CN102227216A - 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 - Google Patents
包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 Download PDFInfo
- Publication number
- CN102227216A CN102227216A CN2009801474835A CN200980147483A CN102227216A CN 102227216 A CN102227216 A CN 102227216A CN 2009801474835 A CN2009801474835 A CN 2009801474835A CN 200980147483 A CN200980147483 A CN 200980147483A CN 102227216 A CN102227216 A CN 102227216A
- Authority
- CN
- China
- Prior art keywords
- dosage form
- pharmaceutical dosage
- antagonist
- angiotensin
- diuretic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 title claims abstract description 119
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 title claims abstract description 108
- 229960001597 nifedipine Drugs 0.000 title claims abstract description 107
- 229940123413 Angiotensin II antagonist Drugs 0.000 title claims abstract description 85
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title claims abstract description 85
- 230000001882 diuretic effect Effects 0.000 title claims abstract description 83
- 239000002934 diuretic Substances 0.000 title claims abstract description 82
- VKQFCGNPDRICFG-UHFFFAOYSA-N methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1C1=CC=CC=C1[N+]([O-])=O VKQFCGNPDRICFG-UHFFFAOYSA-N 0.000 title claims abstract description 73
- 229960000227 nisoldipine Drugs 0.000 title claims abstract description 73
- 238000000576 coating method Methods 0.000 claims description 130
- 239000011248 coating agent Substances 0.000 claims description 129
- 238000000034 method Methods 0.000 claims description 63
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims description 61
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 claims description 47
- 239000000203 mixture Substances 0.000 claims description 40
- 238000002360 preparation method Methods 0.000 claims description 39
- 229920001223 polyethylene glycol Polymers 0.000 claims description 35
- 239000005537 C09CA07 - Telmisartan Substances 0.000 claims description 32
- 239000002202 Polyethylene glycol Substances 0.000 claims description 29
- 229960005187 telmisartan Drugs 0.000 claims description 29
- 229960004349 candesartan cilexetil Drugs 0.000 claims description 28
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims description 27
- 229920000642 polymer Polymers 0.000 claims description 25
- 239000000725 suspension Substances 0.000 claims description 24
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 23
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 23
- 230000008595 infiltration Effects 0.000 claims description 20
- 238000001764 infiltration Methods 0.000 claims description 20
- 239000002053 C09CA06 - Candesartan Substances 0.000 claims description 18
- 229960000932 candesartan Drugs 0.000 claims description 18
- 229960002003 hydrochlorothiazide Drugs 0.000 claims description 18
- 230000004048 modification Effects 0.000 claims description 17
- 238000012986 modification Methods 0.000 claims description 17
- -1 hydroxymethyl-propyl Chemical group 0.000 claims description 16
- 239000000651 prodrug Substances 0.000 claims description 15
- 229940002612 prodrug Drugs 0.000 claims description 15
- 229920002301 cellulose acetate Polymers 0.000 claims description 14
- 229960001523 chlortalidone Drugs 0.000 claims description 14
- JIVPVXMEBJLZRO-UHFFFAOYSA-N chlorthalidone Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-UHFFFAOYSA-N 0.000 claims description 14
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 13
- 239000005480 Olmesartan Substances 0.000 claims description 12
- 229960005117 olmesartan Drugs 0.000 claims description 12
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 claims description 12
- 239000002083 C09CA01 - Losartan Substances 0.000 claims description 11
- 230000007062 hydrolysis Effects 0.000 claims description 11
- 238000006460 hydrolysis reaction Methods 0.000 claims description 11
- 239000002080 C09CA02 - Eprosartan Substances 0.000 claims description 8
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims description 8
- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims description 8
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 8
- 229960004563 eprosartan Drugs 0.000 claims description 8
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims description 8
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 8
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 8
- 238000009434 installation Methods 0.000 claims description 8
- 229960002198 irbesartan Drugs 0.000 claims description 8
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims description 8
- 229960004773 losartan Drugs 0.000 claims description 8
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 claims description 8
- 229920002689 polyvinyl acetate Polymers 0.000 claims description 8
- 239000011118 polyvinyl acetate Substances 0.000 claims description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 229960004699 valsartan Drugs 0.000 claims description 7
- SMNOERSLNYGGOU-UHFFFAOYSA-N Mefruside Chemical compound C=1C=C(Cl)C(S(N)(=O)=O)=CC=1S(=O)(=O)N(C)CC1(C)CCCO1 SMNOERSLNYGGOU-UHFFFAOYSA-N 0.000 claims description 6
- UJEWTUDSLQGTOA-UHFFFAOYSA-N Piretanide Chemical compound C=1C=CC=CC=1OC=1C(S(=O)(=O)N)=CC(C(O)=O)=CC=1N1CCCC1 UJEWTUDSLQGTOA-UHFFFAOYSA-N 0.000 claims description 6
- NDDAHWYSQHTHNT-UHFFFAOYSA-N indapamide Chemical compound CC1CC2=CC=CC=C2N1NC(=O)C1=CC=C(Cl)C(S(N)(=O)=O)=C1 NDDAHWYSQHTHNT-UHFFFAOYSA-N 0.000 claims description 6
- 229960004569 indapamide Drugs 0.000 claims description 6
- 229960004678 mefruside Drugs 0.000 claims description 6
- 229960001085 piretanide Drugs 0.000 claims description 6
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 229960003883 furosemide Drugs 0.000 claims description 5
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims description 4
- 229950006127 embusartan Drugs 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- LYVGOAYMIAQLHI-UHFFFAOYSA-N methyl 2-butyl-1-[[2-fluoro-4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-6-oxopyridine-4-carboxylate Chemical compound CCCCC1=CC(C(=O)OC)=CC(=O)N1CC1=CC=C(C=2C(=CC=CC=2)C2=NNN=N2)C=C1F LYVGOAYMIAQLHI-UHFFFAOYSA-N 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229960002256 spironolactone Drugs 0.000 claims description 4
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- 239000002051 C09CA08 - Olmesartan medoxomil Substances 0.000 claims description 3
- UQGKUQLKSCSZGY-UHFFFAOYSA-N Olmesartan medoxomil Chemical compound C=1C=C(C=2C(=CC=CC=2)C2=NNN=N2)C=CC=1CN1C(CCC)=NC(C(C)(C)O)=C1C(=O)OCC=1OC(=O)OC=1C UQGKUQLKSCSZGY-UHFFFAOYSA-N 0.000 claims description 3
- NGBFQHCMQULJNZ-UHFFFAOYSA-N Torsemide Chemical compound CC(C)NC(=O)NS(=O)(=O)C1=CN=CC=C1NC1=CC=CC(C)=C1 NGBFQHCMQULJNZ-UHFFFAOYSA-N 0.000 claims description 3
- FNYLWPVRPXGIIP-UHFFFAOYSA-N Triamterene Chemical compound NC1=NC2=NC(N)=NC(N)=C2N=C1C1=CC=CC=C1 FNYLWPVRPXGIIP-UHFFFAOYSA-N 0.000 claims description 3
- 229960000571 acetazolamide Drugs 0.000 claims description 3
- BZKPWHYZMXOIDC-UHFFFAOYSA-N acetazolamide Chemical compound CC(=O)NC1=NN=C(S(N)(=O)=O)S1 BZKPWHYZMXOIDC-UHFFFAOYSA-N 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 229960002576 amiloride Drugs 0.000 claims description 3
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims description 3
- 229960004064 bumetanide Drugs 0.000 claims description 3
- MAEIEVLCKWDQJH-UHFFFAOYSA-N bumetanide Chemical compound CCCCNC1=CC(C(O)=O)=CC(S(N)(=O)=O)=C1OC1=CC=CC=C1 MAEIEVLCKWDQJH-UHFFFAOYSA-N 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000011247 coating layer Substances 0.000 claims description 3
- 229960001208 eplerenone Drugs 0.000 claims description 3
- JUKPWJGBANNWMW-VWBFHTRKSA-N eplerenone Chemical compound C([C@@H]1[C@]2(C)C[C@H]3O[C@]33[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)C(=O)OC)C[C@@]21CCC(=O)O1 JUKPWJGBANNWMW-VWBFHTRKSA-N 0.000 claims description 3
- AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 claims description 3
- 229960003199 etacrynic acid Drugs 0.000 claims description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- AQCHWTWZEMGIFD-UHFFFAOYSA-N metolazone Chemical compound CC1NC2=CC(Cl)=C(S(N)(=O)=O)C=C2C(=O)N1C1=CC=CC=C1C AQCHWTWZEMGIFD-UHFFFAOYSA-N 0.000 claims description 3
- 229960002817 metolazone Drugs 0.000 claims description 3
- 229960001199 olmesartan medoxomil Drugs 0.000 claims description 3
- 229960000206 potassium canrenoate Drugs 0.000 claims description 3
- JTZQCHFUGHIPDF-RYVBEKKQSA-M potassium canrenoate Chemical compound [K+].O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)CCC([O-])=O)[C@@H]4[C@@H]3C=CC2=C1 JTZQCHFUGHIPDF-RYVBEKKQSA-M 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 229920001059 synthetic polymer Polymers 0.000 claims description 3
- 229960005461 torasemide Drugs 0.000 claims description 3
- 229960001288 triamterene Drugs 0.000 claims description 3
- MTZBBNMLMNBNJL-UHFFFAOYSA-N xipamide Chemical compound CC1=CC=CC(C)=C1NC(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1O MTZBBNMLMNBNJL-UHFFFAOYSA-N 0.000 claims description 3
- 229960000537 xipamide Drugs 0.000 claims description 3
- 102000005862 Angiotensin II Human genes 0.000 claims description 2
- 101800000733 Angiotensin-2 Proteins 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 229950006323 angiotensin ii Drugs 0.000 claims description 2
- 229940099387 daranide Drugs 0.000 claims description 2
- GJQPMPFPNINLKP-UHFFFAOYSA-N diclofenamide Chemical compound NS(=O)(=O)C1=CC(Cl)=C(Cl)C(S(N)(=O)=O)=C1 GJQPMPFPNINLKP-UHFFFAOYSA-N 0.000 claims description 2
- FLOSMHQXBMRNHR-DAXSKMNVSA-N methazolamide Chemical compound CC(=O)\N=C1/SC(S(N)(=O)=O)=NN1C FLOSMHQXBMRNHR-DAXSKMNVSA-N 0.000 claims description 2
- 229960004083 methazolamide Drugs 0.000 claims description 2
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 17
- 239000003814 drug Substances 0.000 abstract description 16
- 239000004480 active ingredient Substances 0.000 abstract description 14
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 239000000306 component Substances 0.000 description 120
- 229940097420 Diuretic Drugs 0.000 description 70
- 239000003826 tablet Substances 0.000 description 70
- 230000035699 permeability Effects 0.000 description 47
- 239000010410 layer Substances 0.000 description 38
- 239000007921 spray Substances 0.000 description 32
- 239000011257 shell material Substances 0.000 description 29
- 238000012360 testing method Methods 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 17
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 16
- 239000004141 Sodium laurylsulphate Substances 0.000 description 16
- 230000008569 process Effects 0.000 description 16
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 16
- 230000008859 change Effects 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 12
- 206010020772 Hypertension Diseases 0.000 description 11
- 239000007787 solid Substances 0.000 description 11
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- 239000000654 additive Substances 0.000 description 10
- 230000000996 additive effect Effects 0.000 description 10
- 230000009863 secondary prevention Effects 0.000 description 10
- 238000005299 abrasion Methods 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 9
- 235000019359 magnesium stearate Nutrition 0.000 description 9
- 239000008363 phosphate buffer Substances 0.000 description 9
- 238000005507 spraying Methods 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000013078 crystal Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 8
- 229960005191 ferric oxide Drugs 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- 229940127291 Calcium channel antagonist Drugs 0.000 description 7
- 208000024172 Cardiovascular disease Diseases 0.000 description 7
- 230000036772 blood pressure Effects 0.000 description 7
- 230000003203 everyday effect Effects 0.000 description 7
- 239000008187 granular material Substances 0.000 description 7
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 239000007916 tablet composition Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000000480 calcium channel blocker Substances 0.000 description 6
- 238000007908 dry granulation Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000002265 prevention Effects 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 239000000454 talc Substances 0.000 description 6
- 235000012222 talc Nutrition 0.000 description 6
- 229910052623 talc Inorganic materials 0.000 description 6
- ACWBQPMHZXGDFX-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=NN1 ACWBQPMHZXGDFX-QFIPXVFZSA-N 0.000 description 6
- 239000008351 acetate buffer Substances 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000007888 film coating Substances 0.000 description 5
- 238000009501 film coating Methods 0.000 description 5
- 238000004128 high performance liquid chromatography Methods 0.000 description 5
- 230000001631 hypertensive effect Effects 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 230000003204 osmotic effect Effects 0.000 description 5
- 239000000049 pigment Substances 0.000 description 5
- 210000002381 plasma Anatomy 0.000 description 5
- 238000004886 process control Methods 0.000 description 5
- 230000007115 recruitment Effects 0.000 description 5
- 238000009097 single-agent therapy Methods 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 description 4
- 229920001214 Polysorbate 60 Polymers 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 4
- 229920000053 polysorbate 80 Polymers 0.000 description 4
- 239000000080 wetting agent Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 229920003083 Kollidon® VA64 Polymers 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 239000008358 core component Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000000892 gravimetry Methods 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 229940124531 pharmaceutical excipient Drugs 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 210000005239 tubule Anatomy 0.000 description 3
- 238000005550 wet granulation Methods 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- 108010072661 Angiotensin Amide Proteins 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102000003846 Carbonic anhydrases Human genes 0.000 description 2
- 108090000209 Carbonic anhydrases Proteins 0.000 description 2
- 206010007558 Cardiac failure chronic Diseases 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 229940122767 Potassium sparing diuretic Drugs 0.000 description 2
- 238000001069 Raman spectroscopy Methods 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 229940121792 Thiazide diuretic Drugs 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229940083712 aldosterone antagonist Drugs 0.000 description 2
- 239000002170 aldosterone antagonist Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 210000002565 arteriole Anatomy 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 2
- 238000011866 long-term treatment Methods 0.000 description 2
- 239000002171 loop diuretic Substances 0.000 description 2
- 229960000519 losartan potassium Drugs 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229940101564 micardis Drugs 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 229940068977 polysorbate 20 Drugs 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000003286 potassium sparing diuretic agent Substances 0.000 description 2
- 229940097241 potassium-sparing diuretic Drugs 0.000 description 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940124530 sulfonamide Drugs 0.000 description 2
- 150000003456 sulfonamides Chemical class 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000003451 thiazide diuretic agent Substances 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 238000000825 ultraviolet detection Methods 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 206010001580 Albuminuria Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010003445 Ascites Diseases 0.000 description 1
- 239000005485 Azilsartan Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 208000032382 Ischaemic stroke Diseases 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000003979 Mineralocorticoid Receptors Human genes 0.000 description 1
- 108090000375 Mineralocorticoid Receptors Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1
- 229920006221 acetate fiber Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 239000003160 antidiuretic agent Substances 0.000 description 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 description 1
- 229940127088 antihypertensive drug Drugs 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229940058087 atacand Drugs 0.000 description 1
- KGSXMPPBFPAXLY-UHFFFAOYSA-N azilsartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NOC(=O)N1 KGSXMPPBFPAXLY-UHFFFAOYSA-N 0.000 description 1
- 229960002731 azilsartan Drugs 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000037058 blood plasma level Effects 0.000 description 1
- 210000000476 body water Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000012928 buffer substance Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- HTQMVQVXFRQIKW-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=NN1 HTQMVQVXFRQIKW-UHFFFAOYSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960002155 chlorothiazide Drugs 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000007950 delayed release tablet Substances 0.000 description 1
- 238000002050 diffraction method Methods 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 229940074619 diovan Drugs 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- DJSLTDBPKHORNY-XMMWENQYSA-N eprosartan methanesulfonate Chemical compound CS(O)(=O)=O.C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 DJSLTDBPKHORNY-XMMWENQYSA-N 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 229940090022 hyzaar Drugs 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 230000036581 peripheral resistance Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229940050929 polyethylene glycol 3350 Drugs 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 239000001062 red colorant Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Description
No. | 硝苯地平 | 坎地沙坦西酯 | 氢氯噻嗪 | 氯噻酮 |
1 | 20 | 4 | ||
2 | 20 | 8 | ||
3 | 20 | 16 | ||
4 | 20 | 32 | ||
5 | 20 | 12.5 | ||
6 | 20 | 25 | ||
7 | 20 | 12.5 | ||
8 | 20 | 25 | ||
9 | 20 | 50 | ||
10 | 30 | 4 | ||
11 | 30 | 8 | ||
12 | 30 | 16 | ||
13 | 30 | 32 | ||
14 | 30 | 12.5 | ||
15 | 30 | 25 | ||
16 | 30 | 12.5 | ||
17 | 30 | 25 | ||
18 | 30 | 50 | ||
19 | 60 | 4 | ||
20 | 60 | 8 | ||
21 | 60 | 16 | ||
22 | 60 | 32 | ||
23 | 60 | 12.5 | ||
24 | 60 | 25 | ||
25 | 60 | 12.5 | ||
26 | 60 | 25 | ||
27 | 60 | 50 |
No. | 硝苯地平 | 坎地沙坦西酯 | 氢氯噻嗪 | 氯噻酮 |
28 | 20 | 4 | 12.5 | |
29 | 20 | 4 | 25 | |
30 | 20 | 4 | 12.5 | |
31 | 20 | 4 | 25 | |
32 | 20 | 4 | 50 | |
33 | 20 | 8 | 12.5 | |
34 | 20 | 8 | 25 | |
35 | 20 | 8 | 12.5 | |
36 | 20 | 8 | 25 | |
37 | 20 | 8 | 50 | |
38 | 20 | 16 | 12.5 | |
39 | 20 | 16 | 25 | |
40 | 20 | 16 | 12.5 | |
41 | 20 | 16 | 25 | |
42 | 20 | 16 | 50 | |
43 | 20 | 32 | 12.5 | |
44 | 20 | 32 | 25 | |
45 | 20 | 32 | 12.5 | |
46 | 20 | 32 | 25 | |
47 | 20 | 32 | 50 | |
48 | 30 | 4 | 12.5 | |
49 | 30 | 4 | 25 | |
50 | 30 | 4 | 12.5 | |
51 | 30 | 4 | 25 | |
52 | 30 | 4 | 50 | |
53 | 30 | 8 | 12.5 | |
54 | 30 | 8 | 25 | |
55 | 30 | 8 | 12.5 | |
56 | 30 | 8 | 25 | |
57 | 30 | 8 | 50 | |
58 | 30 | 16 | 12.5 | |
59 | 30 | 16 | 25 | |
60 | 30 | 16 | 12.5 | |
61 | 30 | 16 | 25 | |
62 | 30 | 16 | 50 | |
63 | 30 | 32 | 12.5 | |
64 | 30 | 32 | 25 | |
65 | 30 | 32 | 12.5 | |
66 | 30 | 32 | 25 | |
67 | 30 | 32 | 50 | |
68 | 60 | 4 | 12.5 | |
69 | 60 | 4 | 25 | |
70 | 60 | 4 | 12.5 | |
71 | 60 | 4 | 25 | |
72 | 60 | 4 | 50 | |
73 | 60 | 8 | 12.5 | |
74 | 60 | 8 | 25 | |
75 | 60 | 8 | 12.5 | |
76 | 60 | 8 | 25 | |
77 | 60 | 8 | 50 | |
78 | 60 | 16 | 12.5 | |
79 | 60 | 16 | 25 | |
80 | 60 | 16 | 12.5 | |
81 | 60 | 16 | 25 | |
82 | 60 | 16 | 50 | |
83 | 60 | 32 | 12.5 | |
84 | 60 | 32 | 25 | |
85 | 60 | 32 | 12.5 | |
86 | 60 | 32 | 25 | |
87 | 60 | 32 | 50 |
时间 [min] | 喷雾速率 [g/min] |
0 – 40 | 6 |
40 – 50 | 7 |
50 – 70 | 8 |
70 – 80 | 9 |
80 – 90 | 10 |
90 – 100 | 11 |
100 – 130 | 12 |
130 – 140 | 13 |
140 – 150 | 14 |
150 – 160 | 15 |
160 – 210 | 16 |
时间 [min] | 重量 [mg] | 标准偏差 [mg] |
0 | 276.6 | 4.8 |
30 | 298.5 | 4.8 |
60 | 311.0 | 5.3 |
90 | 326.3 | 6.8 |
120 | 351.6 | 9.1 |
150 | 380.4 | 8.4 |
180 | 414.4 | 10.9 |
210 | 446.1 | 12.2 |
时间 [min] | 重量[mg] | 标准偏差 [mg] |
0 | 531.0 | 3.9 |
30 | 544.8 | 4.1 |
60 | 558.3 | 4.6 |
90 | 572.9 | 3.4 |
120 | 593.2 | 6.4 |
150 | 612.6 | 6.5 |
时间 [min] | 重量[mg] | 标准偏差 [mg] |
0 | 216.0 | 3.9 |
30 | 226.9 | 4.3 |
60 | 238.2 | 4.1 |
90 | 255.5 | 6.3 |
120 | 274.0 | 5.2 |
150 | 290.9 | 3.7 |
180 | 309.5 | 6.8 |
210 | 331.8 | 8.0 |
240 | 350.1 | 7.2 |
270 | 373.6 | 7.9 |
300 | 389.5 | 8.1 |
Claims (17)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610762795.9A CN106214659A (zh) | 2008-11-27 | 2009-11-19 | 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008059206A DE102008059206A1 (de) | 2008-11-27 | 2008-11-27 | Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum |
DE102008059206.4 | 2008-11-27 | ||
PCT/EP2009/008232 WO2010060564A1 (de) | 2008-11-27 | 2009-11-19 | Pharmazeutische darreichungsform enthaltend nifedipin oder nisoldipin und einen angiotensin-ii antagonisten und/oder ein diuretikum |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610762795.9A Division CN106214659A (zh) | 2008-11-27 | 2009-11-19 | 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102227216A true CN102227216A (zh) | 2011-10-26 |
Family
ID=41566078
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801474835A Pending CN102227216A (zh) | 2008-11-27 | 2009-11-19 | 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 |
CN201610762795.9A Pending CN106214659A (zh) | 2008-11-27 | 2009-11-19 | 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610762795.9A Pending CN106214659A (zh) | 2008-11-27 | 2009-11-19 | 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 |
Country Status (36)
Country | Link |
---|---|
US (1) | US9993432B2 (zh) |
EP (1) | EP2370065B1 (zh) |
JP (2) | JP2012509918A (zh) |
KR (1) | KR101418632B1 (zh) |
CN (2) | CN102227216A (zh) |
AR (1) | AR073423A1 (zh) |
AU (1) | AU2009319362B2 (zh) |
BR (1) | BRPI0922306A2 (zh) |
CA (1) | CA2744515C (zh) |
CL (1) | CL2011001091A1 (zh) |
CO (1) | CO6382107A2 (zh) |
CR (1) | CR20110260A (zh) |
CU (1) | CU24065B1 (zh) |
CY (1) | CY1118183T1 (zh) |
DE (1) | DE102008059206A1 (zh) |
DK (1) | DK2370065T3 (zh) |
DO (1) | DOP2011000137A (zh) |
EA (1) | EA025485B1 (zh) |
EC (1) | ECSP11011052A (zh) |
ES (1) | ES2585731T3 (zh) |
HR (1) | HRP20160987T1 (zh) |
HU (1) | HUE029085T2 (zh) |
IL (1) | IL212599A (zh) |
MX (1) | MX2011005023A (zh) |
MY (1) | MY160000A (zh) |
NZ (1) | NZ593045A (zh) |
PA (1) | PA8849701A1 (zh) |
PE (2) | PE20110927A1 (zh) |
PL (1) | PL2370065T3 (zh) |
PT (1) | PT2370065T (zh) |
SI (1) | SI2370065T1 (zh) |
SV (1) | SV2011003905A (zh) |
TW (1) | TWI484957B (zh) |
UA (1) | UA103347C2 (zh) |
UY (1) | UY32260A (zh) |
WO (1) | WO2010060564A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103169697A (zh) * | 2011-12-23 | 2013-06-26 | 天津泰普医药知识产权流转储备中心有限公司 | 包含坎地沙坦或其酯以及氯噻酮的药物组合物及其应用 |
CN104507459A (zh) * | 2012-05-07 | 2015-04-08 | 拜耳制药股份公司 | 包含硝苯地平和坎地沙坦酯的药物剂型的制造方法 |
CN104758289A (zh) * | 2015-03-09 | 2015-07-08 | 西安力邦制药有限公司 | 一种含美托法宗的复方降压药物组合及其应用 |
CN105658209A (zh) * | 2013-09-13 | 2016-06-08 | 拜耳制药股份公司 | 含有瑞法美替的药物组合物 |
CN107648240A (zh) * | 2017-11-08 | 2018-02-02 | 罗昌兴 | 一种抗高血压药物复方制剂 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2210595A1 (en) * | 2009-01-14 | 2010-07-28 | LEK Pharmaceuticals d.d. | Active coating of pharmaceutical dosage forms |
CN102274223B (zh) * | 2010-06-12 | 2012-10-24 | 重庆市力扬医药开发有限公司 | 含替米沙坦和氨氯地平的复方制剂 |
WO2012080833A2 (en) * | 2010-12-13 | 2012-06-21 | Purdue Pharma L.P. | Controlled release dosage forms |
DE102011007272A1 (de) | 2011-04-13 | 2012-10-18 | Bayer Pharma Aktiengesellschaft | Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung |
JP5934610B2 (ja) * | 2011-08-30 | 2016-06-15 | 第一三共ヘルスケア株式会社 | イブプロフェンを含有するフィルムコーティング製剤 |
WO2013098831A2 (en) * | 2011-09-23 | 2013-07-04 | Emcure Pharmaceuticals Limited | Controlled release formulations of nisoldipine |
JP6304675B2 (ja) * | 2012-07-18 | 2018-04-04 | 国立大学法人北陸先端科学技術大学院大学 | 炭酸脱水酵素阻害剤のスクリーニング方法 |
MX367970B (es) * | 2012-08-17 | 2019-09-11 | Hoffmann La Roche | Tratamientos de combinación para melanoma que comprenden la administración de cobimetinib y vemurafinib. |
TW201427720A (zh) * | 2012-10-12 | 2014-07-16 | Ajinomoto Kk | 含有鈣拮抗劑及血管張力素ii受體拮抗劑之醫藥製劑之製造方法 |
KR101710441B1 (ko) | 2015-12-28 | 2017-02-28 | 신풍제약주식회사 | 안정성 및 용출성이 향상된 정제 |
SI3573620T1 (sl) | 2017-01-25 | 2023-05-31 | The George Institute for Global Health | Sestavki za zdravljenje hipertenzije |
DE102017008656B4 (de) | 2017-09-15 | 2020-12-03 | Glatt Maschinen- Und Apparatebau Ag | Verfahren zur Regelung des Massen- oder Volumenstroms des Zerstäubergases einer Düse; Vorrichtung zur Regelung des Massen- oder Volumenstroms des Zerstäubergases einer Düse; Verwendung eines Verfahrens oder einer Vorrichtung zur Regelung des Massen- oder Volumenstroms des Zerstäubergases |
US10905667B2 (en) | 2018-07-24 | 2021-02-02 | Bayer Pharma Aktiengesellschaft | Orally administrable modified-release pharmaceutical dosage form |
UY38308A (es) | 2018-07-24 | 2020-02-28 | Bayer Pharma AG | Forma de dosificación farmacéutica administrable por vía oral con liberación modificada |
EP3826619A1 (de) | 2018-07-24 | 2021-06-02 | Bayer Aktiengesellschaft | Oral applizierbare pharmazeutische darreichungsform mit modifizierter freisetzung |
KR20210038931A (ko) * | 2018-07-26 | 2021-04-08 | 더 조지 인스티튜트 포 글로벌 헬스 | 고혈압 치료용 조성물 |
CN109557042B (zh) * | 2018-11-26 | 2021-10-08 | 广东朗研科技有限公司 | 基于半导体镀纳米介孔金属薄膜结构及太赫兹波增强系统 |
MX2021016044A (es) * | 2019-06-18 | 2022-04-06 | Composiciones de diclorfenamida y metodos de uso. | |
CN113135915B (zh) * | 2021-04-27 | 2022-12-09 | 湖北美林药业有限公司 | 一种氨苯蝶啶及氨苯蝶啶组合物制剂 |
CN114931559A (zh) * | 2022-06-02 | 2022-08-23 | 南京白敬宇制药有限责任公司 | 硝苯地平缓释片优化包衣工艺方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008044862A1 (en) * | 2006-10-10 | 2008-04-17 | Hanall Pharmaceutical Co., Ltd. | Combined preparation for the treatment of cardiovascular diseases based on chronotherapy theory |
CN101257946A (zh) * | 2005-07-06 | 2008-09-03 | 拜耳医药保健股份公司 | 包含硝苯地平和/或尼索地平和血管紧张素ⅱ拮抗剂的活性成分组合的药物剂型 |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670827C3 (de) | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4576604A (en) * | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
US4673405A (en) * | 1983-03-04 | 1987-06-16 | Alza Corporation | Osmotic system with instant drug availability |
US5082668A (en) | 1983-05-11 | 1992-01-21 | Alza Corporation | Controlled-release system with constant pushing source |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
NZ206600A (en) | 1983-05-11 | 1987-01-23 | Alza Corp | Osmotic drug delivery device |
DK383086A (da) | 1985-08-21 | 1987-02-22 | Rohm & Haas | (2-cyano-2-arylethyl)pyridiner, deres fremstilling og deres anvendelse som fungicider |
US4948592A (en) | 1986-05-09 | 1990-08-14 | Alza Corporation | Pulsed drug delivery |
US4842867A (en) * | 1986-05-09 | 1989-06-27 | Alza Corporation | Pulsed drug delivery of doxylamine |
DE3720757A1 (de) | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
US4931285A (en) | 1988-04-28 | 1990-06-05 | Alza Corporation | Aqueous based pharmaceutical coating composition for dosage forms |
ATE79029T1 (de) | 1989-02-11 | 1992-08-15 | Bayer Ag | Arzneimittel mit kontrollierter wirkstoffabgabe. |
US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
DK0565634T3 (da) | 1990-12-14 | 1999-09-27 | Smithkline Beecham Corp | Angiotensin-II-receptorblokkersammensætninger |
US5160744A (en) | 1991-06-27 | 1992-11-03 | Alza Corporation | Verapmil therapy |
US5178867A (en) | 1991-08-19 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug in short-time period |
US5543154A (en) | 1991-12-27 | 1996-08-06 | Merck & Co., Inc. | Controlled release nifedipine delivery device |
CA2125251C (en) | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
TW483763B (en) * | 1994-09-02 | 2002-04-21 | Astra Ab | Pharmaceutical composition comprising of ramipril and dihydropyridine compound |
JP3220373B2 (ja) | 1995-11-28 | 2001-10-22 | バイエル薬品株式会社 | 持続性ニフエジピン製剤 |
US6919373B1 (en) | 1996-11-12 | 2005-07-19 | Alza Corporation | Methods and devices for providing prolonged drug therapy |
ATE250929T1 (de) | 1997-05-30 | 2003-10-15 | Osmotica Corp | Mehrlagige osmosevorrichtung |
AU9202398A (en) * | 1997-09-29 | 1999-04-23 | Becton Dickinson & Company | Injection device and drug cartridge for preventing cross-use of the device and drug cartridge |
DE19747261A1 (de) * | 1997-10-25 | 1999-04-29 | Bayer Ag | Osmotisches Arzneimittelfreisetzungssystem |
GB9722426D0 (en) | 1997-10-23 | 1997-12-24 | Univ London Pharmacy | Controlled release formulations |
DE19812688A1 (de) * | 1998-03-23 | 1999-09-30 | Basf Ag | Verfahren zur Herstellung von festen Dosierungsformen |
DE19901921C2 (de) | 1999-01-19 | 2001-01-04 | Boehringer Ingelheim Pharma | Polymorphe von Telmisartan, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung eines Arzneimittels |
AU4221300A (en) | 1999-04-06 | 2000-10-23 | Kamal K. Midha | Pharmaceutical dosage form for pulsatile delivery of (d-threo)-methylphenidate and a second cns stimulant |
US20040115134A1 (en) | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
NZ518739A (en) * | 1999-11-02 | 2004-12-24 | Depomed Inc | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach |
DE19954421A1 (de) * | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen |
US6569456B2 (en) | 2000-01-13 | 2003-05-27 | Osmotica Corp. | Osmotic device containing diltiazem and an ACE inhibitor or diuretic |
EP1595540A1 (en) | 2000-11-21 | 2005-11-16 | Sankyo Company Limited | Composition containing an angiotensin II receptor antagonist and a diuretic and its use for the treatment of hypertension |
JP2002316928A (ja) * | 2001-04-17 | 2002-10-31 | Lion Corp | コーティング錠及びコーティング錠のはがれを防止する方法 |
EP1413315A4 (en) | 2001-08-03 | 2006-08-16 | Takeda Pharmaceutical | DRUGS WITH CONTINUOUS RELEASE |
JP2005508358A (ja) | 2001-10-25 | 2005-03-31 | デポメド・インコーポレイテッド | 胃滞留型ロサルタン投与量を用いる治療方法 |
US20030161882A1 (en) | 2002-02-01 | 2003-08-28 | Waterman Kenneth C. | Osmotic delivery system |
JP3751287B2 (ja) | 2002-03-27 | 2006-03-01 | バイエル薬品株式会社 | 小型化されたニフェジピン有核錠剤 |
WO2003080057A1 (fr) | 2002-03-27 | 2003-10-02 | Bayer Aktiengesellschaft | Comprime-noyau de taille reduite contenant de la nifedipine |
EG24716A (en) * | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
PE20040468A1 (es) | 2002-05-17 | 2004-09-14 | Novartis Ag | Combinacion de compuestos organicos |
US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
JP4694841B2 (ja) * | 2002-09-20 | 2011-06-08 | アンドルックス ラボズ リミテッド ライアビリティ カンパニー | ビグアニドおよびチアゾリジンジオン誘導体を含有する多段階製剤 |
AR043395A1 (es) | 2003-02-28 | 2005-07-27 | Recordati Ireland Ltd | Terapia de combinacion para la hipertension utilizando lercanidipina y un bloqueante de los receptores de angiotensina ii |
US8029822B2 (en) | 2003-05-22 | 2011-10-04 | Osmotica Kereskedelmi és Seolgáltató KFT | Rupturing controlled release device having a preformed passageway |
AU2003249492A1 (en) | 2003-07-24 | 2005-02-14 | Eswaran Krishnan Iyer | Oral compositions for treatment of diseases |
WO2005070398A2 (en) | 2004-01-23 | 2005-08-04 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of candesartan cilexetil stabilized with co-solvents |
WO2005079751A2 (en) | 2004-01-23 | 2005-09-01 | Ranbaxy Laboratories Limited | Oral pharmaceutical compositions of candesartan cilexetil |
WO2005084648A1 (en) | 2004-02-27 | 2005-09-15 | Ranbaxy Laboratories Limited | Pharmaceutical compositions comprising candesartan cilexetil |
TWI354569B (en) | 2004-05-28 | 2011-12-21 | Bristol Myers Squibb Co | Coated tablet formulation and method |
DE102004062475A1 (de) * | 2004-12-24 | 2006-07-06 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung |
MY146830A (en) | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
RS53690B1 (en) * | 2005-07-26 | 2015-04-30 | Ucb Pharma, S.A. | PHARMACEUTICAL COMPOSITIONS CONTAINING LEVETIRACETAM AND THE PROCESS FOR THEIR PREPARATION |
US20070128281A1 (en) * | 2005-12-02 | 2007-06-07 | Patel Hasmukh B | Oral osmotic drug delivery system |
BRPI0712532A2 (pt) * | 2006-06-01 | 2013-04-02 | Schering Plough Healthcare Prod Inc | formulaÇÕes e composiÇÕes farmacÊuticas de fenilefrina para absorÇço colânica |
WO2008035360A2 (en) | 2006-06-13 | 2008-03-27 | Alembic Limited | Novel crystalline forms of candesartan cilexetil, candesartan, tritylated candesartan and tritylated candesartan cilexetil |
WO2008045006A1 (en) | 2006-10-11 | 2008-04-17 | Fako Ilaclari A. S. | Formulations of candesartan |
WO2008065097A2 (en) | 2006-11-28 | 2008-06-05 | Laboratorios Liconsa, S.A. | Stabilized solid pharmaceutical composition of candesartan cilexetil |
US20090093542A1 (en) * | 2007-10-04 | 2009-04-09 | Cooper Garth J S | Copper antagonist compositions |
CA2703365A1 (en) | 2007-10-25 | 2009-04-30 | Yuka Yamanouchi | Nifedipine-containing press coated tablet and method of preparing the same |
EP2364143A1 (en) * | 2008-10-31 | 2011-09-14 | McNeil-PPC, Inc. | Osmotic tablet with a compressed outer coating |
UY34856A (es) * | 2012-07-03 | 2013-12-31 | Bayer Pharma AG | Formas de presentación farmacéuticas que contienen 5-cloro-n-({(5s)-2-oxo-3-[4-(3-oxo-4- morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida |
-
2008
- 2008-11-27 DE DE102008059206A patent/DE102008059206A1/de not_active Withdrawn
-
2009
- 2009-11-19 BR BRPI0922306A patent/BRPI0922306A2/pt not_active IP Right Cessation
- 2009-11-19 US US13/130,294 patent/US9993432B2/en not_active Expired - Fee Related
- 2009-11-19 AU AU2009319362A patent/AU2009319362B2/en not_active Ceased
- 2009-11-19 DK DK09755847.2T patent/DK2370065T3/en active
- 2009-11-19 ES ES09755847.2T patent/ES2585731T3/es active Active
- 2009-11-19 CN CN2009801474835A patent/CN102227216A/zh active Pending
- 2009-11-19 UA UAA201107955A patent/UA103347C2/ru unknown
- 2009-11-19 EA EA201100814A patent/EA025485B1/ru not_active IP Right Cessation
- 2009-11-19 EP EP09755847.2A patent/EP2370065B1/de active Active
- 2009-11-19 HU HUE09755847A patent/HUE029085T2/hu unknown
- 2009-11-19 KR KR1020117012023A patent/KR101418632B1/ko active IP Right Grant
- 2009-11-19 MY MYPI2011002364A patent/MY160000A/en unknown
- 2009-11-19 PL PL09755847.2T patent/PL2370065T3/pl unknown
- 2009-11-19 CN CN201610762795.9A patent/CN106214659A/zh active Pending
- 2009-11-19 PE PE2011001011A patent/PE20110927A1/es not_active Application Discontinuation
- 2009-11-19 SI SI200931491A patent/SI2370065T1/sl unknown
- 2009-11-19 CA CA2744515A patent/CA2744515C/en not_active Expired - Fee Related
- 2009-11-19 PE PE2014001645A patent/PE20142192A1/es not_active Application Discontinuation
- 2009-11-19 NZ NZ593045A patent/NZ593045A/xx not_active IP Right Cessation
- 2009-11-19 WO PCT/EP2009/008232 patent/WO2010060564A1/de active Application Filing
- 2009-11-19 JP JP2011537877A patent/JP2012509918A/ja active Pending
- 2009-11-19 PT PT97558472T patent/PT2370065T/pt unknown
- 2009-11-19 MX MX2011005023A patent/MX2011005023A/es not_active Application Discontinuation
- 2009-11-24 PA PA20098849701A patent/PA8849701A1/es unknown
- 2009-11-24 AR ARP090104528A patent/AR073423A1/es unknown
- 2009-11-24 UY UY0001032260A patent/UY32260A/es not_active Application Discontinuation
- 2009-11-26 TW TW098140257A patent/TWI484957B/zh not_active IP Right Cessation
-
2011
- 2011-05-01 IL IL212599A patent/IL212599A/en not_active IP Right Cessation
- 2011-05-12 SV SV2011003905A patent/SV2011003905A/es unknown
- 2011-05-12 CO CO11058534A patent/CO6382107A2/es not_active Application Discontinuation
- 2011-05-13 EC EC2011011052A patent/ECSP11011052A/es unknown
- 2011-05-13 DO DO2011000137A patent/DOP2011000137A/es unknown
- 2011-05-13 CL CL2011001091A patent/CL2011001091A1/es unknown
- 2011-05-16 CR CR20110260A patent/CR20110260A/es unknown
- 2011-05-16 CU CU2011000110A patent/CU24065B1/es active IP Right Grant
-
2015
- 2015-02-13 JP JP2015026777A patent/JP6017604B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-01 CY CY20161100755T patent/CY1118183T1/el unknown
- 2016-08-02 HR HRP20160987TT patent/HRP20160987T1/hr unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101257946A (zh) * | 2005-07-06 | 2008-09-03 | 拜耳医药保健股份公司 | 包含硝苯地平和/或尼索地平和血管紧张素ⅱ拮抗剂的活性成分组合的药物剂型 |
WO2008044862A1 (en) * | 2006-10-10 | 2008-04-17 | Hanall Pharmaceutical Co., Ltd. | Combined preparation for the treatment of cardiovascular diseases based on chronotherapy theory |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103169697A (zh) * | 2011-12-23 | 2013-06-26 | 天津泰普医药知识产权流转储备中心有限公司 | 包含坎地沙坦或其酯以及氯噻酮的药物组合物及其应用 |
WO2013091574A1 (zh) * | 2011-12-23 | 2013-06-27 | 天津泰普医药知识产权流转储备中心有限公司 | 包含坎地沙坦或其酯以及氯噻酮的药物组合物及其应用 |
US9216169B2 (en) | 2011-12-23 | 2015-12-22 | Tianjin Institute Of Pharmaceutical Research | Pharmaceutical composition comprising candesartan or ester thereof and chlortalidone, and use thereof |
CN104507459A (zh) * | 2012-05-07 | 2015-04-08 | 拜耳制药股份公司 | 包含硝苯地平和坎地沙坦酯的药物剂型的制造方法 |
CN105658209A (zh) * | 2013-09-13 | 2016-06-08 | 拜耳制药股份公司 | 含有瑞法美替的药物组合物 |
CN104758289A (zh) * | 2015-03-09 | 2015-07-08 | 西安力邦制药有限公司 | 一种含美托法宗的复方降压药物组合及其应用 |
CN104758289B (zh) * | 2015-03-09 | 2019-05-03 | 西安力邦制药有限公司 | 一种含美托法宗的复方降压药物组合及其应用 |
CN107648240A (zh) * | 2017-11-08 | 2018-02-02 | 罗昌兴 | 一种抗高血压药物复方制剂 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102227216A (zh) | 包含硝苯地平或尼索地平和血管紧张素ii拮抗剂和/或利尿剂的药物剂型 | |
CN101257946B (zh) | 包含硝苯地平和/或尼索地平和血管紧张素ⅱ拮抗剂的活性成分组合的药物剂型 | |
JP5285913B2 (ja) | 経口投与できる固体の放出改変型医薬投与形 | |
EP2830618B1 (en) | Pharmaceutical composition comprising olmesartan medoxomil and rosuvastatin or its salt | |
TW201436823A (zh) | 托法替尼(tofacitinib)口服持續釋放劑型 | |
KR20060123493A (ko) | 제어된 전달을 위한 약물 조성물의 용해도를 증가시키는방법 및 제형 | |
JP2005536568A (ja) | トピラメートの調節分配用の調剤および投薬形態 | |
CA2649243A1 (en) | An osmotic drug delivery system | |
JP2009513543A (ja) | クロルタリドンの組み合わせ | |
TR201802207T4 (tr) | Kontrollü Salımlı Farmasötik Bileşim. | |
JPH01313427A (ja) | ジヒドロピリジン類を含有する徐放性製剤 | |
JP2007503389A (ja) | 長期間にわたるトピラメートの段階的送達 | |
BRPI0808801A2 (pt) | Formulação farmacêutica. | |
TW201617075A (zh) | 包含氨氯地平(amlodipine)及洛沙坦(losartan)之固體藥學組成物 | |
EP2438911A1 (en) | Pharmaceuticals compositions comprising sulphonylurea-class insulin secretagogue and polyethylene glycol castor oil | |
US20100008956A1 (en) | Composition and combinations of carboxylic acid losartan in dosage forms | |
AU2013203217B2 (en) | Pharmaceutical dosage form comprising nifedipine or nisoldipine and an angiotensin-II antagonist and/or a diuretic | |
CN107929253A (zh) | 一种单硝酸异山梨酯渗透泵控释片及其制备方法 | |
KR20090107960A (ko) | 심혈관계 질환 치료용 약제학적 제제 | |
WO2008068727A2 (en) | Pharmaceutical composition comprising candesartan cilexetil | |
KR20050016377A (ko) | 옥시코돈의 전달을 조절하기 위한 방법 및 복용형 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1160767 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH Free format text: FORMER OWNER: BAYER PHARMACEUTICALS AG Effective date: 20130322 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Berlin Applicant after: BAYER PHARMA AG Address before: Berlin Applicant before: Bayer Schering Pharma AG |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: BAYER SCHERING PHARMA AG TO: BAYER PHARMACEUTICALS AG |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20130322 Address after: German Monheim Applicant after: BAYER INTELLECTUAL PROPERTY GmbH Address before: Berlin Applicant before: BAYER PHARMA AG |
|
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20111026 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1160767 Country of ref document: HK |