JP2012503025A - 精製されたポリペプチド組成物を調製するための方法 - Google Patents

精製されたポリペプチド組成物を調製するための方法 Download PDF

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Publication number
JP2012503025A
JP2012503025A JP2011528083A JP2011528083A JP2012503025A JP 2012503025 A JP2012503025 A JP 2012503025A JP 2011528083 A JP2011528083 A JP 2011528083A JP 2011528083 A JP2011528083 A JP 2011528083A JP 2012503025 A JP2012503025 A JP 2012503025A
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Prior art keywords
amino acid
peptidomimetic macrocycle
composition
peptidomimetic
macrocycle
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JP2012503025A5 (https=
Inventor
ヒュー エム． ナッシュ，
マシュー アイアダンサ，
クリストファー ライタイサー，
ノリユキ カワハタ，
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Rein Therapeutics Inc
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Aileron Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof

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  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
JP2011528083A 2008-09-22 2009-09-22 精製されたポリペプチド組成物を調製するための方法 Withdrawn JP2012503025A (ja)

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US9909908P 2008-09-22 2008-09-22
US61/099,099 2008-09-22
PCT/US2009/057931 WO2010034032A2 (en) 2008-09-22 2009-09-22 Methods for preparing purified polypeptide compositions

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JP2012503025A5 JP2012503025A5 (https=) 2013-04-25

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JP2011528083A Withdrawn JP2012503025A (ja) 2008-09-22 2009-09-22 精製されたポリペプチド組成物を調製するための方法
JP2015037711A Active JP6196640B2 (ja) 2008-09-22 2015-02-27 精製されたポリペプチド組成物を調製するための方法
JP2017118507A Pending JP2017155063A (ja) 2008-09-22 2017-06-16 精製されたポリペプチド組成物を調製するための方法
JP2019153604A Pending JP2019214614A (ja) 2008-09-22 2019-08-26 精製されたポリペプチド組成物を調製するための方法
JP2019172908A Pending JP2020015748A (ja) 2008-09-22 2019-09-24 精製されたポリペプチド組成物を調製するための方法

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JP2017118507A Pending JP2017155063A (ja) 2008-09-22 2017-06-16 精製されたポリペプチド組成物を調製するための方法
JP2019153604A Pending JP2019214614A (ja) 2008-09-22 2019-08-26 精製されたポリペプチド組成物を調製するための方法
JP2019172908A Pending JP2020015748A (ja) 2008-09-22 2019-09-24 精製されたポリペプチド組成物を調製するための方法

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US (5) US9206223B2 (https=)
EP (2) EP2342221B1 (https=)
JP (5) JP2012503025A (https=)
CN (2) CN102203126A (https=)
AU (1) AU2009294875C1 (https=)
BR (1) BRPI0918838A2 (https=)
CA (1) CA2737921C (https=)
IL (2) IL211837A (https=)
WO (1) WO2010034032A2 (https=)

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JP2015509940A (ja) * 2012-02-15 2015-04-02 エイルロン セラピューティクス，インコーポレイテッド ペプチドミメティック大環状化合物
JP2016537413A (ja) * 2013-10-28 2016-12-01 ノーレックス インコーポレイテッド Ｎｍｄａ受容体モジュレーター及びプロドラッグ、塩、並びにこれらの使用
JP2017513826A (ja) * 2014-04-02 2017-06-01 ユニバーシティー オブ ロチェスター アルファヘリックスを模倣した大環状ペプチドミメティック
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US10202431B2 (en) 2007-01-31 2019-02-12 Aileron Therapeutics, Inc. Stabilized P53 peptides and uses thereof
US10227380B2 (en) 2012-02-15 2019-03-12 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
US10246491B2 (en) 2013-03-06 2019-04-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating HIF1alpha
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10301351B2 (en) 2007-03-28 2019-05-28 President And Fellows Of Harvard College Stitched polypeptides
US10308699B2 (en) 2011-10-18 2019-06-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10471120B2 (en) 2014-09-24 2019-11-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10703780B2 (en) 2010-08-13 2020-07-07 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof

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US7981998B2 (en) * 2006-12-14 2011-07-19 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
TWI433674B (zh) 2006-12-28 2014-04-11 Infinity Discovery Inc 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
ES2398310T3 (es) 2007-02-23 2013-03-15 Aileron Therapeutics, Inc. Péptidos macrocíclicos unidos a triazol
AU2008345097A1 (en) 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Methods for stereoselective reduction
ES2666458T3 (es) 2008-09-22 2018-05-04 Aileron Therapeutics, Inc. Macrociclos peptidomiméticos
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
EP2352507A4 (en) 2008-11-24 2012-04-25 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
WO2010083347A2 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP6141015B2 (ja) 2009-08-05 2017-06-07 インフィニティ ファーマスーティカルズ、インク． シクロパミン類似体の酵素によるアミノ基転移
US20130072439A1 (en) 2009-09-22 2013-03-21 Huw M. Nash Peptidomimetic macrocycles
US9394313B2 (en) 2010-09-14 2016-07-19 Infinity Pharmaceuticals, Inc. Transfer hydrogenation of cyclopamine analogs
US9029332B2 (en) 2010-12-15 2015-05-12 The Research Foundation For The State University Of New York Cross-linked peptides and proteins, methods of making same, and uses thereof
EP2714701B1 (en) * 2011-06-03 2016-07-13 Hetero Research Foundation Process for fosaprepitant
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
CN105189465B (zh) 2013-03-21 2019-02-26 赛诺菲-安万特德国有限公司 合成含有乙内酰脲的肽产物
WO2014147129A1 (en) 2013-03-21 2014-09-25 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
WO2015035097A1 (en) 2013-09-04 2015-03-12 California Institute Of Technology Functionalized linear and cyclic polyolefins
CN105792851B (zh) 2013-09-13 2023-10-10 斯克利普斯研究所 修饰的治疗剂及其组合物
AU2014364589B2 (en) 2013-12-18 2020-02-27 The California Institute For Biomedical Research Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
CA2988289C (en) 2015-06-04 2023-12-05 PellePharm, Inc. Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN109414470A (zh) * 2016-03-21 2019-03-01 艾瑞朗医疗公司 用于拟肽大环化合物的伴随诊断工具
CA3081594A1 (en) 2017-11-09 2019-05-16 Wntrx Pharmaceuticals Inc. Bcl9 peptides and variants thereof
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
AU2020397917A1 (en) 2019-12-04 2022-06-23 The Scripps Research Institute GLP2 receptor agonists and methods of use
MX2023014771A (es) 2021-06-09 2024-03-19 Scripps Research Inst Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso.

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