CN102459163B - 羟吲哚类和邻位取代的苯胺的制备方法及其作为合成中间产物的用途 - Google Patents
羟吲哚类和邻位取代的苯胺的制备方法及其作为合成中间产物的用途 Download PDFInfo
- Publication number
- CN102459163B CN102459163B CN201080030137.1A CN201080030137A CN102459163B CN 102459163 B CN102459163 B CN 102459163B CN 201080030137 A CN201080030137 A CN 201080030137A CN 102459163 B CN102459163 B CN 102459163B
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- alkyl
- compound
- aniline
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09006050.0 | 2009-05-02 | ||
| EP09006050A EP2246326A1 (de) | 2009-05-02 | 2009-05-02 | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| PCT/EP2010/002566 WO2010127786A1 (de) | 2009-05-02 | 2010-04-27 | Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102459163A CN102459163A (zh) | 2012-05-16 |
| CN102459163B true CN102459163B (zh) | 2015-05-13 |
Family
ID=41050783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201080030137.1A Active CN102459163B (zh) | 2009-05-02 | 2010-04-27 | 羟吲哚类和邻位取代的苯胺的制备方法及其作为合成中间产物的用途 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8492590B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2246326A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5826167B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101782961B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102459163B (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1015123B1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2424835T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2548024T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL216051A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2011011547A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI547473B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010127786A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201108035B (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008037631A1 (de) | 2008-08-14 | 2010-02-18 | Bayer Cropscience Ag | Herbizid-Kombination mit Dimethoxytriazinyl-substituierten Difluormethansulfonylaniliden |
| WO2012028162A1 (de) * | 2010-09-01 | 2012-03-08 | Bayer Cropscience Ag | Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen |
| US9527808B2 (en) | 2012-09-17 | 2016-12-27 | Bayer Cropscience Ag | Continuous method for producing ortho-substituted anilines in a flow reactor |
| US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972894A (en) * | 1973-04-27 | 1976-08-03 | The Ohio State University Research Foundation | Synthesis of oxindoles from anilines and β-thio carboxylic esters or amides |
| WO1996041799A1 (de) * | 1995-06-12 | 1996-12-27 | Hoechst Schering Agrevo Gmbh | Sulfonamide als herbizide und pflanzenwachstumsregulatoren |
| CN1949968A (zh) * | 2004-05-12 | 2007-04-18 | 拜尔作物科学有限公司 | 植物生长调节作用 |
| JP2008101014A (ja) * | 2007-11-22 | 2008-05-01 | Dainippon Printing Co Ltd | ２−オキシインドール誘導体の製造法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4690943A (en) * | 1984-09-19 | 1987-09-01 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| FR2708605A1 (fr) | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| CN1161333C (zh) * | 1998-08-20 | 2004-08-11 | 住友制药株式会社 | 作为生长激素释放剂的2-羟基吲哚衍生物 |
| AU6595000A (en) * | 1999-08-20 | 2001-03-19 | Takeda Chemical Industries Ltd. | Dihydrobenzofuran derivatives, process for the preparation thereof and agents |
| US6906096B2 (en) * | 2002-06-28 | 2005-06-14 | Irm Llc | 4,7-Disubstituted indoles and methods of making |
| MXPA06004438A (es) * | 2003-10-24 | 2006-06-20 | Schering Ag | Derivados de indolinona y su uso en el tratamiento de enfermedades como el cancer. |
| US20080280891A1 (en) | 2006-06-27 | 2008-11-13 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
-
2009
- 2009-05-02 EP EP09006050A patent/EP2246326A1/de not_active Withdrawn
-
2010
- 2010-04-27 WO PCT/EP2010/002566 patent/WO2010127786A1/de not_active Ceased
- 2010-04-27 KR KR1020117028793A patent/KR101782961B1/ko active Active
- 2010-04-27 MX MX2011011547A patent/MX2011011547A/es active IP Right Grant
- 2010-04-27 BR BRPI1015123-0A patent/BRPI1015123B1/pt active IP Right Grant
- 2010-04-27 DK DK10715721.6T patent/DK2424835T3/en active
- 2010-04-27 KR KR1020177016800A patent/KR101862230B1/ko active Active
- 2010-04-27 EP EP10715721.6A patent/EP2424835B1/de active Active
- 2010-04-27 CN CN201080030137.1A patent/CN102459163B/zh active Active
- 2010-04-27 ES ES10715721.6T patent/ES2548024T3/es active Active
- 2010-04-27 MX MX2013013279A patent/MX367426B/es unknown
- 2010-04-27 JP JP2012507632A patent/JP5826167B2/ja active Active
- 2010-04-28 US US12/769,302 patent/US8492590B2/en active Active
- 2010-04-29 TW TW099113608A patent/TWI547473B/zh active
-
2011
- 2011-10-30 IL IL216051A patent/IL216051A/en active IP Right Grant
- 2011-11-02 ZA ZA2011/08035A patent/ZA201108035B/en unknown
-
2013
- 2013-06-12 US US13/915,898 patent/US9242934B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972894A (en) * | 1973-04-27 | 1976-08-03 | The Ohio State University Research Foundation | Synthesis of oxindoles from anilines and β-thio carboxylic esters or amides |
| WO1996041799A1 (de) * | 1995-06-12 | 1996-12-27 | Hoechst Schering Agrevo Gmbh | Sulfonamide als herbizide und pflanzenwachstumsregulatoren |
| CN1949968A (zh) * | 2004-05-12 | 2007-04-18 | 拜尔作物科学有限公司 | 植物生长调节作用 |
| JP2008101014A (ja) * | 2007-11-22 | 2008-05-01 | Dainippon Printing Co Ltd | ２−オキシインドール誘導体の製造法 |
Non-Patent Citations (10)
| Title |
|---|
| A Convenient Modification of the Gassman Oxindole Synthesis;Stephen W.Wright 等;《Tetrahedron Letters》;19961231;第37卷(第27期);第4631-4634页 * |
| A General Method for the Synthesis of Indoles;Paul G. Gassman 等;《Journal of the American chemical society》;19740831;第96卷(第17期);第5495-5508页 * |
| Antiinflammatory Agents. 3.l Synthesis and Pharmacological Evaluation of 2-Amino-3-benzoylphenylacetic A cid and Analogues;David A.Walsh 等;《Journal of Medicinal Chemistry》;19841130;第27卷(第11期);第1379-1388页 * |
| Azasulfonium Salts. Intermediates in a General Procedure for the Alkylation of Aroma tic Amines;Paul G. Gassman 等;《Journal of the American chemical society》;19740821;第96卷(第17期);第5487-5495页 * |
| Generation of Azasulfonium Salts from Halogen-Sulfide Complexes and Anilines. Oxindoles, and Alkylated Aromatic Amines Bearing Cation Stabilizing Substituents;Paul G. Gassman 等;《Journal of the American chemical society》;19740821;第96卷(第17期);第5512-5517页 * |
| Oxindoles. A New, General Method of Synthesis;Paul G. Gassman 等;《journal of the American chemical society》;19740821;第96卷(第17期);第5508-5512页 * |
| Regioselectie [2,3] sigmatropic rearrangement to the pyrrolo[3.2-e] indole ring system of cc-1065;Martha A.Warpehoski 等;《Tetrahedron Letters》;19861231;第27卷(第24期);第2735-2738页 * |
| simple synthetic routes to 5-(3,6-dihydro-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-diones and their derivatives;I.Delimoge 等;《Journal of Heterocyclic chemistry》;19911031;第28卷;第1525-1532页 * |
| The Chemistry of Isatins: a Review from 1975 to 1999;Joaquim F. M. da Silva等;《J. Braz. Chem. Soc.》;20011231;第12卷(第3期);第273-324页 * |
| Total Synthesis of U-71,184, A Potent New Antitumor Agent Modeled on CC-1065;Martha A.Warpehoski;《Tetrahedron Letters》;19861231;第27卷(第35期);第4103-4106页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102459163A (zh) | 2012-05-16 |
| WO2010127786A8 (de) | 2011-11-10 |
| EP2424835B1 (de) | 2015-07-01 |
| MX2011011547A (es) | 2011-11-29 |
| ES2548024T3 (es) | 2015-10-13 |
| BRPI1015123B1 (pt) | 2021-05-04 |
| US9242934B2 (en) | 2016-01-26 |
| EP2246326A1 (de) | 2010-11-03 |
| TWI547473B (zh) | 2016-09-01 |
| KR101782961B1 (ko) | 2017-09-28 |
| BRPI1015123A2 (pt) | 2019-04-09 |
| KR101862230B1 (ko) | 2018-05-29 |
| TW201111331A (en) | 2011-04-01 |
| IL216051A (en) | 2015-03-31 |
| JP2012526045A (ja) | 2012-10-25 |
| JP5826167B2 (ja) | 2015-12-02 |
| KR20170073738A (ko) | 2017-06-28 |
| US8492590B2 (en) | 2013-07-23 |
| WO2010127786A1 (de) | 2010-11-11 |
| ZA201108035B (en) | 2013-01-30 |
| DK2424835T3 (en) | 2015-10-05 |
| EP2424835A1 (de) | 2012-03-07 |
| KR20120016123A (ko) | 2012-02-22 |
| MX367426B (es) | 2019-08-21 |
| US20110118478A1 (en) | 2011-05-19 |
| US20130281711A1 (en) | 2013-10-24 |
| IL216051A0 (en) | 2012-01-31 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH Free format text: FORMER OWNER: BAYER LANDWIRTSCHAFTLICHE KULTURPFLANZEN SCIENCE AG Effective date: 20150721 |
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| C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20150721 Address after: German Monheim Patentee after: BAYER INTELLECTUAL PROPERTY GmbH Address before: German Monheim Patentee before: BAYER CROPSCIENCE AG |
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Address after: 50 Alfred Nobel Street, Monheim, Rhine, Germany 40789 Patentee after: BAYER INTELLECTUAL PROPERTY GmbH Address before: Germany Patentee before: BAYER INTELLECTUAL PROPERTY GmbH |
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Effective date of registration: 20240108 Address after: 50 Alfred Nobel Street, Monheim, Rhine, Germany 40789 Patentee after: BAYER CROPSCIENCE AG Address before: 50 Alfred Nobel Street, Monheim, Rhine, Germany 40789 Patentee before: BAYER INTELLECTUAL PROPERTY GmbH |
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| TR01 | Transfer of patent right |