MX2012008989A - Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma. - Google Patents
Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma.Info
- Publication number
- MX2012008989A MX2012008989A MX2012008989A MX2012008989A MX2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A
- Authority
- MX
- Mexico
- Prior art keywords
- abdnaz
- bromoacetyl
- synthesizing
- isolating
- dnaz
- Prior art date
Links
- JODKFOVZURLVTG-UHFFFAOYSA-N 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone Chemical compound [O-][N+](=O)C1([N+]([O-])=O)CN(C(=O)CBr)C1 JODKFOVZURLVTG-UHFFFAOYSA-N 0.000 title abstract 11
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- 239000002904 solvent Substances 0.000 abstract 5
- 239000008346 aqueous phase Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- KZMGYPLQYOPHEL-UHFFFAOYSA-N Boron trifluoride etherate Chemical compound FB(F)F.CCOCC KZMGYPLQYOPHEL-UHFFFAOYSA-N 0.000 abstract 2
- 239000012074 organic phase Substances 0.000 abstract 2
- LSTRKXWIZZZYAS-UHFFFAOYSA-N 2-bromoacetyl bromide Chemical compound BrCC(Br)=O LSTRKXWIZZZYAS-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/702,782 US8471041B2 (en) | 2010-02-09 | 2010-02-09 | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
| PCT/US2011/021500 WO2011100090A1 (en) | 2010-02-09 | 2011-01-18 | Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2012008989A true MX2012008989A (es) | 2012-08-23 |
Family
ID=43875262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012008989A MX2012008989A (es) | 2010-02-09 | 2011-01-18 | Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8471041B2 (https=) |
| EP (1) | EP2534131B1 (https=) |
| JP (1) | JP5461712B2 (https=) |
| KR (1) | KR101456438B1 (https=) |
| CN (1) | CN102762535B (https=) |
| AU (1) | AU2011216176B2 (https=) |
| CA (1) | CA2788459C (https=) |
| DK (1) | DK2534131T3 (https=) |
| ES (1) | ES2460040T3 (https=) |
| IL (1) | IL221141A (https=) |
| MX (1) | MX2012008989A (https=) |
| WO (1) | WO2011100090A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
| US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| CA2850723C (en) | 2011-10-07 | 2019-07-09 | Radiorx, Inc. | Organonitro thioether compounds and medical uses thereof |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| CN109069420A (zh) | 2016-01-11 | 2018-12-21 | 埃皮辛特瑞柯斯公司 | 2-溴-1-(3，3-二硝基氮杂环丁烷-1-基)乙酮静脉施用的组合物和方法 |
| SG11201903312VA (en) | 2016-10-14 | 2019-05-30 | Epicentrix Inc | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
| EP3648740A1 (en) | 2017-07-07 | 2020-05-13 | EpicentRx, Inc. | Compositions for parenteral administration of therapeutic agents |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| BR112023025535A2 (pt) | 2021-06-09 | 2024-02-27 | Epicentrx Inc | Composições de abdnaz cristalinas e métodos para fazer e usar as mesmas |
| WO2024145484A1 (en) | 2022-12-29 | 2024-07-04 | Epicentrx, Inc. | Rrx-001 for treating reproductive-related disorders |
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| EP1791544A4 (en) | 2004-09-08 | 2007-09-12 | Chelsea Therapeutics Inc | CHINAZOLINE DERIVATIVES AS METABOLIC INERT ANTIFOLATE |
| US7507842B2 (en) * | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| JP2009510073A (ja) | 2005-09-27 | 2009-03-12 | ノバルティス アクチエンゲゼルシャフト | カルボキシアミン化合物およびその使用方法 |
| KR100967848B1 (ko) * | 2008-05-28 | 2010-07-05 | 국방과학연구소 | 분자화약이 도입된, 고에너지 결합제용1-글리시딜-3,3-디니트로아제티딘 및 그의 제조방법 |
| WO2012078992A1 (en) | 2010-12-09 | 2012-06-14 | Radiorx, Inc. | Organonitro compounds for use in treating non-hodgkin's lymphoma and leukemia, and methods relating thereto |
-
2010
- 2010-02-09 US US12/702,782 patent/US8471041B2/en active Active
-
2011
- 2011-01-18 CN CN201180008968.3A patent/CN102762535B/zh active Active
- 2011-01-18 JP JP2012552884A patent/JP5461712B2/ja active Active
- 2011-01-18 EP EP11700989.4A patent/EP2534131B1/en active Active
- 2011-01-18 CA CA2788459A patent/CA2788459C/en active Active
- 2011-01-18 KR KR1020127022598A patent/KR101456438B1/ko active Active
- 2011-01-18 WO PCT/US2011/021500 patent/WO2011100090A1/en not_active Ceased
- 2011-01-18 AU AU2011216176A patent/AU2011216176B2/en active Active
- 2011-01-18 MX MX2012008989A patent/MX2012008989A/es active IP Right Grant
- 2011-01-18 ES ES11700989.4T patent/ES2460040T3/es active Active
- 2011-01-18 DK DK11700989.4T patent/DK2534131T3/da active
-
2012
- 2012-07-26 IL IL221141A patent/IL221141A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130053385A (ko) | 2013-05-23 |
| CA2788459C (en) | 2016-01-05 |
| JP5461712B2 (ja) | 2014-04-02 |
| AU2011216176A1 (en) | 2012-08-23 |
| EP2534131B1 (en) | 2014-03-19 |
| EP2534131A1 (en) | 2012-12-19 |
| WO2011100090A1 (en) | 2011-08-18 |
| KR101456438B1 (ko) | 2014-10-31 |
| ES2460040T3 (es) | 2014-05-13 |
| IL221141A0 (en) | 2012-09-24 |
| US8471041B2 (en) | 2013-06-25 |
| JP2013518925A (ja) | 2013-05-23 |
| CA2788459A1 (en) | 2011-08-18 |
| DK2534131T3 (da) | 2014-04-07 |
| CN102762535A (zh) | 2012-10-31 |
| CN102762535B (zh) | 2014-09-03 |
| IL221141A (en) | 2016-08-31 |
| US20110195947A1 (en) | 2011-08-11 |
| AU2011216176B2 (en) | 2013-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |