CN102791715B - 用作激酶抑制剂的三环化合物 - Google Patents

用作激酶抑制剂的三环化合物 Download PDF

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Publication number
CN102791715B
CN102791715B CN201080064929.0A CN201080064929A CN102791715B CN 102791715 B CN102791715 B CN 102791715B CN 201080064929 A CN201080064929 A CN 201080064929A CN 102791715 B CN102791715 B CN 102791715B
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methyl
phenyl
base
dihydro
oxa
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CN102791715A (zh
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华金·帕斯托费尔南德斯
弗朗西斯科·哈维尔·拉莫斯利马
安娜·伊莎贝尔·埃尔南德斯伊格拉斯
索尼娅·马丁内斯冈萨雷斯
何塞·伊格纳西奥·马丁埃纳尔多
卡尔-古斯塔夫·彼雷·萨卢斯特
埃丝特·冈萨雷斯坎塔拉彼德拉
卡门·布兰科阿帕里西奥
安东尼奥·罗德里格斯埃尔格塔
安娜·玛丽亚·加西亚科利亚索
安东尼奥·萨尔加多塞拉诺
比阿特丽斯·诺亚马里尼奥
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National Public Sector Foundation Carlos Iii National Oncology Research Center FSPCnio
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Spanish National Cancer Research Centre
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

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  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
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CN201080064929.0A 2009-12-31 2010-12-31 用作激酶抑制剂的三环化合物 Expired - Fee Related CN102791715B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09380202.3 2009-12-31
EP09380202 2009-12-31
PCT/GB2010/002348 WO2011080510A1 (en) 2009-12-31 2010-12-31 Tricyclic compounds for use as kinase inhibitors

Publications (2)

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CN102791715A CN102791715A (zh) 2012-11-21
CN102791715B true CN102791715B (zh) 2016-04-27

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US (1) US9682991B2 (enExample)
EP (1) EP2519526B1 (enExample)
JP (1) JP5913126B2 (enExample)
KR (1) KR20120111739A (enExample)
CN (1) CN102791715B (enExample)
AU (1) AU2010338038B2 (enExample)
CA (1) CA2786002C (enExample)
IL (1) IL220701A0 (enExample)
NZ (1) NZ601033A (enExample)
PH (1) PH12012501361A1 (enExample)
SG (1) SG182297A1 (enExample)
WO (1) WO2011080510A1 (enExample)

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TWI617559B (zh) 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
WO2013005057A1 (en) * 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013005041A1 (en) * 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) * 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
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CN108931633B (zh) * 2018-05-22 2021-08-27 郑州大学第一附属医院 胆囊癌诊断和预后判断标志物pim1
AU2021360636A1 (en) * 2020-10-16 2023-06-15 Shanghai De Novo Pharmatech Co., Ltd. Triheterocyclic derivative, and pharmaceutical composition and application thereof
CN113214255B (zh) * 2021-04-22 2023-09-29 无锡合全药业有限公司 2,6-二氮杂螺[3.5]壬烷-6-甲酸叔丁基酯及其盐的合成方法
US20250042918A1 (en) * 2021-12-01 2025-02-06 Fundación Del Sector Públlco Estatal Centro Nacional De Investigaciones Oncológicas Carlos III Compounds
EP4279074A1 (en) * 2022-05-19 2023-11-22 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Azolo compounds for treatment of fibrotic diseases
EP4458358A1 (en) * 2023-05-02 2024-11-06 Tietze Chemical Consulting UG Pyridazine compounds for antifibrotic therapy

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US20130065881A1 (en) 2013-03-14
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