ZA201108035B - Method for producing oxindoles and ortho-substituted amilines and the use thereof as intermediate products for syntheses - Google Patents
Method for producing oxindoles and ortho-substituted amilines and the use thereof as intermediate products for synthesesInfo
- Publication number
- ZA201108035B ZA201108035B ZA2011/08035A ZA201108035A ZA201108035B ZA 201108035 B ZA201108035 B ZA 201108035B ZA 2011/08035 A ZA2011/08035 A ZA 2011/08035A ZA 201108035 A ZA201108035 A ZA 201108035A ZA 201108035 B ZA201108035 B ZA 201108035B
- Authority
- ZA
- South Africa
- Prior art keywords
- amilines
- syntheses
- ortho
- substituted
- intermediate products
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000005623 oxindoles Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09006050A EP2246326A1 (de) | 2009-05-02 | 2009-05-02 | Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen |
| PCT/EP2010/002566 WO2010127786A1 (de) | 2009-05-02 | 2010-04-27 | Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201108035B true ZA201108035B (en) | 2013-01-30 |
Family
ID=41050783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2011/08035A ZA201108035B (en) | 2009-05-02 | 2011-11-02 | Method for producing oxindoles and ortho-substituted amilines and the use thereof as intermediate products for syntheses |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8492590B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2246326A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5826167B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR101782961B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102459163B (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI1015123B1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2424835T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2548024T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL216051A (cg-RX-API-DMAC7.html) |
| MX (2) | MX2011011547A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI547473B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010127786A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201108035B (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008037631A1 (de) | 2008-08-14 | 2010-02-18 | Bayer Cropscience Ag | Herbizid-Kombination mit Dimethoxytriazinyl-substituierten Difluormethansulfonylaniliden |
| WO2012028162A1 (de) * | 2010-09-01 | 2012-03-08 | Bayer Cropscience Ag | Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen |
| US9527808B2 (en) | 2012-09-17 | 2016-12-27 | Bayer Cropscience Ag | Continuous method for producing ortho-substituted anilines in a flow reactor |
| US9850203B2 (en) | 2013-09-26 | 2017-12-26 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972894A (en) * | 1973-04-27 | 1976-08-03 | The Ohio State University Research Foundation | Synthesis of oxindoles from anilines and β-thio carboxylic esters or amides |
| US4690943A (en) * | 1984-09-19 | 1987-09-01 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| FR2708605A1 (fr) | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| DE19521355A1 (de) | 1995-06-12 | 1996-12-19 | Hoechst Schering Agrevo Gmbh | Sulfonamide, Verfahren zu deren Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| CN1161333C (zh) * | 1998-08-20 | 2004-08-11 | 住友制药株式会社 | 作为生长激素释放剂的2-羟基吲哚衍生物 |
| AU6595000A (en) * | 1999-08-20 | 2001-03-19 | Takeda Chemical Industries Ltd. | Dihydrobenzofuran derivatives, process for the preparation thereof and agents |
| US6906096B2 (en) * | 2002-06-28 | 2005-06-14 | Irm Llc | 4,7-Disubstituted indoles and methods of making |
| MXPA06004438A (es) * | 2003-10-24 | 2006-06-20 | Schering Ag | Derivados de indolinona y su uso en el tratamiento de enfermedades como el cancer. |
| BRPI0511057A (pt) * | 2004-05-12 | 2007-11-27 | Bayer Cropscience Gmbh | regulação de crescimento da planta |
| US20080280891A1 (en) | 2006-06-27 | 2008-11-13 | Locus Pharmaceuticals, Inc. | Anti-cancer agents and uses thereof |
| JP4770826B2 (ja) | 2007-11-22 | 2011-09-14 | 大日本印刷株式会社 | ２−オキシインドール誘導体の製造法 |
-
2009
- 2009-05-02 EP EP09006050A patent/EP2246326A1/de not_active Withdrawn
-
2010
- 2010-04-27 WO PCT/EP2010/002566 patent/WO2010127786A1/de not_active Ceased
- 2010-04-27 KR KR1020117028793A patent/KR101782961B1/ko active Active
- 2010-04-27 MX MX2011011547A patent/MX2011011547A/es active IP Right Grant
- 2010-04-27 BR BRPI1015123-0A patent/BRPI1015123B1/pt active IP Right Grant
- 2010-04-27 DK DK10715721.6T patent/DK2424835T3/en active
- 2010-04-27 KR KR1020177016800A patent/KR101862230B1/ko active Active
- 2010-04-27 EP EP10715721.6A patent/EP2424835B1/de active Active
- 2010-04-27 CN CN201080030137.1A patent/CN102459163B/zh active Active
- 2010-04-27 ES ES10715721.6T patent/ES2548024T3/es active Active
- 2010-04-27 MX MX2013013279A patent/MX367426B/es unknown
- 2010-04-27 JP JP2012507632A patent/JP5826167B2/ja active Active
- 2010-04-28 US US12/769,302 patent/US8492590B2/en active Active
- 2010-04-29 TW TW099113608A patent/TWI547473B/zh active
-
2011
- 2011-10-30 IL IL216051A patent/IL216051A/en active IP Right Grant
- 2011-11-02 ZA ZA2011/08035A patent/ZA201108035B/en unknown
-
2013
- 2013-06-12 US US13/915,898 patent/US9242934B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102459163A (zh) | 2012-05-16 |
| WO2010127786A8 (de) | 2011-11-10 |
| EP2424835B1 (de) | 2015-07-01 |
| MX2011011547A (es) | 2011-11-29 |
| ES2548024T3 (es) | 2015-10-13 |
| BRPI1015123B1 (pt) | 2021-05-04 |
| US9242934B2 (en) | 2016-01-26 |
| EP2246326A1 (de) | 2010-11-03 |
| TWI547473B (zh) | 2016-09-01 |
| KR101782961B1 (ko) | 2017-09-28 |
| BRPI1015123A2 (pt) | 2019-04-09 |
| KR101862230B1 (ko) | 2018-05-29 |
| TW201111331A (en) | 2011-04-01 |
| IL216051A (en) | 2015-03-31 |
| JP2012526045A (ja) | 2012-10-25 |
| JP5826167B2 (ja) | 2015-12-02 |
| KR20170073738A (ko) | 2017-06-28 |
| US8492590B2 (en) | 2013-07-23 |
| WO2010127786A1 (de) | 2010-11-11 |
| DK2424835T3 (en) | 2015-10-05 |
| CN102459163B (zh) | 2015-05-13 |
| EP2424835A1 (de) | 2012-03-07 |
| KR20120016123A (ko) | 2012-02-22 |
| MX367426B (es) | 2019-08-21 |
| US20110118478A1 (en) | 2011-05-19 |
| US20130281711A1 (en) | 2013-10-24 |
| IL216051A0 (en) | 2012-01-31 |
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