CN102438975B - 取代的芳香化合物及其药物用途 - Google Patents

取代的芳香化合物及其药物用途 Download PDF

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CN102438975B
CN102438975B CN201080023204.7A CN201080023204A CN102438975B CN 102438975 B CN102438975 B CN 102438975B CN 201080023204 A CN201080023204 A CN 201080023204A CN 102438975 B CN102438975 B CN 102438975B
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compound
disease
alkyl
kidney
compounds
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CN102438975A (zh
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B·扎卡里
C·彭尼
L·加农
J-F·比恩韦奴
V·佩龙
B·格鲁伊克斯
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Prometic Biosciences Inc
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
CN201080023204.7A 2009-05-04 2010-05-03 取代的芳香化合物及其药物用途 Expired - Fee Related CN102438975B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17523509P 2009-05-04 2009-05-04
US61/175,235 2009-05-04
PCT/CA2010/000677 WO2010127440A1 (en) 2009-05-04 2010-05-03 Substituted aromatic compounds and pharmaceutical uses thereof

Publications (2)

Publication Number Publication Date
CN102438975A CN102438975A (zh) 2012-05-02
CN102438975B true CN102438975B (zh) 2015-12-16

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US (4) US8927765B2 (https=)
EP (1) EP2427416B1 (https=)
JP (2) JP2012526052A (https=)
KR (2) KR20120024696A (https=)
CN (1) CN102438975B (https=)
AU (1) AU2010244930B2 (https=)
BR (1) BRPI1015124B8 (https=)
CA (1) CA2761018C (https=)
DK (1) DK2427416T3 (https=)
EA (1) EA022445B1 (https=)
ES (1) ES2575100T3 (https=)
HU (1) HUE029126T2 (https=)
IL (1) IL216006A (https=)
MX (1) MX2011011757A (https=)
MY (1) MY156780A (https=)
NZ (1) NZ595978A (https=)
PL (1) PL2427416T3 (https=)
PT (1) PT2427416E (https=)
SG (1) SG175855A1 (https=)
TW (1) TWI485134B (https=)
WO (1) WO2010127440A1 (https=)

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MX2011011756A (es) * 2009-05-04 2012-01-25 Prometic Biosciences Inc Sales de acido 3-pentilfenilacetico y usos farmaceuticos.
PT2427416E (pt) 2009-05-04 2016-06-15 Prometic Pharma Smt Ltd Compostos aromáticos substituídos e seus usos farmacêuticos
AT509045B1 (de) * 2010-01-29 2011-06-15 Planta Naturstoffe Vertriebsges M B H Verbindungen zur behandlung von asthma bronchiale
MX365807B (es) * 2010-10-27 2019-06-14 Prometic Pharma Smt Ltd Compuestos y composiciones para el tratamiento del cáncer.
CA2816094A1 (en) * 2010-10-27 2012-07-26 Prometic Biosciences Inc. Compounds and pharmaceutical compositions for uses in diabetes
TWI742541B (zh) 2013-03-15 2021-10-11 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
TWI689490B (zh) 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
CA2930584A1 (en) 2013-11-15 2015-05-21 The Wistar Institute Of Anatomy And Biology Ebna1 inhibitors and their method of use
GB201416017D0 (en) * 2014-09-10 2014-10-22 New Royal Holloway & Bedford An Anticonvulsant Compound
ES2785317T3 (es) * 2014-10-10 2020-10-06 Liminal Biosciences Ltd Compuestos aromáticos sustituidos y composiciones farmacéuticas para la prevención y el tratamiento de la osteoporosis
KR20170072352A (ko) * 2014-11-12 2017-06-26 프로메틱 파마 에스엠티 리미티드 조직 자가-회복 및 재생을 위한 치환된 방향족 화합물 및 약제학적 조성물
AU2016262572B2 (en) 2015-05-14 2020-04-30 The Wistar Institute Of Anatomy And Biology EBNA1 inhibitors and methods using same
EP3793546B1 (en) 2018-05-17 2025-11-19 The Wistar Institute Ebna1 inhibitor crystalline forms, and methods of preparing and using same
CN108997202A (zh) * 2018-07-10 2018-12-14 湖南华腾制药有限公司 一种（5-三氟甲基-吡啶-2-基）-乙酸盐的制备方法
MA53188A1 (fr) 2018-10-11 2021-12-31 Basf As Composés aromatiques et leurs utilisations pharmaceutiques
WO2020113340A1 (en) * 2018-12-05 2020-06-11 Liminal Biosciences Limited Use of sodium 2-(3-pentylphenyl)acetate in the treatment of alström syndrome
EP4051659B1 (en) * 2019-10-31 2026-01-28 Assia Chemical Industries Ltd. Solid state forms of fezagepras and process for preparation thereof
CN115974773B (zh) * 2022-12-30 2024-07-02 广东省科学院生物与医学工程研究所 甘蔗内生真菌所产的化合物及其在抑菌和抗氧化中的应用
WO2024217515A1 (zh) * 2023-04-19 2024-10-24 上海复宏汉霖生物技术股份有限公司 一种杂环取代的芳香化合物、其制备方法及用途

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