CN102316872B - 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 - Google Patents

治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 Download PDF

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Publication number
CN102316872B
CN102316872B CN200980155848.9A CN200980155848A CN102316872B CN 102316872 B CN102316872 B CN 102316872B CN 200980155848 A CN200980155848 A CN 200980155848A CN 102316872 B CN102316872 B CN 102316872B
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certain embodiments
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CN102316872A (zh
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A·A·杨
B·格杜林
霍华德·E·格林
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Satiogen Pharmaceuticals Inc
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Diabetes (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CN200980155848.9A 2008-11-26 2009-11-23 治疗肥胖症和糖尿病的胆汁酸再循环抑制剂 Expired - Fee Related CN102316872B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US11835608P 2008-11-26 2008-11-26
US61/118356 2008-11-26
US23965709P 2009-09-03 2009-09-03
US23966309P 2009-09-03 2009-09-03
US23963609P 2009-09-03 2009-09-03
US61/239663 2009-09-03
US61/239657 2009-09-03
US61/239636 2009-09-03
US25520509P 2009-10-27 2009-10-27
US61/255205 2009-10-27
PCT/US2009/065577 WO2010062861A2 (en) 2008-11-26 2009-11-23 Bile acid recycling inhibitors for treatment of obesity and diabetes

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CN102316872A CN102316872A (zh) 2012-01-11
CN102316872B true CN102316872B (zh) 2016-12-21

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US (3) US9339480B2 (https=)
EP (1) EP2367554A4 (https=)
JP (3) JP2012509891A (https=)
CN (1) CN102316872B (https=)
CA (1) CA2744817C (https=)
GB (1) GB2465879B (https=)
WO (1) WO2010062861A2 (https=)

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CA2744817C (en) 2008-11-26 2020-07-07 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of obesity and diabetes
RS56054B1 (sr) 2009-01-12 2017-09-29 Biokier Inc Smeša i metod za lečenje dijabetesa
US9006288B2 (en) 2009-01-12 2015-04-14 Biokier, Inc. Composition and method for treatment of diabetes
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
CN102711800A (zh) 2009-09-23 2012-10-03 拜奥基尔公司 治疗糖尿病的组合物和方法
CN102781922A (zh) * 2009-12-11 2012-11-14 埃克塞利希斯股份有限公司 Tgr5激动剂
US20130273154A1 (en) * 2011-03-02 2013-10-17 Joseph M. Fayad Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes
JO3131B1 (ar) * 2010-04-27 2017-09-20 Glaxosmithkline Llc مركبات كيميائية
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
PL3400944T3 (pl) 2010-11-04 2020-11-16 Albireo Ab Inhibitory ibat w leczeniu chorób wątroby
JP6097695B2 (ja) 2010-11-08 2017-03-15 アルビレオ アクチエボラグ Ｉｂａｔ阻害剤および胆汁酸結合剤を含む薬学的組み合わせ
MX2013005110A (es) * 2010-11-08 2013-08-21 Albireo Ab Inhibidores del ibat para el tratamiento de padecimientos metabolicos y condiciones relacionadas.
KR20190060879A (ko) 2011-03-02 2019-06-03 제롬 쉔타그 단독으로 또는 c형 간염 바이러스 감염과 결합되는 간 지방증의 치료를 위한 조성물, 방법 및 진단
CA2842707A1 (en) * 2011-08-04 2013-02-07 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of pancreatitis
CA2852957C (en) 2011-10-28 2020-08-04 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
CN104023727B (zh) * 2011-10-28 2017-04-05 鲁美纳医药公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
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