CN102471805A - 检测核酸差异的探针形式 - Google Patents

检测核酸差异的探针形式 Download PDF

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Publication number
CN102471805A
CN102471805A CN2010800360045A CN201080036004A CN102471805A CN 102471805 A CN102471805 A CN 102471805A CN 2010800360045 A CN2010800360045 A CN 2010800360045A CN 201080036004 A CN201080036004 A CN 201080036004A CN 102471805 A CN102471805 A CN 102471805A
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structural domain
nucleic acid
reporter
deadman
nucleotide
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Chinese (zh)
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S.G.威尔
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Priority to CN201710655783.0A priority Critical patent/CN107254540B/zh
Publication of CN102471805A publication Critical patent/CN102471805A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN2010800360045A 2009-08-14 2010-08-13 检测核酸差异的探针形式 Pending CN102471805A (zh)

Priority Applications (1)

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CN201710655783.0A CN107254540B (zh) 2009-08-14 2010-08-13 检测核酸差异的探针形式

Applications Claiming Priority (3)

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US23418909P 2009-08-14 2009-08-14
US61/234189 2009-08-14
PCT/EP2010/004963 WO2011018232A1 (en) 2009-08-14 2010-08-13 Format of probes to detect nucleic acid differences

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CN102471805A true CN102471805A (zh) 2012-05-23

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CN2010800360045A Pending CN102471805A (zh) 2009-08-14 2010-08-13 检测核酸差异的探针形式
CN201710655783.0A Active CN107254540B (zh) 2009-08-14 2010-08-13 检测核酸差异的探针形式

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US (2) US8409802B2 (enExample)
EP (1) EP2464745B1 (enExample)
JP (1) JP5632476B2 (enExample)
CN (2) CN102471805A (enExample)
CA (1) CA2770241C (enExample)
ES (1) ES2608455T3 (enExample)
WO (1) WO2011018232A1 (enExample)

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CN107109398A (zh) * 2014-12-19 2017-08-29 荣研化学株式会社 单核苷酸多态性检测用寡核苷酸探针及单核苷酸多态性检测方法

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WO2013132700A1 (ja) * 2012-03-05 2013-09-12 日本碍子株式会社 標的核酸の検出方法
US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences
PL3246416T3 (pl) 2011-04-15 2024-09-30 The Johns Hopkins University Bezpieczny system sekwencjonowania
EP3382039B1 (en) * 2011-05-04 2023-09-13 Biocept, Inc. Methods for detecting nucleic acid sequence variants
EP2762562B1 (en) * 2011-09-14 2019-05-22 NGK Insulators, Ltd. Method for detecting target nucleic acid
GB201116131D0 (en) * 2011-09-19 2011-11-02 Epistem Ltd Probe
JP2014533506A (ja) * 2011-11-16 2014-12-15 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 高度に相同的なゲノム領域での突然変異の検出
CN109457030B (zh) 2012-10-29 2022-02-18 约翰·霍普金斯大学 卵巢和子宫内膜癌的帕帕尼科拉乌测试
US9637791B2 (en) * 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
CA2997120A1 (en) * 2015-09-03 2017-03-09 Nanostring Technologies, Inc. Multivalent probes having single nucleotide resolution
US20190211377A1 (en) * 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
EP3665308A1 (en) 2017-08-07 2020-06-17 The Johns Hopkins University Methods and materials for assessing and treating cancer
BR112022015909A2 (pt) 2020-02-14 2022-10-04 Univ Johns Hopkins Métodos e materiais para avaliação de ácidos nucleicos
CN117778575A (zh) * 2023-12-25 2024-03-29 深圳海普洛斯医学检验实验室 一种用于检测SNV位点的TaqMan探针及其应用

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CN1952178A (zh) * 2006-11-03 2007-04-25 罗光华 检测脱氧核糖核酸的单核苷酸多态性的方法
CN101074450A (zh) * 2001-09-24 2007-11-21 一兰姆达公司 诊断探针检测系统
WO2008066730A2 (en) * 2006-11-22 2008-06-05 Massachusetts Institute Of Technology Pna-dna oligomers and methods of use thereof
CN102257163A (zh) * 2008-12-22 2011-11-23 霍夫曼-拉罗奇有限公司 在样品中检测目标核酸的方法

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US8409802B2 (en) 2009-08-14 2013-04-02 Roche Molecular Systems, Inc. Format of probes to detect nucleic acid differences

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CN101074450A (zh) * 2001-09-24 2007-11-21 一兰姆达公司 诊断探针检测系统
WO2004098386A2 (en) * 2003-05-01 2004-11-18 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch
WO2004098386A3 (en) * 2003-05-01 2005-05-12 Gen Probe Inc Oligonucleotides comprising a molecular switch
CN1952178A (zh) * 2006-11-03 2007-04-25 罗光华 检测脱氧核糖核酸的单核苷酸多态性的方法
WO2008066730A2 (en) * 2006-11-22 2008-06-05 Massachusetts Institute Of Technology Pna-dna oligomers and methods of use thereof
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CN102257163A (zh) * 2008-12-22 2011-11-23 霍夫曼-拉罗奇有限公司 在样品中检测目标核酸的方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107109398A (zh) * 2014-12-19 2017-08-29 荣研化学株式会社 单核苷酸多态性检测用寡核苷酸探针及单核苷酸多态性检测方法
US11512343B2 (en) 2014-12-19 2022-11-29 Eiken Kagaku Kabushiki Kaisha Oligonucleotide probe for detecting single nucleotide polymorphism, and method for detecting single nucleotide polymorphism

Also Published As

Publication number Publication date
CN107254540B (zh) 2021-11-16
CN107254540A (zh) 2017-10-17
US20130266938A1 (en) 2013-10-10
ES2608455T3 (es) 2017-04-11
US8409802B2 (en) 2013-04-02
EP2464745A1 (en) 2012-06-20
JP2013501508A (ja) 2013-01-17
CA2770241A1 (en) 2011-02-17
US20110039264A1 (en) 2011-02-17
WO2011018232A1 (en) 2011-02-17
EP2464745B1 (en) 2016-11-09
US9068225B2 (en) 2015-06-30
JP5632476B2 (ja) 2014-11-26
CA2770241C (en) 2016-03-29

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