CN102131783A - 作为axl激酶抑制剂的喹啉衍生物 - Google Patents
作为axl激酶抑制剂的喹啉衍生物 Download PDFInfo
- Publication number
- CN102131783A CN102131783A CN2009801129869A CN200980112986A CN102131783A CN 102131783 A CN102131783 A CN 102131783A CN 2009801129869 A CN2009801129869 A CN 2009801129869A CN 200980112986 A CN200980112986 A CN 200980112986A CN 102131783 A CN102131783 A CN 102131783A
- Authority
- CN
- China
- Prior art keywords
- phenyl
- fluoro
- quinolyl
- oxygen base
- dimethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 COc1cc2c(*c(cc3)cc(F)c3NS(c3cc(Cl)cc(Cl)c3)(=O)=O)ccnc2cc1OC Chemical compound COc1cc2c(*c(cc3)cc(F)c3NS(c3cc(Cl)cc(Cl)c3)(=O)=O)ccnc2cc1OC 0.000 description 3
- RNKITPKDGNVIQD-UHFFFAOYSA-N CC(C(c1c2)Oc(cc3)c(C)cc3NS(c(cc3)c(cccc4)c4c3OC)(=O)=O)C=Nc1cc(OC)c2OC Chemical compound CC(C(c1c2)Oc(cc3)c(C)cc3NS(c(cc3)c(cccc4)c4c3OC)(=O)=O)C=Nc1cc(OC)c2OC RNKITPKDGNVIQD-UHFFFAOYSA-N 0.000 description 1
- UYKJAMOSSBXCGJ-UHFFFAOYSA-N CC(c(cccc1)c1S(Nc(cc1)cc(F)c1Oc1c(cc(c(OCCCN)c2)OC)c2ncc1)(=O)=O)(F)F Chemical compound CC(c(cccc1)c1S(Nc(cc1)cc(F)c1Oc1c(cc(c(OCCCN)c2)OC)c2ncc1)(=O)=O)(F)F UYKJAMOSSBXCGJ-UHFFFAOYSA-N 0.000 description 1
- QGWANWMXPLJGCH-UHFFFAOYSA-N CCCS(Cc(cc1)cc(F)c1Oc1c(cc(c(OCCCN2CCC(C)CC2)c2)OC)c2ncc1)(=O)=O Chemical compound CCCS(Cc(cc1)cc(F)c1Oc1c(cc(c(OCCCN2CCC(C)CC2)c2)OC)c2ncc1)(=O)=O QGWANWMXPLJGCH-UHFFFAOYSA-N 0.000 description 1
- NIEBODPRPFUYPU-UHFFFAOYSA-N CCc1cc2cccc(Oc(ccc(NS(c3cccc(Oc4ccccc4)c3)(=O)=O)c3)c3F)c2cc1OC Chemical compound CCc1cc2cccc(Oc(ccc(NS(c3cccc(Oc4ccccc4)c3)(=O)=O)c3)c3F)c2cc1OC NIEBODPRPFUYPU-UHFFFAOYSA-N 0.000 description 1
- ROWGSKQMKOFDSC-UHFFFAOYSA-N CNc(cc(c1c2)[IH][I]=CC=C1Oc(cc1)cc(F)c1NS(c(cc1)c(cccc3)c3c1OC)(=O)=O)c2OC Chemical compound CNc(cc(c1c2)[IH][I]=CC=C1Oc(cc1)cc(F)c1NS(c(cc1)c(cccc3)c3c1OC)(=O)=O)c2OC ROWGSKQMKOFDSC-UHFFFAOYSA-N 0.000 description 1
- ZHICDYCCWSHRHV-UHFFFAOYSA-N COc(c(OC)cc1ncc2)cc1c2Oc(cc1)cc(F)c1NS(c(cccc1)c1N)(=O)=O Chemical compound COc(c(OC)cc1ncc2)cc1c2Oc(cc1)cc(F)c1NS(c(cccc1)c1N)(=O)=O ZHICDYCCWSHRHV-UHFFFAOYSA-N 0.000 description 1
- LIIIKKJBUCTUNP-UHFFFAOYSA-N COc(ccc(Cl)c1)c1S(Nc(cc1)ccc1Oc1c(cc(c(OC)c2)OC)c2ncc1)(=O)=O Chemical compound COc(ccc(Cl)c1)c1S(Nc(cc1)ccc1Oc1c(cc(c(OC)c2)OC)c2ncc1)(=O)=O LIIIKKJBUCTUNP-UHFFFAOYSA-N 0.000 description 1
- UPDPHLWJXBYILK-UHFFFAOYSA-N Cc([nH]1)ncc1S(Nc(cc1)ccc1Oc1c(cc(c(OC)c2)OC)c2ncc1)(=O)=O Chemical compound Cc([nH]1)ncc1S(Nc(cc1)ccc1Oc1c(cc(c(OC)c2)OC)c2ncc1)(=O)=O UPDPHLWJXBYILK-UHFFFAOYSA-N 0.000 description 1
- SACCQJZNCZRVFV-UHFFFAOYSA-N Cc(cc(c1c2)Oc(cc3)ccc3NS(c3cc(Cl)cc(N)c3OC)(=O)=O)nc1ccc2F Chemical compound Cc(cc(c1c2)Oc(cc3)ccc3NS(c3cc(Cl)cc(N)c3OC)(=O)=O)nc1ccc2F SACCQJZNCZRVFV-UHFFFAOYSA-N 0.000 description 1
- LGCWFJPSZYDDGE-UHFFFAOYSA-N Cc(cc(cc1)Oc2c(cc(c(OC)c3)OC)c3ncc2)c1NS(c1c(C(F)(F)F)cccc1)(=O)=O Chemical compound Cc(cc(cc1)Oc2c(cc(c(OC)c3)OC)c3ncc2)c1NS(c1c(C(F)(F)F)cccc1)(=O)=O LGCWFJPSZYDDGE-UHFFFAOYSA-N 0.000 description 1
- CDGAWYXJDLVXDH-UHFFFAOYSA-N Cc1cc(S(Nc(c(F)c2)ccc2OC2=CC=NC(C3)C2=CC(OC)=C3OC)(=O)=O)cc(F)c1 Chemical compound Cc1cc(S(Nc(c(F)c2)ccc2OC2=CC=NC(C3)C2=CC(OC)=C3OC)(=O)=O)cc(F)c1 CDGAWYXJDLVXDH-UHFFFAOYSA-N 0.000 description 1
- UTWQBHFTQJWFTQ-UHFFFAOYSA-N Cc1cc(c(C(F)(F)F)ccc2)c2c(Oc(cc2)cc(F)c2NS(c2cccc3c2cccc3)(=O)=O)c1 Chemical compound Cc1cc(c(C(F)(F)F)ccc2)c2c(Oc(cc2)cc(F)c2NS(c2cccc3c2cccc3)(=O)=O)c1 UTWQBHFTQJWFTQ-UHFFFAOYSA-N 0.000 description 1
- IMLNGKAJJBDEHO-UHFFFAOYSA-N Cc1nc2c(C(F)(F)F)cccc2c(Oc(cc2)cc(F)c2N[IH]S(c(cc2Cl)ccc2I)(=O)=O)c1 Chemical compound Cc1nc2c(C(F)(F)F)cccc2c(Oc(cc2)cc(F)c2N[IH]S(c(cc2Cl)ccc2I)(=O)=O)c1 IMLNGKAJJBDEHO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4539808P | 2008-04-16 | 2008-04-16 | |
| US61/045,398 | 2008-04-16 | ||
| PCT/EP2009/002798 WO2009127417A1 (en) | 2008-04-16 | 2009-04-16 | Quinoline derivatives as axl kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102131783A true CN102131783A (zh) | 2011-07-20 |
Family
ID=40999731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801129869A Pending CN102131783A (zh) | 2008-04-16 | 2009-04-16 | 作为axl激酶抑制剂的喹啉衍生物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9206130B2 (https=) |
| EP (1) | EP2262772B8 (https=) |
| JP (1) | JP5746015B2 (https=) |
| KR (1) | KR101325237B1 (https=) |
| CN (1) | CN102131783A (https=) |
| AU (1) | AU2009237938A1 (https=) |
| CA (1) | CA2718538A1 (https=) |
| ES (1) | ES2391373T3 (https=) |
| IL (1) | IL208103A (https=) |
| MX (1) | MX2010011224A (https=) |
| RU (1) | RU2010146474A (https=) |
| WO (1) | WO2009127417A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103958497A (zh) * | 2011-11-14 | 2014-07-30 | 赛福伦公司 | 作为AXL和c-MET激酶抑制剂的尿嘧啶衍生物 |
| WO2018121228A1 (zh) * | 2016-12-28 | 2018-07-05 | 中国科学院上海药物研究所 | 一种具有axl抑制活性的化合物及其制备和应用 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2311809A1 (en) * | 2009-10-16 | 2011-04-20 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Quinolinyloxyphenylsulfonamides |
| EP2423208A1 (en) | 2010-08-28 | 2012-02-29 | Lead Discovery Center GmbH | Pharmaceutically active compounds as Axl inhibitors |
| ITRM20100537A1 (it) | 2010-10-12 | 2012-04-12 | Consiglio Nazionale Ricerche | Aptamero inibitore del recettore tirosina chinasi axl per uso in terapia |
| RS55728B1 (sr) | 2012-01-31 | 2017-07-31 | Daiichi Sankyo Co Ltd | Derivat piridona |
| CA2879542A1 (en) | 2012-07-25 | 2014-01-30 | Salk Institute For Biological Studies | Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidylserine |
| TWI649308B (zh) | 2013-07-24 | 2019-02-01 | 小野藥品工業股份有限公司 | 喹啉衍生物 |
| JP6527513B2 (ja) | 2013-11-20 | 2019-06-05 | シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｔａｍファミリーキナーゼ阻害剤としてのキナゾリン誘導体 |
| CA2922542A1 (en) | 2013-11-22 | 2015-05-28 | University Of Kentucky Research Foundation | Arylquinoline and analog compounds and use thereof to treat cancer |
| JP6496731B2 (ja) | 2013-11-27 | 2019-04-03 | シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｔａｍファミリーキナーゼ阻害剤としてのアミノピリジン誘導体 |
| TWI690525B (zh) | 2014-07-07 | 2020-04-11 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
| WO2016104617A1 (ja) * | 2014-12-25 | 2016-06-30 | 小野薬品工業株式会社 | キノリン誘導体 |
| US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
| WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
| US10053465B2 (en) | 2015-08-26 | 2018-08-21 | Incyte Corporation | Pyrrolopyrimidine derivatives as TAM inhibitors |
| WO2017146236A1 (ja) | 2016-02-26 | 2017-08-31 | 小野薬品工業株式会社 | Ａｘｌ阻害剤と免疫チェックポイント阻害剤とを組み合わせて投与することを特徴とする癌治療のための医薬 |
| MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
| EP3575293B1 (en) | 2017-01-26 | 2021-03-10 | ONO Pharmaceutical Co., Ltd. | Ethanesulfonate salt of n-{5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide |
| JP7156287B2 (ja) | 2017-08-23 | 2022-10-19 | 小野薬品工業株式会社 | Ａｘｌ阻害剤を有効成分として含むがん治療剤 |
| MX2020002183A (es) * | 2017-08-31 | 2020-10-05 | Abbvie Inc | Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos. |
| SI3687996T1 (sl) | 2017-09-27 | 2022-04-29 | Incyte Corporation | Soli pirolotriazinskih derivatov, ki so uporabne kot zaviralci TAM |
| EP3695839A4 (en) | 2017-10-13 | 2021-07-14 | ONO Pharmaceutical Co., Ltd. | THERAPEUTIC AGENT WITH AXL INHIBITOR AS AN ACTIVE INGREDIENT FOR SOLID TUMORS |
| MD3813800T2 (ro) | 2018-06-29 | 2025-10-31 | Incyte Corp | Formulări de inhibitor al AXL/MER |
| US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4054579A1 (en) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| EP4114401A1 (en) | 2020-03-06 | 2023-01-11 | Incyte Corporation | Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors |
| JP2023525757A (ja) * | 2020-05-08 | 2023-06-19 | ジョージアミューン・インコーポレイテッド | Ａｋｔ３モジュレーター |
| JP2022104746A (ja) * | 2020-12-29 | 2022-07-11 | 国立研究開発法人国立がん研究センター | 抗がん剤 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| IL144461A0 (en) | 1999-01-22 | 2002-05-23 | Kirin Brewery | Quinoline and quinazoline derivatives and pharmaceutical compositions containing them |
| US7041691B1 (en) * | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| AU2003280599A1 (en) * | 2002-10-29 | 2004-05-25 | Kirin Beer Kabushiki Kaisha | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF Flt3 AND MEDICINAL COMPOSITIONS CONTAINING THE SAME |
| PT2213661E (pt) * | 2003-09-26 | 2011-12-15 | Exelixis Inc | Moduladores de c-met e métodos de uso |
| GB0509227D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Intracellular enzyme inhibitors |
| CA2619037A1 (en) * | 2005-08-22 | 2007-03-01 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles medicaments comprising said compounds use and method for production thereof |
| JP2009539878A (ja) * | 2006-06-08 | 2009-11-19 | アレイ バイオファーマ、インコーポレイテッド | キノリン化合物および使用方法 |
| WO2008076415A1 (en) | 2006-12-14 | 2008-06-26 | Exelixis, Inc. | Methods of using mek inhibitors |
-
2009
- 2009-04-16 EP EP09731679A patent/EP2262772B8/en active Active
- 2009-04-16 RU RU2010146474/04A patent/RU2010146474A/ru not_active Application Discontinuation
- 2009-04-16 ES ES09731679T patent/ES2391373T3/es active Active
- 2009-04-16 MX MX2010011224A patent/MX2010011224A/es not_active Application Discontinuation
- 2009-04-16 AU AU2009237938A patent/AU2009237938A1/en not_active Abandoned
- 2009-04-16 JP JP2011504377A patent/JP5746015B2/ja active Active
- 2009-04-16 WO PCT/EP2009/002798 patent/WO2009127417A1/en not_active Ceased
- 2009-04-16 CA CA2718538A patent/CA2718538A1/en not_active Abandoned
- 2009-04-16 CN CN2009801129869A patent/CN102131783A/zh active Pending
- 2009-04-16 KR KR1020107023097A patent/KR101325237B1/ko active Active
- 2009-04-16 US US12/933,070 patent/US9206130B2/en active Active
-
2010
- 2010-09-13 IL IL208103A patent/IL208103A/en active IP Right Grant
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103958497A (zh) * | 2011-11-14 | 2014-07-30 | 赛福伦公司 | 作为AXL和c-MET激酶抑制剂的尿嘧啶衍生物 |
| US9120778B2 (en) | 2011-11-14 | 2015-09-01 | Ignyta, Inc. | Uracil derivatives as AXL and c-MET kinase inhibitors |
| US9522902B2 (en) | 2011-11-14 | 2016-12-20 | Ignyta, Inc. | Uracil derivatives as AXL and c-MET kinase inhibitors |
| TWI562989B (en) * | 2011-11-14 | 2016-12-21 | Ignyta Inc | Uracil derivatives as axl and c-met kinase inhibitors |
| US9745283B2 (en) | 2011-11-14 | 2017-08-29 | Ignyta, Inc. | Uracil derivatives as AXL and c-MET kinase inhibitors |
| CN103958497B (zh) * | 2011-11-14 | 2017-09-01 | 亚尼塔公司 | 作为AXL和c‑MET激酶抑制剂的尿嘧啶衍生物 |
| US10017496B2 (en) | 2011-11-14 | 2018-07-10 | Ignyta, Inc. | Uracil derivatives as AXL and c-MET kinase inhibitors |
| WO2018121228A1 (zh) * | 2016-12-28 | 2018-07-05 | 中国科学院上海药物研究所 | 一种具有axl抑制活性的化合物及其制备和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL208103A (en) | 2015-08-31 |
| RU2010146474A (ru) | 2012-05-27 |
| MX2010011224A (es) | 2011-02-25 |
| US20110092503A1 (en) | 2011-04-21 |
| WO2009127417A1 (en) | 2009-10-22 |
| IL208103A0 (en) | 2010-12-30 |
| CA2718538A1 (en) | 2009-10-22 |
| KR101325237B1 (ko) | 2013-11-04 |
| AU2009237938A1 (en) | 2009-10-22 |
| EP2262772B1 (en) | 2012-07-18 |
| ES2391373T3 (es) | 2012-11-23 |
| US9206130B2 (en) | 2015-12-08 |
| EP2262772A1 (en) | 2010-12-22 |
| KR20100132038A (ko) | 2010-12-16 |
| JP2011517689A (ja) | 2011-06-16 |
| EP2262772B8 (en) | 2013-03-13 |
| JP5746015B2 (ja) | 2015-07-08 |
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