JP2012503025A - 精製されたポリペプチド組成物を調製するための方法 - Google Patents

精製されたポリペプチド組成物を調製するための方法 Download PDF

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Publication number
JP2012503025A
JP2012503025A JP2011528083A JP2011528083A JP2012503025A JP 2012503025 A JP2012503025 A JP 2012503025A JP 2011528083 A JP2011528083 A JP 2011528083A JP 2011528083 A JP2011528083 A JP 2011528083A JP 2012503025 A JP2012503025 A JP 2012503025A
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Prior art keywords
amino acid
peptidomimetic macrocycle
composition
peptidomimetic
macrocycle
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JP2012503025A5 (https=
Inventor
ヒュー エム． ナッシュ，
マシュー アイアダンサ，
クリストファー ライタイサー，
ノリユキ カワハタ，
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Rein Therapeutics Inc
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Aileron Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof

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  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
JP2011528083A 2008-09-22 2009-09-22 精製されたポリペプチド組成物を調製するための方法 Withdrawn JP2012503025A (ja)

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US9909908P 2008-09-22 2008-09-22
US61/099,099 2008-09-22
PCT/US2009/057931 WO2010034032A2 (en) 2008-09-22 2009-09-22 Methods for preparing purified polypeptide compositions

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JP2012503025A5 JP2012503025A5 (https=) 2013-04-25

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JP2011528083A Withdrawn JP2012503025A (ja) 2008-09-22 2009-09-22 精製されたポリペプチド組成物を調製するための方法
JP2015037711A Active JP6196640B2 (ja) 2008-09-22 2015-02-27 精製されたポリペプチド組成物を調製するための方法
JP2017118507A Pending JP2017155063A (ja) 2008-09-22 2017-06-16 精製されたポリペプチド組成物を調製するための方法
JP2019153604A Pending JP2019214614A (ja) 2008-09-22 2019-08-26 精製されたポリペプチド組成物を調製するための方法
JP2019172908A Pending JP2020015748A (ja) 2008-09-22 2019-09-24 精製されたポリペプチド組成物を調製するための方法

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JP2017118507A Pending JP2017155063A (ja) 2008-09-22 2017-06-16 精製されたポリペプチド組成物を調製するための方法
JP2019153604A Pending JP2019214614A (ja) 2008-09-22 2019-08-26 精製されたポリペプチド組成物を調製するための方法
JP2019172908A Pending JP2020015748A (ja) 2008-09-22 2019-09-24 精製されたポリペプチド組成物を調製するための方法

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US (5) US9206223B2 (https=)
EP (2) EP3492492A1 (https=)
JP (5) JP2012503025A (https=)
CN (2) CN102203126A (https=)
AU (1) AU2009294875C1 (https=)
BR (1) BRPI0918838A2 (https=)
CA (1) CA2737921C (https=)
IL (2) IL211837A (https=)
WO (1) WO2010034032A2 (https=)

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JP2015509940A (ja) * 2012-02-15 2015-04-02 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
JP2016537413A (ja) * 2013-10-28 2016-12-01 ノーレックス インコーポレイテッド Ｎｍｄａ受容体モジュレーター及びプロドラッグ、塩、並びにこれらの使用
JP2017513826A (ja) * 2014-04-02 2017-06-01 ユニバーシティー オブ ロチェスター アルファヘリックスを模倣した大環状ペプチドミメティック
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US10202431B2 (en) 2007-01-31 2019-02-12 Aileron Therapeutics, Inc. Stabilized P53 peptides and uses thereof
US10227380B2 (en) 2012-02-15 2019-03-12 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US10246491B2 (en) 2013-03-06 2019-04-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating HIF1alpha
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10301351B2 (en) 2007-03-28 2019-05-28 President And Fellows Of Harvard College Stitched polypeptides
US10308699B2 (en) 2011-10-18 2019-06-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10703780B2 (en) 2010-08-13 2020-07-07 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof

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US7981998B2 (en) * 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
ES2649941T3 (es) 2007-02-23 2018-01-16 Aileron Therapeutics, Inc. Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol
CA2710858A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
CA2737922A1 (en) 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
AU2010279325B2 (en) 2009-08-05 2016-10-20 Infinity Pharmaceuticals, Inc. Enzymatic transamination of cyclopamine analogs
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
US9394313B2 (en) 2010-09-14 2016-07-19 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
WO2012083078A2 (en) 2010-12-15 2012-06-21 The Research Foundation Of State University Of New York Croos-linked peptides and proteins, methods of making same, and uses thereof
EP2714701B1 (en) * 2011-06-03 2016-07-13 Hetero Research Foundation Process for fosaprepitant
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US9890239B2 (en) 2013-09-04 2018-02-13 California Institute Of Technology Functionalized linear and cyclic polyolefins
JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
KR102455171B1 (ko) 2013-12-18 2022-10-14 더 스크립스 리서치 인스티튜트 변형된 치료제, 스테이플드 펩티드 지질 접합체, 및 이의 조성물
PL3302428T3 (pl) 2015-06-04 2026-04-13 Sol-Gel Technologies Ltd. Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2019520304A (ja) * 2016-03-21 2019-07-18 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子に関するコンパニオン診断ツール
CA3081594A1 (en) 2017-11-09 2019-05-16 Wntrx Pharmaceuticals Inc. Bcl9 peptides and variants thereof
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
MX2022006861A (es) 2019-12-04 2022-07-11 Scripps Research Inst Agonistas del receptor glp2 y metodos de uso.
KR20240032010A (ko) 2021-06-09 2024-03-08 더 스크립스 리서치 인스티튜트 장기 지속형 이중 gip/glp-1 펩타이드 접합체 및 사용 방법

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JP2006503891A (ja) * 2002-10-24 2006-02-02 ダウ グローバル テクノロジーズ インコーポレイティド オレフィン複分解生成混合物の安定化
JP2008501623A (ja) * 2003-11-05 2008-01-24 ダナ−ファーバー キャンサー インスティテュート インク． 安定化させたαヘリックスペプチドおよびその使用法

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