CN102711796A - Prg4及其治疗调制的应用和用途 - Google Patents

Prg4及其治疗调制的应用和用途 Download PDF

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Publication number
CN102711796A
CN102711796A CN2010800337956A CN201080033795A CN102711796A CN 102711796 A CN102711796 A CN 102711796A CN 2010800337956 A CN2010800337956 A CN 2010800337956A CN 201080033795 A CN201080033795 A CN 201080033795A CN 102711796 A CN102711796 A CN 102711796A
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Prior art keywords
prg4
compositions
effective dose
oral
oil
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Pending
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CN2010800337956A
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English (en)
Chinese (zh)
Inventor
B·萨利文
T·施米德特
E·R·特勒伊特
N·B·J·特勒伊特
D·萨利文
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Schepens Eye Research Institute Inc
Singularis Inc
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Schepens Eye Research Institute Inc
Singularis Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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    • A61K9/0058—Chewing gums
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Engineering & Computer Science (AREA)
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  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Natural Medicines & Medicinal Plants (AREA)
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  • Biotechnology (AREA)
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  • Medical Informatics (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Marine Sciences & Fisheries (AREA)
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CN2010800337956A 2009-05-22 2010-05-24 Prg4及其治疗调制的应用和用途 Pending CN102711796A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18052509P 2009-05-22 2009-05-22
US61/180,525 2009-05-22
PCT/US2010/035956 WO2010135736A2 (en) 2009-05-22 2010-05-24 Application and uses of prg4 and therapeutic modulation thereof

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CN102711796A true CN102711796A (zh) 2012-10-03

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US (2) US9730865B2 (enExample)
EP (1) EP2432492B1 (enExample)
JP (4) JP2012527485A (enExample)
CN (1) CN102711796A (enExample)
CA (2) CA3110817C (enExample)
ES (1) ES2532526T3 (enExample)
WO (1) WO2010135736A2 (enExample)

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CN108157358A (zh) * 2018-03-02 2018-06-15 沈阳汇翼宁消毒科技有限公司 一种消毒液及其制备方法
CN111944595A (zh) * 2020-08-21 2020-11-17 江苏省健尔康医用敷料有限公司 一种医用外科器械用润滑剂及其制备和使用方法
WO2020248239A1 (en) * 2019-06-14 2020-12-17 The Procter & Gamble Company Leave-on oral care compositions
WO2020248232A1 (en) * 2019-06-14 2020-12-17 The Procter & Gamble Company Leave-on oral care compositions
CN112351792A (zh) * 2018-06-21 2021-02-09 卢布里斯有限责任公司 用于创伤愈合的润滑素
CN113908257A (zh) * 2015-01-26 2022-01-11 卢布里斯有限责任公司 Prg4作为抗炎剂的应用

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US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
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JP6571101B2 (ja) * 2013-11-26 2019-09-04 ルブリス，エルエルシー． 細胞間相互作用を阻害するための組成物及び方法
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CN105055949A (zh) * 2015-08-10 2015-11-18 孙霞 一种治疗小儿口腔溃疡的中药
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113908257A (zh) * 2015-01-26 2022-01-11 卢布里斯有限责任公司 Prg4作为抗炎剂的应用
CN108157358A (zh) * 2018-03-02 2018-06-15 沈阳汇翼宁消毒科技有限公司 一种消毒液及其制备方法
CN112351792A (zh) * 2018-06-21 2021-02-09 卢布里斯有限责任公司 用于创伤愈合的润滑素
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WO2020248232A1 (en) * 2019-06-14 2020-12-17 The Procter & Gamble Company Leave-on oral care compositions
CN111944595A (zh) * 2020-08-21 2020-11-17 江苏省健尔康医用敷料有限公司 一种医用外科器械用润滑剂及其制备和使用方法

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WO2010135736A3 (en) 2011-04-28
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CA2762989C (en) 2021-04-13
US20120134925A1 (en) 2012-05-31
US10383796B2 (en) 2019-08-20
JP2012527485A (ja) 2012-11-08
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