ES2583259T3 - Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina - Google Patents
Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina Download PDFInfo
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- ES2583259T3 ES2583259T3 ES10788057.7T ES10788057T ES2583259T3 ES 2583259 T3 ES2583259 T3 ES 2583259T3 ES 10788057 T ES10788057 T ES 10788057T ES 2583259 T3 ES2583259 T3 ES 2583259T3
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/02—Amidine-lyases (4.3.2)
- C12Y403/02005—Peptidylamidoglycolate lyase (4.3.2.5)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09177593 | 2009-12-01 | ||
| EP09177593 | 2009-12-01 | ||
| US26671109P | 2009-12-04 | 2009-12-04 | |
| US266711P | 2009-12-04 | ||
| PCT/EP2010/068630 WO2011067283A1 (en) | 2009-12-01 | 2010-12-01 | Novel peptidyl alpha-hydroxyglycine alpha-amidating lyases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2583259T3 true ES2583259T3 (es) | 2016-09-20 |
Family
ID=44114627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10788057.7T Active ES2583259T3 (es) | 2009-12-01 | 2010-12-01 | Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9096843B2 (enExample) |
| EP (1) | EP2507258B1 (enExample) |
| JP (1) | JP5931738B2 (enExample) |
| CN (1) | CN102666570B (enExample) |
| ES (1) | ES2583259T3 (enExample) |
| WO (1) | WO2011067283A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2016129516A (ru) * | 2013-12-20 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | ПРИМЕНЕНИЕ ПЕПТИДИЛГЛИЦИН-α-АМИДИРУЮЩЕЙ МОНООКСИДАЗЫ (РАМ) ДЛЯ С-КОНЦЕВОГО АМИДИРОВАНИЯ |
| CN105985995A (zh) * | 2015-01-29 | 2016-10-05 | 暨南大学 | 一种利用家蚕生物反应器生产普兰林肽(pa)的方法 |
| EP3899003A1 (en) * | 2018-12-18 | 2021-10-27 | Patheon Austria GmbH & Co KG | Single step biocatalytic amidation |
| CN110034855B (zh) * | 2019-04-10 | 2021-12-14 | 国网辽宁省电力有限公司 | 一种信息传输校验方法及系统 |
| US20230097988A1 (en) * | 2020-02-26 | 2023-03-30 | Pam Theragnostics Gmbh | Methods for determining peptidylglycine alpha-amidating monooxygenase (pam) and its use for diagnostic purpose |
| BR112022015949A2 (pt) * | 2020-02-26 | 2022-10-04 | Pam Theragnostics Gmbh | Peptidilglicina alfa-amidante mono-oxigenase (pam), seu uso, formulação farmacêutica, método para determinar a atividade de pam em uma amostra de fluido corporal de um indivíduo, e kits para realizar o método para diagnóstico, prognóstico ou prevenção de risco de uma doença em um indivíduo, para a detecção do nível de pam, e para realizar o método para determinar a atividade de pam |
| CA3182368A1 (en) | 2020-05-01 | 2021-11-04 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| CA3255003A1 (en) * | 2022-03-23 | 2023-09-28 | Kashiv Biosciences Llc | IMPROVED METHOD FOR SEPARATION AND ANALYSIS OF PANCREATIC ENZYMES |
| WO2025133225A1 (en) * | 2023-12-22 | 2025-06-26 | Pam Theragnostics Gmbh | Pharmaceutical combination of peptide-gly and peptidylglycine alpha-amidating monooxygenase (pam) |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4203570A (en) | 1978-08-23 | 1980-05-20 | The Western States Machine Company | Power-operated loading gate for centrifugal machines incorporating an auxiliary drive device |
| US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
| US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
| JPS60501140A (ja) | 1983-04-22 | 1985-07-25 | アムジエン | 酵母による外因性ポリペプチドの分泌 |
| NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
| US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
| DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
| US4708934A (en) | 1984-09-27 | 1987-11-24 | Unigene Laboratories, Inc. | α-amidation enzyme |
| US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US4885249A (en) | 1984-12-05 | 1989-12-05 | Allelix, Inc. | Aspergillus niger transformation system |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| EP0625577A1 (en) | 1985-08-29 | 1994-11-23 | Genencor International, Inc. | Heterologous polypeptides expressed in filamentous fungi, processes for their preparation, and vectors for their preparation |
| US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
| UA41863C2 (uk) | 1985-10-25 | 2001-10-15 | Займодженетікс Інк. | Спосіб одержання гетерологічного поліпептиду в еукаріотичних мікроорганізмах |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| GB8720115D0 (en) | 1987-08-26 | 1987-09-30 | Cooper G J S | Treatment of diabetes mellitus |
| US5789234A (en) | 1987-08-14 | 1998-08-04 | Unigene Laboratories, Inc. | Expression systems for amidating enzyme |
| EP0383779B2 (en) | 1987-09-04 | 2000-05-31 | Novo Nordisk A/S | PROCESS FOR THE PRODUCTION OF PROTEIN PRODUCTS IN $i(ASPERGILLUS) AND PROMOTERS FOR USE IN $i(ASPERGILLUS) |
| DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
| US6255067B1 (en) | 1987-09-15 | 2001-07-03 | The Johns Hopkins University | cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM) |
| US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
| JP2535398B2 (ja) | 1989-01-17 | 1996-09-18 | サントリー株式会社 | アミド化ペプチドの製造方法 |
| JP2845468B2 (ja) | 1989-01-17 | 1999-01-13 | サントリー株式会社 | ヒト甲状腺由来Ｃ―末端α―アミド化酵素 |
| EP0448513A3 (en) | 1990-03-21 | 1991-12-27 | Japat Ltd | Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof |
| ES2079054T3 (es) | 1990-06-01 | 1996-01-01 | Ciba Geigy Ag | Peptidilhidroxiglicina n-c-liasa y adn codificante de la misma. |
| DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
| US6495514B1 (en) * | 1998-01-21 | 2002-12-17 | Mercer University | Method for reducing inflammation and inducing an analgesic effect and compounds thereof |
| WO2001049856A2 (en) | 2000-01-06 | 2001-07-12 | Genoptera, Llc | Drosophila enzymes, encoding nucleic acids and methods of use |
| EP1351984A2 (en) | 2000-12-13 | 2003-10-15 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
| KR101070036B1 (ko) | 2003-07-23 | 2011-10-04 | 노르딕 바이오사이언스 에이/에스 | 골관절염에 대한 칼시토닌의 용도 |
| EP1874798A1 (en) | 2005-04-15 | 2008-01-09 | Novo Nordisk A/S | Basic protein purification tags from thermophilic bacteria |
| US8815583B2 (en) | 2005-06-24 | 2014-08-26 | Enteris Biopharma, Inc. | Cell lines for expressing enzyme useful in the preparation of amidated products |
| WO2008043847A1 (en) | 2006-10-13 | 2008-04-17 | Novo Nordisk Health Care Ag | Processing enzymes fused to basic protein tags |
| CA2691374A1 (en) | 2007-06-29 | 2009-01-08 | Asubio Pharma Co., Ltd. | Recombinant c-terminal .alpha.-amidating enzyme derivative |
-
2010
- 2010-12-01 CN CN201080054717.4A patent/CN102666570B/zh not_active Expired - Fee Related
- 2010-12-01 ES ES10788057.7T patent/ES2583259T3/es active Active
- 2010-12-01 JP JP2012541487A patent/JP5931738B2/ja not_active Expired - Fee Related
- 2010-12-01 US US13/513,049 patent/US9096843B2/en not_active Expired - Fee Related
- 2010-12-01 EP EP10788057.7A patent/EP2507258B1/en not_active Not-in-force
- 2010-12-01 WO PCT/EP2010/068630 patent/WO2011067283A1/en not_active Ceased
-
2015
- 2015-06-30 US US14/755,183 patent/US20160083713A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2507258A1 (en) | 2012-10-10 |
| CN102666570B (zh) | 2015-12-02 |
| CN102666570A (zh) | 2012-09-12 |
| WO2011067283A1 (en) | 2011-06-09 |
| US20160083713A1 (en) | 2016-03-24 |
| US20120322733A1 (en) | 2012-12-20 |
| JP2013511997A (ja) | 2013-04-11 |
| JP5931738B2 (ja) | 2016-06-08 |
| US9096843B2 (en) | 2015-08-04 |
| EP2507258B1 (en) | 2016-04-20 |
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