weight of to hyperuricemia to the goat image; 4. azotemia because of reducing glomerular filtration rate, increases the weight of azotemia and renal function is further worsened the renal insufficiency patient, and this product diuretic effect is poor, so careful usefulness of renal failure patient or forbidding; 5. ammonirrhea reduces, and may the H+ secretion be reduced because of suppressing carbonic anhydrase, and the ammonia secretion also reduces.During hepatic disfunction, can bring out hepatic coma; 6. parathyroid gland effect: take for a long time and can cause hypercalcemia, low serum p disease and parathyroid hyperplasia; 7. other: skin erythema, photoallergic dermatitis, pancreatitis, intrahepatic cholestasis, bone marrow depression, especially thrombocytopenia can cause the announcements that all appear in the newspapers such as purpura, neutrophilic granulocyte minimizing, hemolytic anemia of newborn, the serum antinuclear antibody positive.2, penicillin: allergy easily takes place in this product, anaphylactic shock (the most dangerous anaphylactic shock particularly, can occur in and do tuerculoderma at that time, only a few can occur in the continuous use process, Delayed Hypersensitivity shock), as untimely rescue, can critical life, so all will improve protection before, during and after the medication, so as to avoid an accident.Attention: before the application, must ask to have or not anaphylactic disease clearly,, must do the penicillin skin test earlier with having or not allergy such as erythra, heating to occur behind the penicillin.3, amoxicillin: accidental erythra, oral can have nauseating, epigastric discomfort, diarrhoea etc. after a large amount of; Pseudomembranous colitis.4, carbenicillin: various types of allergy can occur.May cause neural poison reaction, pulmonary edema after heavy dose of administration, may occur the transience transaminase during the medication and raise and granulocytopenia.5, reserpine: nasal obstruction, gastric acid secretion increase, times of defecation increases and aroused in interest slack-off etc., even apathetic expression can appear in long-term extensive application, drowsiness, spirit depressing causes extrapyramidal symptoms, the performance muscular tremor.1. to activeness Peptic Ulcers and dysthymia person's forbidding; 2. reserpine can enter fetal tissue by Placenta Hominis, if the antenatal application of anemia of pregnant woman can cause neonate nasal obstruction, respiratory tract obstruction, should try one's best need not.6, captopril: important side effect is Toxicity of Kidney and granulocytopenia, is erythra, dysgeusia and cough secondly.Heavy dose can cause hemodynamic change, symptomatic hypotension etc.7, bendazol: headache, hyperhidrosis, heating sense are arranged.
Summary of the invention
For overcoming above-mentioned shortcoming, the objective of the invention is to invent the brightic Chinese medicinal preparation method of a kind of treatment heat and noxious type acute.Acute glomerulonephritis is called for short acute nephritis, is one group of common glomerule illness.Onset is anxious, is its Clinical symptoms with hematuria, oliguria, albuminuria, edema and hypertension etc.Acute nephritis can be because of due to the Different types of etiopathogenises, and wherein modal is post-streptococcal infection nephritis, and other causes of disease still have antibacterial (as staphylococcus), virus (as hepatitis B virus), protozoon (as plasmodium) etc.Primary disease belongs to " edema due to wind pathogen ", the category of " YANG edema " and " hematuria " in the Chinese medicine " edema ".
Etiology and pathogenesis:Acute glomerulonephritis is a main clinical manifestation with hematuria, edema,proteinuria,hypertension.Human liquid's metabolism relies on the logical of lung qi to transfer, the transferring of temper, and opening of kidney qi is entire, thereby makes three warmers bring into play the duty that it is certainly shown disrespect on.Ailment said due to cold or exposure, water are wet in order to experience for the primary disease cause of disease, noxious dampness, damp and hot heresy, invasion and attack flesh table, and internal injury is in lung, impairment of dispersing and descending function of the lung; Or in belong to spleen, spleen loses fortuneization; Under injure kidney, kidney loses folding, disturbance in water passage then, and be edema.In the acute nephritis edema stage, the main diseases position is at lung, spleen, based on inhibited pulmonary QI.If hematuria is obvious, how by the damp-heat accumulation bladder, injury of blood collaterals by heat is due to venation is impaired.If the intenseness of heat wind symptom, disturb sun clearly on the wind-fire, dizziness headache then appears, even the evil cards of violating conscience such as convulsions, coma.Spleen-QI failing to rise up, deficiency of kidney-QI, smart closing admittedly, albuminuria then appears in the separating clear and excreting turbid dereliction of duty.So the sick position of primary disease is dirty at lung, spleen, kidney three, syndrome develop be from table and in, reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels by the part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, develop to simulataneous insufficiency and excessive from real.Plain body intrinsic heat, " the very fire of heat, the very poison of fire ".Disease is sent out primary disease for a long time.
Clinical manifestation:Fever of the body is vexed, and thirst with desire to drink is flushing.Onset is more anxious, and state of an illness weight does not wait.Most of patients has clear and definite streptococcal infection history, as upper respiratory tract infection, pharyngitis, tonsillitis and skin infection etc.Sudden onset, first symptom mostly is edema and hematuria.1, edema: the lighter only plays blepharoedema morning, and complexion is paler, is " nephritis face ".Weight person prolongs and whole body, and finger pressure skin can not have significant depressions, and body weight also increases thereupon.2, hypertension: see 80% case, mostly be light moderate hypertension, diastolic pressure is less than 14kpa.The hypertension of acute nephritis mostly is a property crossed, and the generation reason is mainly water, sodium retention makes due to the blood volume expansion.3, urine is unusual: 1. oliguria: the most of patients onset has oliguria often, as every day the urine amount be less than 500ml person, slight azotemia can appear.2. hematuria: see all acute nephritis patients, can be gross hematuria, or muddy coffee-like, general persistence is not long, promptly transfers microscopic hematuria to.3. albuminuria: most of patients all has 4. whole body performance of albuminuria in various degree: tired, lumbago, anorexia, feel sick, vomiting, the person of being in a bad way can have headache, dizziness, drowsiness, blurred vision etc.Red tongue, yellow fur, rapid pulse.
Its technical scheme is:Get Herba Patriniae 3 weight portions, Radix Changii 3 weight portions, Radix Hemsleyae Macrospermae 6 weight portions, the Rhizoma Anemarrhenae 6 weight portions, Radix Tinosporae 9 weight portions, Flos Trollii 3 weight portions, Flos Lonicerae 3 weight portions, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 6 weight portions, Herba Houttuyniae 6 weight portions, Herba Lespedezae Cuneatae 3 weight portions, Herba Hyperici perforati 9 weight portions, Herba Sedi 3 weight portions, Herba Phyllanthi Urinariae 6 weight portions, calabash 3 weight portions, Herba Commelinae 9 weight portion Herba Polygoni Avicularis 6 weight portions, Herba Dianthi 6 weight portions, Caulis Akebiae 3 weight portions, Medulla Tetrapanacis 3 weight portions, Medulla Junci 3 weight portions, Radix et Rhizoma Dysosmatis 6 weight portions, Folium Isatidis 9 weight portions and Radix Glycyrrhizae 9 weight portions, above 23 flavor Chinese medicines are put into 1800 ml waters, soaked 35 minutes, slow fire is fried 30 minutes then, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the brightic Chinese medicine of treatment heat and noxious type acute.
The advantage of this invention is:We's 23 flavor Chinese medicines all can have been bought in pharmacy, make simply, and the herb liquid toxic and side effects of making is little, short treating period, cure rate height.Monarch, just right.When using Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine to cause.Herba Patriniae, Radix Changii, Radix Hemsleyae Macrospermae, the Rhizoma Anemarrhenae, Radix Tinosporae, Flos Trollii, Flos Lonicerae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Houttuyniae, Herba Lespedezae Cuneatae, Herba Hyperici perforati, Herba Sedi, Herba Phyllanthi Urinariae.More than 13 flavor medical instruments the effect of eliminating carbuncle suppuration, stasis-dispelling and pain-killing, cooling blood for hemostasis, reducing swelling and alleviating pain, clearing away heat-fire is arranged.In the brightic process of treatment heat and noxious type acute, play main therapeutical effect, so be monarch drug.Calabash, Herba Commelinae, Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Medulla Tetrapanacis, Medulla Junci.More than 7 flavor medical instruments the effect of the relieving distension of heat clearing away row water, blood pressure lowering, clearing heat secreting bile, inducing diuresis for treating stranguria syndrome is arranged.In the brightic process of treatment heat and noxious type acute, can assist principal agent performance therapeutical effect, so be ministerial drug.Radix et Rhizoma Dysosmatis: bitter, hot, flat.Go into the heart, lung, kidney three warps.Heat-clearing and toxic substances removing, removing blood stasis to reduce swelling, relieving cough and resolving phlegm, kidney tonifying is prevented labor.Folium Isatidis: hardship, cold.Go into the heart, stomach two warps.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.More than the through focus of 2 flavor medicine energy rates all medicines, so be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate the toxicity of all medicines again, so be messenger drug.Herba Patriniae, Radix Changii, Radix Hemsleyae Macrospermae, the Rhizoma Anemarrhenae, Radix Tinosporae, Flos Trollii, Flos Lonicerae, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae), Herba Houttuyniae, Herba Lespedezae Cuneatae, Herba Hyperici perforati, Herba Sedi, Herba Phyllanthi Urinariae, calabash, Herba Commelinae, Herba Polygoni Avicularis, Herba Dianthi, Caulis Akebiae, Medulla Tetrapanacis, Medulla Junci, Radix et Rhizoma Dysosmatis, Folium Isatidis, Radix Glycyrrhizae, this 23 flavor medicine compatibility is used, and plays the effect of eliminating carbuncle suppuration, stasis-dispelling and pain-killing, cooling blood for hemostasis, removing heat from the lung and dissipating phlegm, invigorating the spleen and regulating the stomach, reducing swelling and alleviating pain, clearing away heat-fire, blood circulation promoting and blood stasis dispelling, the relieving distension of heat clearing away row water, blood pressure lowering, clearing heat secreting bile, inducing diuresis for treating stranguria syndrome, a surname's promoting blood circulation jointly.Monarch, compatibility is proper, is the brightic optimum formula of treatment heat and noxious type acute.Herba Patriniae: hot, bitter, be slightly cold.Go into stomach, large intestine, liver three warps.Heat-clearing and toxic substances removing, eliminating carbuncle suppuration, stasis-dispelling and pain-killing, cooling blood for hemostasis, killing parasites for relieving itching.Radix Changii: sweet, little hardship is slightly cold.Go into lung, spleen, liver three warps.Removing heat from the lung and dissipating phlegm, suppressing the hyperactive liver are only dizzy, invigorating the spleen and regulating the stomach, heat-clearing and toxic substances removing.Radix Hemsleyae Macrospermae: hardship, cold, poisonous.Go into stomach, large intestine two warps.Heat-clearing and toxic substances removing, expelling wind and removing dampness, cooling blood for hemostasis, reducing swelling and alleviating pain.The Rhizoma Anemarrhenae: hardship, cold.Go into lung, stomach, kidney three warps.Clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, laxation relieving constipation, inducing diuresis to remove edema.Radix Tinosporae: hardship, cold.Go into lung, spleen, liver three warps.Heat-clearing and toxic substances removing, liver heat removing and eyesight improving, heat clearing away antitussive.Flos Trollii: hardship, cold, nontoxic.Go into the heart, liver two warps.Heat-clearing and toxic substances removing, liver heat removing and eyesight improving, ward off dirty detoxifcation.Flos Lonicerae: sweet, cold.Go into lung, stomach, the heart, spleen four warps.Relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae): bitter, sweet, light, flat.Go into lung, large intestine, spleen, stomach four warps.Wind and heat dispersing, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, promoting digestion and removing stagnation.Herba Houttuyniae: hot, cold.Go into liver, lung two warps.Heat-clearing and toxic substances removing, removing toxicity for eliminating carbuncles, inducing diuresis to remove edema.Herba Lespedezae Cuneatae: bitter, hot, cold.Go into lung, liver, kidney three warps.Liver and kidney tonifying, relieving cough and asthma, detumescence dissipating blood stasis, liver-benefiting eye-brightening.Herba Hyperici perforati: hot, puckery, little hardship, flat.Go into lung, large intestine, stomach three warps.Heat-clearing and toxic substances removing, hemostasis with astringents, expelling wind and removing dampness, thin sharp lactogenesis.Herba Sedi: sweet, light, little acid, cold.Go into liver, gallbladder, the heart, small intestinal four warps.Heat-clearing and toxic substances removing, detumescence and apocenosis, treatment herpes zoster, worm venom, empyrosis.Herba Phyllanthi Urinariae: sweet, bitter, cold.Go into liver, lung two warps.Disappear infantile malnutrition, suppressing the hyperactive liver of clearing away heat and promoting diuresis, heat-clearing and toxic substances removing, spleen invigorating makes eye bright.Calabash: sweet, flat, sliding.Go into the heart, small intestine meridian.Inducing diuresis to remove edema.Herba Commelinae: sweet.Cold.Go into kidney, urinary bladder channel.Inducing diuresis to remove edema, heat-clearing and toxic substances removing.Herba Polygoni Avicularis: hardship, flat, go into stomach, urinary bladder channel.Inducing diuresis for treating stranguria syndrome, damp eliminating jaundice eliminating, killing parasites for relieving itching.Herba Dianthi: hardship, cold.Go into the heart, small intestine meridian.Inducing diuresis for treating stranguria syndrome, promoting blood circulation to restore menstrual flow.Caulis Akebiae: hardship, cold.Go into the heart, lung, small intestinal, urinary bladder channel.Pathogenic fire reducing diuresis, a surname's promoting blood circulation.Medulla Tetrapanacis: sweet, light, cold.Go into lung, stomach warp.Clearing away heat and promoting diuresis, ventilation stimulating milk secretion.Medulla Junci: sweet, light, be slightly cold.Go into the heart, lung, small intestine meridian.Clearing away heat and promoting diuresis, relieving restlessness clears away heart-fire.Radix et Rhizoma Dysosmatis: bitter, hot, flat.Go into the heart, lung, kidney three warps.Heat-clearing and toxic substances removing, removing blood stasis to reduce swelling, relieving cough and resolving phlegm, kidney tonifying is prevented labor.Folium Isatidis: hardship, cold.Go into the heart, stomach two warps.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.
The specific embodiment
Get Herba Patriniae 3g, Radix Changii 3g, Radix Hemsleyae Macrospermae 6g, Rhizoma Anemarrhenae 6g, Radix Tinosporae 9g, Flos Trollii 3g, Flos Lonicerae 3g, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 6g, Herba Houttuyniae 6g, Herba Lespedezae Cuneatae 3g, Herba Hyperici perforati 9g, Herba Sedi 3g, Herba Phyllanthi Urinariae 6g, calabash 3g, Herba Commelinae 9g, Herba Polygoni Avicularis 6g, Herba Dianthi 6g, Caulis Akebiae 3g, Medulla Tetrapanacis 3g, Medulla Junci 3g, Radix et Rhizoma Dysosmatis 6g, Folium Isatidis 9g and Radix Glycyrrhizae 9g, more than 23 the flavor medicines put into 1800 ml waters together, soaked 35 minutes, slow fire is fried 30 minutes then, filter and remove residue, fried medicinal liquid are the brightic Chinese medicine of treatment heat and noxious type acute.Boil medicine altogether 390 milliliters of liquid, when the brightic patient of heat and noxious type acute need treat, making fluid temperature was 36 ℃, each 130 milliliters, oral, every day three times, two is a course of treatment, if symptom is still deposited, obeys for second course of treatment again, so that recovery from illness.
Among the 298 routine heat and noxious type acute glomerulonephritis patients, male's 157 examples account for 52.68%; Women's 141 examples account for 47.32%.The male is more than the women.
Table one, 298 routine heat and noxious type acute glomerulonephritis patient's age scopes
Table two, 298 routine heat and noxious type acute glomerulonephritis patient curative effect tables
Table three, 298 routine heat and noxious type acute glomerulonephritis patients show the course of treatment
| The treatment natural law | 3～5 | 6～10 | 11～15 | 16～26 |
| The example number | 12 | 208 | 75 | 3 |
| Percentage ratio | 4.03% | 69.79% | 25.17% | 1.01% |
Information slip before and after table four, the 298 routine heat and noxious type acute glomerulonephritis patient treatments
Claims (1)
1. treat the brightic Chinese medicinal preparation method of heat and noxious type acute for one kind, it is characterized in that: get Herba Patriniae 3 grams, Radix Changii 3 grams, Radix Hemsleyae Macrospermae 6 grams, the Rhizoma Anemarrhenae 6 grams, Radix Tinosporae 9 grams, Flos Trollii 3 grams, Flos Lonicerae 3 grams, Herba Bidentis Bipinnate (Herba Bidentis Pilosae, Herba Bidentis Pilosae) 6 grams, Herba Houttuyniae 6 grams, Herba Lespedezae Cuneatae 3 grams, Herba Hyperici perforati 9 grams, Herba Sedi 3 grams, Herba Phyllanthi Urinariae 6 grams, calabash 3 grams, Herba Commelinae 9 gram Herba Polygoni Avicularis 6 grams, Herba Dianthi 6 grams, Caulis Akebiae 3 grams, Medulla Tetrapanacis 3 grams, Medulla Junci 3 grams, Radix et Rhizoma Dysosmatis 6 grams, Folium Isatidis 9 grams and Radix Glycyrrhizae 9 grams, above 23 flavor Chinese medicines are put into 1800 ml waters, soaked 35 minutes, slow fire is fried 30 minutes then, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the brightic Chinese medicine of treatment heat and noxious type acute.
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| CN103251836A (en) * | 2013-05-25 | 2013-08-21 | 于虎 | Preparation method of traditional Chinese medicine for treating cardia inflammation induced by addiction to green onions |
| CN103251834A (en) * | 2013-05-25 | 2013-08-21 | 顾克峰 | Preparation method of traditional Chinese medicine for treating cardia inflammation induced by addiction to fresh gingers |
| CN103239645A (en) * | 2013-05-25 | 2013-08-14 | 张其江 | Preparation method of traditional Chinese medicine for treating cardia inflammation caused by excessive drinking |
| CN103251838A (en) * | 2013-05-25 | 2013-08-21 | 刘国利 | Preparation method of traditional Chinese medicine for treating cardia inflammation induced by addiction to chillies |
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