CN102762535B - 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 - Google Patents

合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 Download PDF

Info

Publication number
CN102762535B
CN102762535B CN201180008968.3A CN201180008968A CN102762535B CN 102762535 B CN102762535 B CN 102762535B CN 201180008968 A CN201180008968 A CN 201180008968A CN 102762535 B CN102762535 B CN 102762535B
Authority
CN
China
Prior art keywords
abdnaz
solvent
dnaz
water
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180008968.3A
Other languages
English (en)
Chinese (zh)
Other versions
CN102762535A (zh
Inventor
N·A·斯特拉斯勒
L·F·卡尼祖
P·李
M·P·克雷默
D·M·罗森堡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northy Grumman Systems Inc
Nuoxi Gruman Innovation System Co ltd
Original Assignee
Alliant Techsystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alliant Techsystems Inc filed Critical Alliant Techsystems Inc
Publication of CN102762535A publication Critical patent/CN102762535A/zh
Application granted granted Critical
Publication of CN102762535B publication Critical patent/CN102762535B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201180008968.3A 2010-02-09 2011-01-18 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物 Active CN102762535B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/702,782 2010-02-09
US12/702,782 US8471041B2 (en) 2010-02-09 2010-02-09 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
PCT/US2011/021500 WO2011100090A1 (en) 2010-02-09 2011-01-18 Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same

Publications (2)

Publication Number Publication Date
CN102762535A CN102762535A (zh) 2012-10-31
CN102762535B true CN102762535B (zh) 2014-09-03

Family

ID=43875262

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180008968.3A Active CN102762535B (zh) 2010-02-09 2011-01-18 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物

Country Status (12)

Country Link
US (1) US8471041B2 (enExample)
EP (1) EP2534131B1 (enExample)
JP (1) JP5461712B2 (enExample)
KR (1) KR101456438B1 (enExample)
CN (1) CN102762535B (enExample)
AU (1) AU2011216176B2 (enExample)
CA (1) CA2788459C (enExample)
DK (1) DK2534131T3 (enExample)
ES (1) ES2460040T3 (enExample)
IL (1) IL221141A (enExample)
MX (1) MX2012008989A (enExample)
WO (1) WO2011100090A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507842B2 (en) 2005-08-12 2009-03-24 Radiorx, Inc. Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
EP2763667B1 (en) 2011-10-07 2022-10-26 EpicentRx, Inc. Organonitro thioether compounds and medical uses thereof
WO2013052803A2 (en) 2011-10-07 2013-04-11 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
AU2017207304B2 (en) 2016-01-11 2022-05-26 Epicentrx, Inc. Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
CA3040479A1 (en) 2016-10-14 2018-04-19 Epicentrx, Inc. Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
IL311727A (en) 2017-07-07 2024-05-01 Epicentrx Inc Preparations for intravenous administration of medical substances
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
TW202313001A (zh) * 2021-06-09 2023-04-01 美商埃皮辛特瑞科斯公司 結晶abdnaz組合物及其製造及使用方法
WO2024145484A1 (en) 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101370492A (zh) * 2005-08-12 2009-02-18 阿利安特技术系统股份有限公司 环状硝基化合物及其药物组合物和用途

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4935450A (en) 1982-09-17 1990-06-19 Therapeutical Systems Corporation Cancer therapy system for effecting oncolysis of malignant neoplasms
JPS60116642A (ja) 1983-11-29 1985-06-24 Nippon Kayaku Co Ltd ２−モノ−置換メチル−５，５−ジメチル−シクロ−２−ヘキセノン誘導体
GB8504253D0 (en) 1985-02-19 1985-03-20 Ici Plc Electrostatic spraying apparatus
GB8728418D0 (en) 1987-12-04 1988-01-13 Jenkins T C Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
US5693794A (en) 1988-09-30 1997-12-02 The United States Of America As Represented By The Secretary Of The Navy Caged polynitramine compound
JP2659614B2 (ja) 1990-11-13 1997-09-30 株式会社日立製作所 表示制御装置
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5336784A (en) 1993-06-07 1994-08-09 The Regents Of The University Of California Synthesis of 1,3,3-trinitroazetidine
JP3211892B2 (ja) 1994-05-27 2001-09-25 セイジィ ファーマスーティカルス インコーポレーテッド 肛門疾患を治療する窒素酸化物供与体及び方法
ATE186222T1 (de) 1995-03-14 1999-11-15 Siemens Ag Ultraschallzerstäuber mit abnehmbarer präzisionsdosiereinheit
ES2177771T3 (es) 1995-03-14 2002-12-16 Siemens Ag Dispositivo atomizador ultrasonico con unidad desmontable de dosificacion de precision.
AU5798996A (en) 1995-05-15 1996-11-29 Sachs, Michael C. Adnaz, compositions and processes
US5580988A (en) 1995-05-15 1996-12-03 The United States Of America As Represented By The Secretary Of The Army Substituted azetidines and processes of using them
US5898038A (en) 1996-03-19 1999-04-27 Board Of Regents, The University Of Texas System Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
JP2001501159A (ja) 1996-10-15 2001-01-30 イーストマン ケミカル カンパニー 爆薬配合物
GB9720797D0 (en) 1997-09-30 1997-12-03 Rhodes John Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome
US5954047A (en) 1997-10-17 1999-09-21 Systemic Pulmonary Development, Ltd. Methods and apparatus for delivering aerosolized medication
US6056966A (en) 1998-05-18 2000-05-02 Baker Norton Pharmaceuticals, Inc. Method and compositions for treating impotence
US7635722B1 (en) 1998-07-27 2009-12-22 Saint Jude Pharmaceuticals, Inc. Chemical induced intracellular hyperthermia
US6448253B1 (en) 1998-09-16 2002-09-10 King Pharmaceuticals Research And Development, Inc. Adenosine A3 receptor modulators
US6245799B1 (en) 1999-11-08 2001-06-12 American Home Products Corp [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders
ES2244599T3 (es) 2000-04-10 2005-12-16 Pfizer Products Inc. Compuestos de benzamido-piperidina como antagonistas de la sustancia p.
JP2002069057A (ja) 2000-07-07 2002-03-08 Kyowa Hakko Kogyo Co Ltd ピペリジン誘導体
DE10111049A1 (de) 2001-03-06 2002-09-12 Beiersdorf Ag Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut
EP1336602A1 (en) 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003282534A1 (en) 2002-10-07 2004-05-04 Radiorx, Inc. X-nitro compounds, pharmaceutical compositions thereof and uses therof
US6870061B2 (en) 2003-01-10 2005-03-22 Alliant Techsystems Inc. Continuous process and system for production of glycidyl nitrate from glycerin, nitric acid and caustic and conversion of glycidyl nitrate to poly(glycidyl nitrate)
EP1603933A2 (en) 2003-03-13 2005-12-14 Nitromed, Inc. Nitrosated and nitrosylated compounds, compositions and methods of use
WO2004113281A1 (en) 2003-06-25 2004-12-29 Je Il Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
GB0326047D0 (en) 2003-11-07 2003-12-10 Univ Sheffield Substance
US7829708B2 (en) 2004-09-08 2010-11-09 Chelsea Therapeutics, Inc. Metabolically inert antifolates for treating disorders of abnormal cellular proliferation and inflammation
US20070135380A1 (en) 2005-08-12 2007-06-14 Radiorx, Inc. O-nitro compounds, pharmaceutical compositions thereof and uses thereof
WO2007038459A2 (en) 2005-09-27 2007-04-05 Novartis Ag Carboxyamine compounds and their use in the treatment of hdac dependent diseases
KR100967848B1 (ko) * 2008-05-28 2010-07-05 국방과학연구소 분자화약이 도입된, 고에너지 결합제용1-글리시딜-3,3-디니트로아제티딘 및 그의 제조방법
US20120149678A1 (en) 2010-12-09 2012-06-14 Oronsky Bryan T Organonitro Compounds for Use in Treating Non-Hodgkin's Lymphoma and Leukemia, and Methods Relating Thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101370492A (zh) * 2005-08-12 2009-02-18 阿利安特技术系统股份有限公司 环状硝基化合物及其药物组合物和用途

Also Published As

Publication number Publication date
US8471041B2 (en) 2013-06-25
KR101456438B1 (ko) 2014-10-31
AU2011216176A1 (en) 2012-08-23
WO2011100090A1 (en) 2011-08-18
DK2534131T3 (da) 2014-04-07
IL221141A0 (en) 2012-09-24
KR20130053385A (ko) 2013-05-23
US20110195947A1 (en) 2011-08-11
EP2534131B1 (en) 2014-03-19
AU2011216176B2 (en) 2013-11-14
EP2534131A1 (en) 2012-12-19
IL221141A (en) 2016-08-31
CA2788459C (en) 2016-01-05
JP5461712B2 (ja) 2014-04-02
CN102762535A (zh) 2012-10-31
MX2012008989A (es) 2012-08-23
ES2460040T3 (es) 2014-05-13
JP2013518925A (ja) 2013-05-23
CA2788459A1 (en) 2011-08-18

Similar Documents

Publication Publication Date Title
CN102762535B (zh) 合成和分离n-(溴乙酰基)-3, 3-二硝基氮杂环丁烷的方法和包括其的组合物
CN102459276A (zh) 从纳曲酮制备盐酸纳美芬
KR100433436B1 (ko) 벤즈이미다졸화합물의합성방법
EP3490973B1 (en) Polymorphic forms of belinostat and processes for preparation thereof
EP2238152A2 (en) Solid and crystalline dutasteride and processes for preparation thereof
JP2008516005A (ja) レトロゾールの改良された調製方法
JP2011006379A (ja) ｛２−アミノ−１，４−ジヒドロ−６−メチル−４−（３−ニトロフェニル）−３，５−ピリジンジカルボン酸３−（１−ジフェニルメチルアゼチジン−３−イル）エステル５−イソプロピルエステル｝（アゼルニジピン）の再結晶方法、アゼルニジピンのイソプロピルアルコール付加体、およびアゼルニジピンの製造方法
JP2006515028A (ja) ４−ヒドロキシカルバモイルフェニル）−カルバミン酸（６−ジエチルアミノメチル−ナフタレン−２−イル）エステルの塩酸一水和物
WO2008087628A1 (en) Process for preparing montelukast sodium containing controlled levels of impurities
JP3230723B2 (ja) ２−（フルフリルチオ）酢酸誘導体の製造方法
JP4397990B2 (ja) ３−アルキルフラバノノール誘導体の精製法
EP1535900A1 (en) Process for the preparation of nateglinide, preferably in b-form
WO2001004094A1 (en) Processes for the preparation of ipidacrine or ipidacrine hydrochloride hydrate
JP2706554B2 (ja) ４―トリフルオロメチルアニリン誘導体及びその製造法
JPH051053A (ja) ６−（３−ジメチルアミノプロピオニル）フオルスコリンの新規製造法
TW202513046A (zh) 製備１－乙基－Ｎ－（（１，２，３，５，６，７－六氫－ｓ－二環戊二烯并苯－４－基）胺甲醯基）哌啶－４－磺醯胺之製備方法
WO2023100110A1 (en) Process for preparing brivaracetam
CN120424079A (zh) 一种巴瑞替尼的精制方法
JP4052786B2 (ja) ２−クロロ−４−（１−ピペリジニルメチル）ピリジンの精製方法
JP2853929B2 (ja) ２−クロロ−４，５−ジフルオロ−３−メトキシ安息香酸の製造方法
WO2025105347A1 (ja) 組成物、フルチカゾンフランカルボン酸エステルの製造方法、フルチカゾンフランカルボン酸エステルの精製方法及び標識化合物の製造方法
JPH07103115B2 (ja) ２−（１０，１１−ジヒドロ−１０−オキソジベンゾ〔ｂ，ｆ〕チエピン−２−イル）プロピオン酸の結晶化方法
EP4568978A1 (en) An improved process for preparing antiviral phosphonate analogues
JP2815438B2 (ja) １，２―ビス（ニコチンアミド）プロパンの精製方法
JP2006290753A (ja) ２−（１０、１１−ジヒドロ−１０−オキシジベンゾ〔ｂ、ｆ〕チエピン−２−イル）プロピオン酸の製造方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee
CP01 Change in the name or title of a patent holder

Address after: The University of Minnesota

Patentee after: Rail ATK Co.,Ltd.

Address before: The University of Minnesota

Patentee before: ALLIANT TECHSYSTEMS Inc.

CP01 Change in the name or title of a patent holder
CP01 Change in the name or title of a patent holder

Address after: The University of Minnesota

Patentee after: Norway Grumman Innovation Systems Inc.

Address before: The University of Minnesota

Patentee before: Rail ATK Co.,Ltd.

CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: American Virginia

Patentee after: Nuoxi Gruman Innovation System Co.,Ltd.

Address before: Minnesota,USA

Patentee before: Norway Grumman Innovation Systems Inc.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20220114

Address after: American Virginia

Patentee after: Northy Grumman Systems Inc.

Address before: American Virginia

Patentee before: Nuoxi Gruman Innovation System Co.,Ltd.