CN102187226A - 鉴定变应原性蛋白质和肽的方法 - Google Patents
鉴定变应原性蛋白质和肽的方法 Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- G01N2500/00—Screening for compounds of potential therapeutic value
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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Abstract
Description
肽 | 序列 | 长度 (aa) | pI | MW (kDa) |
Cas1 | RPKHPIKHQGLPQEVLNENLLRFFVAPFPEVC | 32 | 8.22 | 3.75 |
Cas2 | FGKEKVNELSKDIGSESTEDQAMEDIKQMEAES | 33 | 4.18 | 3.70 |
Cas3 | ISSSEEIVPNSVEQKHIQKEDVPSERYLGYEQLLRC | 36 | 4.80 | 4.21 |
Cas4 | CLKKYKVPQLEIVPNSAEERLHSMKEGIHAQQKE | 34 | 8.14 | 3.96 |
Cas5 | CPMIGVNQELAYFYPELFRQFYQLDAYPSGAWYYV | 35 | 4.14 | 4.24 |
Cas6 | PLGTQYTDAPSFSDIPNPIGSENSEKTTMPLWC | 33 | 3.92 | 3.60 |
BSA F1 | MRGVFRRDTHKSEIAHRFKDLGEEHFKGLVLIAFSQYLQQCPFDEHVKLVNELTEFAKTCVADESHAGCEKSLHTLFGDELCKVASLRETYGDMADCCEKQEPERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARRHPYFYAPELLYYANKYNGVFQECCQAEDKGACLLPKIETMREKVLTSSHHHHHH | 190 | 5.95 | 23.9 |
BSA F2 | MARQRLRCASIQKFGERALKAWSVARLSQKFPKAEFVEVTKLVTDLTKVHKECCHGDLLECADDRADLAKYICDNQDTISSKLKECCDKPLLEKSHCIAEVEKDAIPENLPPLTADFAEDKDVCKNYQEAKDAFLGSFLYEYSRRHPEYAVSVLLRLAKEYEATLEECCAKDDPHACYSTVFDKLKHLVDEHHHHHH | 189 | 5.94 | 22.6 |
BSA F3 | MPQNLIKQNCDQFEKLGEYGFQNALIVRYTRKVPQVSTPTLVEVSRSLGKVGTRCCTKPESERMPCTEDYLSLILNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYVPKAFDEKLFTFHADICTLPDTEKQIKKQTALVELLKHKPKATEEQLKTVMENFVAFVDKCCAADDKEACFAVEGPKLVVSTQTALAHHHHHH | 200 | 7.54 | 23.4 |
肽 | 序列 | 长度 (aa) | pI | MW (kDa) |
cas b-1 | HQPHQPLPPTV | 11 | 6.92 | 1.25 |
cas b-2 | VYPFPGPIPNS | 11 | 5.49 | 1.19 |
cas b-3 | LSSSEE | 6 | 4.24 | 0.65 |
cas b-4 | PVVVPPFL | 8 | 5.96 | 0.87 |
肽 | 序列 | 长度 (aa) | pI | MW (kDa) |
Lac1 | EQLTKCEVFRELKDLKGYG | 19 | 6.34 | 2.26 |
Lac2 | LKGYGGVSLPEWVCTTFHTS | 20 | 6.74 | 2.18 |
Lac3 | TFHTSGYDTQAIVQNNDSTE | 20 | 4.31 | 2.23 |
Lac4 | NDSTEYGLFQINNKIWCKDD | 20 | 4.42 | 2.40 |
Lac5 | WCKDDQNPHSSNICNISCDK | 20 | 5.30 | 2.31 |
Lac6 | ISCDKFLDDDLTDDIMCVKK | 20 | 4.11 | 2.32 |
Lac7 | MCVKKILDKVGINYWLAHKA | 20 | 9.52 | 2.33 |
Lac8 | LAHKALCSEKLDQWLCEKL | 19 | 6.74 | 2.23 |
n=36 | IgE结合 (患者的%) | |
重组ALA | rALA | 100.0 |
合成的ALA 肽 | Lac1 | 30.6 |
Lac2 | 33.3 | |
Lac3 | 0 | |
Lac4 | 5.6 | |
Lac5 | 2.8 | |
Lac6 | 2.8 | |
Lac7 | 2.8 | |
Lac8 | 11.1 |
Claims (24)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19641608P | 2008-10-17 | 2008-10-17 | |
US61/196416 | 2008-10-17 | ||
PCT/EP2009/063696 WO2010043724A1 (en) | 2008-10-17 | 2009-10-19 | Method for identifying allergenic proteins and peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102187226A true CN102187226A (zh) | 2011-09-14 |
CN102187226B CN102187226B (zh) | 2014-05-14 |
Family
ID=41480083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980140631.0A Expired - Fee Related CN102187226B (zh) | 2008-10-17 | 2009-10-19 | 鉴定变应原性蛋白质和肽的方法 |
Country Status (17)
Country | Link |
---|---|
US (1) | US8859210B2 (zh) |
EP (1) | EP2347264B1 (zh) |
CN (1) | CN102187226B (zh) |
BR (1) | BRPI0919789A2 (zh) |
CA (1) | CA2740255A1 (zh) |
CO (1) | CO6351822A2 (zh) |
CZ (1) | CZ305786B6 (zh) |
ES (1) | ES2445869T3 (zh) |
HK (1) | HK1161913A1 (zh) |
MX (1) | MX2011002975A (zh) |
MY (1) | MY153980A (zh) |
NO (1) | NO342293B1 (zh) |
PE (1) | PE20110709A1 (zh) |
PL (1) | PL2347264T3 (zh) |
RU (1) | RU2519674C2 (zh) |
TW (1) | TWI471565B (zh) |
WO (1) | WO2010043724A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107817311A (zh) * | 2017-09-27 | 2018-03-20 | 绿城农科检测技术有限公司 | 一种液质联用检测配方奶粉中酪蛋白磷酸肽含量的方法 |
CN111766324A (zh) * | 2020-07-10 | 2020-10-13 | 中国检验检疫科学研究院 | 一种用于检测水牛奶中掺入牛奶的特征肽组合及方法 |
CN114437238A (zh) * | 2022-01-26 | 2022-05-06 | 浙江工业大学 | 胶原蛋白肽-牛乳铁蛋白肽融合蛋白、基因及其表达方法 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US8859210B2 (en) * | 2008-10-17 | 2014-10-14 | Mead Johnson Nutrition Company | Method for identifying allergenic proteins and peptides |
EP2332428B1 (en) * | 2009-12-04 | 2014-08-20 | MJN U.S. Holdings LLC | Nutritional Formulation comprising a cow's milk peptide-containing hydrolysate and/or peptides derived thereof for tolerance induction |
US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
US9345741B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
US9345727B2 (en) * | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
US11215615B2 (en) | 2014-04-03 | 2022-01-04 | AllerGenis LLC | Peptides, reagents and methods for detecting food allergy |
CN107635584B (zh) * | 2015-04-09 | 2022-06-17 | 康奈尔大学 | 基因治疗以预防对过敏原的反应 |
CN104777303B (zh) * | 2015-04-29 | 2017-02-01 | 何韶衡 | 一种嗜碱性粒细胞激活、脱颗粒的鉴定方法 |
CN104807988B (zh) * | 2015-04-29 | 2017-02-01 | 何韶衡 | 一种嗜碱性粒细胞的特异性免疫识别方法 |
RU2666254C1 (ru) * | 2017-05-11 | 2018-09-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный педиатрический медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПбГПМУ Минздрава России) | Способ диагностики пищевой аллергии у детей |
US11408895B1 (en) | 2018-04-09 | 2022-08-09 | Hob Biotech Group Corp., Ltd. | Allergen characterization, potent allergen product formulation, comprehensive allergen reagent, and allergy assay |
US20230251269A1 (en) * | 2020-07-15 | 2023-08-10 | The Johns Hopkins University | Comprehensive analysis of anti-allergen antibodies using phage display |
JP2022157411A (ja) * | 2021-03-31 | 2022-10-14 | 学校法人藤田学園 | 牛乳アレルギーの新規抗原 |
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CN101178406A (zh) * | 2007-12-05 | 2008-05-14 | 杭州浙大生物基因工程有限公司 | 过敏原特异性抗体IgE ELISA检测试剂盒及其制备方法 |
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US8859210B2 (en) * | 2008-10-17 | 2014-10-14 | Mead Johnson Nutrition Company | Method for identifying allergenic proteins and peptides |
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2009
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- 2009-10-19 CZ CZ2011-223A patent/CZ305786B6/cs not_active IP Right Cessation
- 2009-10-19 BR BRPI0919789A patent/BRPI0919789A2/pt not_active Application Discontinuation
- 2009-10-19 CN CN200980140631.0A patent/CN102187226B/zh not_active Expired - Fee Related
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107817311A (zh) * | 2017-09-27 | 2018-03-20 | 绿城农科检测技术有限公司 | 一种液质联用检测配方奶粉中酪蛋白磷酸肽含量的方法 |
CN107817311B (zh) * | 2017-09-27 | 2019-08-23 | 绿城农科检测技术有限公司 | 一种液质联用检测配方奶粉中酪蛋白磷酸肽含量的方法 |
CN111766324A (zh) * | 2020-07-10 | 2020-10-13 | 中国检验检疫科学研究院 | 一种用于检测水牛奶中掺入牛奶的特征肽组合及方法 |
CN111766324B (zh) * | 2020-07-10 | 2022-12-06 | 中国检验检疫科学研究院 | 一种用于检测水牛奶中掺入牛奶的特征肽组合及方法 |
CN114437238A (zh) * | 2022-01-26 | 2022-05-06 | 浙江工业大学 | 胶原蛋白肽-牛乳铁蛋白肽融合蛋白、基因及其表达方法 |
CN114437238B (zh) * | 2022-01-26 | 2024-03-26 | 浙江工业大学 | 胶原蛋白肽-牛乳铁蛋白肽融合蛋白、基因及其表达方法 |
Also Published As
Publication number | Publication date |
---|---|
CZ2011223A3 (cs) | 2012-03-21 |
CO6351822A2 (es) | 2011-12-20 |
EP2347264A1 (en) | 2011-07-27 |
MY153980A (en) | 2015-04-30 |
CN102187226B (zh) | 2014-05-14 |
RU2519674C2 (ru) | 2014-06-20 |
ES2445869T3 (es) | 2014-03-05 |
BRPI0919789A2 (pt) | 2016-05-03 |
US8859210B2 (en) | 2014-10-14 |
NO342293B1 (no) | 2018-04-30 |
TW201030341A (en) | 2010-08-16 |
US20100143262A1 (en) | 2010-06-10 |
WO2010043724A1 (en) | 2010-04-22 |
CZ305786B6 (cs) | 2016-03-16 |
PE20110709A1 (es) | 2011-11-13 |
TWI471565B (zh) | 2015-02-01 |
EP2347264B1 (en) | 2013-11-27 |
NO20110426A1 (no) | 2011-04-28 |
HK1161913A1 (zh) | 2012-08-10 |
MX2011002975A (es) | 2011-04-11 |
CA2740255A1 (en) | 2010-04-22 |
RU2011119613A (ru) | 2012-11-27 |
PL2347264T3 (pl) | 2014-06-30 |
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