CN102813846B - Preparation method of traditional Chinese medicine for treating high fat-type acute glomerulonephritis - Google Patents

Abstract

The invention discloses a preparation method of a traditional Chinese medicine for treating high fat-type acute glomerulonephritis and belongs to the technical field of traditional Chinese medicine preparation. Captopril used for treating high fat-type acute glomerulonephritis at present has main side effects of producing nephrotoxicity and reducing granulocytes and also has side effects of rash,dysgeusia and cough. The preparation method comprises the following steps of immersing 27 traditional Chinese medicines of haw, rice sprout, lris tectorum, carrot, endothelium corneum gigeriae galli,buckwheat, medicated leaven, radish seed, papaya, quince, tangerine seed, orange peel, orange, buck-eye seed, tobacco, citron fruit, rhizoma cyperi, officinal magnolia bark, lychee seed, lychee, kamuning, aspongopus, sword bean, ambergris, sweet basil, bitter orange and liquorice root in water, and carrying out decoction by a slow fire to obtain a decoction, wherein the decoction is the traditional Chinese medicine for treating high fat-type acute glomerulonephritis. The traditional Chinese medicine for treating high fat-type acute glomerulonephritis has a short treatment course and a high cure rate, and realizes just right utilization of the monarch drugs, the minister drugs, the assistant drugs and the guide drugs. The traditional Chinese medicine for treating high fat-type acute glomerulonephritis utilizes traditional Chinese medicines as raw materials, and prevents adverse reactions, anaphylactic reactions and toxic reactions caused by western medicines.

Description

A kind of Chinese medicinal preparation method for the treatment of high fat type acute glomerulonephritis

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, is a kind of Chinese medicinal preparation method for the treatment of high fat type acute glomerulonephritis more specifically.

Background technology

The high fat type acute glomerulonephritis for the treatment of, generally employing at present: 1, captopril: main side effect is Toxicity of Kidney and granulocytopenia, is erythra, dysgeusia and cough secondly.Heavy dose can cause hemodynamic change, symptomatic hypotension etc.2, reserpine: nasal obstruction, gastric acid secretion increase, times of defecation increases and aroused in interest slack-off etc., even apathetic expression can appear in long-term extensive application, drowsiness, spirit depressing causes extrapyramidal symptoms, the performance muscular tremor.1. to activeness Peptic Ulcers and dysthymia person's forbidding; 2. reserpine can enter fetal tissue by Placenta Hominis, if the antenatal application of anemia of pregnant woman can cause neonate nasal obstruction, respiratory tract obstruction, should try one's best need not.3, penicillin: allergy easily takes place in this product, anaphylactic shock (the most dangerous anaphylactic shock particularly, can occur in and do tuerculoderma at that time, only a few can occur in the continuous use process, Delayed Hypersensitivity shock), as untimely rescue, can critical life, so all will improve protection before, during and after the medication, so as to avoid an accident.Attention: before the application, must ask to have or not anaphylactic disease clearly, with having or not allergy such as erythra, heating to occur behind the penicillin, must do the penicillin skin test earlier.4, carbenicillin: various types of allergy can occur.May cause neural poison reaction, pulmonary edema after heavy dose of administration, may occur the transience transaminase during the medication and raise and granulocytopenia.5, bendazol: headache, hyperhidrosis, heating sense are arranged.

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of high fat type acute glomerulonephritis.Acute glomerulonephritis is called for short acute nephritis, is one group of common glomerule illness.Onset is anxious, is its Clinical symptoms with hematuria, oliguria, albuminuria, edema and hypertension etc.Acute nephritis can be because of due to the Different types of etiopathogenises, and wherein modal is post-streptococcal infection nephritis, and other causes of disease still have antibacterial (as staphylococcus), virus (as hepatitis B virus), protozoon (as plasmodium) etc.Primary disease belongs to " edema due to wind pathogen ", the category of " YANG edema " and " hematuria " in the Chinese medicine " edema ".

Etiology and pathogenesis: anxiousThe property glomerulonephritis is main clinical manifestation with hematuria, edema,proteinuria,hypertension.Human liquid's metabolism relies on the logical of lung qi to transfer, the transferring of temper, and opening of kidney qi is entire, thereby makes three warmers bring into play the duty that it is certainly shown disrespect on.Ailment said due to cold or exposure, water are wet in order to experience for the primary disease cause of disease, noxious dampness, damp and hot heresy, invasion and attack flesh table, and internal injury is in lung, impairment of dispersing and descending function of the lung; Or in be attributed to spleen, spleen loses fortuneization; Under injure kidney, kidney loses folding, disturbance in water passage then, and be edema.In the acute nephritis edema stage, the main diseases position is at lung, spleen, based on inhibited pulmonary QI.If hematuria is obvious, how by the damp-heat accumulation bladder, injury of blood collaterals by heat is due to venation is impaired.If the intenseness of heat wind symptom, disturb sun clearly on the wind-fire, dizziness headache then appears, even the evil cards of violating conscience such as convulsions, coma.Spleen-QI failing to rise up, deficiency of kidney-QI, smart closing admittedly, albuminuria then appears in the separating clear and excreting turbid dereliction of duty.So the sick position of primary disease is dirty at lung, spleen, kidney three, syndrome develop be from table and in, reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels by the part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, develop to simulataneous insufficiency and excessive from real.Because the product of surfeit delicious food, obesity, blood fat increases, and causes or brings out primary disease.

Clinical manifestation:Obesity, the blood fat height.Onset is more anxious, and state of an illness weight does not wait.Most of patients has clear and definite streptococcal infection history, as upper respiratory tract infection, pharyngitis, tonsillitis and skin infection etc.Sudden onset, first symptom mostly is edema and hematuria.1, edema: the lighter only plays blepharoedema morning, and complexion is paler, is " nephritis face ".Weight person prolongs and whole body, and finger pressure skin can not have significant depressions, and body weight also increases thereupon.2, hypertension: see 80% case, mostly be light moderate hypertension, diastolic pressure is less than 14kpa.The hypertension of acute nephritis mostly is a property crossed, and the generation reason is mainly water, sodium retention makes due to the blood volume expansion.3, urine is unusual: 1. oliguria: the most of patients onset has oliguria often, as every day the urine amount be less than 500ml person, slight azotemia can appear.2. hematuria: see all acute nephritis patients, can be gross hematuria, or muddy coffee-like, general persistence is not long, namely transfers microscopic hematuria to.3. albuminuria: most of patients all has 4. whole body performance of albuminuria in various degree: tired, lumbago, anorexia, feel sick, vomiting, the person of being in a bad way can have headache, dizziness, drowsiness, blurred vision etc.Body of the tongue is light red, greasy fur, slippery and rapid pulse.

Its technical scheme is:Get Fructus Crataegi 9 weight portions, Fructus Setariae Germinatus 9 weight portions, Rhizoma Iridis Tectori 1 weight portion, Radix Dauci Sativae 9 weight portions, Endothelium Corneum Gigeriae Galli 6 weight portions, Semen Fagopyri Esculenti 9 weight portions, Massa Medicata Fermentata 6 weight portions, Semen Raphani 6 weight portions, Fructus Caricae 9 weight portion Fructus cydoniae oblongae 6 weight portions, Semen Citri Reticulatae 3 weight portions, Pericarpium Citri tangerinae 9 weight portions, Fructus Citri junoris 6 weight portions, Semen Aesculi 3 weight portions, Nicotiana tabacum L. 1 weight portion, Fructus Citri 9 weight portions, Rhizoma Cyperi 9 weight portions, Cortex Magnoliae Officinalis 6 weight portions, Semen Litchi 9 weight portions, Fructus Litchi 9 weight portions, Folium Et Cacumen Murrayae 6 weight portions, Aspongopus 3 weight portions, Semen Canavaliae 6 weight portions, Ambra Grisea 6 weight portions, Herba Ocimi (Herba Ocimi Pilosi) 6 weight portions, Citrus aurantium L. var. amara Engl. 3 weight portions and Radix Glycyrrhizae 9 weight portions, above 27 flavor Chinese medicines are put into 1800 ml waters, soaked 35 minutes, slow fire is fried 30 minutes then, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of the high fat type acute glomerulonephritis for the treatment of.

The advantage of this invention is:We's 27 flavor Chinese medicines all can have been bought in pharmacy, make simply, and the herb liquid toxic and side effects of making is little, short treating period, cure rate height.Monarch, just right.When using Chinese medicine, untoward reaction, anaphylaxis and the toxic reaction of having avoided Western medicine to cause.Fructus Crataegi, Fructus Setariae Germinatus, Rhizoma Iridis Tectori, Radix Dauci Sativae, Endothelium Corneum Gigeriae Galli, Semen Fagopyri Esculenti, Massa Medicata Fermentata, Semen Raphani, Fructus Caricae, Fructus cydoniae oblongae, more than 10 flavor medical instruments the effect of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis, relieving dyspepsia, alleviating distention in middle-JIAO spleen invigorating, invigorating the spleen and regulating the stomach, appetizing removing food stagnancy, pain relieving is arranged.In the process of the high fat type acute glomerulonephritis for the treatment of, play main therapeutical effect, so be monarch drug.

Semen Citri Reticulatae, Pericarpium Citri tangerinae, Fructus Citri junoris, Semen Aesculi, Nicotiana tabacum L., Fructus Citri, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Semen Litchi, Fructus Litchi, Folium Et Cacumen Murrayae, Aspongopus, Semen Canavaliae, Ambra Grisea, more than 14 flavor medical instruments the promoting the circulation of QI relieving stuffiness of the chest by dispersing aggregation of pathogens is arranged, the effect of the chest stuffiness relieving of regulating the flow of vital energy, heat-clearing and toxic substances removing, hemostasis.In the process of the high fat type acute glomerulonephritis for the treatment of, can assist principal agent performance therapeutical effect, so be ministerial drug.Herba Ocimi (Herba Ocimi Pilosi): suffering, temperature.Go into lung, spleen, stomach, large intestine four warps.The dispelling wind circulation of qi promoting, removing dampness helps digestion, and restores menstrual flow and invigorates blood circulation detoxifying and relieving itching, expelling cold and freeing bi.Citrus aurantium L. var. amara Engl.: sweet, little hardship, temperature.Go into liver, stomach two warps.Depressed liver-energy dispersing and QI regulating, stomach function regulating relieves the pain.The all medicines of the energy rate focus of going directly is so be adjuvant drug.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.The spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.Can entangle the bias of all medicines, can alleviate the toxicity of all medicines again, so be messenger drug.Fructus Crataegi, Fructus Setariae Germinatus, Rhizoma Iridis Tectori, Radix Dauci Sativae, Endothelium Corneum Gigeriae Galli, Semen Fagopyri Esculenti, Massa Medicata Fermentata, Semen Raphani, Fructus Caricae, Fructus cydoniae oblongae, Semen Citri Reticulatae, Pericarpium Citri tangerinae, Fructus Citri junoris, Semen Aesculi, Nicotiana tabacum L., Fructus Citri, Rhizoma Cyperi, Cortex Magnoliae Officinalis, Semen Litchi, Fructus Litchi, Folium Et Cacumen Murrayae, Aspongopus, Semen Canavaliae, Ambra Grisea, Herba Ocimi (Herba Ocimi Pilosi), Citrus aurantium L. var. amara Engl., Radix Glycyrrhizae, more than 27 flavor medical instruments the effect of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis, relieving dyspepsia, alleviating distention in middle-JIAO spleen invigorating, invigorating the spleen and regulating the stomach, appetizing removing food stagnancy, pain relieving, promoting the circulation of QI relieving stuffiness of the chest by dispersing aggregation of pathogens, the chest stuffiness relieving of regulating the flow of vital energy, heat-clearing and toxic substances removing, hemostasis, depressed liver-energy dispersing and QI regulating is arranged.Monarch, compatibility is proper, is the optimum formula of the high fat type acute glomerulonephritis for the treatment of.Fructus Crataegi: sour, sweet, tepor.Go into spleen, stomach, liver three warps.Promoting digestion and removing stagnation, the circulation of qi promoting dissipating blood stasis.Fructus Setariae Germinatus: sweet, temperature.Go into spleen, stomach warp.With in help digestion, spleen benefiting and stimulating the appetite, excessive thirst is hindered in treatment pyretic toxicity dysentery, Tianjin.Rhizoma Iridis Tectori: hot, bitter, cold, poisonous.Go into lung, liver, spleen three warps.Promoting digestion and removing stagnation, blood circulation promoting and blood stasis dispelling, line water detumescence, heat-clearing and toxic substances removing, suppressing the hyperactive liver are only dizzy.Radix Dauci Sativae: sweet, hot, flat.Go into lung, spleen, stomach, kidney four warps.Invigorating the spleen and regulating the stomach, relieving dyspepsia, warming the kidney to invigorate YANG, detoxifcation rash, nourishing the lung to arrest cough.Endothelium Corneum Gigeriae Galli: sweet, flat.Go into spleen, stomach, large intestine, urinary bladder channel.Relieving dyspepsia, the alleviating distention in middle-JIAO spleen invigorating, removing toxic substances and promoting subsidence of swelling, astringent or styptic treatment for spontaneous sweating ending lost.Semen Fagopyri Esculenti: sweet, acid, cold.Go into spleen, stomach, large intestine channel.The appetizing removing food stagnancy, skin ulcer is treated in detoxifcation.Massa Medicata Fermentata: sweet, suffering, temperature.Go into spleen, stomach warp.The treatment diseases caused by exogenous pathogenic factor are got ill from overeating, insufficiency of the spleen distension, galactopoiesis in puerperal, removing food stagnancy dysentery relieving, therapeutic method to keep the adverse QI flowing downwards expectorant.Semen Raphani: hot, sweet, flat.Go into spleen, stomach warp.Promoting digestion and removing stagnation, lowering the adverse-rising QI to relieve dyspnea, expectorant antitussive.Fructus Caricae: sweet, flat.Go into spleen, stomach warp.The pain relieving that helps digestion, the row water conservancy is wet.Fructus cydoniae oblongae: hot, acid, sweet, temperature.Go into spleen, stomach warp.The therapeutic method to keep the adverse QI flowing downwards helps digestion, and deodorization is relieved the effect of alcohol.Semen Citri Reticulatae: hardship, flat, nontoxic.Go into liver, kidney two warps.Regulate the flow of vital energy cold expelling, the treatment acute mastitis from the beginning of.Pericarpium Citri tangerinae: hot, bitter, temperature, nontoxic.Go into spleen, lung two warps.Spleen invigorating is regulated the flow of vital energy, drying dampness to eliminate phlegm, inducing diuresis for treating stranguria syndrome.Fructus Citri junoris: acid, cold, nontoxic.Go into lung, liver, stomach three warps.Regulating the stomach and sending down the abnormal ascending QI, the chest stuffiness relieving relieving accumulation of pathogens, the wart that disappears, the poison that kills the fish Eriocheir sinensis.Semen Aesculi: sweet, hot, warm.Go into spleen, stomach, lung three warps.Depressed liver-energy dispersing and QI regulating, alleviating distention in middle-JIAO stomach function regulating.Nicotiana tabacum L.: hot, bitter, temperature, poisonous.Go into lung, spleen, stomach three warps.Promoting the circulation of QI to relieve pain, detoxifcation parasite killing.Fructus Citri: hot, bitter, sour, temperature.Go into liver, lung, spleen three warps.Depressed liver-energy dispersing and QI regulating and in reduce phlegm, sharp diaphragm preventing or arresting vomiting.Rhizoma Cyperi: hot, little hardship, little sweet, flat.Go into liver, three warmers two warps.Soothing liver-QI for relieving depression, menstruction regulating and pain relieving, warming for eliminaring cold-damp.Cortex Magnoliae Officinalis: bitter, hot, temperature.Go into spleen, lung, stomach, large intestine four warps.That dampness is loose is full, the diffusing painful abdominal mass that helps digestion, lowering the adverse-rising QI to subdue asthma, treatment cholera and stomachache.Semen Litchi: hot, sweet, temperature.Go into liver, kidney two warps.Regulating QI to relieve pain, warming spleen and stomach for dispelling cold.Fructus Litchi: hot, acid, sweet, temperature.Go into spleen, liver two warps.Regulating QI to relieve pain, dispersing swelling and dissipating binds, benefiting qi and checking blood, promoting the production of body fluid to quench thirst.Folium Et Cacumen Murrayae: hot, bitter, temperature.Go into the heart, liver, lung three warps.Promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, expelling wind and removing dampness, hard masses softening and resolving.Aspongopus: salty, sweet, temperature, nontoxic.Go into liver,spleen,kidney three warps.Promoting the circulation of QI to relieve pain, warming the kidney to invigorate YANG, warming middle-JIAO to stop diarrhea.Semen Canavaliae: sweet, flat, nontoxic.Go into spleen, stomach, large intestine, kidney four warps.Warming the middle warmer and descending qi, kidney tonifying complement, eliminating phlegm and relieving asthma, promoting the circulation of QI to relieve pain.Ambra Grisea: sweet, sour, gas raw meat, tepor.Go into the heart, lung, liver, kidney four warps.Promoting flow of QI and blood, relieving stranguria by diuresis, relieving cough and asthma promotes the production of body fluid and is full of cheek, wards off dirty detoxifcation.Herba Ocimi (Herba Ocimi Pilosi): suffering, temperature.Go into lung, spleen, stomach, large intestine four warps.The dispelling wind circulation of qi promoting, removing dampness helps digestion, and restores menstrual flow and invigorates blood circulation detoxifying and relieving itching, expelling cold and freeing bi.Citrus aurantium L. var. amara Engl.: sweet, little hardship, temperature.Go into liver, stomach two warps.Depressed liver-energy dispersing and QI regulating, stomach function regulating relieves the pain.Radix Glycyrrhizae: sweet, flat.Go into 12 warps.Spleen reinforcing lung moistening, Yiqi and vein recovery, relieving spasm to stop pain, heat-clearing and toxic substances removing, the mediation property of medicine.

The specific embodiment

Get Fructus Crataegi 9g, Fructus Setariae Germinatus 9g, Rhizoma Iridis Tectori 1g, Radix Dauci Sativae 9g, Endothelium Corneum Gigeriae Galli 6g, Semen Fagopyri Esculenti 9g, Massa Medicata Fermentata 6g, Semen Raphani 6g, Fructus Caricae 9g Fructus cydoniae oblongae 6g, Semen Citri Reticulatae 3g, Pericarpium Citri tangerinae 9g, Fructus Citri junoris 6g, Semen Aesculi 3g, Nicotiana tabacum L. 1g, Fructus Citri 9g, Rhizoma Cyperi 9g, Cortex Magnoliae Officinalis 6g, Semen Litchi 9g, Fructus Litchi 9g, Folium Et Cacumen Murrayae 6g, Aspongopus 3g, Semen Canavaliae 6g, Ambra Grisea 6g, Herba Ocimi (Herba Ocimi Pilosi) 6g, Citrus aurantium L. var. amara Engl. 3g and Radix Glycyrrhizae 9g, more than 27 the flavor medicines put into 1800 ml waters together, soaked 35 minutes, slow fire is fried 30 minutes then, filter and remove residue, fried medicinal liquid are the Chinese medicine of the high fat type acute glomerulonephritis for the treatment of.Boil medicine altogether 390 milliliters of liquid, when the patient of high fat type acute glomerulonephritis need treat, making fluid temperature was 36 ℃, each 130 milliliters, oral, every day three times, two is a course for the treatment of, if symptom is still deposited, obeys for second course for the treatment of again, so that recovery from illness.

Among the 390 routine high fat type acute glomerulonephritis patients, male's 178 examples account for 45.64%; Women's 212 examples account for 54.36%.The women is more than the male.

Table one, 390 routine high fat type acute glomerulonephritis patient's age scopes

Age (year)	18～20	21～30	31～50	51～61
					The example number	8	280	99	3
Percentage ratio	2.05%	71.79%	25.39%	0.77%

Table two, 390 routine high fat type acute glomerulonephritis patient curative effect tables

Curative effect	Cure	Take a turn for the better	Invalid
				The example number	387	3	Do not have
Percentage ratio	99.23%	0.77%	Do not have

Table three, 390 routine high fat type acute glomerulonephritis patients show the course for the treatment of

The treatment natural law	3～5	6～9	10～15	16～20
					The example number	12	290	81	7
Percentage ratio	3.08%	74.36%	20.77%	1.79%

Information slip before and after table four, the 390 routine high fat type acute glomerulonephritis patient treatments

Claims (1)

1. One kind the treatment high fat type acute glomerulonephritis Chinese medicinal preparation method, it is characterized in that: get Fructus Crataegi 9 grams, Fructus Setariae Germinatus 9 grams, Rhizoma Iridis Tectori 1 gram, Radix Dauci Sativae 9 grams, Endothelium Corneum Gigeriae Galli 6 grams, Semen Fagopyri Esculenti 9 grams, Massa Medicata Fermentata 6 grams, Semen Raphani 6 grams, Fructus Caricae 9 gram Fructus cydoniae oblongae 6 grams, Semen Citri Reticulatae 3 grams, Pericarpium Citri tangerinae 9 grams, Fructus Citri junoris 6 grams, Semen Aesculi 3 grams, Nicotiana tabacum L. 1 gram, Fructus Citri 9 grams, Rhizoma Cyperi 9 grams, Cortex Magnoliae Officinalis 6 grams, Semen Litchi 9 grams, Fructus Litchi 9 grams, Folium Et Cacumen Murrayae 6 grams, Aspongopus 3 grams, Semen Canavaliae 6 grams, Ambra Grisea 6 grams, Herba Ocimi (Herba Ocimi Pilosi) 6 grams, Citrus aurantium L. var. amara Engl. 3 grams and Radix Glycyrrhizae 9 grams, above 27 flavor Chinese medicines are put into 1800 ml waters, soaked 35 minutes, slow fire is fried 30 minutes then, boil medicine altogether 390 milliliters of liquid of filter and remove residue, fried medicinal liquid is the Chinese medicine of the high fat type acute glomerulonephritis for the treatment of.