CN102741255B - 作为双氢乳清酸脱氢酶抑制剂的抗疟剂 - Google Patents

作为双氢乳清酸脱氢酶抑制剂的抗疟剂 Download PDF

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Publication number
CN102741255B
CN102741255B CN201080043385.XA CN201080043385A CN102741255B CN 102741255 B CN102741255 B CN 102741255B CN 201080043385 A CN201080043385 A CN 201080043385A CN 102741255 B CN102741255 B CN 102741255B
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CN
China
Prior art keywords
compound
methyl
mmol
synthesis
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080043385.XA
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English (en)
Chinese (zh)
Other versions
CN102741255A (zh
Inventor
P·K·拉索德
D·弗洛伊德
J·布罗斯
A·马瓦哈
R·古加
J·科特隆-洛佩兹
M·菲利普斯
S·A·查曼
D·马修斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
MMV Medicines for Malaria Venture
GlaxoSmithKline Investigacion y Desarrollo SL
University of Washington
University of Texas at Austin
Original Assignee
Monash University
MMV Medicines for Malaria Venture
GlaxoSmithKline Investigacion y Desarrollo SL
University of Washington
University of Texas at Austin
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Filing date
Publication date
Application filed by Monash University, MMV Medicines for Malaria Venture, GlaxoSmithKline Investigacion y Desarrollo SL, University of Washington, University of Texas at Austin filed Critical Monash University
Publication of CN102741255A publication Critical patent/CN102741255A/zh
Application granted granted Critical
Publication of CN102741255B publication Critical patent/CN102741255B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201080043385.XA 2009-09-29 2010-09-28 作为双氢乳清酸脱氢酶抑制剂的抗疟剂 Expired - Fee Related CN102741255B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
US61/246,863 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (2)

Publication Number Publication Date
CN102741255A CN102741255A (zh) 2012-10-17
CN102741255B true CN102741255B (zh) 2015-10-07

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080043385.XA Expired - Fee Related CN102741255B (zh) 2009-09-29 2010-09-28 作为双氢乳清酸脱氢酶抑制剂的抗疟剂

Country Status (15)

Country Link
US (1) US9238653B2 (https=)
EP (1) EP2483274B1 (https=)
JP (1) JP5818266B2 (https=)
CN (1) CN102741255B (https=)
BR (1) BR112012007179B8 (https=)
CA (1) CA2775354C (https=)
DK (1) DK2483274T3 (https=)
ES (1) ES2527835T3 (https=)
HR (1) HRP20150066T1 (https=)
ME (1) ME02020B (https=)
PL (1) PL2483274T3 (https=)
PT (1) PT2483274E (https=)
SI (1) SI2483274T1 (https=)
SM (1) SMT201500071B (https=)
WO (1) WO2011041304A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI674263B (zh) * 2013-12-19 2019-10-11 瑞士商諾華公司 用於治療寄生蟲疾病之化合物及組合物
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
US20200048259A1 (en) * 2016-10-12 2020-02-13 Merck Sharp & Dohme Corp. Kdm5 inhibitors
JP7595413B2 (ja) 2016-11-30 2024-12-06 ケース ウエスタン リザーブ ユニバーシティ １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CA3059255A1 (en) 2017-04-07 2018-10-11 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
CN120463721A (zh) 2018-11-21 2025-08-12 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20080027079A1 (en) 2006-06-22 2008-01-31 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
CN101622001A (zh) * 2007-01-26 2010-01-06 Irm责任有限公司 作为激酶抑制剂用于治疗疟原虫相关疾病的嘌呤化合物和组合物
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
CA2775354C (en) 2019-01-15
HRP20150066T1 (hr) 2015-02-27
HK1174639A1 (en) 2013-06-14
EP2483274B1 (en) 2014-10-29
EP2483274A2 (en) 2012-08-08
JP5818266B2 (ja) 2015-11-18
US9238653B2 (en) 2016-01-19
WO2011041304A2 (en) 2011-04-07
DK2483274T3 (en) 2015-01-19
BR112012007179A8 (pt) 2018-01-23
SMT201500071B (it) 2015-05-05
ES2527835T3 (es) 2015-01-30
PL2483274T3 (pl) 2015-04-30
BR112012007179B1 (pt) 2020-12-01
CA2775354A1 (en) 2011-04-07
CN102741255A (zh) 2012-10-17
JP2013506004A (ja) 2013-02-21
SI2483274T1 (sl) 2015-02-27
ME02020B (me) 2015-05-20
US20120302586A1 (en) 2012-11-29
WO2011041304A3 (en) 2011-08-04
BR112012007179B8 (pt) 2021-05-25
EP2483274A4 (en) 2013-03-06
BR112012007179A2 (pt) 2017-07-25
PT2483274E (pt) 2015-02-04

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