MX2012008989A - Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma. - Google Patents

Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma.

Info

Publication number
MX2012008989A
MX2012008989A MX2012008989A MX2012008989A MX2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A MX 2012008989 A MX2012008989 A MX 2012008989A
Authority
MX
Mexico
Prior art keywords
abdnaz
bromoacetyl
synthesizing
isolating
dnaz
Prior art date
Application number
MX2012008989A
Other languages
English (en)
Spanish (es)
Inventor
Nicholas A Straessler
Louis F Cannizzo
Ping Li
Michael P Kramer
David M Rosenberg
Original Assignee
Alliant Techsystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alliant Techsystems Inc filed Critical Alliant Techsystems Inc
Publication of MX2012008989A publication Critical patent/MX2012008989A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
MX2012008989A 2010-02-09 2011-01-18 Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma. MX2012008989A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/702,782 US8471041B2 (en) 2010-02-09 2010-02-09 Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same
PCT/US2011/021500 WO2011100090A1 (en) 2010-02-09 2011-01-18 Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same

Publications (1)

Publication Number Publication Date
MX2012008989A true MX2012008989A (es) 2012-08-23

Family

ID=43875262

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012008989A MX2012008989A (es) 2010-02-09 2011-01-18 Metodos de sintetizacion y aislamiento de n-(bromoacetil)-3,3-dini troazetidina y composicion que incluye la misma.

Country Status (12)

Country Link
US (1) US8471041B2 (enExample)
EP (1) EP2534131B1 (enExample)
JP (1) JP5461712B2 (enExample)
KR (1) KR101456438B1 (enExample)
CN (1) CN102762535B (enExample)
AU (1) AU2011216176B2 (enExample)
CA (1) CA2788459C (enExample)
DK (1) DK2534131T3 (enExample)
ES (1) ES2460040T3 (enExample)
IL (1) IL221141A (enExample)
MX (1) MX2012008989A (enExample)
WO (1) WO2011100090A1 (enExample)

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US8664247B2 (en) 2011-08-26 2014-03-04 Radiorx, Inc. Acyclic organonitro compounds for use in treating cancer
JP6019126B2 (ja) 2011-10-07 2016-11-02 エピセントアーレックス・インコーポレイテッドＥｐｉｃｅｎｔＲｘ， Ｉｎｃ． 有機ニトロチオエーテル化合物およびその医療用途
US20140308260A1 (en) 2011-10-07 2014-10-16 Radiorx, Inc. Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products
US10342778B1 (en) 2015-10-20 2019-07-09 Epicentrx, Inc. Treatment of brain metastases using organonitro compound combination therapy
US9987270B1 (en) 2015-10-29 2018-06-05 Epicentrix, Inc. Treatment of gliomas using organonitro compound combination therapy
SG11201805942UA (en) 2016-01-11 2018-08-30 Epicentrx Inc Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone
EA201990949A1 (ru) 2016-10-14 2019-10-31 Сульфоксиалкильные органические нитросоединения и родственные соединения и фармацевтические композиции для применения в медицине
KR102869384B1 (ko) 2017-07-07 2025-10-15 에피센트알엑스, 인코포레이티드 치료제의 비경구 투여를 위한 조성물
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
TW202313001A (zh) 2021-06-09 2023-04-01 美商埃皮辛特瑞科斯公司 結晶abdnaz組合物及其製造及使用方法
WO2024145484A1 (en) 2022-12-29 2024-07-04 Epicentrx, Inc. Rrx-001 for treating reproductive-related disorders

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Also Published As

Publication number Publication date
US20110195947A1 (en) 2011-08-11
CA2788459C (en) 2016-01-05
CN102762535A (zh) 2012-10-31
EP2534131A1 (en) 2012-12-19
IL221141A0 (en) 2012-09-24
KR20130053385A (ko) 2013-05-23
KR101456438B1 (ko) 2014-10-31
CA2788459A1 (en) 2011-08-18
ES2460040T3 (es) 2014-05-13
CN102762535B (zh) 2014-09-03
DK2534131T3 (da) 2014-04-07
JP5461712B2 (ja) 2014-04-02
IL221141A (en) 2016-08-31
JP2013518925A (ja) 2013-05-23
AU2011216176A1 (en) 2012-08-23
AU2011216176B2 (en) 2013-11-14
EP2534131B1 (en) 2014-03-19
WO2011100090A1 (en) 2011-08-18
US8471041B2 (en) 2013-06-25

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