CN102215840B - 降低毒性和治疗或预防疾病的化合物、组合物和方法 - Google Patents
降低毒性和治疗或预防疾病的化合物、组合物和方法 Download PDFInfo
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- CN102215840B CN102215840B CN200980143766.2A CN200980143766A CN102215840B CN 102215840 B CN102215840 B CN 102215840B CN 200980143766 A CN200980143766 A CN 200980143766A CN 102215840 B CN102215840 B CN 102215840B
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- 0 *[C@@]([C@@](*)N)*=C Chemical compound *[C@@]([C@@](*)N)*=C 0.000 description 10
- OVFDIXHCQXBDII-RTBURBONSA-N CCCCCCC[C@H]1OC(C)(C)O[C@@H]1CC#CC#CC(C=C)=O Chemical compound CCCCCCC[C@H]1OC(C)(C)O[C@@H]1CC#CC#CC(C=C)=O OVFDIXHCQXBDII-RTBURBONSA-N 0.000 description 2
- UUCPBMMYJZTIBO-ZIAGYGMSSA-N CCCCCCC[C@H]1OC(C)(C)O[C@@H]1CC#C Chemical compound CCCCCCC[C@H]1OC(C)(C)O[C@@H]1CC#C UUCPBMMYJZTIBO-ZIAGYGMSSA-N 0.000 description 1
- JVJTWOPEMAGFNK-GUDVDZBRSA-N CCCCCCC[C@H]1OC(C)(C)O[C@@H]1CC#CC#C[C@@H](C=C)O Chemical compound CCCCCCC[C@H]1OC(C)(C)O[C@@H]1CC#CC#C[C@@H](C=C)O JVJTWOPEMAGFNK-GUDVDZBRSA-N 0.000 description 1
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| PCT/US2008/074444 WO2009105123A1 (en) | 2008-02-22 | 2008-08-27 | Compounds, compositions and methods for treating or preventing diseases |
| US12226808P | 2008-12-12 | 2008-12-12 | |
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| US22808309P | 2009-07-23 | 2009-07-23 | |
| US61/228,083 | 2009-07-23 | ||
| PCT/US2009/055221 WO2010025272A1 (en) | 2008-08-27 | 2009-08-27 | Compounds, compositions and methods for reducing toxicity and treating or preventing diseases |
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| CN102215840A CN102215840A (zh) | 2011-10-12 |
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| KR (1) | KR101496508B1 (https=) |
| CN (1) | CN102215840B (https=) |
| WO (1) | WO2010025272A1 (https=) |
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| CN102146369A (zh) * | 2010-12-24 | 2011-08-10 | 吉林大学 | 一种基于配位作用的固相介质提取dna的方法 |
| CN102743795A (zh) * | 2012-05-11 | 2012-10-24 | 天津大学 | 虎杖甙填充胶原支架及其制备方法和应用 |
| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| WO2014113635A1 (en) * | 2013-01-18 | 2014-07-24 | Sloan-Kettering Institute For Cancer Research | Reduction of toxicities by synthetic panaxytriol analogs |
| US9868730B2 (en) | 2013-02-18 | 2018-01-16 | The Trustees Of Columbia University In The City Of New York | Kappa opioid receptor selective compounds, compositions, and uses thereof |
| US10201623B2 (en) | 2013-03-15 | 2019-02-12 | Memorial Sloan Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| CA2961894C (en) | 2014-09-19 | 2023-12-12 | Memorial Sloan-Kettering Cancer Center | Methods for treating brain metastatis using gap junction inhibitors |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| CN106831366A (zh) * | 2017-01-20 | 2017-06-13 | 山西大学 | 一种共轭二炔一醇类化合物及其制备方法和应用 |
| CN106748827B (zh) * | 2017-01-20 | 2019-04-02 | 山西大学 | 一种8-胺基-4,6-二炔-1-醇类化合物及其制备方法和应用 |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| CN109704926B (zh) * | 2019-01-29 | 2022-02-08 | 南京工业大学 | 抗癌活性分子骨架1,4-烯炔类化合物及其制备方法与应用 |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| CN111467347A (zh) * | 2020-04-30 | 2020-07-31 | 河北医科大学第二医院 | 苯并菲啶生物碱类化合物用于制备ano1 编码的钙激活氯离子通道阻断剂的用途 |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| CN113372355B (zh) * | 2021-05-13 | 2023-02-17 | 山东大学 | 六氢苯并菲啶类生物碱及其制备方法和应用 |
| WO2023143988A1 (en) * | 2022-01-26 | 2023-08-03 | Eth Zurich | New compounds and their use as anti-aging agent or as exercise enhancer |
| CN120987853B (zh) * | 2025-07-22 | 2026-04-17 | 中国科学技术大学 | 一种NQO1响应性的mRNA翻译掩蔽剂及其应用、产品和方法 |
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| CN1571673A (zh) * | 2001-09-21 | 2005-01-26 | 博新药业股份有限公司 | 原人参萜二醇和原人参萜三醇及其作为协同抗癌剂的应用 |
| WO2007059250A2 (en) * | 2005-11-15 | 2007-05-24 | Access Business Group International Llc | Plant-based formulations for improving liver health |
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| JPH07103024B2 (ja) * | 1986-03-07 | 1995-11-08 | 理化学研究所 | ジイン化合物を含む制癌剤 |
| JP2720176B2 (ja) * | 1988-09-08 | 1998-02-25 | 理化学研究所 | パナキサコール類の製造方法 |
| JPH03200736A (ja) * | 1989-12-28 | 1991-09-02 | Tsumura & Co | 新規ポリアセチレン系化合物類およびポリアセチレン系化合物類を有効成分とする抗腫瘍剤 |
| JPH05163202A (ja) * | 1991-02-26 | 1993-06-29 | Tsumura & Co | 新規ポリアセチレン系化合物類およびポリアセチレン系化合物類を有効成分とする5−リポキシゲナーゼ阻害剤 |
| CA2307393A1 (en) * | 2000-05-01 | 2001-11-01 | The University Of British Columbia | Ginsenoside chemotherapy |
| US20070065526A1 (en) * | 2005-09-19 | 2007-03-22 | Gow Robert T | Methods and compositions comprising Panax species |
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- 2009-08-27 JP JP2011525203A patent/JP2012510953A/ja active Pending
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- 2009-08-27 WO PCT/US2009/055221 patent/WO2010025272A1/en not_active Ceased
- 2009-08-27 CN CN200980143766.2A patent/CN102215840B/zh not_active Expired - Fee Related
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1571673A (zh) * | 2001-09-21 | 2005-01-26 | 博新药业股份有限公司 | 原人参萜二醇和原人参萜三醇及其作为协同抗癌剂的应用 |
| WO2007059250A2 (en) * | 2005-11-15 | 2007-05-24 | Access Business Group International Llc | Plant-based formulations for improving liver health |
Non-Patent Citations (1)
| Title |
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| Total Synthesis as a Resource in Drug Discovery: The First In Vivo Evaluation of Panaxytriol and Its Derivatives;Heedong Yun et al.;《Journal of Organic Chemistry》;20051211;第70卷(第25期);10375-10380 * |
Also Published As
| Publication number | Publication date |
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| KR101496508B1 (ko) | 2015-03-03 |
| EP2331093A1 (en) | 2011-06-15 |
| KR20110089842A (ko) | 2011-08-09 |
| CN102215840A (zh) | 2011-10-12 |
| EP2331093A4 (en) | 2016-06-01 |
| JP2014237656A (ja) | 2014-12-18 |
| WO2010025272A1 (en) | 2010-03-04 |
| JP2012510953A (ja) | 2012-05-17 |
| US20110312904A1 (en) | 2011-12-22 |
| US8859615B2 (en) | 2014-10-14 |
| JP5822991B2 (ja) | 2015-11-25 |
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