CN102203126A - 用于制备纯化的多肽组合物的方法 - Google Patents

用于制备纯化的多肽组合物的方法 Download PDF

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Publication number
CN102203126A
CN102203126A CN2009801425171A CN200980142517A CN102203126A CN 102203126 A CN102203126 A CN 102203126A CN 2009801425171 A CN2009801425171 A CN 2009801425171A CN 200980142517 A CN200980142517 A CN 200980142517A CN 102203126 A CN102203126 A CN 102203126A
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China
Prior art keywords
amino acid
composition
alpha
peptide
peptidomimetic macrocycle
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Pending
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CN2009801425171A
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English (en)
Chinese (zh)
Inventor
H·M·纳什
M·雅丹扎
C·雷泰瑟
川端纪之
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Rein Therapeutics Inc
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Aileron Therapeutics Inc
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Application filed by Aileron Therapeutics Inc filed Critical Aileron Therapeutics Inc
Priority to CN201510159021.2A priority Critical patent/CN104961795A/zh
Publication of CN102203126A publication Critical patent/CN102203126A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
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  • Obesity (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
CN2009801425171A 2008-09-22 2009-09-22 用于制备纯化的多肽组合物的方法 Pending CN102203126A (zh)

Priority Applications (1)

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CN201510159021.2A CN104961795A (zh) 2008-09-22 2009-09-22 用于制备纯化的多肽组合物的方法

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US9909908P 2008-09-22 2008-09-22
US61/099,099 2008-09-22
PCT/US2009/057931 WO2010034032A2 (en) 2008-09-22 2009-09-22 Methods for preparing purified polypeptide compositions

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CN201510159021.2A Pending CN104961795A (zh) 2008-09-22 2009-09-22 用于制备纯化的多肽组合物的方法

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US (5) US9206223B2 (https=)
EP (2) EP2342221B1 (https=)
JP (5) JP2012503025A (https=)
CN (2) CN102203126A (https=)
AU (1) AU2009294875C1 (https=)
BR (1) BRPI0918838A2 (https=)
CA (1) CA2737921C (https=)
IL (2) IL211837A (https=)
WO (1) WO2010034032A2 (https=)

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CN112245565A (zh) * 2014-09-24 2021-01-22 艾瑞朗医疗公司 拟肽大环化合物及其用途
CN112500466A (zh) * 2012-02-15 2021-03-16 艾瑞朗医疗公司 拟肽大环化合物

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CN105189465B (zh) 2013-03-21 2019-02-26 赛诺菲-安万特德国有限公司 合成含有乙内酰脲的肽产物
WO2014147129A1 (en) 2013-03-21 2014-09-25 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
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CN105792851B (zh) 2013-09-13 2023-10-10 斯克利普斯研究所 修饰的治疗剂及其组合物
AU2014342624A1 (en) * 2013-10-28 2016-06-02 Naurex, Inc. NMDA receptor modulators and prodrugs, salts, and uses thereof
AU2014364589B2 (en) 2013-12-18 2020-02-27 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
JP6642887B2 (ja) * 2014-04-02 2020-02-12 ユニバーシティー オブ ロチェスター アルファヘリックスを模倣した大環状ペプチドミメティック
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CA2988289C (en) 2015-06-04 2023-12-05 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
CN109414470A (zh) * 2016-03-21 2019-03-01 艾瑞朗医疗公司 用于拟肽大环化合物的伴随诊断工具
CA3081594A1 (en) 2017-11-09 2019-05-16 Wntrx Pharmaceuticals Inc. Bcl9 peptides and variants thereof
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2020397917A1 (en) 2019-12-04 2022-06-23 The Scripps Research Institute GLP2 receptor agonists and methods of use
MX2023014771A (es) 2021-06-09 2024-03-19 Scripps Research Inst Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso.

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