CN102154139A - 热带假丝酵母细胞及其用途 - Google Patents
热带假丝酵母细胞及其用途 Download PDFInfo
- Publication number
- CN102154139A CN102154139A CN2010106107682A CN201010610768A CN102154139A CN 102154139 A CN102154139 A CN 102154139A CN 2010106107682 A CN2010106107682 A CN 2010106107682A CN 201010610768 A CN201010610768 A CN 201010610768A CN 102154139 A CN102154139 A CN 102154139A
- Authority
- CN
- China
- Prior art keywords
- sequence number
- candida tropicalis
- hydroxyl
- gene
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000222178 Candida tropicalis Species 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 claims abstract description 45
- 108090000623 proteins and genes Proteins 0.000 claims description 49
- 230000000694 effects Effects 0.000 claims description 21
- 239000002773 nucleotide Substances 0.000 claims description 16
- 125000003729 nucleotide group Chemical group 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 10
- 150000002148 esters Chemical class 0.000 claims description 9
- 125000004432 carbon atom Chemical group C* 0.000 claims description 8
- 239000003550 marker Substances 0.000 claims description 7
- 230000001580 bacterial effect Effects 0.000 claims description 6
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims description 5
- 230000009467 reduction Effects 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims description 4
- 150000004703 alkoxides Chemical class 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 230000007423 decrease Effects 0.000 claims description 4
- 230000009368 gene silencing by RNA Effects 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 2
- 239000002253 acid Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- UQDUPQYQJKYHQI-UHFFFAOYSA-N methyl laurate Chemical compound CCCCCCCCCCCC(=O)OC UQDUPQYQJKYHQI-UHFFFAOYSA-N 0.000 description 4
- 150000007523 nucleic acids Chemical group 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 150000004702 methyl esters Chemical class 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 101150053659 POX4 gene Proteins 0.000 description 2
- 101150004239 POX5 gene Proteins 0.000 description 2
- 238000005576 amination reaction Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- -1 polysiloxane Polymers 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- ZDHCZVWCTKTBRY-UHFFFAOYSA-N 12-hydroxylauric acid Chemical compound OCCCCCCCCCCCC(O)=O ZDHCZVWCTKTBRY-UHFFFAOYSA-N 0.000 description 1
- WTKWFNIIIXNTDO-UHFFFAOYSA-N 3-isocyanato-5-methyl-2-(trifluoromethyl)furan Chemical compound CC1=CC(N=C=O)=C(C(F)(F)F)O1 WTKWFNIIIXNTDO-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 101100161762 Candida tropicalis POX5 gene Proteins 0.000 description 1
- 101100084403 Homo sapiens PRODH gene Proteins 0.000 description 1
- 102000008109 Mixed Function Oxygenases Human genes 0.000 description 1
- 108010074633 Mixed Function Oxygenases Proteins 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 101710157860 Oxydoreductase Proteins 0.000 description 1
- 101150059359 POX2 gene Proteins 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 101001010097 Shigella phage SfV Bactoprenol-linked glucose translocase Proteins 0.000 description 1
- 241000218636 Thuja Species 0.000 description 1
- 101100029251 Zea mays PER2 gene Proteins 0.000 description 1
- XBJFCYDKBDVADW-UHFFFAOYSA-N acetonitrile;formic acid Chemical compound CC#N.OC=O XBJFCYDKBDVADW-UHFFFAOYSA-N 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000036983 biotransformation Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000000769 gas chromatography-flame ionisation detection Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000012022 methylating agents Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- TVIDDXQYHWJXFK-UHFFFAOYSA-N n-Dodecanedioic acid Natural products OC(=O)CCCCCCCCCCC(O)=O TVIDDXQYHWJXFK-UHFFFAOYSA-N 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- HQHCYKULIHKCEB-UHFFFAOYSA-N tetradecanedioic acid Natural products OC(=O)CCCCCCCCCCCCC(O)=O HQHCYKULIHKCEB-UHFFFAOYSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 150000003544 thiamines Chemical class 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- MDTPTXSNPBAUHX-UHFFFAOYSA-M trimethylsulfanium;hydroxide Chemical compound [OH-].C[S+](C)C MDTPTXSNPBAUHX-UHFFFAOYSA-M 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
- C07C67/42—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester by oxidation of secondary alcohols or ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/004—Cytochrome-b5 reductase (1.6.2.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01001—Alcohol dehydrogenase (1.1.1.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009046626A DE102009046626A1 (de) | 2009-11-11 | 2009-11-11 | Candida tropicalis Zellen und deren Verwendung |
| DE102009046626.6 | 2009-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102154139A true CN102154139A (zh) | 2011-08-17 |
Family
ID=43558054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010106107682A Pending CN102154139A (zh) | 2009-11-11 | 2010-11-10 | 热带假丝酵母细胞及其用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20110118433A1 (enExample) |
| EP (5) | EP2602313B1 (enExample) |
| JP (2) | JP2011101643A (enExample) |
| CN (1) | CN102154139A (enExample) |
| DE (1) | DE102009046626A1 (enExample) |
| ES (3) | ES2631987T3 (enExample) |
| SG (2) | SG171538A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104745490A (zh) * | 2015-03-20 | 2015-07-01 | 上海应用技术学院 | 一种热带假丝酵母菌及利用其作为生物催化剂制备异辛酸的方法 |
| CN106497912A (zh) * | 2016-10-13 | 2017-03-15 | 江苏大学 | 一种扫频超声处理对数中期热带假丝酵母促进增殖的方法 |
| CN108779470A (zh) * | 2015-12-17 | 2018-11-09 | 赢创德固赛(中国)投资有限公司 | 用于酵母细胞中同源重组敲除的基因盒 |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006025821A1 (de) * | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| DE102007052463A1 (de) * | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges |
| DE102007060705A1 (de) * | 2007-12-17 | 2009-06-18 | Evonik Degussa Gmbh | ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen |
| DE102008002715A1 (de) * | 2008-06-27 | 2009-12-31 | Evonik Röhm Gmbh | 2-Hydroxyisobuttersäure produzierende rekombinante Zelle |
| DE102009009580A1 (de) | 2009-02-19 | 2010-08-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung freier Säuren aus ihren Salzen |
| DE102009046626A1 (de) | 2009-11-11 | 2011-05-12 | Evonik Degussa Gmbh | Candida tropicalis Zellen und deren Verwendung |
| DE102009046623A1 (de) | 2009-11-11 | 2011-05-12 | Evonik Röhm Gmbh | Verwendung eines zu einem MeaB-Protein homologen Proteins zur Erhöhung der enzymatischen Aktivität einer 3-Hydroxycarbonsäure-CoA-Mutase |
| DE102010014680A1 (de) | 2009-11-18 | 2011-08-18 | Evonik Degussa GmbH, 45128 | Zellen, Nukleinsäuren, Enzyme und deren Verwendung sowie Verfahren zur Herstellung von Sophorolipiden |
| DE102010015807A1 (de) | 2010-04-20 | 2011-10-20 | Evonik Degussa Gmbh | Biokatalytisches Oxidationsverfahren mit alkL-Genprodukt |
| DE102011004465A1 (de) | 2010-09-10 | 2012-03-15 | Evonik Degussa Gmbh | Verfahren zur direkten Aminierung sekundärer Alkohole mit Ammoniak zu primären Aminen |
| DE102010043470A1 (de) | 2010-11-05 | 2012-05-10 | Evonik Degussa Gmbh | Zusammensetzung aus Polyamiden mit niedriger Konzentration an Carbonsäureamidgruppen und elektrisch leitfähigem Kohlenstoff |
| DE102011075162A1 (de) | 2010-12-08 | 2012-06-14 | Evonik Degussa Gmbh | Verfahren zur homogen-katalysierte, hochselektiven direkten Aminierung von primären Alkoholen mit Ammoniak zu primären Aminen bei hohem Volumenverhältnis von Flüssig- zu Gasphase und/oder hohen Drücken |
| UA112980C2 (uk) | 2011-02-16 | 2016-11-25 | Евонік Дегусса Гмбх | Рідкі катіоніти |
| JP5933599B2 (ja) | 2011-02-21 | 2016-06-15 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | キサントホス触媒系を用いた、第一級アミンを得るための、アンモニアによるアルコールの直接アミノ化法 |
| EP2734631B1 (de) | 2011-07-20 | 2016-08-31 | Evonik Degussa GmbH | Oxidation und aminierung von primären alkoholen |
| DE102011110946A1 (de) | 2011-08-15 | 2016-01-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen |
| DE102011084518A1 (de) | 2011-10-14 | 2013-04-18 | Evonik Industries Ag | Verwendung einer Mehrschichtfolie mit Polyamid- und Polyesterschichten fürdie Herstellung photovoltaischer Module |
| EP2602328A1 (de) | 2011-12-05 | 2013-06-12 | Evonik Industries AG | Verfahren zur Oxidation von Alkanen unter Verwendung einer AlkB Alkan 1-Monooxygenase |
| EP2607479A1 (en) | 2011-12-22 | 2013-06-26 | Evonik Industries AG | Biotechnological production of alcohols and derivatives thereof |
| EP2607490A1 (de) | 2011-12-22 | 2013-06-26 | Evonik Industries AG | Verfahren zur verbesserten Abtrennung einer hydrophoben organischen Lösung von einem wässrigen Kulturmedium |
| EP2631298A1 (en) | 2012-02-22 | 2013-08-28 | Evonik Industries AG | Biotechnological method for producing butanol and butyric acid |
| EP2639308A1 (de) * | 2012-03-12 | 2013-09-18 | Evonik Industries AG | Enzymatische omega-Oxidation und -Aminierung von Fettsäuren |
| EP2647696A1 (de) | 2012-04-02 | 2013-10-09 | Evonik Degussa GmbH | Verfahren zur aeroben Herstellung von Alanin oder einer unter Verbrauch von Alanin entstehenden Verbindung |
| DE102012207921A1 (de) | 2012-05-11 | 2013-11-14 | Evonik Industries Ag | Mehrstufiges Syntheseverfahren mit Synthesegas |
| EP2700448A1 (de) | 2012-08-21 | 2014-02-26 | Evonik Industries AG | Verzweigte Fettsäuren als flüssige Kationenaustauscher |
| EP2706076B1 (de) | 2012-09-07 | 2014-12-17 | Evonik Industries AG | Härtbare Zusammensetzungen auf der Basis von Epoxidharzen ohne Benzylalkohol |
| EP2730655A1 (de) | 2012-11-12 | 2014-05-14 | Evonik Industries AG | Verfahren zur Umsetzung eines Carbonsäureesters unter Verwendung BioH-defizienter Zellen |
| JP2016501040A (ja) | 2012-12-19 | 2016-01-18 | ヴェルデザイン,インコーポレーテッド | 脂肪族ジカルボン酸を調製するための生物学的方法 |
| US9850493B2 (en) | 2012-12-19 | 2017-12-26 | Verdezyne, Inc. | Biological methods for preparing a fatty dicarboxylic acid |
| EP2746400A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon |
| EP2746397A1 (de) | 2012-12-21 | 2014-06-25 | Evonik Industries AG | Herstellung von Omega-Aminofettsäuren |
| EP2759598A1 (de) * | 2013-01-24 | 2014-07-30 | Evonik Industries AG | Verfahren zur Herstellung von alpha, omega-Alkandiol |
| EP2944697A1 (en) | 2014-05-13 | 2015-11-18 | Evonik Degussa GmbH | Method of producing nylon |
| US9695404B2 (en) | 2014-07-18 | 2017-07-04 | Industrial Technology Research Institute | Genetically modified microorganism for producing long-chain dicarboxylic acid and method of using thereof |
| EP3050967A1 (en) | 2015-01-28 | 2016-08-03 | Evonik Degussa GmbH | A method of producing higher alcohols |
| CA2937594A1 (en) | 2015-02-26 | 2016-08-26 | Evonik Degussa Gmbh | Alkene production |
| US10351881B2 (en) | 2015-03-10 | 2019-07-16 | The Regents Of The University Of California | Host cells and methods for producing diacid compounds |
| EP3173478A1 (en) | 2015-11-25 | 2017-05-31 | Evonik Degussa GmbH | Biotechnological production of omega-functionalised carboxylic acids and esters thereof |
| WO2017102952A1 (en) | 2015-12-17 | 2017-06-22 | Evonik Degussa Gmbh | A genetically modified acetogenic cell |
| WO2018019867A1 (en) | 2016-07-27 | 2018-02-01 | Evonik Degussa Gmbh | N-acetyl homoserine |
| US11091742B2 (en) | 2018-04-04 | 2021-08-17 | Cathay Biotech Inc. | Directed evolution of CYP52A12 gene and its use in dicarboxylic acid production |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009077461A1 (de) * | 2007-12-17 | 2009-06-25 | Evonik Degussa Gmbh | ω-AMINOCARBONSÄUREN, ω-AMINOCARBONSÄUREESTER ODER IHRE LACTAME HERSTELLENDE, REKOMBINANTE ZELLEN |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254466A (en) * | 1989-11-06 | 1993-10-19 | Henkel Research Corporation | Site-specific modification of the candida tropicals genome |
| US5962285A (en) | 1995-09-08 | 1999-10-05 | Henkel Corporation | Process for making polycarboxylic acids |
| US20030077795A1 (en) * | 1999-03-10 | 2003-04-24 | Wilson C. Ron | Cytochrome P450 monooxygenase and NADPH Cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of candida tropicals and methods relating thereto |
| US6066480A (en) | 1998-09-21 | 2000-05-23 | General Electric Company | Method for high specific bioproductivity of α,ω-alkanedicarboxylic acids |
| CA2349868C (en) | 1998-10-05 | 2010-07-20 | Cognis Corporation | Cytochrome p450 monooxygenase and nadph cytochrome p450 oxidoreductase genes and proteins related to the omega hydroxylase complex of candida tropicalis and methods relating thereto |
| EP1350788A3 (de) | 2002-03-28 | 2003-11-12 | Degussa AG | Verfahren zur Herstellung von Hexamethylendiamin aus Butadien |
| ATE538197T1 (de) | 2002-04-19 | 2012-01-15 | Cognis Ip Man Gmbh | Fettalkoholoxidase-gene und -proteine aus candida tropicalis und damit verbundene verfahren |
| JP2006513693A (ja) * | 2002-05-23 | 2006-04-27 | コグニス コーポレーション | 非復帰変異可能なβ−酸化遮断カンジダ・トロピカリス |
| EP1506302A4 (en) | 2002-05-23 | 2006-02-08 | Cognis Ip Man Gmbh | CANDIDA TROPICALIS BLOCKED BY OXIDATION BETA NON REVERSIBLE |
| BRPI0519168B1 (pt) | 2004-12-20 | 2015-04-07 | Uhde Gmbh | Processo para recuperação de metanol |
| WO2007131720A1 (en) | 2006-05-11 | 2007-11-22 | Cosmoferm B.V. | Improved production of sphingoid bases using genetically engineered microbial strains |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| DE102007005072A1 (de) | 2007-02-01 | 2008-08-07 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Cadaverin |
| DE102007015583A1 (de) | 2007-03-29 | 2008-10-02 | Albert-Ludwigs-Universität Freiburg | Ein Enzym zur Herstellung von Methylmalonyl-Coenzym A oder Ethylmalonyl-Coenzym A sowie dessen Verwendung |
| DE102007031689A1 (de) | 2007-07-06 | 2009-01-08 | Evonik Goldschmidt Gmbh | Enzympräparate |
| DE102007052463A1 (de) | 2007-11-02 | 2009-05-07 | Evonik Degussa Gmbh | Fermentative Gewinnung von Aceton aus erneuerbaren Rohstoffen mittels neuen Stoffwechselweges |
| DE102008004726A1 (de) | 2008-01-16 | 2009-07-23 | Evonik Goldschmidt Gmbh | Verfahren zur enzymatischen Herstellung von Carbonsäureestern |
| DE102008004725A1 (de) | 2008-01-16 | 2009-07-23 | Evonik Goldschmidt Gmbh | Verfahren zur heterogenkatalysierten Herstellung von Carbonsäurederivaten |
| DE102008002715A1 (de) | 2008-06-27 | 2009-12-31 | Evonik Röhm Gmbh | 2-Hydroxyisobuttersäure produzierende rekombinante Zelle |
| DE102008040193A1 (de) | 2008-07-04 | 2010-01-07 | Evonik Röhm Gmbh | Verfahren zur Herstellung freier Carbonsäuren |
| DE102008040415A1 (de) | 2008-07-15 | 2010-01-21 | Evonik Röhm Gmbh | Thermisches Salzspalten von Ammoniumcarboxylaten |
| DE102008041754A1 (de) | 2008-09-02 | 2010-03-04 | Evonik Goldschmidt Gmbh | Enzympräparate |
| DE102009000592A1 (de) | 2009-02-04 | 2010-08-05 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Aminogruppen tragenden, multizyklischen Ringsystemen |
| DE102009009580A1 (de) | 2009-02-19 | 2010-08-26 | Evonik Degussa Gmbh | Verfahren zur Herstellung freier Säuren aus ihren Salzen |
| DE102009002811A1 (de) | 2009-05-05 | 2010-11-11 | Evonik Degussa Gmbh | Enzymatisches Verfahren zur Herstellung von Aldehyden |
| US8158391B2 (en) * | 2009-05-06 | 2012-04-17 | Dna Twopointo, Inc. | Production of an α-carboxyl-ω-hydroxy fatty acid using a genetically modified Candida strain |
| DE102009046626A1 (de) | 2009-11-11 | 2011-05-12 | Evonik Degussa Gmbh | Candida tropicalis Zellen und deren Verwendung |
| DE102009046623A1 (de) | 2009-11-11 | 2011-05-12 | Evonik Röhm Gmbh | Verwendung eines zu einem MeaB-Protein homologen Proteins zur Erhöhung der enzymatischen Aktivität einer 3-Hydroxycarbonsäure-CoA-Mutase |
| DE102010014680A1 (de) | 2009-11-18 | 2011-08-18 | Evonik Degussa GmbH, 45128 | Zellen, Nukleinsäuren, Enzyme und deren Verwendung sowie Verfahren zur Herstellung von Sophorolipiden |
| DE102010002809A1 (de) | 2010-03-12 | 2011-11-17 | Evonik Degussa Gmbh | Verfahren zur Herstellung von linearen alpha,omega-Dicarbonsäurediestern |
| DE102010015807A1 (de) | 2010-04-20 | 2011-10-20 | Evonik Degussa Gmbh | Biokatalytisches Oxidationsverfahren mit alkL-Genprodukt |
| DE102010026196A1 (de) | 2010-06-25 | 2011-12-29 | Evonik Degussa Gmbh | Synthese von omega-Aminocarbonsäuren und deren Estern aus ungesättigten Fettsäurederivaten |
| DE102010032484A1 (de) | 2010-07-28 | 2012-02-02 | Evonik Goldschmidt Gmbh | Zellen und Verfahren zur Herstellung von Rhamnolipiden |
| DE102011004465A1 (de) | 2010-09-10 | 2012-03-15 | Evonik Degussa Gmbh | Verfahren zur direkten Aminierung sekundärer Alkohole mit Ammoniak zu primären Aminen |
| DE102011075162A1 (de) | 2010-12-08 | 2012-06-14 | Evonik Degussa Gmbh | Verfahren zur homogen-katalysierte, hochselektiven direkten Aminierung von primären Alkoholen mit Ammoniak zu primären Aminen bei hohem Volumenverhältnis von Flüssig- zu Gasphase und/oder hohen Drücken |
| JP5933599B2 (ja) | 2011-02-21 | 2016-06-15 | エボニック デグサ ゲーエムベーハーEvonik Degussa GmbH | キサントホス触媒系を用いた、第一級アミンを得るための、アンモニアによるアルコールの直接アミノ化法 |
| DE102011015150A1 (de) | 2011-03-25 | 2012-09-27 | Evonik Degussa Gmbh | Syntese von alpha, omega-Dicarbonsäuren und deren Estern aus ungesättigten Fettsäurederivaten |
| DE102011110959A1 (de) | 2011-08-18 | 2013-02-21 | Evonik Degussa Gmbh | Pichia ciferrii Zellen und deren Verwendung |
| DE102011084518A1 (de) | 2011-10-14 | 2013-04-18 | Evonik Industries Ag | Verwendung einer Mehrschichtfolie mit Polyamid- und Polyesterschichten fürdie Herstellung photovoltaischer Module |
-
2009
- 2009-11-11 DE DE102009046626A patent/DE102009046626A1/de not_active Ceased
-
2010
- 2010-10-27 EP EP13158312.2A patent/EP2602313B1/de not_active Not-in-force
- 2010-10-27 ES ES13158305.6T patent/ES2631987T3/es active Active
- 2010-10-27 EP EP13158308.0A patent/EP2602312B1/de active Active
- 2010-10-27 EP EP11173560A patent/EP2377944A1/de not_active Withdrawn
- 2010-10-27 EP EP10188993A patent/EP2322598A3/de not_active Withdrawn
- 2010-10-27 ES ES13158308.0T patent/ES2658421T3/es active Active
- 2010-10-27 EP EP13158305.6A patent/EP2602311B1/de not_active Not-in-force
- 2010-10-27 ES ES13158312.2T patent/ES2626442T3/es active Active
- 2010-11-10 SG SG201008216-2A patent/SG171538A1/en unknown
- 2010-11-10 SG SG10201407242RA patent/SG10201407242RA/en unknown
- 2010-11-10 CN CN2010106107682A patent/CN102154139A/zh active Pending
- 2010-11-10 US US12/943,145 patent/US20110118433A1/en not_active Abandoned
- 2010-11-11 JP JP2010253092A patent/JP2011101643A/ja active Pending
-
2013
- 2013-02-12 US US13/764,996 patent/US8999684B2/en not_active Expired - Fee Related
-
2015
- 2015-01-30 US US14/609,714 patent/US9150890B2/en not_active Expired - Fee Related
- 2015-12-16 JP JP2015244822A patent/JP2016034289A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009077461A1 (de) * | 2007-12-17 | 2009-06-25 | Evonik Degussa Gmbh | ω-AMINOCARBONSÄUREN, ω-AMINOCARBONSÄUREESTER ODER IHRE LACTAME HERSTELLENDE, REKOMBINANTE ZELLEN |
Non-Patent Citations (3)
| Title |
|---|
| NESS,J.E.: "GU056283.1", 《GENBANK》, 21 October 2009 (2009-10-21) * |
| NESS,J.E.: "GU056284.1", 《GENBANK》, 21 October 2009 (2009-10-21) * |
| NESS,J.E.: "GU056287.1", 《GENBANK》, 21 October 2009 (2009-10-21) * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104745490A (zh) * | 2015-03-20 | 2015-07-01 | 上海应用技术学院 | 一种热带假丝酵母菌及利用其作为生物催化剂制备异辛酸的方法 |
| CN104745490B (zh) * | 2015-03-20 | 2017-08-25 | 上海应用技术学院 | 一种热带假丝酵母菌及利用其作为生物催化剂制备异辛酸的方法 |
| CN108779470A (zh) * | 2015-12-17 | 2018-11-09 | 赢创德固赛(中国)投资有限公司 | 用于酵母细胞中同源重组敲除的基因盒 |
| CN106497912A (zh) * | 2016-10-13 | 2017-03-15 | 江苏大学 | 一种扫频超声处理对数中期热带假丝酵母促进增殖的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2322598A3 (de) | 2011-07-13 |
| JP2016034289A (ja) | 2016-03-17 |
| EP2377944A1 (de) | 2011-10-19 |
| SG171538A1 (en) | 2011-06-29 |
| ES2626442T3 (es) | 2017-07-25 |
| EP2602311B1 (de) | 2017-04-12 |
| EP2602313B1 (de) | 2017-04-12 |
| US8999684B2 (en) | 2015-04-07 |
| US9150890B2 (en) | 2015-10-06 |
| EP2602312A1 (de) | 2013-06-12 |
| ES2631987T3 (es) | 2017-09-07 |
| EP2322598A2 (de) | 2011-05-18 |
| US20110118433A1 (en) | 2011-05-19 |
| SG10201407242RA (en) | 2014-12-30 |
| JP2011101643A (ja) | 2011-05-26 |
| US20130183725A1 (en) | 2013-07-18 |
| ES2658421T3 (es) | 2018-03-09 |
| EP2602312B1 (de) | 2017-04-12 |
| DE102009046626A1 (de) | 2011-05-12 |
| EP2602313A1 (de) | 2013-06-12 |
| EP2602311A1 (de) | 2013-06-12 |
| US20150140617A1 (en) | 2015-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102154139A (zh) | 热带假丝酵母细胞及其用途 | |
| EP1513923B1 (en) | Methods and materials for the production of d-lactic acid in yeast | |
| KR102000317B1 (ko) | 수성 배양 배지로부터 소수성 유기 용액을 분리하는 개선된 방법 | |
| Okamoto et al. | Production of itaconic acid using metabolically engineered Escherichia coli | |
| KR20150020619A (ko) | 재조합 미생물 및 그에 대한 용도 | |
| KR20170121147A (ko) | 발효 경로를 통해 플럭스 증가를 나타내는 재조합 미생물 | |
| KR102727729B1 (ko) | 엑토인-생산 효모 | |
| CN118956710A (zh) | 从乙二醇生产乙醇酸盐以及相关微生物工程改造 | |
| CN112126610A (zh) | 一种用于生产羟基酪醇的工程菌 | |
| JP2022046736A (ja) | グリコール酸および/またはグリオキシル酸の製造のための方法および微生物 | |
| Mao et al. | Succession of microbial community of the pit mud under the impact of Daqu of Nongxiang Baijiu | |
| CN107619817B (zh) | 生产3-脱氢莽草酸大肠杆菌重组菌株及其构建方法与应用 | |
| EP2899270A1 (en) | Method for producing butanediol | |
| EP3205728B1 (en) | Process for producing 7-dehydrocholesterol and vitamin d3 | |
| CN107223152B (zh) | 具有改变的一氧化碳脱氢酶(codh)活性的遗传工程细菌 | |
| Bäumchen et al. | Myo-inositol facilitators IolT1 and IolT2 enhance D-mannitol formation from D-fructose in Corynebacterium glutamicum | |
| JP2014023528A (ja) | 改変微生物及び該改変微生物を利用した1,4−ブタンジオールの生産方法 | |
| EP4506462A1 (en) | Method for preparing glycine, acetyl coenzyme a, and acetyl coenzyme a derivative by using threonine | |
| KR102605543B1 (ko) | 메티오닌-생산 효모 | |
| KR101863239B1 (ko) | 아세트산을 유일 탄소원으로 이용할 수 있는 미생물 | |
| KR101555867B1 (ko) | 3-하이드록시프로피온산을 분해하지 않는 슈도모나스 데니트리피칸스 결실 변이균주 및 이를 이용한 3-하이드록시프로피온산의 생산방법 | |
| JP5737650B2 (ja) | アセトイン産生細胞および当該細胞を用いたアセトインの製造方法 | |
| KR20150051880A (ko) | 철에 의해 조절되는 abc 트란스포터의 활성이 증가된 미생물 및 이를 이용한 히드록시카르복실산의 제조방법 | |
| AU2008201598A1 (en) | Methods and materials for the production of D-lactic acid in yeast |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20110817 |
|
| RJ01 | Rejection of invention patent application after publication |