CA2727620A1 - Tricyclic indole derivatives and methods of use thereof - Google Patents

Tricyclic indole derivatives and methods of use thereof Download PDF

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Publication number
CA2727620A1
CA2727620A1 CA2727620A CA2727620A CA2727620A1 CA 2727620 A1 CA2727620 A1 CA 2727620A1 CA 2727620 A CA2727620 A CA 2727620A CA 2727620 A CA2727620 A CA 2727620A CA 2727620 A1 CA2727620 A1 CA 2727620A1
Authority
CA
Canada
Prior art keywords
compound
mmol
inhibitor
additional antiviral
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2727620A
Other languages
English (en)
French (fr)
Inventor
Srikanth Venkatraman
Gopinadhan N. Anilkumar
Kevin X. Chen
Francisco Velazquez
Qingbei Zeng
Duan Liu
Yueheng Jiang
Joseph A. Kozlowski
F. George Njoroge
Stuart B. Rosenblum
Stephen J. Gavalas
Patrick A. Pinto
Oleg B. Selyutin
Bancha Vibulbhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2727620A1 publication Critical patent/CA2727620A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2727620A 2008-06-13 2009-06-10 Tricyclic indole derivatives and methods of use thereof Abandoned CA2727620A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6134408P 2008-06-13 2008-06-13
US61/061,344 2008-06-13
PCT/US2009/046822 WO2009152200A1 (en) 2008-06-13 2009-06-10 Tricyclic indole derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2727620A1 true CA2727620A1 (en) 2009-12-17

Family

ID=40943627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2727620A Abandoned CA2727620A1 (en) 2008-06-13 2009-06-10 Tricyclic indole derivatives and methods of use thereof

Country Status (9)

Country Link
US (1) US8901139B2 (https=)
EP (1) EP2303893B1 (https=)
JP (1) JP5580814B2 (https=)
CN (1) CN102159579B (https=)
AR (1) AR072088A1 (https=)
CA (1) CA2727620A1 (https=)
MX (1) MX2010013630A (https=)
TW (1) TW201011030A (https=)
WO (1) WO2009152200A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007339382B2 (en) 2006-12-22 2013-05-02 Merck Sharp & Dohme Llc 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
KR102127406B1 (ko) 2012-09-20 2020-06-29 유디씨 아일랜드 리미티드 전자 응용을 위한 아자디벤조푸란
ES2688147T3 (es) 2014-03-21 2018-10-31 Bristol-Myers Squibb Company Compuestos de 6H-furo[2,3-e]indol para el tratamiento de la hepatitis C
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
WO2018151239A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６－ジヒドロ－２Ｈ－フロ［２，３－ｅ］インドール化合物
CN116063310A (zh) * 2022-12-23 2023-05-05 齐鲁工业大学 一种呋喃并[3,4-b]吲哚衍生物及其合成方法

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Also Published As

Publication number Publication date
JP2011524359A (ja) 2011-09-01
EP2303893A1 (en) 2011-04-06
AR072088A1 (es) 2010-08-04
CN102159579B (zh) 2015-03-25
JP5580814B2 (ja) 2014-08-27
TW201011030A (en) 2010-03-16
US8901139B2 (en) 2014-12-02
US20110189127A1 (en) 2011-08-04
WO2009152200A1 (en) 2009-12-17
MX2010013630A (es) 2010-12-21
EP2303893B1 (en) 2016-12-07
CN102159579A (zh) 2011-08-17

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140610

FZDE Dead

Effective date: 20180327