CN102753199A - 癌干细胞标记物及其用途 - Google Patents
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| CN111363008A (zh) * | 2020-03-18 | 2020-07-03 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用 |
| CN113804531A (zh) * | 2021-09-10 | 2021-12-17 | 北京大学 | 一种细胞高活性染色方法 |
| CN115916349A (zh) * | 2020-06-30 | 2023-04-04 | 葛莱高托普有限公司 | 针对Lewis Y的人源化抗体 |
| CN116718774A (zh) * | 2023-07-07 | 2023-09-08 | 杭州准星医学科技有限公司 | 一种用于肿瘤体外诊断的试剂盒及其使用方法 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020192223A1 (en) * | 1989-06-30 | 2002-12-19 | Ingegerg Hellstrom | Novel antibody conjugates reactive with human carcinomas |
| US20060251668A1 (en) * | 2002-11-29 | 2006-11-09 | Steffen Goletz | Tumor-specific recognition molecules |
| US7374755B2 (en) * | 2004-07-26 | 2008-05-20 | The Research Foundation Of State University Of New York | Therapeutic use of anti-TF-Antigen antibody |
| US20090041836A1 (en) * | 2006-01-03 | 2009-02-12 | University Of Georgia Research Foundation, Inc. | Glycolipopeptide and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005017130A2 (en) | 2003-08-18 | 2005-02-24 | Glycotope Gmbh | Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof |
| US20110190166A1 (en) * | 2006-05-26 | 2011-08-04 | Susan Wong | Erythroid progenitor cells and methods for producing parvovirus b19 therein |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020192223A1 (en) * | 1989-06-30 | 2002-12-19 | Ingegerg Hellstrom | Novel antibody conjugates reactive with human carcinomas |
| US20060251668A1 (en) * | 2002-11-29 | 2006-11-09 | Steffen Goletz | Tumor-specific recognition molecules |
| US7374755B2 (en) * | 2004-07-26 | 2008-05-20 | The Research Foundation Of State University Of New York | Therapeutic use of anti-TF-Antigen antibody |
| US20090041836A1 (en) * | 2006-01-03 | 2009-02-12 | University Of Georgia Research Foundation, Inc. | Glycolipopeptide and uses thereof |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103969437A (zh) * | 2014-04-22 | 2014-08-06 | 广州恒泰生物科技有限公司 | 用于卵巢癌早中期快速诊断试剂盒的制备方法 |
| CN111363008A (zh) * | 2020-03-18 | 2020-07-03 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用 |
| CN113388023A (zh) * | 2020-03-18 | 2021-09-14 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用 |
| CN113429473A (zh) * | 2020-03-18 | 2021-09-24 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用 |
| CN111363008B (zh) * | 2020-03-18 | 2021-11-16 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用 |
| CN113429473B (zh) * | 2020-03-18 | 2022-11-04 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原、输卵管癌靶标抗原刺激培养的ctl细胞及其应用 |
| CN115916349A (zh) * | 2020-06-30 | 2023-04-04 | 葛莱高托普有限公司 | 针对Lewis Y的人源化抗体 |
| US12415864B2 (en) | 2020-06-30 | 2025-09-16 | Pentixapharm Ag | Humanized antibodies against Lewis Y |
| CN113804531A (zh) * | 2021-09-10 | 2021-12-17 | 北京大学 | 一种细胞高活性染色方法 |
| CN113804531B (zh) * | 2021-09-10 | 2024-02-06 | 北京大学 | 一种细胞高活性染色方法 |
| CN116718774A (zh) * | 2023-07-07 | 2023-09-08 | 杭州准星医学科技有限公司 | 一种用于肿瘤体外诊断的试剂盒及其使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011208874B2 (en) | 2015-06-25 |
| JP2016047848A (ja) | 2016-04-07 |
| WO2011089004A1 (en) | 2011-07-28 |
| EP2525832A1 (en) | 2012-11-28 |
| BR112012018132A2 (pt) | 2017-06-20 |
| JP2013517487A (ja) | 2013-05-16 |
| CA2786212A1 (en) | 2011-07-28 |
| US20120294859A1 (en) | 2012-11-22 |
| AU2011208874A1 (en) | 2012-08-02 |
| EP2347769A1 (en) | 2011-07-27 |
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