BRPI1015123A2 - método para a fabricação de oxindoles e anilinas orto-substituídas e seu uso como produtos intermediários para sínteses - Google Patents

método para a fabricação de oxindoles e anilinas orto-substituídas e seu uso como produtos intermediários para sínteses

Info

Publication number
BRPI1015123A2
BRPI1015123A2 BRPI1015123-0A BRPI1015123A BRPI1015123A2 BR PI1015123 A2 BRPI1015123 A2 BR PI1015123A2 BR PI1015123 A BRPI1015123 A BR PI1015123A BR PI1015123 A2 BRPI1015123 A2 BR PI1015123A2
Authority
BR
Brazil
Prior art keywords
manufacture
anilines
ortho
formula
intermediate products
Prior art date
Application number
BRPI1015123-0A
Other languages
English (en)
Inventor
James Ford Mark
Karig Gunter
Original Assignee
Bayer Cropscience Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Cropscience Ag filed Critical Bayer Cropscience Ag
Publication of BRPI1015123A2 publication Critical patent/BRPI1015123A2/pt
Publication of BRPI1015123B1 publication Critical patent/BRPI1015123B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

método para a fabricação de oxindoles · e anilinas orlo-substituídas e seu uso como produtos intermediários para sínteses método para a fabricação de oxindoles e anilinas orto-substituídas e seu uso como produtos intermediários para sínteses. método para a fabricação de compostos da fórmula (4): em que se transforma uma mistura de uma anilina (composto da fórmula q) com um tioéter (composto da fórmula w): na presença de um agente de cloração e de um solvente orgânico a uma temperatura de reação numa faixa entre -60°c e -10°c. em um procedimento seguinte, este composto é novamente transformado, na presença de um catalisador ácido, para o indole da fórmula (7) ou para o oxindole da fórmula (8).
BRPI1015123-0A 2009-05-02 2010-04-27 Métodos para a fabricação de oxindoles e anilinas orto-substituídas BRPI1015123B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09006050.0 2009-05-02
EP09006050A EP2246326A1 (de) 2009-05-02 2009-05-02 Verfahren zur Herstellung von Oxindolen und ortho-substituierten Anilinen und ihre Verwendung als Zwischenprodukte für Synthesen
PCT/EP2010/002566 WO2010127786A1 (de) 2009-05-02 2010-04-27 Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen

Publications (2)

Publication Number Publication Date
BRPI1015123A2 true BRPI1015123A2 (pt) 2019-04-09
BRPI1015123B1 BRPI1015123B1 (pt) 2021-05-04

Family

ID=41050783

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015123-0A BRPI1015123B1 (pt) 2009-05-02 2010-04-27 Métodos para a fabricação de oxindoles e anilinas orto-substituídas

Country Status (13)

Country Link
US (2) US8492590B2 (pt)
EP (2) EP2246326A1 (pt)
JP (1) JP5826167B2 (pt)
KR (2) KR101782961B1 (pt)
CN (1) CN102459163B (pt)
BR (1) BRPI1015123B1 (pt)
DK (1) DK2424835T3 (pt)
ES (1) ES2548024T3 (pt)
IL (1) IL216051A (pt)
MX (2) MX367426B (pt)
TW (1) TWI547473B (pt)
WO (1) WO2010127786A1 (pt)
ZA (1) ZA201108035B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008037631A1 (de) 2008-08-14 2010-02-18 Bayer Cropscience Ag Herbizid-Kombination mit Dimethoxytriazinyl-substituierten Difluormethansulfonylaniliden
WO2012028162A1 (de) * 2010-09-01 2012-03-08 Bayer Cropscience Ag Verfahren zur herstellung von oxindolen und ortho-substituierten anilinen und ihre verwendung als zwischenprodukte für synthesen
US9527808B2 (en) 2012-09-17 2016-12-27 Bayer Cropscience Ag Continuous method for producing ortho-substituted anilines in a flow reactor
WO2015048301A1 (en) 2013-09-26 2015-04-02 Pharmakea, Inc. Autotaxin inhibitor compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3972894A (en) * 1973-04-27 1976-08-03 The Ohio State University Research Foundation Synthesis of oxindoles from anilines and β-thio carboxylic esters or amides
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US5663431A (en) * 1992-01-30 1997-09-02 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (fr) 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
DE19521355A1 (de) 1995-06-12 1996-12-19 Hoechst Schering Agrevo Gmbh Sulfonamide, Verfahren zu deren Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
ES2237135T3 (es) * 1998-08-20 2005-07-16 Sumitomo Pharmaceuticals Company, Limited Derivados de oxindol como liberadores de la hormona del crecimiento.
US7008940B1 (en) * 1999-08-20 2006-03-07 Takeda Pharmaceutical Company Limited Dihydrobenzofuran derivatives, process for the preparing thereof and agents
BR0307406A (pt) * 2002-02-01 2004-12-28 Hoffmann La Roche Indóis substituìdos como agonistas alfa-1
US6906096B2 (en) * 2002-06-28 2005-06-14 Irm Llc 4,7-Disubstituted indoles and methods of making
RU2006117635A (ru) * 2003-10-24 2007-12-10 Шеринг Акциенгезельшафт (De) Производные индолинона и их применение для лечения патологических состояний, таких как злокачественное новообразование
WO2005107466A1 (en) * 2004-05-12 2005-11-17 Bayer Cropscience Gmbh Plant growth regulation
US20080280891A1 (en) 2006-06-27 2008-11-13 Locus Pharmaceuticals, Inc. Anti-cancer agents and uses thereof
JP4770826B2 (ja) 2007-11-22 2011-09-14 大日本印刷株式会社 ２−オキシインドール誘導体の製造法

Also Published As

Publication number Publication date
JP5826167B2 (ja) 2015-12-02
KR101862230B1 (ko) 2018-05-29
KR20170073738A (ko) 2017-06-28
MX2011011547A (es) 2011-11-29
WO2010127786A1 (de) 2010-11-11
EP2246326A1 (de) 2010-11-03
CN102459163B (zh) 2015-05-13
IL216051A (en) 2015-03-31
KR20120016123A (ko) 2012-02-22
DK2424835T3 (en) 2015-10-05
ZA201108035B (en) 2013-01-30
ES2548024T3 (es) 2015-10-13
US20110118478A1 (en) 2011-05-19
WO2010127786A8 (de) 2011-11-10
MX367426B (es) 2019-08-21
EP2424835A1 (de) 2012-03-07
EP2424835B1 (de) 2015-07-01
CN102459163A (zh) 2012-05-16
US9242934B2 (en) 2016-01-26
BRPI1015123B1 (pt) 2021-05-04
TWI547473B (zh) 2016-09-01
KR101782961B1 (ko) 2017-09-28
TW201111331A (en) 2011-04-01
IL216051A0 (en) 2012-01-31
US8492590B2 (en) 2013-07-23
US20130281711A1 (en) 2013-10-24
JP2012526045A (ja) 2012-10-25

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/05/2021, OBSERVADAS AS CONDICOES LEGAIS.

B25G Requested change of headquarter approved

Owner name: BAYER INTELLECTUAL PROPERTY GMBH (DE)

B25A Requested transfer of rights approved

Owner name: BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE)