JP5580814B2 - ３環式インドール誘導体およびその使用方法 - Google Patents

３環式インドール誘導体およびその使用方法 Download PDF

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Publication number
JP5580814B2
JP5580814B2 JP2011513649A JP2011513649A JP5580814B2 JP 5580814 B2 JP5580814 B2 JP 5580814B2 JP 2011513649 A JP2011513649 A JP 2011513649A JP 2011513649 A JP2011513649 A JP 2011513649A JP 5580814 B2 JP5580814 B2 JP 5580814B2
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Japan
Prior art keywords
compound
pharmaceutically acceptable
mmol
acceptable salt
additional antiviral
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JP2011513649A
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English (en)
Japanese (ja)
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JP2011524359A5 (https=
JP2011524359A (ja
Inventor
スリカンス ベンカトラマン，
ゴピナダン エヌ． アニルクマール，
ケビン エックス． チェン，
フランシスコ ベラクエス，
チンベイ ツェン，
デュアン リュー，
ユーヘン チャン，
ジョセフ エー． コズロウスキー，
エフ． ジョージ ヌジョロージュ，
ステュアート ビー． ローセンブラム，
スティーブン ジェイ． ガバラス，
パトリック エー． ピント，
オレグ ビー． セルユーティン，
バンチャ ビバルバーン，
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of JP2011524359A publication Critical patent/JP2011524359A/ja
Publication of JP2011524359A5 publication Critical patent/JP2011524359A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011513649A 2008-06-13 2009-06-10 ３環式インドール誘導体およびその使用方法 Active JP5580814B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6134408P 2008-06-13 2008-06-13
US61/061,344 2008-06-13
PCT/US2009/046822 WO2009152200A1 (en) 2008-06-13 2009-06-10 Tricyclic indole derivatives and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2011524359A JP2011524359A (ja) 2011-09-01
JP2011524359A5 JP2011524359A5 (https=) 2012-06-07
JP5580814B2 true JP5580814B2 (ja) 2014-08-27

Family

ID=40943627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011513649A Active JP5580814B2 (ja) 2008-06-13 2009-06-10 ３環式インドール誘導体およびその使用方法

Country Status (9)

Country Link
US (1) US8901139B2 (https=)
EP (1) EP2303893B1 (https=)
JP (1) JP5580814B2 (https=)
CN (1) CN102159579B (https=)
AR (1) AR072088A1 (https=)
CA (1) CA2727620A1 (https=)
MX (1) MX2010013630A (https=)
TW (1) TW201011030A (https=)
WO (1) WO2009152200A1 (https=)

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US8557848B2 (en) 2006-12-22 2013-10-15 Merck Sharp & Dohme Corp. 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
WO2014044722A1 (en) 2012-09-20 2014-03-27 Basf Se Azadibenzofurans for electronic applications
WO2015143257A1 (en) * 2014-03-21 2015-09-24 Bristol-Myers Squibb Company 6h-furo[2,3-e]indole compounds for the treatment of hepatitis c
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
WO2018151239A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６－ジヒドロ－２Ｈ－フロ［２，３－ｅ］インドール化合物
CN116063310A (zh) * 2022-12-23 2023-05-05 齐鲁工业大学 一种呋喃并[3,4-b]吲哚衍生物及其合成方法

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Also Published As

Publication number Publication date
AR072088A1 (es) 2010-08-04
EP2303893A1 (en) 2011-04-06
WO2009152200A1 (en) 2009-12-17
CN102159579B (zh) 2015-03-25
US8901139B2 (en) 2014-12-02
TW201011030A (en) 2010-03-16
MX2010013630A (es) 2010-12-21
CA2727620A1 (en) 2009-12-17
JP2011524359A (ja) 2011-09-01
EP2303893B1 (en) 2016-12-07
US20110189127A1 (en) 2011-08-04
CN102159579A (zh) 2011-08-17

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