CN102164892A - 抗疟疾化合物 - Google Patents

抗疟疾化合物 Download PDF

Info

Publication number
CN102164892A
CN102164892A CN2009801378005A CN200980137800A CN102164892A CN 102164892 A CN102164892 A CN 102164892A CN 2009801378005 A CN2009801378005 A CN 2009801378005A CN 200980137800 A CN200980137800 A CN 200980137800A CN 102164892 A CN102164892 A CN 102164892A
Authority
CN
China
Prior art keywords
independently
described method
compound
halogen
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801378005A
Other languages
English (en)
Chinese (zh)
Inventor
理查德·W·斯科特
多龙·格林鲍姆
刘大慧
范晓东
徐永江
唐海忠
埃哈布·哈利勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Polymedix Inc
Original Assignee
University of Pennsylvania Penn
Polymedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn, Polymedix Inc filed Critical University of Pennsylvania Penn
Publication of CN102164892A publication Critical patent/CN102164892A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/90—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a six-membered aromatic ring, e.g. amino-diphenylethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2009801378005A 2008-07-28 2009-07-28 抗疟疾化合物 Pending CN102164892A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8397208P 2008-07-28 2008-07-28
US61/083,972 2008-07-28
US16246709P 2009-03-23 2009-03-23
US61/162,467 2009-03-23
PCT/US2009/051909 WO2010014573A1 (en) 2008-07-28 2009-07-28 Anti-malarial compounds

Publications (1)

Publication Number Publication Date
CN102164892A true CN102164892A (zh) 2011-08-24

Family

ID=41610687

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801378005A Pending CN102164892A (zh) 2008-07-28 2009-07-28 抗疟疾化合物

Country Status (12)

Country Link
US (2) US8796275B2 (US06894165-20050517-C00155.png)
EP (1) EP2321275A4 (US06894165-20050517-C00155.png)
JP (1) JP2011529502A (US06894165-20050517-C00155.png)
KR (1) KR20110063435A (US06894165-20050517-C00155.png)
CN (1) CN102164892A (US06894165-20050517-C00155.png)
AU (1) AU2009276744A1 (US06894165-20050517-C00155.png)
BR (1) BRPI0916649A2 (US06894165-20050517-C00155.png)
CA (1) CA2732572A1 (US06894165-20050517-C00155.png)
IL (1) IL210935A0 (US06894165-20050517-C00155.png)
MX (1) MX2011000971A (US06894165-20050517-C00155.png)
RU (1) RU2530899C2 (US06894165-20050517-C00155.png)
WO (1) WO2010014573A1 (US06894165-20050517-C00155.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110869350A (zh) * 2017-07-04 2020-03-06 赛诺菲 炔基化合物，其制备及其治疗用途

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090092574A1 (en) * 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
US8278309B2 (en) * 2008-10-27 2012-10-02 Polymedix, Inc. Synthetic mimetics of host defense and uses thereof
JP2013516470A (ja) * 2010-01-07 2013-05-13 ポリメディックス・インコーポレーテッド 抗ヘパリン化合物
US20120258141A9 (en) * 2010-07-07 2012-10-11 University Of Medicine And Dentistry Of New Jersey Methods Of Immune Modulation
TW201208677A (en) * 2010-08-21 2012-03-01 Polymedix Inc Facially amphiphilic compounds, compositions, and uses thereof in treating cancer
RU2453533C1 (ru) * 2011-02-08 2012-06-20 Государственное образовательное учреждение высшего профессионального образования "Ярославский государственный университет им. П.Г. Демидова" Способ получения 1,3- и 1,4-бис(2-амино-4-(трифторметил)фенокси)бензола
CN103957710B (zh) 2011-05-16 2016-04-20 塞尔西优蒂克斯公司 用于治疗粘膜炎的化合物
SG11201403215TA (en) 2011-12-13 2014-09-26 Cellceutix Corp Cyclic compounds and methods of making and using the same
KR101939710B1 (ko) * 2011-12-21 2019-01-17 노비라 테라퓨틱스, 인코포레이티드 B형 간염의 항바이러스성 제제
US20150094294A1 (en) * 2012-02-29 2015-04-02 Cellceutix Corporation Compounds and methods for treating malaria
KR102307287B1 (ko) * 2013-08-30 2021-09-29 가부시키가이샤 한도오따이 에네루기 켄큐쇼 유기 화합물, 발광 소자, 발광 장치, 전자 기기, 및 조명 장치
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB951797A (en) * 1960-12-20 1964-03-11 Monsanto Chemicals Heterocyclic compounds
US3450772A (en) * 1964-12-04 1969-06-17 Mobil Oil Corp Polyphenyl ethers
SU425905A1 (ru) * 1972-07-27 1974-04-30 Ю. А. Москвичев, Г. С. Миронов, М. И. Фарберов, СПОСОБ ПОЛУЧЕНИЯ п,п'-БИС-
SU1121264A1 (ru) * 1983-04-29 1984-10-30 Московский ордена Ленина и ордена Трудового Красного Знамени химико-технологический институт им.Д.И.Менделеева Способ получени 3,6-бис(диметиламино)тиоксантен-10,10-диоксида
US5310726A (en) * 1990-03-19 1994-05-10 Merck & Co., Inc. Lipopeptide compounds
US5066409A (en) * 1990-09-12 1991-11-19 The Dow Chemical Company Novel aryl ether sulfones
JPH07506340A (ja) * 1991-12-31 1995-07-13 ザ　ウースター　ファウンデイション　フォア　バイオメディカル　リサーチ 薬剤耐性マラリアに対する駆虫性オリゴヌクレオチドの活性
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
RU2067572C1 (ru) * 1994-02-04 1996-10-10 Ярославский государственный технический университет Многоядерные бисазиды
US5641737A (en) * 1995-12-18 1997-06-24 The United States Of America As Represented By The Secretary Of The Air Force Powdered sulfones as high temperature lubricants
JP2003523927A (ja) * 1998-08-20 2003-08-12 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル ジカチオンジベンゾフランおよびジベンゾチオフェン化合物並びにその使用法
US6229012B1 (en) * 1998-10-01 2001-05-08 Xerox Corporation Triazine compositions
US6645531B1 (en) * 2000-01-06 2003-11-11 Marantech Holding Llc Multivalent electron active compositions and methods of making and using same
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
TW532048B (en) 2000-03-27 2003-05-11 Idemitsu Kosan Co Organic electroluminescence element
US6420342B1 (en) * 2000-05-08 2002-07-16 N.V. Nutricia Nutritional preparation comprising ribose and medical use thereof
WO2002039987A2 (en) 2000-11-14 2002-05-23 Neurosearch A/S Use of malaria parasite anion channel blockers for treating malaria
CA2433772C (en) * 2001-02-14 2008-10-07 Warner-Lambert Company Llc Pyrimidine matrix metalloproteinase inhibitors
DE10109204A1 (de) * 2001-02-26 2002-09-19 4Sc Ag Verbindungen zur Behandlung von Protozoen-Erkrankungen
CN100366703C (zh) 2002-03-22 2008-02-06 出光兴产株式会社 用于有机电致发光器件的材料以及使用该材料的有机电致发光器件
WO2004035577A2 (en) * 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
EP1608313A4 (en) * 2003-03-17 2009-05-06 Univ Pennsylvania AMPHIPHILIC SURFACE POLYMERS AND OLIGOMERS AND USES THEREOF
US7169857B2 (en) * 2003-10-03 2007-01-30 Virginia Commonwealth University Homogenous compositions of fluoropolymers and crystalline solids or cross-linking agents and methods of making the same
JP5112601B2 (ja) * 2003-10-07 2013-01-09 三井化学株式会社 複素環化合物および該化合物を含有する有機電界発光素子
WO2006021833A2 (en) * 2003-11-25 2006-03-02 University Of Cincinnati Bisbenzamidines for the treatment of pneumonia
EP1711455A4 (en) * 2004-01-23 2007-11-07 Univ Pennsylvania POLYARYL AND POLYARYLALKYNYL OLIGOMERS AMPHIPHILES AT THE FACIAL LEVEL
US7504769B2 (en) * 2004-12-16 2009-03-17 E. I. Du Pont De Nemours + Company Aromatic chalcogen compounds and their use
CA2599205A1 (en) * 2005-02-25 2006-09-08 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer
RU2296756C2 (ru) * 2005-05-17 2007-04-10 Федеральное унитарное государственное предприятие "Государственный научно-исследовательский институт биологического приборостроения" (ГосНИИ БП) Комплексообразующие дибензосодержащие пятичленные циклические соединения, содержащие два симметричных бета-дикарбонильных заместителя с фторированными радикалами
US20070224446A1 (en) * 2006-03-24 2007-09-27 Idemitsu Kosan Co., Ltd. Material for organic electroluminescence device and organic electroluminescence device using the same
JP2008137978A (ja) * 2006-12-05 2008-06-19 Canon Inc カルバゾール誘導体及びこれを用いた有機発光素子
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110869350A (zh) * 2017-07-04 2020-03-06 赛诺菲 炔基化合物，其制备及其治疗用途
CN110869350B (zh) * 2017-07-04 2023-05-02 赛诺菲 炔基化合物，其制备及其治疗用途

Also Published As

Publication number Publication date
RU2530899C2 (ru) 2014-10-20
IL210935A0 (en) 2011-07-31
BRPI0916649A2 (pt) 2015-08-04
KR20110063435A (ko) 2011-06-10
US8796275B2 (en) 2014-08-05
MX2011000971A (es) 2011-06-24
RU2011107295A (ru) 2012-09-10
AU2009276744A1 (en) 2010-02-04
WO2010014573A1 (en) 2010-02-04
US20150072997A1 (en) 2015-03-12
EP2321275A4 (en) 2012-05-09
US20100081665A1 (en) 2010-04-01
EP2321275A1 (en) 2011-05-18
JP2011529502A (ja) 2011-12-08
CA2732572A1 (en) 2010-02-04

Similar Documents

Publication Publication Date Title
CN102164892A (zh) 抗疟疾化合物
CN102947265B (zh) 赖氨酸特异性脱甲基酶-1抑制剂及其应用
CN105392483B (zh) 用于抑制磷酸盐转运的nhe3结合化合物和方法
ES2741444T3 (es) Inhibidores de la replicación de virus de la gripe
US20140329833A1 (en) Lysine demethylase inhibitors for inflammatory diseases or conditions
CN102369202A (zh) 氮杂喹啉酮衍生物及其应用
CN102548986A (zh) 氨基吡咯烷酮衍生物及其用途
US20220119384A1 (en) Potent antiviral pyrazolopyridine compounds
JP2016029053A (ja) クコアミンｂの塩及び製造方法と応用
CN103957710A (zh) 用于治疗粘膜炎的化合物
KR101376231B1 (ko) 새싹보리 추출물을 포함하는 뉴라미니데이즈 활성 억제용 조성물 및 인플루엔자 바이러스 감염 질환의 예방 및 치료용 약학적 조성물
CN102906110B (zh) 基于氯高铁血红素衍生物的抗微生物剂
CN103347849B (zh) 富勒烯с60的均聚氨基酸和杂多氨基酸衍生物、其制备方法和基于该衍生物的药物组合物
EP3409664B1 (en) Application of substituted cinnamamide derivatives in preparation of anti-anxiety medications
JP2009537511A (ja) ガエグリン５から合成され取り出された抗菌性及び抗癌性の新規ペプチド類縁体
CN105348222B (zh) 化合物pac-1或其盐及包含它们的药物组合物
JP2010520236A (ja) リソフィリンアナログとその使用法
US20130052137A1 (en) Para amino benzoic acid based nanotubes
US10596193B2 (en) Copper (I) complexes with glycine, pyruvate, and succinate
CN113185447A (zh) 邻苯二甲酰半胱酰胺类化合物、其制备方法和用途
CN102291991A (zh) 用于治疗分枝杆菌的多重耐药和广泛耐药菌株的抗菌分子
CN104447481A (zh) 苯甲酸硫脲类抗流感病毒化合物及其制备方法和用途
CN114989246B (zh) Fk3多肽类似物及其应用
US20120122822A1 (en) Compositions for reducing beta-amyloid-induced neurotoxicity comprising beta-secretase inhibitor
WO2023155757A1 (zh) 基于菝契皂苷元结构的衍生物及其药物组合物的用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: CELSI YOUTIX CORP.

Free format text: FORMER OWNER: POLYMEDIX INC

Effective date: 20140415

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20140415

Address after: Massachusetts, USA

Applicant after: POLYMEDIX INC.

Applicant after: The Trustees of The University of Pennsylvania

Address before: American Pennsylvania

Applicant before: Polymedix Inc

Applicant before: The Trustees of The University of Pennsylvania

AD01 Patent right deemed abandoned

Effective date of abandoning: 20110824

C20 Patent right or utility model deemed to be abandoned or is abandoned