CN102319218B - 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法 - Google Patents

一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法 Download PDF

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CN102319218B
CN102319218B CN201110284698.0A CN201110284698A CN102319218B CN 102319218 B CN102319218 B CN 102319218B CN 201110284698 A CN201110284698 A CN 201110284698A CN 102319218 B CN102319218 B CN 102319218B
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sustained
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adjuvant
preparation
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CN102319218A (zh
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赵建成
石宗丰
刘岐
慕晓军
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BEWOT MEDICAL TECHNOLOGY (SHANGHAI) Co Ltd
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BEWOT MEDICAL TECHNOLOGY (SHANGHAI) Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
CN201110284698.0A 2011-09-22 2011-09-22 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法 Active CN102319218B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201110284698.0A CN102319218B (zh) 2011-09-22 2011-09-22 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法
PCT/CN2012/071756 WO2013040873A1 (fr) 2011-09-22 2012-02-29 Formulation de microgranules à libération prolongée et contrôlée pour le traitement d'un trouble intestinal et procédé de préparation associé

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Application Number Priority Date Filing Date Title
CN201110284698.0A CN102319218B (zh) 2011-09-22 2011-09-22 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法

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CN102319218A CN102319218A (zh) 2012-01-18
CN102319218B true CN102319218B (zh) 2014-10-01

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WO (1) WO2013040873A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102319218B (zh) * 2011-09-22 2014-10-01 贝沃特医药技术(上海)有限公司 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法
EP3187171B1 (fr) 2012-04-30 2024-09-25 Tillotts Pharma AG Formulation de médicament à libération retardée
JP6273356B2 (ja) * 2013-10-29 2018-01-31 ティロッツ・ファルマ・アクチエンゲゼルシャフトＴｉｌｌｏｔｔｓ Ｐｈａｒｍａ Ａｇ 遅延放出性薬物製剤
RU2016135933A (ru) 2014-02-07 2018-03-15 Тон Вха Фарм. Ко., Лтд. Композиция для противоракового вспомогательного лекарственного средства, содержащая средство, индуцирующее экспрессию rip3, в качестве активного ингредиента, способ скрининга противоракового вспомогательного лекарственного средства, повышающего чувствительность к противораковому лекарственному средству путем стимуляции экспрессии rip3, и способ контроля чувствительности к противораковому лекарственному средству
WO2015193788A1 (fr) * 2014-06-16 2015-12-23 Valpharma International S.P.A. Formulation pour administration par voie orale contenant de la mésalazine
CN104257669A (zh) * 2014-09-25 2015-01-07 合肥平光制药有限公司 一种用于向肠道递送水杨酸类药物的口服给药组合物
CN104546907B (zh) * 2014-12-24 2017-10-10 浙江万方生物科技有限公司 一种肠溶纳米氧化锌制剂及其制备方法
CN104922090B (zh) * 2015-07-03 2017-11-14 湖南方盛制药股份有限公司 美沙拉秦肠溶缓释微丸
CN105456223B (zh) * 2015-12-16 2019-01-11 西南药业股份有限公司 美沙拉秦缓释微丸及其制备方法和美沙拉秦缓释胶囊
CN105687158B (zh) * 2016-01-21 2019-06-07 贝沃特医药技术(上海)有限公司 一种时间依赖释放机制的美沙拉嗪微粒制剂及其制备方法
CN105616386B (zh) * 2016-01-21 2018-11-09 贝沃特医药技术(上海)有限公司 一种治疗肠病的延缓和延长释放的微丸制剂及其制备方法
CN105902500B (zh) * 2016-04-27 2019-11-29 上海理工大学 一种美沙拉嗪肠溶定位控释制剂及其制备方法
CN108201140A (zh) * 2018-01-31 2018-06-26 无限极（中国）有限公司 一种核桃肽结肠定位微丸及其制备方法
CN110856692B (zh) * 2018-08-22 2024-08-09 深圳善康医药科技股份有限公司 植入剂自动包膜装置及包膜工艺
CN112315929B (zh) * 2019-07-20 2022-10-28 辽宁华瑞联合制药有限公司 一种四层包衣系统美沙拉嗪肠溶片的组合物及其制备方法
CN112891321B (zh) * 2019-12-03 2024-07-09 广东东阳光药业股份有限公司 一种高载药量的美沙拉秦缓释制剂及其制备方法
CN111166729A (zh) * 2020-03-19 2020-05-19 珠海赛隆药业股份有限公司 一种口服的替加环素肠溶微球及其制备方法
CN114073720B (zh) * 2020-08-10 2023-03-21 大理大学 一种治疗湿热型溃疡性结肠炎的复方中药及其制备方法和应用
CN112545997A (zh) * 2020-12-25 2021-03-26 正大制药（青岛）有限公司 一种氟骨化醇制剂及其制备方法
CN115707455A (zh) * 2021-08-18 2023-02-21 越洋医药开发(广州)有限公司 允许睡眠调节类药物分段释放的片剂及其制备方法
CN115245501B (zh) * 2021-08-26 2024-08-30 海南合瑞制药股份有限公司 一种脉冲式释放的美沙拉秦肠溶缓释微丸及其制备方法
CN113621182A (zh) * 2021-09-07 2021-11-09 山东友成生物科技有限公司 一种乳酸纤维素酞酸酯缓释材料的制备工艺和设备
CN115192547B (zh) * 2022-07-20 2023-06-27 浙江维康药业股份有限公司 一种用于滴丸的耐高温肠溶缓释型包衣及银黄滴丸
CN115501207A (zh) * 2022-07-29 2022-12-23 上海安必生制药技术有限公司 左乙拉西坦缓释制剂及其制备方法
CN115998705A (zh) * 2022-08-26 2023-04-25 苏州弘森药业股份有限公司 一种非布司他纳米包合物的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1112417A (zh) * 1994-03-23 1995-11-29 弗·哈夫曼-拉罗切有限公司 药物组合物
CN1233170A (zh) * 1996-10-11 1999-10-27 普罗克特和甘保尔公司 具有多重肠溶聚合物包衣的供结肠释放的药物剂型
CN101530387A (zh) * 2009-04-03 2009-09-16 澳门大学 口服迟释药物制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023199A1 (fr) * 1995-12-21 1997-07-03 Farmaceutisk Laboratorium Ferring A/S Composition pharmaceutique orale a liberation modifiee contenant 5-asa et procede de traitement de maladies intestinales
CN101496794B (zh) * 2008-02-02 2013-12-11 清远华能制药有限公司 肠溶性长效涂覆芯与药物剂型及其制造方法
US8865688B2 (en) * 2008-10-03 2014-10-21 Dr. Falk Pharma Gmbh Compositions and methods for treatment of bowel diseases with granulated mesalamine
CA2746767A1 (fr) * 2008-12-17 2010-07-08 Altheus Therapeutics, Inc. Formules orales
CN101780055A (zh) * 2010-02-02 2010-07-21 浙江大学 一种控释型结肠靶向给药制剂及制备方法
CN102319218B (zh) * 2011-09-22 2014-10-01 贝沃特医药技术(上海)有限公司 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1112417A (zh) * 1994-03-23 1995-11-29 弗·哈夫曼-拉罗切有限公司 药物组合物
CN1233170A (zh) * 1996-10-11 1999-10-27 普罗克特和甘保尔公司 具有多重肠溶聚合物包衣的供结肠释放的药物剂型
CN101530387A (zh) * 2009-04-03 2009-09-16 澳门大学 口服迟释药物制剂

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WO2013040873A1 (fr) 2013-03-28

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Inventor after: Zhao Jiancheng

Inventor after: Shi Zongfeng

Inventor after: Liu Qi

Inventor after: Mu Xiaojun

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Inventor before: Mu Xiaojun

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Free format text: CORRECT: INVENTOR; FROM: ZHAO JIANCHENG SHI ZONGFENG MU XIAOJUN TO: ZHAO JIANCHENG SHI ZONGFENG LIUQI MU XIAOJUN

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