CN102159579B - 三环吲哚衍生物及其使用方法 - Google Patents

三环吲哚衍生物及其使用方法 Download PDF

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Publication number
CN102159579B
CN102159579B CN200980131569.9A CN200980131569A CN102159579B CN 102159579 B CN102159579 B CN 102159579B CN 200980131569 A CN200980131569 A CN 200980131569A CN 102159579 B CN102159579 B CN 102159579B
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China
Prior art keywords
compound
mmol
antiviral agent
agent comprises
extra
Prior art date
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CN200980131569.9A
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English (en)
Chinese (zh)
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CN102159579A (zh
Inventor
S.文卡特拉曼
G.N.阿尼尔库马
K.X.陈
F.贝拉斯克斯
Q.曾
D.刘
Y.蒋
J.A.科兹洛夫斯基
F.G.约罗格
S.B.罗森布卢姆
S.J.加瓦拉斯
P.A.平托
O.B.赛柳丁
B.维布尔班
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Merck Sharp & Dohme BV
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Schering Corp
Merck Sharp & Dohme LLC
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Publication of CN102159579A publication Critical patent/CN102159579A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980131569.9A 2008-06-13 2009-06-10 三环吲哚衍生物及其使用方法 Active CN102159579B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6134408P 2008-06-13 2008-06-13
US61/061344 2008-06-13
US61/061,344 2008-06-13
PCT/US2009/046822 WO2009152200A1 (en) 2008-06-13 2009-06-10 Tricyclic indole derivatives and methods of use thereof

Publications (2)

Publication Number Publication Date
CN102159579A CN102159579A (zh) 2011-08-17
CN102159579B true CN102159579B (zh) 2015-03-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980131569.9A Active CN102159579B (zh) 2008-06-13 2009-06-10 三环吲哚衍生物及其使用方法

Country Status (9)

Country Link
US (1) US8901139B2 (cg-RX-API-DMAC10.html)
EP (1) EP2303893B1 (cg-RX-API-DMAC10.html)
JP (1) JP5580814B2 (cg-RX-API-DMAC10.html)
CN (1) CN102159579B (cg-RX-API-DMAC10.html)
AR (1) AR072088A1 (cg-RX-API-DMAC10.html)
CA (1) CA2727620A1 (cg-RX-API-DMAC10.html)
MX (1) MX2010013630A (cg-RX-API-DMAC10.html)
TW (1) TW201011030A (cg-RX-API-DMAC10.html)
WO (1) WO2009152200A1 (cg-RX-API-DMAC10.html)

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JP5079818B2 (ja) 2006-12-22 2012-11-21 メルク・シャープ・アンド・ドーム・コーポレーション Ｈｃｖおよび関連するウイルス疾患の治療または予防のための４，５−環インドール誘導体
CN113943306A (zh) 2012-09-20 2022-01-18 Udc 爱尔兰有限责任公司 供电子应用的氮杂二苯并呋喃和包含氮杂二苯并呋喃的电子器件
ES2688147T3 (es) 2014-03-21 2018-10-31 Bristol-Myers Squibb Company Compuestos de 6H-furo[2,3-e]indol para el tratamiento de la hepatitis C
WO2015160636A1 (en) 2014-04-16 2015-10-22 Merck Sharp & Dohme Corp. Factor ixa inhibitors
WO2018151239A1 (ja) * 2017-02-17 2018-08-23 第一三共株式会社 ３，６－ジヒドロ－２Ｈ－フロ［２，３－ｅ］インドール化合物
CN116063310A (zh) * 2022-12-23 2023-05-05 齐鲁工业大学 一种呋喃并[3,4-b]吲哚衍生物及其合成方法

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CN1863528A (zh) * 2003-10-10 2006-11-15 P.安杰莱蒂分子生物学研究所 作为抗病毒剂的吲哚和吖吲哚
CN101098695A (zh) * 2004-03-01 2008-01-02 维洛药品公司 吡喃并吲哚衍生物及其用于治疗丙型肝炎病毒感染或者疾病的用途
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Also Published As

Publication number Publication date
TW201011030A (en) 2010-03-16
AR072088A1 (es) 2010-08-04
US20110189127A1 (en) 2011-08-04
CA2727620A1 (en) 2009-12-17
EP2303893A1 (en) 2011-04-06
JP5580814B2 (ja) 2014-08-27
JP2011524359A (ja) 2011-09-01
US8901139B2 (en) 2014-12-02
WO2009152200A1 (en) 2009-12-17
CN102159579A (zh) 2011-08-17
EP2303893B1 (en) 2016-12-07
MX2010013630A (es) 2010-12-21

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Address after: New jersey, USA

Applicant after: MERCK SHARP & DOHME Corp.

Address before: New jersey, USA

Applicant before: SCHERING Corp.

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Address before: new jersey

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TR01 Transfer of patent right