CN102597853B - 接触镜 - Google Patents
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
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- G02C7/046—Contact lenses having an iris pattern
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- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00317—Production of lenses with markings or patterns
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00865—Applying coatings; tinting; colouring
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Abstract
制备接触镜的方法，其包括：将包括颜料、甲基丙烯酸2-羟乙酯和N-乙烯基吡咯烷酮的共聚物、以及交联单体的着色剂组合物沉积在接触镜模具的模制表面的一部分上。
Description
在先申请的优先权
本申请要求2009年7月24日提交的临时专利申请第61/228,220号的优先权，其整体引入本文作为参考。
技术领域
本发明提供了接触镜，其包括亲水性共聚物基材和在基材表面上的含着色剂组合物。所述含着色剂合物包括颜料、甲基丙烯酸2-羟乙酯和N-乙烯基吡咯烷酮的共聚物、以及交联单体。
背景技术
代表性的交联单体是乙二醇二甲基丙烯酸酯或1，4-丁二醇二丙烯酸酯。代表性的颜料是氧化铁黑或氧化铁棕。
含着色剂的组合物可含有其他成分。第一个实例是亲水性共聚单体，例如甲基丙烯酸2-羟乙酯。第二个实例是疏水性共聚单体，例如丙烯酸2-丁氧基乙酯。第三个实例是乳酸乙酯。此外，这些组合物通常包括聚合引发剂。
接触镜基材可由任何已知的亲水性共聚物制备。优选的共聚物是hilafilcon B，其是包含甲基丙烯酸2-羟乙酯、N-乙烯基吡咯烷酮、乙二醇二甲基丙烯酸酯和甲基丙烯酸烯丙酯的单体混合物的聚合产物。
优选地，所述含着色剂组合物在表面上具有同心环形。最优选地，当将接触镜放置于眼上时，所述同心环基本上与人虹膜位置一致，其可以具有比人虹膜更大的外径。
发明内容
本发明提供了制备接触镜的方法，其包括：
在接触镜模具的模制表面的一部分上沉积包括颜料、甲基丙烯酸2-羟乙酯和N-乙烯基吡咯烷酮的共聚物、以及交联单体的着色剂组合物，通过暴露在热或光能下至少部分地固化该着色剂组合物，以及
将形成透镜的单体混合物放置在模具中，并固化该形成透镜的单体混合物，其中所述着色剂组合物在固化的接触镜的表面上。
优选地，所述接触镜模具由聚烯烃制备，最优选聚丙烯。着色剂组合物沉积在接触镜模具的模制表面的一部分上，所述接触镜模具优选为前接触镜模具。着色剂组合物可以使用衬垫施用。例如，着色剂组合物首先从具有需要着色剂图案的底板施用到衬垫上，随后从衬垫上转移到接触镜模制表面。
如前所述，着色剂组合物优选施用为形成同心环形状，当接触镜放置在眼上时，该形状基本上与人虹膜的位置一致。
在将形成透镜的单体混合物放置在模具中之前，着色剂组合物至少是部分固化的。固化的优选方法是将着色剂组合物暴露在光能下，最优选UV光。
形成透镜的单体混合物固化后，接触镜从模具中释放出来，优选通过干释放方法。
着色剂组合物具有接近亲水性接触镜基材共聚物的各种物理性能是重要的。这些性能包括膨胀系数和含水量。此外，固化的着色剂组合物可以不充分结合接触镜基材。这在接触镜从模具中干释放时尤其重要，这样着色剂组合物和接触镜基材共聚物均没有与模具材料之间显著不同的粘合性。
然而，着色剂组合物可印制在模制表面上也是重要的。聚丙烯是相对疏水的，当使用亲水性着色剂组合物时，所述组合物有成珠的倾向。之前的解决该问题的方法涉及将接触镜模制表面用高能量源处理，例如电晕放电。然而，这样的处理难以控制，并且这样的处理需要更长的生产时间和更高的生产成本。对于本发明，优选所述接触镜模具未进行任何这样的高能量处理。相反，着色剂组合物可使用水混溶性溶剂，使得着色剂组合物的表面张力与模具材料的表面张力更好的匹配。同样，使用具有充分高粘度(至少2000cp)的着色剂组合物可抵消组合物的高表面张力，防止在模具表面上成珠。
具体实施方式
以下实施例说明了本发明的不同实施方案。
实施例1-聚(HEMA-共-NVP)的合成
向装有机械搅拌、冷凝管和氮气入口的2L3-颈圆底烧瓶中加入甲基丙烯酸2-羟乙酯(HEMA)(344.4g，2.65摩尔)，N-乙烯基吡咯烷酮(NVP)(165g，1.48摩尔)，2-巯基乙醇(4.68g，0.06摩尔)和环戊酮(684g，720ml)。上述混合物通过吹入氮气净化15分钟，随后加入Vazo 64引发剂。反应加热至38℃48小时，随后70℃过夜。该溶液用1200ml异丙醇(IPA)稀释。所得溶液在机械搅拌器剧烈搅拌下由加料漏斗缓慢滴加入6L乙醚中。过滤并在70℃烘箱中真空(30mmHg)干燥过夜后获得500g白色粉末。
反应如下图所示
实施例2-含聚(HEM A-共-NVP)共聚物的油墨
a.含氧化铁黑糊剂的形成
向500-ml陶瓷罐中加入210g氧化锆陶瓷介质、210g氧化铁黑和210g乳酸乙酯，使用涂料震荡器完全混合200分钟。糊剂的粒度为5μm。该糊剂与陶瓷介质加入装有滤网的广口瓶中，随后该广口瓶用其盖子和反广口瓶密封。离心该组件，所有的糊剂通过滤网沉积在广口瓶的底部，所有的陶瓷珠粒保留在滤网中。该氧化铁黑的粒度是5μm。
b.粘合剂溶液的形成
将53.27g聚(HEMA-共-NVP)(WM＝20，810)和35.51g(-)乳酸乙酯加入500-ml塑料杯中，完全混合10分钟，并在混合后放置过夜。制得88.97g含有60％共聚物的粘合剂溶液。
c.活化溶液的形成
将14.00g HEMA加入带磁力棒的30-ml棕色玻璃瓶中，随后依次加入3g EGDMA和3g Lucirin TPO引发剂。搅拌混合物直到固体引发剂溶解(约10分钟)。获得20g活化溶液。
d.油墨组合物的形成
将88.79g含氧化铁黑的糊剂、88.79g粘合剂溶液和19.73g活化溶液依次加入到500ml塑料杯中，混合10分钟，获得197.30g油墨组合物，其含有下列成分：
表1
| 成分 | 重量％ |
| 氧化铁黑 | 22.5 |
| 聚(HEMA-共-NVP) | 27 |
| (-)乳酸乙酯 | 40.5 |
| HEMA | 7 |
| EGDMA | 1.50 |
| Lucirin TPO引发剂 | 1.50 |
| 总量 | 100.00 |
该油墨组合物具有下列粘度性质，使用Brookfield数字粘度计测定，Model DV-II+，Spindle：SPE-51；温度：25.4℃。
| 速度(cP) | ％扭矩 | 粘度 |
| 0.5 | 4.9 | 5074 |
| 1 | 7 | 3625 |
| 2 | 9.4 | 2434 |
| 2.5 | 11.4 | 2361 |
| 4 | 14.7 | 1903 |
| 5 | 16.6 | 1719 |
比较实施例3-聚(HEMA)油墨组合物
从下列成分制备油墨组合物
表2
| 成分 | 重量％ |
| 氧化铁黑 | 22.00 |
| 聚HEMA | 27.60 |
| 乳酸乙酯 | 22.00 |
| 环戊酮 | 18.40 |
| HEMA | 9.00 |
| EGDMA | 0.50 |
| Lucirin TPO引发剂 | 0.50 |
| 总量 | 100.00 |
a.粘合剂溶液的形成
将41.40g聚HEMA(WM＝20,000)和27.60g环戊酮加入到500-ml塑料杯中，完全混合10分钟，在混合后放置过夜。获得67.57g的60％聚HEMA粘合剂溶液。
b.活化溶液
将13.5.00g HEMA加入到带磁力搅拌棒的30-ml棕色玻璃瓶中。依次加入0.73g EGDMA和0.73g Lucirin TPO引发剂。搅拌混合物直到固体引发剂溶解(约10分钟)。获得15.00g活化溶液。
c.油墨组合物
将实施例2a中的64.63g含氧化铁黑糊剂、67.57g聚HEMA粘合剂溶液和14.69g活化溶液依次加入到500ml塑料杯中，混合10分钟。该油墨组合物具有下列粘度性质，使用Brookfield数字粘度计测定，ModelDV-II+，Spindle：SPE-51；温度：25.4℃。
| 速度(cP) | ％扭矩 | 粘度 |
| 0.5 | 4.5 | 4660 |
| 1 | 7.3 | 3780 |
| 2 | 10.1 | 2615 |
| 2.5 | 12.2 | 2527 |
| 4 | 15.2 | 1968 |
| 5 | 17.1 | 1771 |
实施例4-含有聚(HEMA-共-NVP)共聚物的油墨
表3
| 最终油墨组成 | 实际重量％ |
| 氧化铁棕 | 20 |
| 聚(HEMA-共-NVP) | 30 |
| 乳酸乙酯 | 40 |
| 丙烯酸2-丁氧基乙酯 | 7 |
| 1，4-丁二醇二丙烯酸酯 | 1.50 |
| Lucirin TPO引发剂 | 1.50 |
| 总量 | 100.00 |
a.根据实施例2a的一般程序，但替之以氧化铁棕颜料，获得颜料糊剂。
b.根据实施例2b的一般程序，合并聚(HEMA-共-NVP)和乳酸乙酯，形成粘合剂溶液。加入500-ml塑料杯中，完全混合10分钟，在混合后放置过夜。获得88.97g含有60％共聚物的粘合剂溶液。
c.根据实施例2c的一般程序，合并丙烯酸2-丁氧基乙酯、1，4-丁二醇二丙烯酸酯和Lucirin TPO引发剂，形成活化溶液。
d.根据实施例2d的一般程序，合并含氧化铁棕的颜料、粘合剂溶液和活化溶液，形成油墨组合物。
所述实施例和实施方案给出了本发明的某些持续释放的实施方案。然而，应当理解这些实施例仅用于说明的目的，不应当理解为限制本发明的条件和范围。本发明已通过各种优选的实施方案进行了描述，在给出说明书的情况下，在不偏离本发明的主旨和所附权利要求的范围情况下进行众多的改变对于本领域技术人员来说是显而易见的。
Claims (8)
1.制备接触镜的方法，其包括:
将着色剂组合物沉积在接触镜模具的模制表面的一部分上；
至少部分固化着色剂组合物；
将形成透镜的单体混合物沉积在模具中，固化形成透镜的单体混合物，
其中所述着色剂组合物在固化的接触镜的表面上；
其特征在于，沉积在接触镜模具的模制表面的一部分上的着色剂组合物包括颜料、甲基丙烯酸2-羟乙酯和N-乙烯基吡咯烷酮的共聚物、以及交联单体，所述着色剂组合物的Brookfield粘度为至少2000cp，所述接触镜模具由聚烯烃制备。
2.根据权利要求1的方法，其中接触镜模具由聚丙烯制得。
3.根据权利要求1的方法，其中着色剂组合物沉积在前接触镜模具的模制表面的一部分上。
4.根据权利要求1的方法，其中形成透镜的单体混合物包括甲基丙烯酸羟乙酯、N-乙烯基吡咯烷酮和交联单体。
5.根据权利要求1的方法，其中着色剂组合物沉积以形成同心环形状。
6.根据权利要求5的方法，其中当接触镜放置在眼上时，同心环基本上与人虹膜的位置一致。
7.根据权利要求6的方法，其中同心环具有比人虹膜大的外径。
8.根据权利要求1的方法，在固化形成透镜的单体混合物后，其还包括从模具中干释放接触镜。
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| JP2013500499A (ja) | 2013-01-07 |
| KR101912572B1 (ko) | 2018-10-26 |
| IN2012DN00299A (zh) | 2015-05-08 |
| WO2011011344A1 (en) | 2011-01-27 |
| BR112012001542B1 (pt) | 2019-08-13 |
| JP5739423B2 (ja) | 2015-06-24 |
| BR112012001542A2 (pt) | 2016-04-19 |
| SG177509A1 (en) | 2012-02-28 |
| KR20180017219A (ko) | 2018-02-20 |
| KR20120041736A (ko) | 2012-05-02 |
| EP2457122A1 (en) | 2012-05-30 |
| US20110063568A1 (en) | 2011-03-17 |
| CA2767058C (en) | 2015-02-17 |
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| US8461226B2 (en) | 2013-06-11 |
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