CN102178800A - 一种治疗类风湿性关节炎的中药组合物及其制备方法 - Google Patents
一种治疗类风湿性关节炎的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN102178800A CN102178800A CN2011101091019A CN201110109101A CN102178800A CN 102178800 A CN102178800 A CN 102178800A CN 2011101091019 A CN2011101091019 A CN 2011101091019A CN 201110109101 A CN201110109101 A CN 201110109101A CN 102178800 A CN102178800 A CN 102178800A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- radix
- medicine
- rheumatoid arthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 188
- 206010039073 rheumatoid arthritis Diseases 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 45
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 238000011282 treatment Methods 0.000 claims abstract description 60
- 229940079593 drug Drugs 0.000 claims abstract description 56
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 50
- 241000522620 Scorpio Species 0.000 claims description 46
- 239000009490 scorpio Substances 0.000 claims description 40
- 241000717739 Boswellia sacra Species 0.000 claims description 34
- 239000000843 powder Substances 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 238000010438 heat treatment Methods 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 24
- 210000000582 semen Anatomy 0.000 claims description 20
- 239000006187 pill Substances 0.000 claims description 19
- 241001489978 Eupolyphaga Species 0.000 claims description 17
- 241001057584 Myrrha Species 0.000 claims description 17
- 241000237636 Pheretima Species 0.000 claims description 17
- 239000009286 sanguis draxonis Substances 0.000 claims description 17
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 15
- 239000000284 extract Substances 0.000 claims description 14
- 235000012907 honey Nutrition 0.000 claims description 13
- 241000545442 Radix Species 0.000 claims description 12
- 239000002552 dosage form Substances 0.000 claims description 11
- 238000002481 ethanol extraction Methods 0.000 claims description 11
- 239000002674 ointment Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 235000011837 pasties Nutrition 0.000 claims description 10
- 238000007670 refining Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 235000009508 confectionery Nutrition 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- 241001446509 Psoralea Species 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- -1 sublimed preparation Substances 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- 230000002829 reductive effect Effects 0.000 claims description 4
- 238000002791 soaking Methods 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 2
- 239000000645 desinfectant Substances 0.000 claims description 2
- 239000008298 dragée Substances 0.000 claims description 2
- 239000002662 enteric coated tablet Substances 0.000 claims description 2
- 239000007941 film coated tablet Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000007902 hard capsule Substances 0.000 claims description 2
- 239000011505 plaster Substances 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims description 2
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000007940 sugar coated tablet Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 208000002193 Pain Diseases 0.000 abstract description 95
- 230000036407 pain Effects 0.000 abstract description 94
- 230000000694 effects Effects 0.000 abstract description 38
- 239000004863 Frankincense Substances 0.000 abstract description 24
- 230000008901 benefit Effects 0.000 abstract description 9
- 235000008216 herbs Nutrition 0.000 abstract description 9
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241001465251 Ephedra sinica Species 0.000 abstract description 2
- 235000003717 Boswellia sacra Nutrition 0.000 abstract 2
- 240000007551 Boswellia serrata Species 0.000 abstract 2
- 235000012035 Boswellia serrata Nutrition 0.000 abstract 2
- 241000112528 Ligusticum striatum Species 0.000 abstract 2
- 241001481692 Mesobuthus martensii Species 0.000 abstract 2
- 235000020061 kirsch Nutrition 0.000 abstract 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 241000243684 Lumbricus Species 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 241001113787 Strychnos Species 0.000 abstract 1
- 240000004824 Trimezia steyermarkii Species 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 68
- 239000008280 blood Substances 0.000 description 68
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 55
- 201000010099 disease Diseases 0.000 description 54
- 208000006820 Arthralgia Diseases 0.000 description 51
- 238000012360 testing method Methods 0.000 description 43
- 230000001737 promoting effect Effects 0.000 description 35
- 238000000034 method Methods 0.000 description 32
- 210000003734 kidney Anatomy 0.000 description 27
- 210000000988 bone and bone Anatomy 0.000 description 26
- 210000003205 muscle Anatomy 0.000 description 23
- 241001465754 Metazoa Species 0.000 description 22
- 241000699670 Mus sp. Species 0.000 description 22
- 208000024891 symptom Diseases 0.000 description 22
- 208000004044 Hypesthesia Diseases 0.000 description 20
- 230000017531 blood circulation Effects 0.000 description 20
- 208000034783 hypoesthesia Diseases 0.000 description 20
- 231100000862 numbness Toxicity 0.000 description 20
- 244000052769 pathogen Species 0.000 description 20
- 230000001717 pathogenic effect Effects 0.000 description 20
- 230000008961 swelling Effects 0.000 description 20
- 230000006870 function Effects 0.000 description 18
- 230000003203 everyday effect Effects 0.000 description 17
- 241000699666 Mus <mouse, genus> Species 0.000 description 16
- 230000007812 deficiency Effects 0.000 description 16
- 229940023488 pill Drugs 0.000 description 16
- 208000011580 syndromic disease Diseases 0.000 description 16
- 210000004185 liver Anatomy 0.000 description 14
- 210000000952 spleen Anatomy 0.000 description 14
- 206010019233 Headaches Diseases 0.000 description 13
- 239000009636 Huang Qi Substances 0.000 description 13
- 231100000869 headache Toxicity 0.000 description 13
- 230000001629 suppression Effects 0.000 description 13
- 210000001835 viscera Anatomy 0.000 description 13
- 206010011224 Cough Diseases 0.000 description 12
- 206010028980 Neoplasm Diseases 0.000 description 12
- 230000037396 body weight Effects 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- 201000000736 Amenorrhea Diseases 0.000 description 11
- 206010001928 Amenorrhoea Diseases 0.000 description 11
- 210000001015 abdomen Anatomy 0.000 description 11
- 231100000540 amenorrhea Toxicity 0.000 description 11
- 208000014674 injury Diseases 0.000 description 11
- 238000005728 strengthening Methods 0.000 description 11
- 208000004880 Polyuria Diseases 0.000 description 10
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 10
- 208000033809 Suppuration Diseases 0.000 description 10
- 239000002390 adhesive tape Substances 0.000 description 10
- 230000000202 analgesic effect Effects 0.000 description 10
- 230000035619 diuresis Effects 0.000 description 10
- 230000036541 health Effects 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 231100000614 poison Toxicity 0.000 description 10
- 238000010792 warming Methods 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 206010013935 Dysmenorrhoea Diseases 0.000 description 9
- 206010061218 Inflammation Diseases 0.000 description 9
- 206010030113 Oedema Diseases 0.000 description 9
- 208000027418 Wounds and injury Diseases 0.000 description 9
- 210000000481 breast Anatomy 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 230000004054 inflammatory process Effects 0.000 description 9
- 210000000629 knee joint Anatomy 0.000 description 9
- 231100000915 pathological change Toxicity 0.000 description 9
- 230000036285 pathological change Effects 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 9
- 206010007247 Carbuncle Diseases 0.000 description 8
- 208000005171 Dysmenorrhea Diseases 0.000 description 8
- 208000025747 Rheumatic disease Diseases 0.000 description 8
- 206010040880 Skin irritation Diseases 0.000 description 8
- 230000008859 change Effects 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 230000033001 locomotion Effects 0.000 description 8
- 230000000552 rheumatic effect Effects 0.000 description 8
- 230000036556 skin irritation Effects 0.000 description 8
- 231100000475 skin irritation Toxicity 0.000 description 8
- 230000008736 traumatic injury Effects 0.000 description 8
- 206010010904 Convulsion Diseases 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 7
- 230000001684 chronic effect Effects 0.000 description 7
- 230000036461 convulsion Effects 0.000 description 7
- 230000034994 death Effects 0.000 description 7
- 230000006735 deficit Effects 0.000 description 7
- 239000003172 expectorant agent Substances 0.000 description 7
- 230000003419 expectorant effect Effects 0.000 description 7
- 230000001617 migratory effect Effects 0.000 description 7
- 208000026435 phlegm Diseases 0.000 description 7
- 239000003755 preservative agent Substances 0.000 description 7
- 230000002335 preservative effect Effects 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- 201000003068 rheumatic fever Diseases 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 231100000397 ulcer Toxicity 0.000 description 7
- 239000000052 vinegar Substances 0.000 description 7
- 235000021419 vinegar Nutrition 0.000 description 7
- 206010000087 Abdominal pain upper Diseases 0.000 description 6
- 206010008190 Cerebrovascular accident Diseases 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- 206010039491 Sarcoma Diseases 0.000 description 6
- 206010070834 Sensitisation Diseases 0.000 description 6
- 208000006011 Stroke Diseases 0.000 description 6
- 206010047700 Vomiting Diseases 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 6
- 230000003213 activating effect Effects 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000000812 cholinergic antagonist Substances 0.000 description 6
- 238000002651 drug therapy Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- 210000002216 heart Anatomy 0.000 description 6
- 210000001624 hip Anatomy 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 230000008313 sensitization Effects 0.000 description 6
- 238000007086 side reaction Methods 0.000 description 6
- 230000002048 spasmolytic effect Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 206010018691 Granuloma Diseases 0.000 description 5
- 208000019255 Menstrual disease Diseases 0.000 description 5
- 230000036592 analgesia Effects 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 230000036528 appetite Effects 0.000 description 5
- 235000019789 appetite Nutrition 0.000 description 5
- 238000003745 diagnosis Methods 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 210000003414 extremity Anatomy 0.000 description 5
- 210000001508 eye Anatomy 0.000 description 5
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 5
- 239000010931 gold Substances 0.000 description 5
- 229910052737 gold Inorganic materials 0.000 description 5
- 241000411851 herbal medicine Species 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 230000010354 integration Effects 0.000 description 5
- 210000001503 joint Anatomy 0.000 description 5
- 210000002751 lymph Anatomy 0.000 description 5
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 5
- 210000004180 plasmocyte Anatomy 0.000 description 5
- 239000002574 poison Substances 0.000 description 5
- 238000004062 sedimentation Methods 0.000 description 5
- 206010040872 skin infection Diseases 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 210000001258 synovial membrane Anatomy 0.000 description 5
- 210000002700 urine Anatomy 0.000 description 5
- 108010074051 C-Reactive Protein Proteins 0.000 description 4
- 102100032752 C-reactive protein Human genes 0.000 description 4
- 241000700199 Cavia porcellus Species 0.000 description 4
- 206010009346 Clonus Diseases 0.000 description 4
- 206010011878 Deafness Diseases 0.000 description 4
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010019468 Hemiplegia Diseases 0.000 description 4
- 208000008454 Hyperhidrosis Diseases 0.000 description 4
- 206010062575 Muscle contracture Diseases 0.000 description 4
- 241000239226 Scorpiones Species 0.000 description 4
- 206010043376 Tetanus Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 4
- 230000002052 anaphylactic effect Effects 0.000 description 4
- 238000010171 animal model Methods 0.000 description 4
- 206010003246 arthritis Diseases 0.000 description 4
- 210000001188 articular cartilage Anatomy 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 210000000845 cartilage Anatomy 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 208000006111 contracture Diseases 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 208000013219 diaphoresis Diseases 0.000 description 4
- 208000001848 dysentery Diseases 0.000 description 4
- 201000006549 dyspepsia Diseases 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 238000007689 inspection Methods 0.000 description 4
- 201000007227 lymph node tuberculosis Diseases 0.000 description 4
- 230000004089 microcirculation Effects 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 230000007096 poisonous effect Effects 0.000 description 4
- 230000003389 potentiating effect Effects 0.000 description 4
- 230000003405 preventing effect Effects 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 230000017423 tissue regeneration Effects 0.000 description 4
- 231100000041 toxicology testing Toxicity 0.000 description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical group CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
- 208000008035 Back Pain Diseases 0.000 description 3
- 208000000059 Dyspnea Diseases 0.000 description 3
- 206010013975 Dyspnoeas Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 208000007875 Femur Head Necrosis Diseases 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 3
- 206010023644 Lacrimation increased Diseases 0.000 description 3
- 208000008930 Low Back Pain Diseases 0.000 description 3
- 206010027336 Menstruation delayed Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 240000001307 Myosotis scorpioides Species 0.000 description 3
- 206010028851 Necrosis Diseases 0.000 description 3
- 206010033557 Palpitations Diseases 0.000 description 3
- 235000003140 Panax quinquefolius Nutrition 0.000 description 3
- 241001111421 Pannus Species 0.000 description 3
- 206010033799 Paralysis Diseases 0.000 description 3
- 206010036030 Polyarthritis Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 208000001431 Psychomotor Agitation Diseases 0.000 description 3
- 206010038743 Restlessness Diseases 0.000 description 3
- 206010040943 Skin Ulcer Diseases 0.000 description 3
- 206010042674 Swelling Diseases 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 206010047115 Vasculitis Diseases 0.000 description 3
- 206010000059 abdominal discomfort Diseases 0.000 description 3
- 231100000293 acute skin toxicity Toxicity 0.000 description 3
- 230000004596 appetite loss Effects 0.000 description 3
- 206010003549 asthenia Diseases 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 230000001914 calming effect Effects 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 230000002950 deficient Effects 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 210000003754 fetus Anatomy 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 210000004247 hand Anatomy 0.000 description 3
- 210000003128 head Anatomy 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000009545 invasion Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 230000004317 lacrimation Effects 0.000 description 3
- 208000019017 loss of appetite Diseases 0.000 description 3
- 235000021266 loss of appetite Nutrition 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 231100000682 maximum tolerated dose Toxicity 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 238000002483 medication Methods 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 208000037920 primary disease Diseases 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 231100000019 skin ulcer Toxicity 0.000 description 3
- 235000014347 soups Nutrition 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 210000002437 synoviocyte Anatomy 0.000 description 3
- 201000004595 synovitis Diseases 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 231100000820 toxicity test Toxicity 0.000 description 3
- 210000001113 umbilicus Anatomy 0.000 description 3
- 230000009978 visual deterioration Effects 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- BGEBZHIAGXMEMV-UHFFFAOYSA-N 5-methoxypsoralen Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OC BGEBZHIAGXMEMV-UHFFFAOYSA-N 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 241000180579 Arca Species 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 206010005963 Bone formation increased Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 206010062746 Carditis Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- VYZAHLCBVHPDDF-UHFFFAOYSA-N Dinitrochlorobenzene Chemical group [O-][N+](=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 VYZAHLCBVHPDDF-UHFFFAOYSA-N 0.000 description 2
- 241000123586 Dipsacaceae Species 0.000 description 2
- 208000004929 Facial Paralysis Diseases 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 2
- 208000000616 Hemoptysis Diseases 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 206010061245 Internal injury Diseases 0.000 description 2
- 241000581650 Ivesia Species 0.000 description 2
- 206010023232 Joint swelling Diseases 0.000 description 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- 208000009525 Myocarditis Diseases 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 208000005141 Otitis Diseases 0.000 description 2
- 208000000114 Pain Threshold Diseases 0.000 description 2
- 206010033425 Pain in extremity Diseases 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 208000004680 Rectal Fistula Diseases 0.000 description 2
- 206010039101 Rhinorrhoea Diseases 0.000 description 2
- 208000019802 Sexually transmitted disease Diseases 0.000 description 2
- 206010067868 Skin mass Diseases 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 206010061372 Streptococcal infection Diseases 0.000 description 2
- 208000018359 Systemic autoimmune disease Diseases 0.000 description 2
- 208000024780 Urticaria Diseases 0.000 description 2
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 206010000210 abortion Diseases 0.000 description 2
- 231100000176 abortion Toxicity 0.000 description 2
- 238000001467 acupuncture Methods 0.000 description 2
- 206010002156 anal fistula Diseases 0.000 description 2
- 230000001166 anti-perspirative effect Effects 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 201000008275 breast carcinoma Diseases 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000035617 depilation Effects 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000002683 foot Anatomy 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 108010074605 gamma-Globulins Proteins 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 210000003714 granulocyte Anatomy 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 208000021646 inflammation of heart layer Diseases 0.000 description 2
- 208000027866 inflammatory disease Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 210000000811 metacarpophalangeal joint Anatomy 0.000 description 2
- 229960000485 methotrexate Drugs 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000037040 pain threshold Effects 0.000 description 2
- 230000003119 painkilling effect Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 201000006292 polyarteritis nodosa Diseases 0.000 description 2
- 208000030428 polyarticular arthritis Diseases 0.000 description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 235000019633 pungent taste Nutrition 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 206010039083 rhinitis Diseases 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000036548 skin texture Effects 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 210000000707 wrist Anatomy 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 208000035657 Abasia Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000544682 Acorus tatarinowii Species 0.000 description 1
- 241000271039 Agkistrodon Species 0.000 description 1
- RLFWWDJHLFCNIJ-UHFFFAOYSA-N Aminoantipyrine Natural products CN1C(C)=C(N)C(=O)N1C1=CC=CC=C1 RLFWWDJHLFCNIJ-UHFFFAOYSA-N 0.000 description 1
- RMMXTBMQSGEXHJ-UHFFFAOYSA-N Aminophenazone Chemical compound O=C1C(N(C)C)=C(C)N(C)N1C1=CC=CC=C1 RMMXTBMQSGEXHJ-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000036487 Arthropathies Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000003910 Baronia <angiosperm> Species 0.000 description 1
- DBMJZOMNXBSRED-UHFFFAOYSA-N Bergamottin Natural products O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)CCC=C(C)C DBMJZOMNXBSRED-UHFFFAOYSA-N 0.000 description 1
- 206010068975 Bone atrophy Diseases 0.000 description 1
- 206010051728 Bone erosion Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 208000020119 Caplan syndrome Diseases 0.000 description 1
- 206010008748 Chorea Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 208000032928 Dyslipidaemia Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000723281 Ephedra equisetina Species 0.000 description 1
- 241000723237 Ephedra intermedia Species 0.000 description 1
- 241000218670 Ephedraceae Species 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000201295 Euphrasia Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 208000028387 Felty syndrome Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010017711 Gangrene Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000012153 HLA-B27 Antigen Human genes 0.000 description 1
- 108010061486 HLA-B27 Antigen Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010048612 Hydrothorax Diseases 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 206010049949 Intercostal neuralgia Diseases 0.000 description 1
- 208000029523 Interstitial Lung disease Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023201 Joint contracture Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000017170 Lipid metabolism disease Diseases 0.000 description 1
- 241000406668 Loxodonta cyclotis Species 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010062049 Lymphocytic infiltration Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 206010026749 Mania Diseases 0.000 description 1
- 208000027530 Meniere disease Diseases 0.000 description 1
- QXKHYNVANLEOEG-UHFFFAOYSA-N Methoxsalen Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OC QXKHYNVANLEOEG-UHFFFAOYSA-N 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 241000590428 Panacea Species 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 208000006735 Periostitis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000012322 Raynaud phenomenon Diseases 0.000 description 1
- 208000009921 Rheumatoid Nodule Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000008765 Sciatica Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 206010061363 Skeletal injury Diseases 0.000 description 1
- 208000026214 Skeletal muscle atrophy Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 206010041660 Splenomegaly Diseases 0.000 description 1
- 241001601725 Sthenias Species 0.000 description 1
- 231100000643 Substance intoxication Toxicity 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 206010053692 Wound complication Diseases 0.000 description 1
- PCWZKQSKUXXDDJ-UHFFFAOYSA-N Xanthotoxin Natural products COCc1c2OC(=O)C=Cc2cc3ccoc13 PCWZKQSKUXXDDJ-UHFFFAOYSA-N 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 208000004631 alopecia areata Diseases 0.000 description 1
- ILKJAFIWWBXGDU-MOGDOJJUSA-N amcinonide Chemical compound O([C@@]1([C@H](O2)C[C@@H]3[C@@]1(C[C@H](O)[C@]1(F)[C@@]4(C)C=CC(=O)C=C4CC[C@H]13)C)C(=O)COC(=O)C)C12CCCC1 ILKJAFIWWBXGDU-MOGDOJJUSA-N 0.000 description 1
- 229960003099 amcinonide Drugs 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
- 206010003230 arteritis Diseases 0.000 description 1
- 210000001306 articular ligament Anatomy 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 229960002045 bergapten Drugs 0.000 description 1
- KGZDKFWCIPZMRK-UHFFFAOYSA-N bergapten Natural products COC1C2=C(Cc3ccoc13)C=CC(=O)O2 KGZDKFWCIPZMRK-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000004221 bone function Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 210000003797 carpal joint Anatomy 0.000 description 1
- 208000012601 choreatic disease Diseases 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000001066 destructive effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000009266 disease activity Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 201000010582 ecthyma Diseases 0.000 description 1
- 210000002310 elbow joint Anatomy 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000023513 hiccough Diseases 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 230000003118 histopathologic effect Effects 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940029329 intrinsic factor Drugs 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 238000009592 kidney function test Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229940127021 low-dose drug Drugs 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- ZDGGJQMSELMHLK-UHFFFAOYSA-N m-Trifluoromethylhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=CC(C(F)(F)F)=C1 ZDGGJQMSELMHLK-UHFFFAOYSA-N 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 229940074869 marquis Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229960004469 methoxsalen Drugs 0.000 description 1
- SQBBOVROCFXYBN-UHFFFAOYSA-N methoxypsoralen Natural products C1=C2OC(=O)C(OC)=CC2=CC2=C1OC=C2 SQBBOVROCFXYBN-UHFFFAOYSA-N 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 208000010553 multiple abscesses Diseases 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000003448 neutrophilic effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 206010029446 nocturia Diseases 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 208000008494 pericarditis Diseases 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 210000004224 pleura Anatomy 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 206010035653 pneumoconiosis Diseases 0.000 description 1
- VBUNOIXRZNJNAD-UHFFFAOYSA-N ponazuril Chemical compound CC1=CC(N2C(N(C)C(=O)NC2=O)=O)=CC=C1OC1=CC=C(S(=O)(=O)C(F)(F)F)C=C1 VBUNOIXRZNJNAD-UHFFFAOYSA-N 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 208000018299 prostration Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 208000002815 pulmonary hypertension Diseases 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000004706 scrotum Anatomy 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000025185 skeletal muscle atrophy Effects 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000021595 spermatogenesis Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 210000005065 subchondral bone plate Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 206010044652 trigeminal neuralgia Diseases 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000000623 ulna Anatomy 0.000 description 1
- 201000002327 urinary tract obstruction Diseases 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000008945 zhigancao decoction Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 给药剂量(g/kg) | 扭体次数 | 抑制率(%) |
基质对照组 | 32.5±2.7 | ||
阿司匹林组 | 0.2 | 18.30±8.78* | 42.2 |
高剂量组 | 0.5 | 11.23±2.4** | 69.1 |
中剂量组 | 0.25 | 15.36±5.12** | 51.67 |
低剂量组 | 0.125 | 19.30±6.35* | 42.6 |
组别 | 给药剂量(g/kg) | 肿胀度(mg) | 抑制率(%) |
基质对照组 | 6.35±1.65 | ||
伤痛膏组 | 0.2 | 1.86±2.48** | 68.57 |
高剂量组 | 0.5 | 3.26±1.57** | 45.67 |
中剂量组 | 0.25 | 4.02±2.06* | 38.89 |
低剂量组 | 0.125 | 4.85±3.68* | 26.18 |
组别 | n | 显效 | 有效 | 无效 | 总有效率 |
治疗组 | 27 | 22(81.4) | 3(11.1) | 2(7.4) | 92.59 |
对照组 | 23 | 11(47.8) | 7(30.4) | 5(21.73) | 78.2 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101091019A CN102178800B (zh) | 2011-04-28 | 2011-04-28 | 一种治疗类风湿性关节炎的中药组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101091019A CN102178800B (zh) | 2011-04-28 | 2011-04-28 | 一种治疗类风湿性关节炎的中药组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102178800A true CN102178800A (zh) | 2011-09-14 |
CN102178800B CN102178800B (zh) | 2012-02-29 |
Family
ID=44565206
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2011101091019A Expired - Fee Related CN102178800B (zh) | 2011-04-28 | 2011-04-28 | 一种治疗类风湿性关节炎的中药组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102178800B (zh) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102397523A (zh) * | 2011-11-28 | 2012-04-04 | 吕会辰 | 一种治疗风湿、类风湿性关节炎和颈肩腰腿疼的药物 |
CN102716262A (zh) * | 2012-06-29 | 2012-10-10 | 隋孝忠 | 一种治疗强直性脊柱炎的中药配方 |
CN102836406A (zh) * | 2012-09-03 | 2012-12-26 | 黄天佑 | 一种筋骨膏及其制备方法 |
CN103705658A (zh) * | 2013-12-29 | 2014-04-09 | 纪忠义 | 一种治疗类风湿性关节炎的中药外敷剂 |
CN104042759A (zh) * | 2014-06-28 | 2014-09-17 | 黄翠萍 | 一种内服外用治疗关节疼痛的中药 |
CN105943705A (zh) * | 2016-01-04 | 2016-09-21 | 青岛申达高新技术开发有限公司 | 一种治疗类风湿性关节炎的中药组合物及其制备方法 |
CN109833433A (zh) * | 2019-03-27 | 2019-06-04 | 刘果林 | 一种有效治疗风湿骨伤病的中药配方 |
CN110478416A (zh) * | 2019-09-27 | 2019-11-22 | 首都医科大学附属北京朝阳医院 | 治疗风湿性类风湿性关节炎的组合物及其制备方法和应用 |
CN111450137A (zh) * | 2020-05-15 | 2020-07-28 | 上海希尔维生物科技有限公司 | 一种促毛发生长的杜仲/淫羊藿植物提取物溶液及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1153663A (zh) * | 1996-11-01 | 1997-07-09 | 任光福 | 治疗风湿性、类风湿性关节炎的大力士丸中成药及其制备方法 |
CN1319414A (zh) * | 2001-01-19 | 2001-10-31 | 刘军 | 用于治疗股骨头坏死的药物 |
CN101991735A (zh) * | 2010-10-13 | 2011-03-30 | 刘广 | 一种外敷膏剂 |
-
2011
- 2011-04-28 CN CN2011101091019A patent/CN102178800B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1153663A (zh) * | 1996-11-01 | 1997-07-09 | 任光福 | 治疗风湿性、类风湿性关节炎的大力士丸中成药及其制备方法 |
CN1319414A (zh) * | 2001-01-19 | 2001-10-31 | 刘军 | 用于治疗股骨头坏死的药物 |
CN101991735A (zh) * | 2010-10-13 | 2011-03-30 | 刘广 | 一种外敷膏剂 |
Non-Patent Citations (3)
Title |
---|
《中华中医药杂志》 20050531 蔡雄,等 类风湿性关节炎的中医临床治疗研究概况 309-311 1-10 第20卷, 第5期 2 * |
《光明中医杂志》 19970331 王万袒 类风湿性关节炎治疗近况 44-48 1-10 , 第3期 2 * |
《山东中医杂志》 20040731 王宗怡 类风湿关节炎四大主症用药体会 413-414 1-10 第23卷, 第7期 2 * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102397523B (zh) * | 2011-11-28 | 2013-03-13 | 吕会辰 | 一种治疗风湿、类风湿性关节炎和颈肩腰腿疼的药物 |
CN102397523A (zh) * | 2011-11-28 | 2012-04-04 | 吕会辰 | 一种治疗风湿、类风湿性关节炎和颈肩腰腿疼的药物 |
CN102716262A (zh) * | 2012-06-29 | 2012-10-10 | 隋孝忠 | 一种治疗强直性脊柱炎的中药配方 |
CN102836406A (zh) * | 2012-09-03 | 2012-12-26 | 黄天佑 | 一种筋骨膏及其制备方法 |
CN102836406B (zh) * | 2012-09-03 | 2014-04-09 | 黄天佑 | 一种筋骨膏及其制备方法 |
CN103705658B (zh) * | 2013-12-29 | 2016-03-30 | 纪忠义 | 一种治疗类风湿性关节炎的中药外敷剂 |
CN103705658A (zh) * | 2013-12-29 | 2014-04-09 | 纪忠义 | 一种治疗类风湿性关节炎的中药外敷剂 |
CN104042759A (zh) * | 2014-06-28 | 2014-09-17 | 黄翠萍 | 一种内服外用治疗关节疼痛的中药 |
CN105943705A (zh) * | 2016-01-04 | 2016-09-21 | 青岛申达高新技术开发有限公司 | 一种治疗类风湿性关节炎的中药组合物及其制备方法 |
CN109833433A (zh) * | 2019-03-27 | 2019-06-04 | 刘果林 | 一种有效治疗风湿骨伤病的中药配方 |
CN110478416A (zh) * | 2019-09-27 | 2019-11-22 | 首都医科大学附属北京朝阳医院 | 治疗风湿性类风湿性关节炎的组合物及其制备方法和应用 |
CN110478416B (zh) * | 2019-09-27 | 2021-10-08 | 首都医科大学附属北京朝阳医院 | 治疗风湿性类风湿性关节炎的组合物及其制备方法和应用 |
CN111450137A (zh) * | 2020-05-15 | 2020-07-28 | 上海希尔维生物科技有限公司 | 一种促毛发生长的杜仲/淫羊藿植物提取物溶液及其应用 |
Also Published As
Publication number | Publication date |
---|---|
CN102178800B (zh) | 2012-02-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102178800B (zh) | 一种治疗类风湿性关节炎的中药组合物及其制备方法 | |
CN102078473B (zh) | 一种治疗慢性乙型肝炎的中药制剂及其制备方法 | |
CN101455738B (zh) | 一种治疗湿疹的中药组合物及其制备方法 | |
CN102178804B (zh) | 一种治疗肛周湿疹的中药组合物及其制备方法 | |
CN101433654B (zh) | 一种治疗妇女慢性盆腔炎的中药制剂及其制备方法 | |
CN102166278B (zh) | 一种治疗小儿类风湿性关节炎的中药组合物及其制备方法 | |
CN103520572A (zh) | 一种用于治疗特应性皮炎的中药组合物及其制备方法 | |
CN101518600B (zh) | 一种治疗细菌或真菌性皮肤病的中药组合物及其制备方法 | |
CN104666698A (zh) | 一种治疗膝关节滑膜炎的中药外用膏剂及其制备方法 | |
CN102488879A (zh) | 一种用于治疗风湿痹症的药物组合物 | |
CN104689226A (zh) | 一种治疗小儿类风湿性关节炎的中药组合物及其制备方法 | |
CN104274788A (zh) | 一种治疗妇女肝火湿热型带下的中药组合物及其制备方法 | |
CN104666579A (zh) | 一种治疗膝关节滑膜炎的中药组合物及其制备方法 | |
CN102000164B (zh) | 一种治疗银屑病的中药组合物及其制备方法 | |
CN103055285B (zh) | 治疗早期肝硬化的中药及其制备方法 | |
CN101897821A (zh) | 一种活血通络止痛的颗粒剂及其制备和质量控制方法 | |
CN102847061B (zh) | 一种治疗小儿病毒性心肌炎的中药制剂及其制备方法 | |
CN102178781B (zh) | 一种治疗阴囊湿疹的中药组合物及其制备方法 | |
CN105943705A (zh) | 一种治疗类风湿性关节炎的中药组合物及其制备方法 | |
CN104771578A (zh) | 用于治疗变应性鼻炎的中药 | |
CN103191399A (zh) | 用于治疗支气管哮喘急性发作期的中药组合物 | |
CN105435131A (zh) | 一种治疗慢性心衰的中药组合物及其制备方法 | |
CN103948856A (zh) | 一种治疗瘀阻脉络证型胸痹心痛的中药 | |
CN103520352A (zh) | 治疗瘀阻脉络证型胸痹心痛的中药 | |
CN102552824B (zh) | 用于治疗银屑病的中成药 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NANTONG WEEK TOURISM DEVELOPMENT CO., LTD. Free format text: FORMER OWNER: KONG JIAN Effective date: 20130829 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 264006 YANTAI, SHANDONG PROVINCE TO: 226121 NANTONG, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20130829 Address after: 226121 Jiangsu province Nantong markets three factory town Road No. 79 Patentee after: NANTONG SUNDAY TOURISM DEVELOPMENT CO.,LTD. Address before: 264006 No. 92, Yantai economic and Technological Development Zone, Shandong, Zhujianglu Road Patentee before: Kong Jian |
|
TR01 | Transfer of patent right |
Effective date of registration: 20181207 Address after: 344000 70 building, A10 building, business incubation base, Fuzhou hi tech Industrial Development Zone, Fuzhou, Jiangxi, China. 2 Patentee after: Jiangxi Bofen Medical Devices Co.,Ltd. Address before: 226121 No. three vegetable market road, three factory town, Nantong, Jiangsu Patentee before: NANTONG SUNDAY TOURISM DEVELOPMENT CO.,LTD. |
|
TR01 | Transfer of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120229 |
|
CF01 | Termination of patent right due to non-payment of annual fee |