CN102159579B - 三环吲哚衍生物及其使用方法 - Google Patents

三环吲哚衍生物及其使用方法 Download PDF

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Publication number
CN102159579B
CN102159579B CN200980131569.9A CN200980131569A CN102159579B CN 102159579 B CN102159579 B CN 102159579B CN 200980131569 A CN200980131569 A CN 200980131569A CN 102159579 B CN102159579 B CN 102159579B
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China
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compound
mmol
antiviral agent
agent comprises
extra
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CN200980131569.9A
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English (en)
Chinese (zh)
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CN102159579A (zh
Inventor
S.文卡特拉曼
G.N.阿尼尔库马
K.X.陈
F.贝拉斯克斯
Q.曾
D.刘
Y.蒋
J.A.科兹洛夫斯基
F.G.约罗格
S.B.罗森布卢姆
S.J.加瓦拉斯
P.A.平托
O.B.赛柳丁
B.维布尔班
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Merck Sharp and Dohme BV
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Merck and Co Inc
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Publication of CN102159579A publication Critical patent/CN102159579A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980131569.9A 2008-06-13 2009-06-10 三环吲哚衍生物及其使用方法 Active CN102159579B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6134408P 2008-06-13 2008-06-13
US61/061344 2008-06-13
US61/061,344 2008-06-13
PCT/US2009/046822 WO2009152200A1 (en) 2008-06-13 2009-06-10 Tricyclic indole derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
CN102159579A CN102159579A (zh) 2011-08-17
CN102159579B true CN102159579B (zh) 2015-03-25

Family

ID=40943627

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980131569.9A Active CN102159579B (zh) 2008-06-13 2009-06-10 三环吲哚衍生物及其使用方法

Country Status (9)

Country Link
US (1) US8901139B2 (https=)
EP (1) EP2303893B1 (https=)
JP (1) JP5580814B2 (https=)
CN (1) CN102159579B (https=)
AR (1) AR072088A1 (https=)
CA (1) CA2727620A1 (https=)
MX (1) MX2010013630A (https=)
TW (1) TW201011030A (https=)
WO (1) WO2009152200A1 (https=)

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AU2007339382B2 (en) 2006-12-22 2013-05-02 Merck Sharp & Dohme Llc 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
KR102127406B1 (ko) 2012-09-20 2020-06-29 유디씨 아일랜드 리미티드 전자 응용을 위한 아자디벤조푸란
ES2688147T3 (es) 2014-03-21 2018-10-31 Bristol-Myers Squibb Company Compuestos de 6H-furo[2,3-e]indol para el tratamiento de la hepatitis C
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
WO2018151239A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６－ジヒドロ－２Ｈ－フロ［２，３－ｅ］インドール化合物
CN116063310A (zh) * 2022-12-23 2023-05-05 齐鲁工业大学 一种呋喃并[3,4-b]吲哚衍生物及其合成方法

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CN101098695A (zh) * 2004-03-01 2008-01-02 维洛药品公司 吡喃并吲哚衍生物及其用于治疗丙型肝炎病毒感染或者疾病的用途
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Also Published As

Publication number Publication date
JP2011524359A (ja) 2011-09-01
EP2303893A1 (en) 2011-04-06
AR072088A1 (es) 2010-08-04
CA2727620A1 (en) 2009-12-17
JP5580814B2 (ja) 2014-08-27
TW201011030A (en) 2010-03-16
US8901139B2 (en) 2014-12-02
US20110189127A1 (en) 2011-08-04
WO2009152200A1 (en) 2009-12-17
MX2010013630A (es) 2010-12-21
EP2303893B1 (en) 2016-12-07
CN102159579A (zh) 2011-08-17

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Legal Events

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C06 Publication
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SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Address after: New jersey, USA

Applicant after: MERCK SHARP & DOHME Corp.

Address before: New jersey, USA

Applicant before: SCHERING Corp.

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: SCHERING CORP (US) TO: MSD CORP.

C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20220901

Address after: new jersey

Patentee after: MERCK SHARP & DOHME B.V.

Address before: new jersey

Patentee before: MERCK SHARP & DOHME Corp.

TR01 Transfer of patent right