ES2460040T3 - Procedimientos de síntesis y aislamiento de N-(bromoacetil)-3,3-dinitroazetidina y una composición que incluye la misma - Google Patents

Procedimientos de síntesis y aislamiento de N-(bromoacetil)-3,3-dinitroazetidina y una composición que incluye la misma Download PDF

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Publication number
ES2460040T3
ES2460040T3 ES11700989.4T ES11700989T ES2460040T3 ES 2460040 T3 ES2460040 T3 ES 2460040T3 ES 11700989 T ES11700989 T ES 11700989T ES 2460040 T3 ES2460040 T3 ES 2460040T3
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ES
Spain
Prior art keywords
abdnaz
solvent
dnaz
dichloromethane
reaction mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11700989.4T
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English (en)
Spanish (es)
Inventor
Nicholas A. Straessler
Louis F. Cannizzo
Ping Li
Michael P. Kramer
David M. Rosenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northrop Grumman Innovation Systems LLC
Original Assignee
Alliant Techsystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alliant Techsystems Inc filed Critical Alliant Techsystems Inc
Application granted granted Critical
Publication of ES2460040T3 publication Critical patent/ES2460040T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES11700989.4T 2010-02-09 2011-01-18 Procedimientos de síntesis y aislamiento de N-(bromoacetil)-3,3-dinitroazetidina y una composición que incluye la misma Active ES2460040T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US702782 2010-02-09
US12/702,782 US8471041B2 (en) 2010-02-09 2010-02-09 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
PCT/US2011/021500 WO2011100090A1 (en) 2010-02-09 2011-01-18 Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same

Publications (1)

Publication Number Publication Date
ES2460040T3 true ES2460040T3 (es) 2014-05-13

Family

ID=43875262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11700989.4T Active ES2460040T3 (es) 2010-02-09 2011-01-18 Procedimientos de síntesis y aislamiento de N-(bromoacetil)-3,3-dinitroazetidina y una composición que incluye la misma

Country Status (12)

Country Link
US (1) US8471041B2 (enExample)
EP (1) EP2534131B1 (enExample)
JP (1) JP5461712B2 (enExample)
KR (1) KR101456438B1 (enExample)
CN (1) CN102762535B (enExample)
AU (1) AU2011216176B2 (enExample)
CA (1) CA2788459C (enExample)
DK (1) DK2534131T3 (enExample)
ES (1) ES2460040T3 (enExample)
IL (1) IL221141A (enExample)
MX (1) MX2012008989A (enExample)
WO (1) WO2011100090A1 (enExample)

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US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
EP2763667B1 (en) 2011-10-07 2022-10-26 EpicentRx, Inc. Organonitro thioether compounds and medical uses thereof
WO2013052803A2 (en) 2011-10-07 2013-04-11 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
AU2017207304B2 (en) 2016-01-11 2022-05-26 Epicentrx, Inc. Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
CA3040479A1 (en) 2016-10-14 2018-04-19 Epicentrx, Inc. Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
IL311727A (en) 2017-07-07 2024-05-01 Epicentrx Inc Preparations for intravenous administration of medical substances
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
TW202313001A (zh) * 2021-06-09 2023-04-01 美商埃皮辛特瑞科斯公司 結晶abdnaz組合物及其製造及使用方法
WO2024145484A1 (en) 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

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Also Published As

Publication number Publication date
US8471041B2 (en) 2013-06-25
KR101456438B1 (ko) 2014-10-31
AU2011216176A1 (en) 2012-08-23
WO2011100090A1 (en) 2011-08-18
DK2534131T3 (da) 2014-04-07
IL221141A0 (en) 2012-09-24
KR20130053385A (ko) 2013-05-23
US20110195947A1 (en) 2011-08-11
EP2534131B1 (en) 2014-03-19
CN102762535B (zh) 2014-09-03
AU2011216176B2 (en) 2013-11-14
EP2534131A1 (en) 2012-12-19
IL221141A (en) 2016-08-31
CA2788459C (en) 2016-01-05
JP5461712B2 (ja) 2014-04-02
CN102762535A (zh) 2012-10-31
MX2012008989A (es) 2012-08-23
JP2013518925A (ja) 2013-05-23
CA2788459A1 (en) 2011-08-18

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