DK2534131T3 - Fremgangsmåder til syntese og isolering af N-(bromacetyl)-3,3-dinitroazetidin samt en sammensætning, der indeholder denne - Google Patents
Fremgangsmåder til syntese og isolering af N-(bromacetyl)-3,3-dinitroazetidin samt en sammensætning, der indeholder denneInfo
- Publication number
- DK2534131T3 DK2534131T3 DK11700989.4T DK11700989T DK2534131T3 DK 2534131 T3 DK2534131 T3 DK 2534131T3 DK 11700989 T DK11700989 T DK 11700989T DK 2534131 T3 DK2534131 T3 DK 2534131T3
- Authority
- DK
- Denmark
- Prior art keywords
- dinitroazetidine
- bromoacetyl
- isolation
- synthesis
- methods
- Prior art date
Links
- JODKFOVZURLVTG-UHFFFAOYSA-N 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone Chemical compound [O-][N+](=O)C1([N+]([O-])=O)CN(C(=O)CBr)C1 JODKFOVZURLVTG-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/702,782 US8471041B2 (en) | 2010-02-09 | 2010-02-09 | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
| PCT/US2011/021500 WO2011100090A1 (en) | 2010-02-09 | 2011-01-18 | Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2534131T3 true DK2534131T3 (da) | 2014-04-07 |
Family
ID=43875262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11700989.4T DK2534131T3 (da) | 2010-02-09 | 2011-01-18 | Fremgangsmåder til syntese og isolering af N-(bromacetyl)-3,3-dinitroazetidin samt en sammensætning, der indeholder denne |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8471041B2 (enExample) |
| EP (1) | EP2534131B1 (enExample) |
| JP (1) | JP5461712B2 (enExample) |
| KR (1) | KR101456438B1 (enExample) |
| CN (1) | CN102762535B (enExample) |
| AU (1) | AU2011216176B2 (enExample) |
| CA (1) | CA2788459C (enExample) |
| DK (1) | DK2534131T3 (enExample) |
| ES (1) | ES2460040T3 (enExample) |
| IL (1) | IL221141A (enExample) |
| MX (1) | MX2012008989A (enExample) |
| WO (1) | WO2011100090A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
| US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| WO2013052164A1 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Organonitro thioether compounds and medical uses thereof |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| DK3402480T3 (da) | 2016-01-11 | 2021-06-28 | Epicentrx Inc | Sammensætninger og fremgangsmåder til intravenøs administration af 2-brom-1-(3,3-dinitroazetidin-1-yl)ethanon |
| WO2018071741A1 (en) | 2016-10-14 | 2018-04-19 | Epicentrix, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
| MX2020000265A (es) | 2017-07-07 | 2020-07-22 | Epicentrx Inc | Composiciones para la administración parenteral de agentes terapéuticos. |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| US20240293360A1 (en) | 2021-06-09 | 2024-09-05 | Epicentrx, Inc. | Crystalline abdnaz compositions and methods of making and using the same |
| WO2024145484A1 (en) | 2022-12-29 | 2024-07-04 | Epicentrx, Inc. | Rrx-001 for treating reproductive-related disorders |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4935450A (en) | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
| JPS60116642A (ja) | 1983-11-29 | 1985-06-24 | Nippon Kayaku Co Ltd | ２−モノ−置換メチル−５，５−ジメチル−シクロ−２−ヘキセノン誘導体 |
| GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| GB8728418D0 (en) | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5693794A (en) | 1988-09-30 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Navy | Caged polynitramine compound |
| JP2659614B2 (ja) | 1990-11-13 | 1997-09-30 | 株式会社日立製作所 | 表示制御装置 |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5336784A (en) | 1993-06-07 | 1994-08-09 | The Regents Of The University Of California | Synthesis of 1,3,3-trinitroazetidine |
| PT719145E (pt) | 1994-05-27 | 2001-01-31 | Cellegy Pharma Inc | Composicao dadora de oxido nitrico para tratamento de desordens anais |
| IL117473A (en) | 1995-03-14 | 2001-08-26 | Siemens Ag | Ultrasonic atomizer device with removable precision dosating unit |
| EP0814861B1 (en) | 1995-03-14 | 2002-06-05 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosing unit |
| WO1996036602A1 (en) | 1995-05-15 | 1996-11-21 | The United States Of America | Adnaz, compositions and processes |
| US5580988A (en) | 1995-05-15 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Army | Substituted azetidines and processes of using them |
| US5898038A (en) | 1996-03-19 | 1999-04-27 | Board Of Regents, The University Of Texas System | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors |
| CA2268768A1 (en) | 1996-10-15 | 1998-04-23 | Eastman Chemical Company | Explosive formulations |
| GB9720797D0 (en) | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
| US5954047A (en) | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
| US6056966A (en) | 1998-05-18 | 2000-05-02 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for treating impotence |
| US7635722B1 (en) | 1998-07-27 | 2009-12-22 | Saint Jude Pharmaceuticals, Inc. | Chemical induced intracellular hyperthermia |
| US6448253B1 (en) | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| US6245799B1 (en) | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
| HUP0300413A2 (hu) | 2000-04-10 | 2003-06-28 | Pfizer Products Inc. | Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| US6861530B2 (en) | 2000-07-07 | 2005-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Piperidine derivatives |
| DE10111049A1 (de) | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut |
| EP1336602A1 (en) | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| JP2005539089A (ja) | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
| EP1556056A4 (en) | 2002-10-07 | 2008-08-06 | Radiorx Inc | X-Nitro Compounds, Pharmaceutical Compositions And Their Uses |
| US6870061B2 (en) | 2003-01-10 | 2005-03-22 | Alliant Techsystems Inc. | Continuous process and system for production of glycidyl nitrate from glycerin, nitric acid and caustic and conversion of glycidyl nitrate to poly(glycidyl nitrate) |
| WO2004098538A2 (en) | 2003-03-13 | 2004-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods of use |
| ES2358801T3 (es) | 2003-06-25 | 2011-05-13 | Je Il Pharmaceutical Co., Ltd. | Derivados tricíclicos o sales farmacéuticamente aceptables de los mismos, sus preparaciones y composiciones farmacéuticas que los contienen. |
| GB0326047D0 (en) | 2003-11-07 | 2003-12-10 | Univ Sheffield | Substance |
| JP2008512490A (ja) | 2004-09-08 | 2008-04-24 | チェルシー・セラピューティクス，インコーポレイテッド | 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤 |
| US7507842B2 (en) * | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| EP1996550A2 (en) | 2005-09-27 | 2008-12-03 | Novartis AG | Carboxyamine compounds and their use in the treatment of hdac dependent diseases |
| KR100967848B1 (ko) * | 2008-05-28 | 2010-07-05 | 국방과학연구소 | 분자화약이 도입된, 고에너지 결합제용1-글리시딜-3,3-디니트로아제티딘 및 그의 제조방법 |
| US20120149678A1 (en) | 2010-12-09 | 2012-06-14 | Oronsky Bryan T | Organonitro Compounds for Use in Treating Non-Hodgkin's Lymphoma and Leukemia, and Methods Relating Thereto |
-
2010
- 2010-02-09 US US12/702,782 patent/US8471041B2/en active Active
-
2011
- 2011-01-18 CA CA2788459A patent/CA2788459C/en active Active
- 2011-01-18 ES ES11700989.4T patent/ES2460040T3/es active Active
- 2011-01-18 AU AU2011216176A patent/AU2011216176B2/en active Active
- 2011-01-18 WO PCT/US2011/021500 patent/WO2011100090A1/en not_active Ceased
- 2011-01-18 MX MX2012008989A patent/MX2012008989A/es active IP Right Grant
- 2011-01-18 KR KR1020127022598A patent/KR101456438B1/ko active Active
- 2011-01-18 JP JP2012552884A patent/JP5461712B2/ja active Active
- 2011-01-18 EP EP11700989.4A patent/EP2534131B1/en active Active
- 2011-01-18 DK DK11700989.4T patent/DK2534131T3/da active
- 2011-01-18 CN CN201180008968.3A patent/CN102762535B/zh active Active
-
2012
- 2012-07-26 IL IL221141A patent/IL221141A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN102762535A (zh) | 2012-10-31 |
| ES2460040T3 (es) | 2014-05-13 |
| MX2012008989A (es) | 2012-08-23 |
| AU2011216176A1 (en) | 2012-08-23 |
| KR101456438B1 (ko) | 2014-10-31 |
| EP2534131A1 (en) | 2012-12-19 |
| US8471041B2 (en) | 2013-06-25 |
| IL221141A (en) | 2016-08-31 |
| US20110195947A1 (en) | 2011-08-11 |
| JP2013518925A (ja) | 2013-05-23 |
| JP5461712B2 (ja) | 2014-04-02 |
| IL221141A0 (en) | 2012-09-24 |
| KR20130053385A (ko) | 2013-05-23 |
| WO2011100090A1 (en) | 2011-08-18 |
| CN102762535B (zh) | 2014-09-03 |
| CA2788459A1 (en) | 2011-08-18 |
| EP2534131B1 (en) | 2014-03-19 |
| AU2011216176B2 (en) | 2013-11-14 |
| CA2788459C (en) | 2016-01-05 |
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| IL221141A0 (en) | Methods of synthesizing and isolating n-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |