CN102762535B - 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 - Google Patents

合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 Download PDF

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Publication number
CN102762535B
CN102762535B CN201180008968.3A CN201180008968A CN102762535B CN 102762535 B CN102762535 B CN 102762535B CN 201180008968 A CN201180008968 A CN 201180008968A CN 102762535 B CN102762535 B CN 102762535B
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abdnaz
solvent
dnaz
water
added
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CN102762535A (zh
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N·A·斯特拉斯勒
L·F·卡尼祖
P·李
M·P·克雷默
D·M·罗森堡
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Northy Grumman Systems Inc
Nuoxi Gruman Innovation System Co ltd
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Alliant Techsystems Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201180008968.3A 2010-02-09 2011-01-18 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 Active CN102762535B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/702,782 US8471041B2 (en) 2010-02-09 2010-02-09 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
US12/702,782 2010-02-09
PCT/US2011/021500 WO2011100090A1 (en) 2010-02-09 2011-01-18 Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same

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CN102762535A CN102762535A (zh) 2012-10-31
CN102762535B true CN102762535B (zh) 2014-09-03

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US (1) US8471041B2 (enExample)
EP (1) EP2534131B1 (enExample)
JP (1) JP5461712B2 (enExample)
KR (1) KR101456438B1 (enExample)
CN (1) CN102762535B (enExample)
AU (1) AU2011216176B2 (enExample)
CA (1) CA2788459C (enExample)
DK (1) DK2534131T3 (enExample)
ES (1) ES2460040T3 (enExample)
IL (1) IL221141A (enExample)
MX (1) MX2012008989A (enExample)
WO (1) WO2011100090A1 (enExample)

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US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
JP6019126B2 (ja) 2011-10-07 2016-11-02 エピセントアーレックス・インコーポレイテッドＥｐｉｃｅｎｔＲｘ， Ｉｎｃ． 有機ニトロチオエーテル化合物およびその医療用途
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
SG11201805942UA (en) 2016-01-11 2018-08-30 Epicentrx Inc Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
EA201990949A1 (ru) 2016-10-14 2019-10-31 Сульфоксиалкильные органические нитросоединения и родственные соединения и фармацевтические композиции для применения в медицине
KR102869384B1 (ko) 2017-07-07 2025-10-15 에피센트알엑스, 인코포레이티드 치료제의 비경구 투여를 위한 조성물
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
TW202313001A (zh) 2021-06-09 2023-04-01 美商埃皮辛特瑞科斯公司 結晶abdnaz組合物及其製造及使用方法
WO2024145484A1 (en) 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

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US20110195947A1 (en) 2011-08-11
CA2788459C (en) 2016-01-05
CN102762535A (zh) 2012-10-31
EP2534131A1 (en) 2012-12-19
IL221141A0 (en) 2012-09-24
KR20130053385A (ko) 2013-05-23
KR101456438B1 (ko) 2014-10-31
CA2788459A1 (en) 2011-08-18
ES2460040T3 (es) 2014-05-13
DK2534131T3 (da) 2014-04-07
JP5461712B2 (ja) 2014-04-02
IL221141A (en) 2016-08-31
JP2013518925A (ja) 2013-05-23
MX2012008989A (es) 2012-08-23
AU2011216176A1 (en) 2012-08-23
AU2011216176B2 (en) 2013-11-14
EP2534131B1 (en) 2014-03-19
WO2011100090A1 (en) 2011-08-18
US8471041B2 (en) 2013-06-25

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