CN102666570B - 新的肽基α-羟基甘氨酸α-酰胺化裂合酶 - Google Patents

新的肽基α-羟基甘氨酸α-酰胺化裂合酶 Download PDF

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Publication number
CN102666570B
CN102666570B CN201080054717.4A CN201080054717A CN102666570B CN 102666570 B CN102666570 B CN 102666570B CN 201080054717 A CN201080054717 A CN 201080054717A CN 102666570 B CN102666570 B CN 102666570B
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gly
enzyme
xaa
polypeptide
val
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Expired - Fee Related
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CN102666570A (zh
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A.C.肖
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/02—Amidine-lyases (4.3.2)
    • C12Y403/02005—Peptidylamidoglycolate lyase (4.3.2.5)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080054717.4A 2009-12-01 2010-12-01 新的肽基α-羟基甘氨酸α-酰胺化裂合酶 Expired - Fee Related CN102666570B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09177593.2 2009-12-01
EP09177593 2009-12-01
US26671109P 2009-12-04 2009-12-04
US61/266711 2009-12-04
PCT/EP2010/068630 WO2011067283A1 (en) 2009-12-01 2010-12-01 Novel peptidyl alpha-hydroxyglycine alpha-amidating lyases

Publications (2)

Publication Number Publication Date
CN102666570A CN102666570A (zh) 2012-09-12
CN102666570B true CN102666570B (zh) 2015-12-02

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CN201080054717.4A Expired - Fee Related CN102666570B (zh) 2009-12-01 2010-12-01 新的肽基α-羟基甘氨酸α-酰胺化裂合酶

Country Status (6)

Country Link
US (2) US9096843B2 (enExample)
EP (1) EP2507258B1 (enExample)
JP (1) JP5931738B2 (enExample)
CN (1) CN102666570B (enExample)
ES (1) ES2583259T3 (enExample)
WO (1) WO2011067283A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105793278A (zh) * 2013-12-20 2016-07-20 豪夫迈·罗氏有限公司 肽基甘氨肽α酰胺化单氧加氧酶(PAM)用于C端酰胺化的用途
CN105985995A (zh) * 2015-01-29 2016-10-05 暨南大学 一种利用家蚕生物反应器生产普兰林肽(pa)的方法
CN113302310B (zh) * 2018-12-18 2024-05-03 帕西昂奥地利有限两合公司 单步生物催化酰胺化
CN110034855B (zh) * 2019-04-10 2021-12-14 国网辽宁省电力有限公司 一种信息传输校验方法及系统
JP2023515981A (ja) * 2020-02-26 2023-04-17 ペーアーエム セラノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング ペプチジルグリシンαアミド化モノオキシゲナーゼ（ＰＡＭ）を決定する方法および診断目的でのその使用
IL295924A (en) * 2020-02-26 2022-10-01 Pam Theragnostics Gmbh Use of peptidylglycine alpha-amidization monooxygenase (pam) for medicinal purposes
US20230167153A1 (en) 2020-05-01 2023-06-01 Kashiv Biosciences, Llc An improved process of purification of protein
EP4487124A1 (en) * 2022-03-23 2025-01-08 Kashiv Biosciences, LLC An improved process for the separation and analysis of pancreatic enzymes
WO2025133225A1 (en) * 2023-12-22 2025-06-26 Pam Theragnostics Gmbh Pharmaceutical combination of peptide-gly and peptidylglycine alpha-amidating monooxygenase (pam)

Citations (2)

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Publication number Priority date Publication date Assignee Title
EP0465404A3 (en) * 1990-06-01 1992-04-08 Ciba-Geigy Ag Peptdidylhydroxylglycine n-c lyase and dna coding therefor
CN101287840A (zh) * 2005-06-24 2008-10-15 尤尼基因实验室公司 表达在酰胺化产物的制备中有用的酶的细胞系

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US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
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EP0465404A3 (en) * 1990-06-01 1992-04-08 Ciba-Geigy Ag Peptdidylhydroxylglycine n-c lyase and dna coding therefor
CN101287840A (zh) * 2005-06-24 2008-10-15 尤尼基因实验室公司 表达在酰胺化产物的制备中有用的酶的细胞系

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Also Published As

Publication number Publication date
EP2507258B1 (en) 2016-04-20
WO2011067283A1 (en) 2011-06-09
CN102666570A (zh) 2012-09-12
ES2583259T3 (es) 2016-09-20
US20160083713A1 (en) 2016-03-24
JP5931738B2 (ja) 2016-06-08
JP2013511997A (ja) 2013-04-11
EP2507258A1 (en) 2012-10-10
US20120322733A1 (en) 2012-12-20
US9096843B2 (en) 2015-08-04

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