CN102131809A - 三环吡唑并吡啶激酶抑制剂 - Google Patents
三环吡唑并吡啶激酶抑制剂 Download PDFInfo
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- CN102131809A CN102131809A CN2009801327408A CN200980132740A CN102131809A CN 102131809 A CN102131809 A CN 102131809A CN 2009801327408 A CN2009801327408 A CN 2009801327408A CN 200980132740 A CN200980132740 A CN 200980132740A CN 102131809 A CN102131809 A CN 102131809A
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US8292408P | 2008-07-23 | 2008-07-23 | |
| US61/082,924 | 2008-07-23 | ||
| PCT/US2009/051430 WO2010011768A1 (en) | 2008-07-23 | 2009-07-22 | Tri-cyclic pyrazolopyridine kinase inhibitors |
Publications (1)
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| EP (1) | EP2328896B1 (enExample) |
| JP (2) | JP5631310B2 (enExample) |
| CN (1) | CN102131809A (enExample) |
| AU (1) | AU2009274023A1 (enExample) |
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| MX (1) | MX2011000837A (enExample) |
| WO (1) | WO2010011768A1 (enExample) |
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| US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| MX2011001319A (es) * | 2008-08-06 | 2011-04-05 | Vertex Pharma | Inhibidores de aminopiridina cinasa. |
| GEP20207129B (en) | 2009-06-17 | 2020-07-10 | Vertex Pharma | Inhibitors of influenza viruses replication |
| EP2528917B1 (en) * | 2010-01-27 | 2016-10-19 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases |
| MX2012008642A (es) * | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| EP2582702A1 (en) * | 2010-01-27 | 2013-04-24 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrimidine kinase inhibitors |
| RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
| JP2013545817A (ja) | 2010-12-16 | 2013-12-26 | バーテックス ファーマシューティカルズ インコーポレイテッド | インフルエンザウイルス複製阻害物質 |
| AU2011343647A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| WO2013184985A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| CA2923765C (en) | 2013-09-18 | 2021-06-29 | University Of Canberra | Stem cell modulation ii |
| PT3068776T (pt) | 2013-11-13 | 2019-08-26 | Vertex Pharma | Inibidores da replicação de vírus da gripe |
| HUE038820T2 (hu) | 2013-11-13 | 2018-11-28 | Vertex Pharma | Eljárás influenzavírusok replikációjának inhibitorai elõállítására |
| AU2015309686B2 (en) | 2014-08-25 | 2020-05-14 | Epiaxis Therapeutics Pty Ltd | Compositions for modulating cancer stem cells and uses therefor |
| CA2960101C (en) | 2014-09-05 | 2024-05-21 | Allosteros Therapeutics, Inc. | Substituted carboline derivative and compositions thereof useful as camkii inhibitors |
| ES2985998T3 (es) * | 2015-01-30 | 2024-11-08 | Ligalli B V | Dispositivo de administración vaginal de fármacos |
| WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| EP3294717B1 (en) | 2015-05-13 | 2020-07-29 | Vertex Pharmaceuticals Inc. | Methods of preparing inhibitors of influenza viruses replication |
| EP3484894B1 (en) | 2016-07-14 | 2020-08-19 | Bristol-Myers Squibb Company | Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors |
| US10730868B2 (en) | 2016-07-14 | 2020-08-04 | Bristol-Myers Squibb Company | Bicyclic heteroaryl substituted compounds |
| ES2823180T3 (es) | 2016-07-14 | 2021-05-06 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos con heteroarilo |
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| AU2005309566A1 (en) * | 2004-11-22 | 2006-06-01 | Vertex Pharmaceuticals Incorporated | Bicyclic inhibitors or Rho kinase |
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| US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
| PT1863818E (pt) | 2005-03-23 | 2010-04-09 | Hoffmann La Roche | Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2 |
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-
2009
- 2009-07-22 MX MX2011000837A patent/MX2011000837A/es not_active Application Discontinuation
- 2009-07-22 JP JP2011520173A patent/JP5631310B2/ja not_active Expired - Fee Related
- 2009-07-22 CA CA2731498A patent/CA2731498A1/en not_active Abandoned
- 2009-07-22 AU AU2009274023A patent/AU2009274023A1/en not_active Abandoned
- 2009-07-22 EP EP09790733.1A patent/EP2328896B1/en not_active Not-in-force
- 2009-07-22 CN CN2009801327408A patent/CN102131809A/zh active Pending
- 2009-07-22 WO PCT/US2009/051430 patent/WO2010011768A1/en not_active Ceased
-
2011
- 2011-12-01 US US13/308,612 patent/US8563576B2/en not_active Expired - Fee Related
-
2014
- 2014-08-08 JP JP2014162132A patent/JP2014208708A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014208708A (ja) | 2014-11-06 |
| US20120184534A1 (en) | 2012-07-19 |
| EP2328896B1 (en) | 2013-10-23 |
| WO2010011768A1 (en) | 2010-01-28 |
| MX2011000837A (es) | 2011-04-05 |
| CA2731498A1 (en) | 2010-01-28 |
| EP2328896A1 (en) | 2011-06-08 |
| AU2009274023A1 (en) | 2010-01-28 |
| JP5631310B2 (ja) | 2014-11-26 |
| JP2011529065A (ja) | 2011-12-01 |
| US8563576B2 (en) | 2013-10-22 |
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