CN102725300B - 蛋白酶体抑制剂及其制备、纯化、和应用的方法 - Google Patents

蛋白酶体抑制剂及其制备、纯化、和应用的方法 Download PDF

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Publication number
CN102725300B
CN102725300B CN201080058991.9A CN201080058991A CN102725300B CN 102725300 B CN102725300 B CN 102725300B CN 201080058991 A CN201080058991 A CN 201080058991A CN 102725300 B CN102725300 B CN 102725300B
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China
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formula
optionally substituted
compound
ester
boronate
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Expired - Fee Related
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CN201080058991.9A
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Chinese (zh)
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CN102725300A (zh
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莱尼·卡洛琳·罗米勒
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Cephalon LLC
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Cephalon LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080058991.9A 2009-12-22 2010-12-22 蛋白酶体抑制剂及其制备、纯化、和应用的方法 Expired - Fee Related CN102725300B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28895709P 2009-12-22 2009-12-22
US61/288,957 2009-12-22
PCT/US2010/061695 WO2011087822A1 (en) 2009-12-22 2010-12-22 Proteasome inhibitors and processes for their preparation, purification and use

Publications (2)

Publication Number Publication Date
CN102725300A CN102725300A (zh) 2012-10-10
CN102725300B true CN102725300B (zh) 2015-03-11

Family

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CN201080058991.9A Expired - Fee Related CN102725300B (zh) 2009-12-22 2010-12-22 蛋白酶体抑制剂及其制备、纯化、和应用的方法

Country Status (10)

Country Link
US (1) US8541590B2 (https=)
EP (1) EP2516449A1 (https=)
JP (1) JP5783659B2 (https=)
CN (1) CN102725300B (https=)
AU (1) AU2010341530B2 (https=)
CA (1) CA2785300A1 (https=)
IL (1) IL220190A0 (https=)
MX (1) MX2012007341A (https=)
NZ (1) NZ600786A (https=)
WO (1) WO2011087822A1 (https=)

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CN103897027A (zh) * 2012-12-29 2014-07-02 曹亚英 关键中间体晶型，制备方法及其在硼替佐米合成中的运用
CN103897026A (zh) * 2012-12-29 2014-07-02 朱继东 硼替佐米关键中间体的晶型，制备方法及其运用
IN2013MU01431A (https=) 2013-04-16 2015-06-26 Cipla Ltd
CZ2015233A3 (cs) 2015-04-03 2016-10-12 Zentiva, K.S. Způsob přípravy Ixazomib citrátu
CZ2015253A3 (cs) 2015-04-15 2016-10-26 Zentiva, K.S. Nové formy Ixazomib citrátu
US10144761B2 (en) 2015-06-19 2018-12-04 Hanlin Scientific Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CZ2016204A3 (cs) 2016-04-08 2017-11-01 Zentiva, K.S. Formulace Ixazomib citrátu formy 3
EP3583110A1 (en) 2017-02-17 2019-12-25 Fresenius Kabi Oncology Ltd An improved process for the preparation of boronic acid esters
JP7086987B2 (ja) * 2017-03-21 2022-06-20 ザ スクリプス リサーチ インスティテュート 銅およびニッケル触媒による脱炭酸ホウ素化反応
CN110540547A (zh) * 2018-05-28 2019-12-06 秦艳茹 一种肽硼酸酯类化合物的合成与用途

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WO2002059130A1 (en) * 2001-01-25 2002-08-01 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Formulation of boronic acid compounds
CN1867572A (zh) * 2003-08-14 2006-11-22 赛福伦公司 蛋白酶体抑制剂及其使用方法

Also Published As

Publication number Publication date
CN102725300A (zh) 2012-10-10
US20120270840A1 (en) 2012-10-25
JP2013515082A (ja) 2013-05-02
AU2010341530A1 (en) 2012-07-19
AU2010341530B2 (en) 2016-03-10
WO2011087822A1 (en) 2011-07-21
MX2012007341A (es) 2012-07-20
NZ600786A (en) 2013-12-20
JP5783659B2 (ja) 2015-09-24
CA2785300A1 (en) 2011-07-21
EP2516449A1 (en) 2012-10-31
US8541590B2 (en) 2013-09-24
IL220190A0 (en) 2012-07-31

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Granted publication date: 20150311

Termination date: 20171222