CA2775354C - Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase - Google Patents

Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase Download PDF

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Publication number
CA2775354C
CA2775354C CA2775354A CA2775354A CA2775354C CA 2775354 C CA2775354 C CA 2775354C CA 2775354 A CA2775354 A CA 2775354A CA 2775354 A CA2775354 A CA 2775354A CA 2775354 C CA2775354 C CA 2775354C
Authority
CA
Canada
Prior art keywords
compound
mmol
pharmaceutically acceptable
synthesis
triazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2775354A
Other languages
English (en)
French (fr)
Other versions
CA2775354A1 (en
Inventor
Margaret Phillips
Pradipsinh K. Rathod
Susan A. Charman
David Floyd
Jeremy Burrows
David Matthews
Alka Marwaha
Ramesh Gujjar
Jose Coteron-Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MMV Medicines for Malaria Venture
University of Washington
University of Texas System
Original Assignee
MMV Medicines for Malaria Venture
University of Washington
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MMV Medicines for Malaria Venture, University of Washington, University of Texas System filed Critical MMV Medicines for Malaria Venture
Publication of CA2775354A1 publication Critical patent/CA2775354A1/en
Application granted granted Critical
Publication of CA2775354C publication Critical patent/CA2775354C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2775354A 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase Expired - Fee Related CA2775354C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24686309P 2009-09-29 2009-09-29
US61/246,863 2009-09-29
PCT/US2010/050532 WO2011041304A2 (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Publications (2)

Publication Number Publication Date
CA2775354A1 CA2775354A1 (en) 2011-04-07
CA2775354C true CA2775354C (en) 2019-01-15

Family

ID=43826848

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2775354A Expired - Fee Related CA2775354C (en) 2009-09-29 2010-09-28 Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Country Status (15)

Country Link
US (1) US9238653B2 (https=)
EP (1) EP2483274B1 (https=)
JP (1) JP5818266B2 (https=)
CN (1) CN102741255B (https=)
BR (1) BR112012007179B8 (https=)
CA (1) CA2775354C (https=)
DK (1) DK2483274T3 (https=)
ES (1) ES2527835T3 (https=)
HR (1) HRP20150066T1 (https=)
ME (1) ME02020B (https=)
PL (1) PL2483274T3 (https=)
PT (1) PT2483274E (https=)
SI (1) SI2483274T1 (https=)
SM (1) SMT201500071B (https=)
WO (1) WO2011041304A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI674263B (zh) * 2013-12-19 2019-10-11 瑞士商諾華公司 用於治療寄生蟲疾病之化合物及組合物
EP3072894A1 (en) 2015-03-26 2016-09-28 Board Of Regents Of the University Of Texas System New substituted triazolopyrimidines as anti-malarial agents
EP3254679A1 (de) 2016-06-09 2017-12-13 Christian-Albrechts-Universität zu Kiel Wirkstoffe gegen protozoen und bakterien
US20200048259A1 (en) * 2016-10-12 2020-02-13 Merck Sharp & Dohme Corp. Kdm5 inhibitors
JP7595413B2 (ja) 2016-11-30 2024-12-06 ケース ウエスタン リザーブ ユニバーシティ １５－ｐｇｄｈ阻害剤とコルチコステロイドおよび／またはｔｎｆ阻害剤との組み合わせならびにその使用
WO2018145080A1 (en) 2017-02-06 2018-08-09 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
CA3059255A1 (en) 2017-04-07 2018-10-11 Case Western Reserve University Inhibitors of short-chain dehydrogenase activity for treating coronary disorders
CN120463721A (zh) 2018-11-21 2025-08-12 卡斯西部储备大学 调节短链脱氢酶活性的组合物和方法
EP3842100A1 (en) 2019-12-24 2021-06-30 The Board Of Regents Of The University Of Texas System Anti-malarial agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5478825A (en) 1991-02-22 1995-12-26 Egis Gyogyszergyar 5-(substituted amino)-1,2,4-triazolo (1,5-A) pyrimidine derivatives
HU208693B (en) 1991-02-22 1993-12-28 Egyt Gyogyszervegyeszeti Gyar Process for producing 1,2,4-triazolo (1,5-a) pyrimidinis derivatives and their carbicycli-tetrahydro-thiofurane-tetrahydrothiopyrane-, or tetrahydropyridine- condensated derivatives or medical preparatives containing them
US8490825B2 (en) 1999-12-08 2013-07-23 Metal Container Corporation Can lid closure and method of joining a can lid closure to a can body
CZ294535B6 (cs) * 2001-08-02 2005-01-12 Ústav Experimentální Botaniky Avčr Heterocyklické sloučeniny na bázi N6-substituovaného adeninu, způsoby jejich přípravy, jejich použití pro přípravu léčiv, kosmetických přípravků a růstových regulátorů, farmaceutické přípravky, kosmetické přípravky a růstové regulátory tyto sloučeniny obsahující
US20080027079A1 (en) 2006-06-22 2008-01-31 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
CN101622001A (zh) * 2007-01-26 2010-01-06 Irm责任有限公司 作为激酶抑制剂用于治疗疟原虫相关疾病的嘌呤化合物和组合物
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Also Published As

Publication number Publication date
HRP20150066T1 (hr) 2015-02-27
HK1174639A1 (en) 2013-06-14
EP2483274B1 (en) 2014-10-29
EP2483274A2 (en) 2012-08-08
JP5818266B2 (ja) 2015-11-18
US9238653B2 (en) 2016-01-19
WO2011041304A2 (en) 2011-04-07
DK2483274T3 (en) 2015-01-19
BR112012007179A8 (pt) 2018-01-23
SMT201500071B (it) 2015-05-05
ES2527835T3 (es) 2015-01-30
PL2483274T3 (pl) 2015-04-30
BR112012007179B1 (pt) 2020-12-01
CA2775354A1 (en) 2011-04-07
CN102741255A (zh) 2012-10-17
JP2013506004A (ja) 2013-02-21
SI2483274T1 (sl) 2015-02-27
ME02020B (me) 2015-05-20
US20120302586A1 (en) 2012-11-29
WO2011041304A3 (en) 2011-08-04
BR112012007179B8 (pt) 2021-05-25
EP2483274A4 (en) 2013-03-06
CN102741255B (zh) 2015-10-07
BR112012007179A2 (pt) 2017-07-25
PT2483274E (pt) 2015-02-04

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Legal Events

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Effective date: 20150707

MKLA Lapsed

Effective date: 20220329

MKLA Lapsed

Effective date: 20200928