CN102762535B - 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 - Google Patents

合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 Download PDF

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Publication number
CN102762535B
CN102762535B CN201180008968.3A CN201180008968A CN102762535B CN 102762535 B CN102762535 B CN 102762535B CN 201180008968 A CN201180008968 A CN 201180008968A CN 102762535 B CN102762535 B CN 102762535B
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abdnaz
solvent
dnaz
water
added
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CN102762535A (zh
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N·A·斯特拉斯勒
L·F·卡尼祖
P·李
M·P·克雷默
D·M·罗森堡
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Northy Grumman Systems Inc
Nuoxi Gruman Innovation System Co ltd
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Alliant Techsystems Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201180008968.3A 2010-02-09 2011-01-18 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 Active CN102762535B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/702,782 US8471041B2 (en) 2010-02-09 2010-02-09 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
US12/702,782 2010-02-09
PCT/US2011/021500 WO2011100090A1 (en) 2010-02-09 2011-01-18 Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same

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CN102762535A CN102762535A (zh) 2012-10-31
CN102762535B true CN102762535B (zh) 2014-09-03

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US (1) US8471041B2 (https=)
EP (1) EP2534131B1 (https=)
JP (1) JP5461712B2 (https=)
KR (1) KR101456438B1 (https=)
CN (1) CN102762535B (https=)
AU (1) AU2011216176B2 (https=)
CA (1) CA2788459C (https=)
DK (1) DK2534131T3 (https=)
ES (1) ES2460040T3 (https=)
IL (1) IL221141A (https=)
MX (1) MX2012008989A (https=)
WO (1) WO2011100090A1 (https=)

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US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
CA2850723C (en) 2011-10-07 2019-07-09 Radiorx, Inc. Organonitro thioether compounds and medical uses thereof
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
CN109069420A (zh) 2016-01-11 2018-12-21 埃皮辛特瑞柯斯公司 2-溴-1-(3，3-二硝基氮杂环丁烷-1-基)乙酮静脉施用的组合物和方法
SG11201903312VA (en) 2016-10-14 2019-05-30 Epicentrix Inc Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
EP3648740A1 (en) 2017-07-07 2020-05-13 EpicentRx, Inc. Compositions for parenteral administration of therapeutic agents
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
BR112023025535A2 (pt) 2021-06-09 2024-02-27 Epicentrx Inc Composições de abdnaz cristalinas e métodos para fazer e usar as mesmas
WO2024145484A1 (en) 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

Citations (1)

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KR20130053385A (ko) 2013-05-23
CA2788459C (en) 2016-01-05
JP5461712B2 (ja) 2014-04-02
AU2011216176A1 (en) 2012-08-23
MX2012008989A (es) 2012-08-23
EP2534131B1 (en) 2014-03-19
EP2534131A1 (en) 2012-12-19
WO2011100090A1 (en) 2011-08-18
KR101456438B1 (ko) 2014-10-31
ES2460040T3 (es) 2014-05-13
IL221141A0 (en) 2012-09-24
US8471041B2 (en) 2013-06-25
JP2013518925A (ja) 2013-05-23
CA2788459A1 (en) 2011-08-18
DK2534131T3 (da) 2014-04-07
CN102762535A (zh) 2012-10-31
IL221141A (en) 2016-08-31
US20110195947A1 (en) 2011-08-11
AU2011216176B2 (en) 2013-11-14

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