CN102325793A - 肌生成抑制素结合蛋白 - Google Patents

肌生成抑制素结合蛋白 Download PDF

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Publication number
CN102325793A
CN102325793A CN2009801573934A CN200980157393A CN102325793A CN 102325793 A CN102325793 A CN 102325793A CN 2009801573934 A CN2009801573934 A CN 2009801573934A CN 200980157393 A CN200980157393 A CN 200980157393A CN 102325793 A CN102325793 A CN 102325793A
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seq
myostatin
antigen binding
binding protein
variant
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Chinese (zh)
Inventor
C·阿什曼
A·比顿
J·H·艾利斯
B·韩
I·柯比
F·库尔
A·路易斯
K·M·林德利
M·A·奥雷基亚
Y·沈
P·威尔逊
T·S·徐
H·张
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
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CN2009801573934A 2008-12-19 2009-12-18 肌生成抑制素结合蛋白 Pending CN102325793A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13898008P 2008-12-19 2008-12-19
US61/138980 2008-12-19
PCT/EP2009/067515 WO2010070094A1 (en) 2008-12-19 2009-12-18 Myostatin binding proteins

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CN102325793A true CN102325793A (zh) 2012-01-18

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US (1) US20110256132A1 (https=)
EP (1) EP2358753A1 (https=)
JP (1) JP2012512641A (https=)
KR (1) KR20110103431A (https=)
CN (1) CN102325793A (https=)
AR (1) AR074777A1 (https=)
AU (1) AU2009329533A1 (https=)
BR (1) BRPI0922405A2 (https=)
CA (1) CA2747062A1 (https=)
CL (1) CL2011001503A1 (https=)
CO (1) CO6400149A2 (https=)
CR (1) CR20110358A (https=)
DO (1) DOP2011000189A (https=)
EA (1) EA201190018A1 (https=)
IL (1) IL213243A0 (https=)
MA (1) MA32980B1 (https=)
MX (1) MX2011006611A (https=)
NZ (1) NZ593297A (https=)
PE (1) PE20120429A1 (https=)
SG (1) SG172039A1 (https=)
TW (1) TW201029662A (https=)
UY (1) UY32341A (https=)
WO (1) WO2010070094A1 (https=)
ZA (1) ZA201104397B (https=)

Cited By (13)

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CN104768969A (zh) * 2012-09-13 2015-07-08 百时美施贵宝公司 结合至肌生成抑制素的基于纤连蛋白的支架结构域蛋白
CN109952102A (zh) * 2016-09-05 2019-06-28 代谢研究所 使用色氨酸代谢物治疗肌肉萎缩
US11053308B2 (en) 2016-08-05 2021-07-06 Chugai Seiyaku Kabushiki Kaisha Method for treating IL-8-related diseases
US11180548B2 (en) 2015-02-05 2021-11-23 Chugai Seiyaku Kabushiki Kaisha Methods of neutralizing IL-8 biological activity
TWI749057B (zh) * 2015-12-18 2021-12-11 日商中外製藥股份有限公司 抗肌抑素抗體、含變異ｆｃ區之多肽及使用方法
US11236168B2 (en) 2012-08-24 2022-02-01 Chugai Seiyaku Kabushiki Kaisha Mouse FcγammaRII-specific Fc antibody
US11248053B2 (en) 2007-09-26 2022-02-15 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US11267868B2 (en) 2013-04-02 2022-03-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
US11359194B2 (en) 2008-04-11 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding two or more antigen molecules repeatedly
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
US11454633B2 (en) 2014-12-19 2022-09-27 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of use
US11891434B2 (en) 2010-11-30 2024-02-06 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
US12473375B2 (en) 2006-03-31 2025-11-18 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies

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JO3340B1 (ar) * 2010-05-26 2019-03-13 Regeneron Pharma مضادات حيوية لـعامل تمايز النمو 8 البشري
KR102014554B1 (ko) * 2011-06-02 2019-08-26 다이액스 코포레이션 Fc 수용체 결합 단백질
AU2012339722B2 (en) 2011-11-14 2017-09-14 Regeneron Pharmaceuticals, Inc. Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and/or Activin A
TW202237660A (zh) 2012-08-24 2022-10-01 日商中外製藥股份有限公司 FcγRIIb特異性Fc區域變異體
HRP20251426T1 (hr) 2013-05-06 2026-01-02 Scholar Rock, Inc. Sastavi i postupci za modulaciju faktora rasta
TW201920262A (zh) 2013-07-30 2019-06-01 美商再生元醫藥公司 抗活化素ａ之抗體及其用途
HK1243940A1 (zh) * 2014-11-06 2018-07-27 Scholar Rock, Inc. 抗原肌肉生长抑制素/潜在肌肉生长抑制素的抗体及其用途
WO2016168613A1 (en) * 2015-04-15 2016-10-20 Regeneron Pharmaceuticals, Inc. Methods of increasing strength and functionality with gdf8 inhibitors
LT3350220T (lt) 2015-09-15 2021-09-27 Scholar Rock, Inc. Anti pro/latentinio miostatino antikūnai ir jų panaudojimas
CN115814077A (zh) 2016-01-08 2023-03-21 供石公司 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法
AU2017283546C1 (en) 2016-06-13 2020-11-19 Scholar Rock, Inc. Use of myostatin inhibitors and combination therapies
KR102306744B1 (ko) * 2016-06-17 2021-09-28 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체 및 사용 방법
ES2944357T3 (es) 2017-01-06 2023-06-20 Scholar Rock Inc Tratamiento de enfermedades metabólicas inhibiendo la activación de miostatina
WO2018129395A1 (en) * 2017-01-06 2018-07-12 Scholar Rock, Inc. Methods for treating metabolic diseases by inhibiting myostatin activation
CN111787981B (zh) 2018-03-01 2025-12-30 瑞泽恩制药公司 增加肌肉量和减少脂肪量的方法
DK3773713T3 (da) 2018-04-06 2025-08-18 Regeneron Pharma Leptinreceptoragonistantistof til anvendelse i forøgelse af knoglemasse hos et individ, der lider af metabolisk dysfunktion eller hypoleptinæmI
KR20210104744A (ko) 2018-12-18 2021-08-25 리제너론 파마슈티칼스 인코포레이티드 렙틴 수용체, gdf8 및 액티빈 a에 대한 길항제를 사용하여 체중 및 제지방 근육량을 향상시키기 위한 조성물 및 방법
TWI836364B (zh) * 2021-04-28 2024-03-21 沛爾生技醫藥股份有限公司 慢病毒包裝系統以及使用其以提高宿主細胞之慢病毒產量的方法
TWI758171B (zh) 2021-04-28 2022-03-11 沛爾生技醫藥股份有限公司 慢病毒包裝系統及使用其以提高宿主細胞之慢病毒產量的方法
WO2023069605A1 (en) * 2021-10-20 2023-04-27 Arizona Board Of Regents On Behalf Of Arizona State University Systems, methods, and apparatuses for implementing a cloud-based health, nutritional, and body composition analysis platform
CN120187750A (zh) 2022-09-21 2025-06-20 瑞泽恩制药公司 治疗肥胖、糖尿病和肝功能障碍的方法
IL321628A (en) 2022-12-22 2025-08-01 Scholar Rock Inc Selective and potent inhibitory antibodies for myostatin activation

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