CN102666553B - 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 - Google Patents

取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 Download PDF

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Publication number
CN102666553B
CN102666553B CN201080042922.9A CN201080042922A CN102666553B CN 102666553 B CN102666553 B CN 102666553B CN 201080042922 A CN201080042922 A CN 201080042922A CN 102666553 B CN102666553 B CN 102666553B
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China
Prior art keywords
salt
crystalline
hcl salt
same
phenoxymethyl
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Expired - Fee Related
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CN201080042922.9A
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English (en)
Chinese (zh)
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CN102666553A (zh
Inventor
宋建高
查尔斯·A·麦克沃特
马芳
马克·安德烈斯
伊戈尔·伊万尼舍维奇
叶卡捷琳娜·艾伯特
帕特里夏·安德烈斯
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CymaBay Therapeutics Inc
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Metabolex Inc
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201080042922.9A 2009-10-01 2010-09-20 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 Expired - Fee Related CN102666553B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24793609P 2009-10-01 2009-10-01
US61/247,936 2009-10-01
PCT/US2010/049486 WO2011041154A1 (en) 2009-10-01 2010-09-20 Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts

Publications (2)

Publication Number Publication Date
CN102666553A CN102666553A (zh) 2012-09-12
CN102666553B true CN102666553B (zh) 2015-05-06

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CN201080042922.9A Expired - Fee Related CN102666553B (zh) 2009-10-01 2010-09-20 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐

Country Status (9)

Country Link
US (3) US8410127B2 (https=)
EP (1) EP2483281B1 (https=)
JP (1) JP5909185B2 (https=)
CN (1) CN102666553B (https=)
AR (1) AR078434A1 (https=)
CA (1) CA2775840C (https=)
ES (1) ES2497566T3 (https=)
TW (1) TW201120034A (https=)
WO (1) WO2011041154A1 (https=)

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US20110160222A1 (en) * 2008-11-26 2011-06-30 Metabolex, Inc. Modulators of glucose homeostasis for the treatment of diabetes and metabolic disorders
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US20110313160A1 (en) * 2010-06-04 2011-12-22 Metabolex, Inc. Preparation of 5-ethyl-2--pyrimidine
JP5847813B2 (ja) * 2010-06-23 2016-01-27 シマベイ セラピューティクス， インコーポレーテッド ５−エチル−２−｛４−［４−（４−テトラゾル−１−イル−フェノキシメチル）−チアゾール−２−イル］−ピペリジン−１−イル｝−ピリミジンの組成物
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CN103910710B (zh) * 2012-12-29 2017-06-16 乳源东阳光药业有限公司 阿格列汀新晶型及其制备方法
US20190008864A1 (en) * 2014-01-23 2019-01-10 Pharmedix.Co., Ltd. Pharmaceutical composition containing gpr119 ligand as effective ingredient for preventing or treating non-alcoholic steatohepatitis
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US8410127B2 (en) 2013-04-02
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JP2013506670A (ja) 2013-02-28
CN102666553A (zh) 2012-09-12
CA2775840A1 (en) 2011-04-07
CA2775840C (en) 2018-02-06
US20110152270A1 (en) 2011-06-23
ES2497566T3 (es) 2014-09-23
EP2483281B1 (en) 2014-06-04
US9150567B2 (en) 2015-10-06
US20140038971A1 (en) 2014-02-06
US8815886B2 (en) 2014-08-26
HK1174617A1 (en) 2013-06-14

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