CN102813895B - Preparation method of traditional Chinese medicine for treating somnolence-type acute glomerulonephritis - Google Patents

Preparation method of traditional Chinese medicine for treating somnolence-type acute glomerulonephritis Download PDF

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CN102813895B
CN102813895B CN201210274116.5A CN201210274116A CN102813895B CN 102813895 B CN102813895 B CN 102813895B CN 201210274116 A CN201210274116 A CN 201210274116A CN 102813895 B CN102813895 B CN 102813895B
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traditional chinese
acute glomerulonephritis
chinese medicine
type acute
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CN201210274116.5A
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CN102813895A (en
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王玉英
杨红云
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王玉英
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Abstract

The invention discloses a preparation method of a traditional Chinese medicine for treating somnolence-type acute glomerulonephritis and belongs to the technical field of traditional Chinese medicine preparation. Penicillin used for treating somnolence-type acute glomerulonephritis can easily cause an allergic reaction and especially cause anaphylactic shock and if rescue is not carried out in time, a patient suffering from anaphylactic shock may have a life risk and thus penicillin safety protection needs to be improved before use, in use and after use so that an accident is avoided. The preparation method comprises the following steps of immersing 21 traditional Chinese medicines of wild cabbage, longan aril, largehead atractylodes rhizome, American ginseng, lotus seed, pilose asiabell root, sharpleaf galangal fruit, milkvetch root, manyflower solomonseal rhizome, polished round-grained rice, dried ginger, beautiful galangal fruit, round cardamom fruit, atractylodes rhizome, fortune eupatorium herb, fruit of Caoguo, katsumada galangal seed, holy basil, wrinkled gianthyssop herb, black-bone chicken and liquorice root in water, and carrying out decoction by a slow fire to obtain a decoction, wherein the decoction is the traditional Chinese medicine for treating somnolence-type acute glomerulonephritis. The traditional Chinese medicine obtained by the preparation method has small toxic or side effects, a short treatment course and a high cure rate, realizes just right utilization of the monarch drugs, the minister drugs, the assistant drugs and the guide drugs, and prevents adverse reactions, anaphylactic reactions and toxic reactions caused by western medicines.

Description

A kind of Chinese medicinal preparation method for the treatment of drowsiness type acute glomerulonephritis
Technical field
The present invention relates to the Chinese medicinal preparation method technical field, more specifically a kind of Chinese medicinal preparation method for the treatment of drowsiness type acute glomerulonephritis.
Background technology
Treat at present drowsiness type acute glomerulonephritis, the general employing: 1, penicillin: allergy easily occurs in this product, anaphylactic shock (the most dangerous anaphylactic shock particularly, can occur in and do tuerculoderma at that time, only a few can occur in the continuous use process, the Delayed Hypersensitivity shock), as rescued not in time, can critical life, thus all to improve protection before, during and after medication, so as to avoid an accident.Attention: before application, must ask and have or not clearly anaphylactic disease, with having or not the allergy such as erythra, heating to occur after penicillin, must first do penicillin skin test.2, amoxicillin: accidental erythra, oral can have nauseating, epigastric discomfort, diarrhoea etc. after a large amount of; Pseudomembranous colitis.3, carbenicillin: various types of allergy can occur.May cause neural poison reaction, pulmonary edema after heavy dose of administration, may occur during medication that the transience transaminase raises and granulocytopenia.4, reserpine: nasal obstruction, gastric acid secretion increase, times of defecation increases and aroused in interest slack-off etc., even long-term extensive application can occur that apathetic expression, drowsiness, spirit depressing cause extrapyramidal symptoms, the performance muscular tremor.1. to activeness Peptic Ulcers and dysthymia person's forbidding; 2. reserpine can enter fetal tissue by Placenta Hominis, if the antenatal application of anemia of pregnant woman can cause neonate nasal obstruction, respiratory tract obstruction, should need not as far as possible.5, hydrochlorothiazide: the low blood chlorine of 1. hypokalemia, and normal companion, hypomagnesemia, hypokalemia can bring out hepatic coma and Folium Digitalis Purpureae institute proarrhythmia, needs timely kalium replenishment or add to stay the potassium diuretic; 2. hyperglycemia reduces carbohydrate tolerance; 3. hyperuricemia, can bring out or increase the weight of symptom to the goat image; 4. azotemia, because reducing glomerular filtration rate, increase the weight of azotemia and renal function further worsened the renal insufficiency patient, and this product diuretic effect is poor, therefore the renal failure patient is cautious use of or forbids; 5. ammonirrhea reduces, and may the H+ secretion be reduced because suppressing carbonic anhydrase, and the ammonia secretion also reduces.During hepatic disfunction, can bring out hepatic coma; 6. parathyroid gland effect: long-term taking can cause hypercalcemia, low serum p disease and parathyroid hyperplasia; 7. other: skin erythema, photoallergic dermatitis, pancreatitis, intrahepatic cholestasis, bone marrow depression, especially thrombocytopenia can cause the announcements that all appear in the newspapers such as purpura, neutrophilic granulocyte minimizing, hemolytic anemia of newborn, the serum antinuclear antibody positive.6, bendazol: headache, hyperhidrosis, heating sense are arranged.7, captopril: important side effect is Toxicity of Kidney and granulocytopenia, is secondly erythra, dysgeusia and cough.Heavy dose can cause hemodynamic change, symptomatic hypotension etc.
Summary of the invention
For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of drowsiness type acute glomerulonephritis.Acute glomerulonephritis, be called for short acute nephritis, is one group of common glomerule illness.Onset is anxious, and take hematuria, oliguria, albuminuria, edema and hypertension etc. is its Clinical symptoms.Acute nephritis can be because of due to Different types of etiopathogenises, and wherein modal is post-streptococcal infection nephritis, and other causes of disease still have antibacterial (as staphylococcus), virus (as hepatitis B virus), protozoon (as plasmodium) etc.Primary disease belongs to " edema due to wind pathogen ", the category of " YANG edema " and " hematuria " in Chinese medicine " edema ".
etiology and pathogenesis: anxiousit is main clinical manifestation that the property glomerulonephritis be take hematuria, edema,proteinuria,hypertension.Human liquid's metabolism, rely on the logical of lung qi to adjust, the transferring of temper, and opening of kidney qi is entire, thereby makes three warmers bring into play the duty that it is certainly shown disrespect on.Ailment said due to cold or exposure, water are wet in order to experience for the primary disease cause of disease, noxious dampness, damp and hot heresy, invasion and attack flesh table, and internal injury is in lung, impairment of dispersing and descending function of the lung; Or in be attributed to spleen, spleen loses transporting; Under injure kidney, kidney loses folding, disturbance in water passage, and be edema.In the acute nephritis edema stage, inhibited pulmonary QI, at lung, spleen, be take as main in the main diseases position.If hematuria is obvious, how by the damp-heat accumulation bladder, injury of blood collaterals by heat, due to venation is impaired.If the intenseness of heat wind symptom, disturb sun clearly on wind-fire, the evil card of violating conscience such as convulsions, coma dizziness headache appears, even.Spleen-QI failing to rise up, deficiency of kidney-QI, essence is closed not solid, and albuminuria, appear in the separating clear and excreting turbid dereliction of duty.Therefore the sick position of primary disease is dirty at lung, spleen, kidney three, syndrome develop be from table and, by the part of the body cavity above the diaphragm housing the heart and lungs, in Jiao and reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, from real, to simulataneous insufficiency and excessive, develop.Due to deficiency of QI in middle-JIAO, the weak fortune of spleen is slow, and causes primary disease.
clinical manifestation:drowsiness is main.Onset is more anxious, and state of an illness weight does not wait.Most of patients has clear and definite streptococcal infection history, as upper respiratory tract infection, pharyngitis, tonsillitis and skin infection etc.Sudden onset, onset symptoms mostly is edema and hematuria.1, edema: the lighter only plays blepharoedema morning, and complexion is paler, is " nephritis face ".Severe one is prolonged and whole body, and finger pressure skin can be without significant depressions, and body weight also increases thereupon.2, hypertension: see 80% case, mostly be light moderate hypertension, diastolic pressure is less than 14kpa.The hypertension of acute nephritis mostly is a property crossed, and the generation reason is mainly water, sodium retention makes due to the blood volume expansion.3, urine is abnormal: 1. oliguria: the most of patients onset has oliguria often, as every day the urine amount be less than 500ml person, slight azotemia can appear.2. hematuria: see all acute nephritis patients, can be gross hematuria, or muddy coffee-like, general persistence is not long, transfers microscopic hematuria to.3. albuminuria: most of patients all has 4. whole body performance of albuminuria in various degree: tired, lumbago, anorexia, feel sick, vomiting, the person of being in a bad way can have headache, dizziness, blurred vision etc.Pale tongue, tongue is white, deep-thready pulse.
its technical scheme is:get Caulis et Folium Brassicae capitatae 6 weight portions, Arillus Longan 6 weight portions, the Rhizoma Atractylodis Macrocephalae 6 weight portions, Radix Panacis Quinquefolii 3 weight portions, Semen Nelumbinis 6 weight portions, Radix Codonopsis 6 weight portions, Fructus Alpiniae Oxyphyllae 3 weight portions, the Radix Astragali 3 weight portions, Rhizoma Polygonati 6 weight portions, Semen oryzae sativae 9 weight portions, Rhizoma Zingiberis 3 weight portions, Semen alpinia zerumbet 6 weight portions, Fructus Amomi Rotundus 3 weight portions, Rhizoma Atractylodis 6 weight portions, Herba Eupatorii 3 weight portions, Fructus Tsaoko 6 weight portions, Semen Alpiniae Katsumadai 6 weight portions, Herba Lysimachiae foenum-graeci 3 weight portions, Herba Pogostemonis 3 weight portions, Gallus Domesticus 3 weight portions and Radix Glycyrrhizae 9 weight portions, above 21 flavor Chinese medicines are put into to 1500 ml waters, soak 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 360 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of the drowsiness type acute glomerulonephritis for the treatment of.
the advantage of this invention is:we's 21 flavor Chinese medicines, all can buy in pharmacy, makes simply, and the herb liquid toxic and side effects of making is little, short treating period, and cure rate is high.Monarch, just right.In the time of application Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine to cause.Caulis et Folium Brassicae capitatae, Arillus Longan, the Rhizoma Atractylodis Macrocephalae, Radix Panacis Quinquefolii, Semen Nelumbinis, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, the Radix Astragali, Rhizoma Polygonati, Semen oryzae sativae, Rhizoma Zingiberis, above 11 flavor medical instruments have the effect of QI invigorating emergency treatment of collapse, strengthening the spleen and nourishing the stomach, warm spleen cold expelling, invigorating the spleen and replenishing QI.In the process of the drowsiness type acute glomerulonephritis for the treatment of, play the primary treatment effect, therefore be monarch drug.Semen alpinia zerumbet, Fructus Amomi Rotundus, Rhizoma Atractylodis, Herba Eupatorii, Fructus Tsaoko, Semen Alpiniae Katsumadai, Herba Lysimachiae foenum-graeci, Herba Pogostemonis, above 8 flavor medical instruments have the effect of dampness cold relieving, circulation of qi promoting removing dampness, removing dampness for regulating stomach, regulating QI hemopoietic, diuresis and phlem dispersing, promoting digestion and removing stagnation, warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, drying damp and strengthening spleen, expelling wind and cold.In the process of the drowsiness type acute glomerulonephritis for the treatment of, can assist principal agent performance therapeutical effect, therefore be ministerial drug.Gallus Domesticus: sweet, flat.Enter liver, kidney two warps.Yin nourishing is brought down a fever.The all medicines of the energy rate focus of going directly, therefore be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate again the toxicity of all medicines, therefore for making medicine.Caulis et Folium Brassicae capitatae, Arillus Longan, the Rhizoma Atractylodis Macrocephalae, Radix Panacis Quinquefolii, Semen Nelumbinis, Radix Codonopsis, Fructus Alpiniae Oxyphyllae, the Radix Astragali, Rhizoma Polygonati, Semen oryzae sativae, Rhizoma Zingiberis, Semen alpinia zerumbet, Fructus Amomi Rotundus, Rhizoma Atractylodis, Herba Eupatorii, Fructus Tsaoko, Semen Alpiniae Katsumadai, Herba Lysimachiae foenum-graeci, Herba Pogostemonis, Gallus Domesticus, Radix Glycyrrhizae, this 21 flavor medicine compatibility application, play QI invigorating emergency treatment of collapse, strengthening the spleen and nourishing the stomach, warm spleen cold expelling, invigorating the spleen and replenishing QI, dampness cold relieving, circulation of qi promoting removing dampness, removing dampness for regulating stomach, regulating QI hemopoietic, diuresis and phlem dispersing, promoting digestion and removing stagnation, drying damp and strengthening spleen effect jointly.Monarch, compatibility is proper, is the optimum formula of the drowsiness type acute glomerulonephritis for the treatment of.Caulis et Folium Brassicae capitatae: sweet, flat, nontoxic.Enter stomach, kidney two warps.Benefit kidney and replenishing marrow and stomach and alleviating pain.Arillus Longan: sweet, warm.Enter the heart, spleen two warps.Invigorating the heart and spleen, nourishing blood to tranquillize the mind, nourishing the lung to arrest cough.The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Enter spleen, stomach two warps.Air making-up and spleen enlivening, drying dampness to eliminate phlegm, diuretic detumescent, expelling wind and cold, strengthening superficial resistance to stop perspiration, QI invigorating are antiabortive.Radix Panacis Quinquefolii: hot, sweet, bitter, cold.Enter the heart, lung, stomach, kidney, the large intestine Five Classics.QI invigorating tonifying YIN, clearing away heat and promoting production of body fluid, clearing away heat to stop bleeding.Semen Nelumbinis: sweet, puckery, flat.Enter the heart, spleen, kidney three warps.Spleen reinforcing antidiarrheal, kidney tonifying are only lost, tranquilizing by nourishing the heart.Radix Codonopsis: sweet, flat.Enter lung, spleen two warps.Replenishing QI to invigorate the spleen, supplementing QI for promoting the production of body fluid, QI invigorating heat extraction.Fructus Alpiniae Oxyphyllae: suffering, temperature.Enter spleen, stomach two warps.Warm spleen cold expelling, the kidney warming tonify deficiency.The Radix Astragali: sweet, tepor, nontoxic.Enter lung, spleen two warps.Tonifying Qi and lifting yang, hemostasis by invigorating QI, QI invigorating row are stagnant, blood stasis removing eliminating stagnation, benefiting QI for strengthening the superficies, QI invigorating tonifying YIN, inducing diuresis to remove edema, warming the interior cold expelling, pus expelling by strengthening vital QI granulation promoting, strong body constitution, life lengthening.Rhizoma Polygonati: sweet, flat, nontoxic.Enter spleen, lung, kidney three warps.Control deficiency of lung-YIN cough, control pulmonary tuberculosis hemoptysis, beneficial able-bodied muscles and bones, control interior-heat and quench one's thirst, control weakness of the spleen and stomach.Semen oryzae sativae: sweet, flat.Enter spleen, stomach two warps.Invigorating the spleen and replenishing QI, invigorating spleen to remove dampness.Rhizoma Zingiberis: hot, hot.Enter spleen, stomach, lung three warps.Warming middle-JIAO by cold, recuperating depleted YANG is promoted blood circulation, the expectorant therapeutic method to keep the adverse QI flowing downwards, warming the lung to resolve fluid-retention, warming the meridian for stopping bleeding, control carbuncle from the beginning of.Semen alpinia zerumbet: hot, puckery, temperature.Enter lung, large intestine, spleen, stomach four warps.The dampness cold relieving, the spleen invigorating warming the stomach, ward off dirty preventing the attack (or recurrence) of malaria.Fructus Amomi Rotundus: suffering, temperature.Enter spleen, stomach, lung three warps.The circulation of qi promoting removing dampness, warming middle-JIAO to arrest vomiting, ward off dirty removing toxic substances.Rhizoma Atractylodis: hot, bitter, sweet, temperature.Enter lung, spleen, liver three warps.Drying damp and strengthening spleen, promoting QI circulation for relieving depression, change turbid keep away dirty, expelling cold and relieving exterior syndrome.Herba Eupatorii: suffering, flat.Enter spleen, stomach two warps.Removing dampness for regulating stomach, diaphoresis expelling summer-heat, promoting the production of body fluid to quench thirst, regulating QI hemopoietic, resolving depression eliminating stagnation, diuresis and phlem dispersing.Fructus Tsaoko: suffering, hot, puckery.Be included into spleen, stomach two warps.Dampness is removed cold, the preventing the attack (or recurrence) of malaria disease of eliminating the phlegm, promoting digestion and removing stagnation.Semen Alpiniae Katsumadai: hot, puckery, temperature.Be included into spleen, stomach two warps.Warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, drying damp and strengthening spleen.Herba Lysimachiae foenum-graeci: acrid, sweet, warm.Enter lung, spleen, stomach three warps.Expelling wind and cold, removing dampness by means of aromatics, QI invigorating warming YANG.Herba Pogostemonis: suffering, tepor.Enter lung, spleen, stomach three warps.Expelling summer-heat and damp, regulating the flow of Qi and the middle Jiao, ward off dirty solution epidemic disease, the stomach function regulating preventing or arresting vomiting.Gallus Domesticus: sweet, flat.Enter liver, kidney two warps.Yin nourishing is brought down a fever.Radix Glycyrrhizae: sweet, flat.Enter 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.
The specific embodiment
Get Caulis et Folium Brassicae capitatae 6g, Arillus Longan 6g, Rhizoma Atractylodis Macrocephalae 6g, Radix Panacis Quinquefolii 3g, Semen Nelumbinis 6g, Radix Codonopsis 6g, Fructus Alpiniae Oxyphyllae 3g, Radix Astragali 3g, Rhizoma Polygonati 6g, Semen oryzae sativae 9g, Rhizoma Zingiberis 3g, Semen alpinia zerumbet 6g, Fructus Amomi Rotundus 3g, Rhizoma Atractylodis 6g, Herba Eupatorii 3g, Fructus Tsaoko 6g, Semen Alpiniae Katsumadai 6g, Herba Lysimachiae foenum-graeci 3g, Herba Pogostemonis 3g, Gallus Domesticus 3g and Radix Glycyrrhizae 9g, above 21 flavor medicines are put into 1500 ml waters together, soak 35 minutes, then slow fire is fried 30 minutes, filter and remove residue, fried medicinal liquid is the Chinese medicine of the drowsiness type acute glomerulonephritis for the treatment of.Boil medicine altogether 360 milliliters of liquid, when the client need treatment of drowsiness type acute glomerulonephritis, making fluid temperature is 36 ℃, each 120 milliliters, oral, every day three times, within 2nd, be a course for the treatment of, if symptom is still deposited, then took for second course for the treatment of, so that recovery from illness.
In 336 routine drowsiness type acute glomerulonephritis patients, male's 171 examples, account for 50.89%; Women's 165 examples, account for 49.11%.The male is more than the women.
The range of age of table one, 336 routine drowsiness type acute glomerulonephritis patients
Age (year) 18~20 21~30 31~50 51~60
Number of cases 13 186 132 5
Percentage ratio 3.87% 55.36% 39.28% 1.49%
Table two, 336 routine drowsiness type acute glomerulonephritis patient curative effect tables
Curative effect Cure Take a turn for the better Invalid
Number of cases 331 5 Nothing
Percentage ratio 98.51% 1.49% Nothing
Table three, 336 routine drowsiness type acute glomerulonephritis patients show the course for the treatment of
The treatment natural law 3~5 6~10 11~16 17~27
Number of cases 11 241 79 5
Percentage ratio 3.27% 71.73% 23.51% 1.49%
Information slip before and after table four, 336 routine drowsiness type acute glomerulonephritis patient treatments

Claims (1)

1. a Chinese medicinal preparation method for the treatment of drowsiness type acute glomerulonephritis, it is characterized in that: get Caulis et Folium Brassicae capitatae 6 grams, Arillus Longan 6 grams, the Rhizoma Atractylodis Macrocephalae 6 grams, Radix Panacis Quinquefolii 3 grams, Semen Nelumbinis 6 grams, Radix Codonopsis 6 grams, Fructus Alpiniae Oxyphyllae 3 grams, the Radix Astragali 3 grams, Rhizoma Polygonati 6 grams, Semen oryzae sativae 9 grams, Rhizoma Zingiberis 3 grams, Semen alpinia zerumbet 6 grams, Fructus Amomi Rotundus 3 grams, Rhizoma Atractylodis 6 grams, Herba Eupatorii 3 grams, Fructus Tsaoko 6 grams, Semen Alpiniae Katsumadai 6 grams, Herba Lysimachiae foenum-graeci 3 grams, Herba Pogostemonis 3 grams, Gallus Domesticus 3 grams and Radix Glycyrrhizae 9 grams, above 21 flavor Chinese medicines are put into to 1500 ml waters, soak 35 minutes, then slow fire is fried 30 minutes, boil medicine altogether 360 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of the drowsiness type acute glomerulonephritis for the treatment of.
CN201210274116.5A 2012-08-03 2012-08-03 Preparation method of traditional Chinese medicine for treating somnolence-type acute glomerulonephritis CN102813895B (en)

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