CN102397531A - Compound propolis composition for treating duck plague and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating the duck plague and a preparation method thereof, relating to the field of animal medicaments. The preparation method of the composition comprises the following steps of: (1) performing ultrafine smashing on various components (except interferon) in a formula respectively, sieving with a 700-mesh sieve; (2) weighing 15-35 parts by weight of propolis, 5-20 parts by weight of interferon for ducks, 10-30 parts by weight of cassia twig and 15-30 parts by weight of coptis root, and mixing for 5-10 minutes to uniform state; (3) weighing 10-40 parts by weight of dangshen, 10-30 parts by weight of Chinese thorowax root, 15-45 parts by weight of indigowoad leaf and 10-35 parts by weight of red paeony root, and mixing for 5-10 minutes to a uniform state; and (4) combining the compositions obtained in the steps (2) and (3), and continually mixing for 10-15 minutes to uniform state to obtain the compound propolis composition. The preparation method has the beneficial effects of reasonable formula and easiness for preparing; the compound propolis composition has the advantages of no toxic or side effect, environmental friendliness, no medicament residue, no medicament tolerance, ultrafine smashing, high bioavailability and very remarkable effect; and as proved by clinical application, the compound propolis composition has a special treatment effect on the duck plague.

Description

A kind of compound bee-glue composition of treating duck pestilence and preparation method thereof

Technical field

The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition of treating duck pestilence and preparation method thereof.

Background technology

Duck pestilence is a kind of acute, hot, the deteriorated blood sexually transmitted disease that is caused by duck plague virus; Mainly show as swollen head, shed tears, the bipod paralysis, arrange green loose stool, fervescence; Esophagus has pseudomembrane property gangrenous inflammation; Blood vessel injury, cloaca hyperemia, edema and necrosis, liver has petechia and the necrosis region that differs in size.The duck of the various length of times of this disease and kind all can infect, and mortality rate can influence growth and the egg laying performance of poultry up to more than 90%.This disease all can take place throughout the year, is one of principal disease of harm poultry husbandry.

The pathogen of primary disease is a duck plague virus, and virus resistance to external world is very strong.This disease almost spreads all over all countries of raising chickens of the world, distributes very extensively.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And the various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.

Therefore researching and developing a kind of drug residue free of duck pestilence, generations that have no drug resistance, the significant specific medicament of clinical effectiveness of treating is one of this field scientific research technical staff urgency new problem to be solved.

Summary of the invention

The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the compound bee-glue composition of effective treatment duck pestilence of drug residue and preparation method thereof.

For realizing above-mentioned purpose; The embodiment that the present invention adopted is following: a kind of compound bee-glue composition of treating duck pestilence, by following component by weight mixed preparing form: propolis 15-35 part, duck are with interferon 5-20 part, Ramulus Cinnamomi 10-30 part, Rhizoma Coptidis 15-30 part, Radix Codonopsis 10-40 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part.

Said various component optimum ratio amount is: 25 parts of propolis, duck are with 10 parts of interferon, 20 parts of Ramulus Cinnamomi, 20 parts of Rhizoma Coptidis, 25 parts of Radix Codonopsis, 20 parts of Radix Bupleuri, 30 parts of Folium Isatidiss, 25 parts of Radix Paeoniae Rubra.

A kind of method for preparing of treating the compound bee-glue composition of duck pestilence, carry out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-35 part, duck by weight with interferon 5-20 part, Ramulus Cinnamomi 10-30 part, Rhizoma Coptidis 15-30 part, mix 5-10 minute to even;

(3) take by weighing Radix Codonopsis 10-40 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is following:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus kill tumor cell; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Ramulus Cinnamomi: hot, sweet, warm, GUIXIN, lung, urinary bladder channel have the function of diaphoresis expelling pathogenic factors from muscles, warming the meridian for promoting the flow of YANG QI; Cure mainly wind and cold sign, arthralgia, retention of water-damp etc.

Rhizoma Coptidis: bitter, cold, return liver, the heart, spleen, stomach, gallbladder, large intestine channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.

Radix Codonopsis: sweet, flat, return spleen, lung meridian, have the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down and take off etc.

Radix Bupleuri: hot, bitter, be slightly cold, return liver, gallbladder, lung meridian, have the function of delivering with lining, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea etc.

Folium Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.

Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, have the function of clearing away heat and cooling blood, eliminating stasis to stop pain; Cure mainly maculae caused by violent heat pathogen, the hot hematochezia of intestinal, conjunctival congestion and swelling pain, too fat to move skin infection, traumatic injury etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism and the clinical symptoms and the pathological change of duck pestilence, bring into play the effect of treating both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, can also can drink water the curative effect highly significant by spice.The present invention is according to Chinese veterinarian's traditional theory; Optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment duck pestilence there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound bee-glue composition of treating duck pestilence and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 150 parts of propolis, duck by weight with 50 parts of interferon, 100 parts of Ramulus Cinnamomi, 150 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing 100 parts of Radix Codonopsis, 100 parts of Radix Bupleuri, 150 parts of Folium Isatidiss, 100 parts of Radix Paeoniae Rubra by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition of treating duck pestilence and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 250 parts of propolis, duck by weight with 120 parts of interferon, 200 parts of Ramulus Cinnamomi, 200 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing 250 parts of Radix Codonopsis, 200 parts of Radix Bupleuri, 300 parts of Folium Isatidiss, 250 parts of Radix Paeoniae Rubra by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition of treating duck pestilence and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 350 parts of propolis, duck by weight with 00 part of interferon alpha-2,300 parts of Ramulus Cinnamomi, 300 parts of Rhizoma Coptidis, mix 5-10 minute to even;

(3) take by weighing 400 parts of Radix Codonopsis, 300 parts of Radix Bupleuri, 450 parts of Folium Isatidiss, 350 parts of Radix Paeoniae Rubra by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 120kg feeds, drinking-water 200kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment duck pestilence:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	45.9	26.2	27.9
II	Duck pestilence is loose and is organized	17.8	70.3	11.9
					III	Chinese medicine composition group of the present invention	10.1	82.7	7.2

This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with duck pestilence and compared difference extremely significantly (P＜0.01) aspect the cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment duck pestilence and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. compound bee-glue composition of treating duck pestilence, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, duck are with interferon 5-20 part, Ramulus Cinnamomi 10-30 part, Rhizoma Coptidis 15-30 part, Radix Codonopsis 10-40 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part.

2. the compound bee-glue composition of treatment duck pestilence according to claim 1, it is characterized in that said various component optimum ratio amount is: 25 parts of propolis, duck are with 10 parts of interferon, 20 parts of Ramulus Cinnamomi, 20 parts of Rhizoma Coptidis, 25 parts of Radix Codonopsis, 20 parts of Radix Bupleuri, 30 parts of Folium Isatidiss, 25 parts of Radix Paeoniae Rubra.

3. the method for preparing of the compound bee-glue composition of a treatment duck pestilence according to claim 1 and 2 is characterized in that carrying out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight and get propolis 15-35 part, duck, mix 5-10 minute to evenly with interferon 5-20 part, Ramulus Cinnamomi 10-30 part, Rhizoma Coptidis 15-30 part;

(3) take by weighing Radix Codonopsis 10-40 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.