CN102106502A - Health-care food with functions of improving skin moisture and reinforcing immunity - Google Patents
Health-care food with functions of improving skin moisture and reinforcing immunity Download PDFInfo
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Abstract
The invention discloses a health-care food with functions of improving skin moisture and reinforcing immunity. The health-care food comprises the following components in percentage by weight: 1.0 to 80.0 percent of collagen peptide powder, 0.1 to 40.0 percent of glucosamine, 0.1 to 30.0 percent of aloe extract, 0.1 to 50.0 percent of vitamin C (ascorbic acid), and 0.0 to 90.0 percent of auxiliary materials. The health-care food can be made into tablets, powder, particles, hard capsules, soft capsules, oral liquids and other oral preparations with various flavors. By virtue of a scientific formula, the raw materials with exact efficacies are compatible reasonably, the collagen peptide powder, the glucosamine, the aloe extract and the vitamin C (ascorbic acid) are selected as main raw materials, and the corresponding auxiliary materials can be selected according to different oral preparations. Furthermore, the selection, purchase, preparation and other aspects of the raw materials are completely operated according to related regulations of health-care foods, so the advancement and stability of the product are ensured; and the health-care food is safe, efficient and stable, and has controllable quality by adopting a modern preparation process matched with a strict quality control method. Toxicological safety tests and function tests prove that the health-care food can be used for effectively improving the human skin moisture and reinforcing the human body immunity.
Description
Technical field
The present invention relates to a kind of health food, more particularly, the present invention relates to a kind of health food that improves moisture of skin and strengthen immunity function that has.
Background technology
Modern medicine thinks that immune physiological function has three: the first, immune defense, and immune response takes place to antigenic substance (pathogenic microorganism, vaccine, toxoid, foreign protei etc.) in it, finally eliminates antigenic substance, plays the effect of resistant to infection immunity.If the defense function of body (comprises innate immune defence mechanism, skin, mucous membrane, complement system, macrophage, NK (NK) etc. and immune structure or function) take place when damaged, as congenital or acquired immunodeficiency patient, then very easily suffer from infectiousness or infectious diseases.The secondth, which immunological homeostasis, lymphocyte can discern and distinguish is " non-own ", and which is the antigenic substance of " oneself ", therefore infectious agent, tumour cell is produced the purpose that immune response reaches elimination.And the antigenic substance in the autologous tissue is in the no response state, and be self tolerance, this state is called immunological homeostasis.When steady unusual, then can cause the generation of malignant tumour and the generation of persistent infection.It three is immune surveillance function (comprise specificity and non-specific identification and kill and wound), and its major function shows body by the antigen on the cell of immunocyte identification canceration, and by special or non-specific killer cell cancer cell is destroyed.
In recent decades, a series of correlative study shows, some nutriment can not only be prevented and treated nutritional deficiency, and immune stimulatory cell in a particular manner, strengthen answering, keep normal, appropriate immune response, the generation of the regulating cell factor and release, alleviate harmful or excessive inflammatory reaction, keep intestinal barrier function etc.Nutrition immune is learned the attention that just more and more is subjected to expert and scholar, really setting up nutrition immune is since 1967, purpose was to provide required energy of body and nitrogenous source at that time, guarantee the material demand of structure metabolism, keep the organism physiology balance, keep each organ function, promote body rehabilitation and reparation.The emphasis of research then is the metabolism of nutritional support with assurance immuning tissue at present, keeps immunologic function, promotes that immunity function enters balance with rehabilitation course; From the pharmacological angle of nutrition, the method that the utilization per os is taken in, various nutritional labelings are regulated immune system.
Dry skin has two types: a kind of is simple type, and promptly skin lacks grease, and the moisture content of skin is evaporated easily, and this often occurs among the women below 35 years old; A kind of is complexity, and this occurs among the elderly, promptly lack grease and lack moisture content again, and skin pine wrinkle, depigmentation of skin or color spot is arranged particularly, subjective sensation then is that skin is tight.Dry skin mainly occurs in face and hand.Reason is to lack VA and B family vitamin in the meals, and skin is subjected to branch to blow the cause of Exposure to Sunlight.
Natural moisture preserving system in the human body skin mainly is made up of water, lipid, NMF (NMF).Lipid is stratiform and is filled between the corneocyte, and main effect is to form the water barrier, prevents that moisture content from losing.Mostly lipid is apolar substance, can limit moisture content inside and outside cell and iuntercellular flow.NMF is the general name that is present in some low molecular weight substances that can combine with water in the cuticula, comprises other materials such as amino acid, 2-pyrrolidone-5-carboxylic acid, lactate.NMF accounts for 10% of corneocyte matrix, attracts hydrone by osmotic pressure.
Summary of the invention
The object of the present invention is to provide a kind of health food that improves moisture of skin and strengthen the immunity effect that has.The present invention is by scientific composition, and each function raw material is reasonably combined, can effectively strengthen body immunity and improve moisture of skin, brings into play corresponding health function.
Of the present invention have a health food that improves moisture of skin and strengthen the immunity effect, comprises following component by weight percentage:
Collagen peptide powder 1.0%～80.0%; Glucosamine 0.1%～40.0%;
Aloe extract 0.1%～30.0%; Vitamin C (ascorbic acid) 0.1%～50.0%;
Auxiliary material 0.0%～90.0%.
In the present invention, described collagen peptide powder is made by following method: be raw material with the fish scale, through decalcification, clean, extract dry back,, under 95-100 ℃ heating condition, extracted 2-6 hour with pure water, filter through mesh screen, extract and residue fish scale are separated, the collagen extract, in the collagen extract, add papain and carry out enzymolysis, treat that enzymolysis finishes back interpolation active carbon to the enzymolysis liquid processing of decolouring, remove by filter active carbon and other impurity, remove the heavy metal plasma through resin, reach refining purpose, adopt vacuum concentration process that enzymolysis liquid is concentrated, through 110 ℃, the high-temperature short-time sterilization of 20-30 second, last spray-drying promptly obtains described collagen peptide powder.
In the present invention, described collagen peptide powder can also be made by following method: the fish-skin raw material from freezer takes out, under natural environment, to thaw 10-24 hour, and the warm water profit that adds about 40 ℃ rises, and makes it soft, is easy to processing.Use the fish-skin after disintegrating machine rises to profit to carry out fragmentation, the pure water that adds simultaneously about 50 ℃ is sized mixing, and slurries is transferred in the enzymatic vessel constant volume, heating also adds ethanol, remove foreign protein, constant volume again after the removal of impurities is regulated PH=7.0-8.5, add chymotrypsin and papain, 40-55 ℃ of enzymolysis 3.5 hours, during do not stop to stir, enzyme goes out after reaction is finished.Enzymolysis liquid carries out centrifugation, removes residue, and clear liquid is behind membrane filtration, and low temperature concentrates, uses activated carbon decolorizing, sterilization, and spray-drying promptly obtains described collagen peptide powder.
The prepared collagen peptide powder of the present invention, its protein content 〉=70%, the above peptide molecular weight in peptide content 〉=60%, 70%≤5000 dalton.
In the present invention, described Glucosamine can be made by the form of various salt, the example hydrochloric acid Glucosamine is made by following method: with shrimp, the crab shell was with about 8% salt acid treatment 24 hours, to ash content≤10%, cleaning to pH value is more than 6, it is below 8 to pH value that above-mentioned clean shrimp and crab shells is handled 3 hours afterwash with 5% sodium hydroxide solution at 100 ℃, above-mentioned cleaned product is dried moisture≤below 15% under 90 ℃-100 ℃ temperature, be the chitin finished product, under 90 ℃ of conditions with chitin with hydrolysis 5h under 〉=31% hydrochloric acid solution, said hydrolyzed liquid is precipitated at normal temperatures, get the aminoglucose hydrochloride crude product after filtering, the aminoglucose hydrochloride crude product is dissolved again, and use activated carbon decolorizing, with the transparent liquid of aminoglucose hydrochloride Concentrated and crystallized in vacuum 8h under≤60 ℃ temperature, above-mentioned crystallization product with 〉=95% edible alcohol wash cleaning solution transparent till, moisture≤0.1% is arrived in the vacuum drying under 80 ℃ of temperature of the aminoglucose hydrochloride of top washes clean, carry out powder essence at last, screening, weighing, packing promptly obtains described aminoglucose hydrochloride.
In the present invention, described aloe extract is made by following method: select full more than 3 years, the ripe aloe leaf of growth cycle for use, soak, clean up with clear water, sterilization, acceptable material is chosen in go-no-go, remove epidermis, the peeling aloe of gained is squeezed the juice, obtain the thick juice of aloe, with the thick juice of aloe under 50 ℃～55 ℃ conditions, use pectinase enzymatic hydrolysis 20min-60min, decolouring with active carbon in the intact back of enzymolysis, gets enzymolysis liquid with concentration after filtration; Subsequently the gained enzymolysis liquid is carried out low-temperature quick-freezing (quick freezing temperature for-20 ℃ to-40 ℃), and be 8% in drying (temperature of charge is controlled at below 60 ℃) to water content under the vacuum of 13～130Pa; Pulverize at last, sieve, packing promptly obtains described aloe extract.
In the present invention, described vitamin C (ascorbic acid) is selected from synthetic vitamin C (ascorbic acid) and various vitamin C salt, coated vitamin C or natural complex C (acerola concentrate powder) and contains the ascorbic Fruit powder of high level, as one or more the mixing in sea-buckthorn powder, the Brazilian large cherry powder etc.
In the present invention, described auxiliary material comprises following component by weight percentage:
Fruit powder 0.0%～40.0%; Flavoring essence 0.0%～20.0%;
Sweetener 0.0%～80.0%; Acid 0.0%～30.0%;
Adhesive 0.0%～20.0%; Filler 0.0%～80.0%;
Lubricant 0.0%～5.0%; Diluent 0.0%～95.0%;
Dressing material 0.0%～10.0%; Local flavor conditioning agent 0.0%～5.0%;
Suspending agent 0.0%～5.0%; Anticorrisive agent 0.0%～5.0%.
Wherein, described Fruit powder is selected from one or more the mixing in sea-buckthorn powder, orange powder, lemon powder, cherry powder, apple powder, strawberry powder, milk powder and the coconut palm powder; Described flavoring essence is selected from one or more the mixing in corn essence, grapefruit essence, orange essence, lemon extract, cherry essence, flavoring apple essence, strawberry essence, milk flavour and the cocoanut flavour; Described sweetener is selected from that Sucralose, steviol glycoside, AK sugar, Aspartame, mogroside, knob are sweet, one or more the mixing in D-sorbite, isomalt, sweet mellow wine, maltitol, lactose and other sugar alcohols; Described acid is selected from one or more the mixing in citric acid, malic acid, lactic acid, tartaric acid and the fumaric acid; Described adhesive is selected from one or more the mixing in HPMC, methylcellulose, PVP, starch slurry, dextrin, Icing Sugar, syrup, rubber cement, gelatin and the microcrystalline cellulose; Described filler is selected from one or more the mixing in fructose, sucrose, starch, dextrin, microcrystalline cellulose, D-sorbite, isomalt, sweet mellow wine, maltitol, lactose and other sugar alcohols; Described lubricant is selected from one or more the mixing in talcum powder, dolomol, silica and the stearic acid; Described diluent is selected from one or more the mixing in alcohol, glycerine, propane diols, polyoxyethylene sorbitan monoleate, water and the edible oil; Described dressing material is selected from HPMC, talcum powder, polyvinyl alcohol, polyethylene glycol, Tween 80, PVP, hydroxyethylcellulose and colouring agent, cover one or more the mixing in the photo etching; Described local flavor conditioning agent is selected from one or more the mixing in malt extract, lipid end and the salt; Described suspending agent is selected from one or more the mixing in carragheen, xanthans, konjac glucomannan, beeswax, sapn, tween and the polyethylene glycol; Described anticorrisive agent is selected from one or more the mixing in parabens, sorbic acid salt and the ditert-butylhydro quinone.
Health food of the present invention can be made into the oral formulations such as tablet, pulvis, granule, hard capsule, soft capsule and oral liquid of various tastes.
The invention has the beneficial effects as follows: the location is unique, functional localization is strengthening immunity and is improving skin moisture, choosing is a primary raw material with collagen peptide powder, aminoglucose hydrochloride, aloe extract, vitamin C (ascorbic acid), according to different oral formulations, selects corresponding auxiliary material.In addition, the present invention is from aspects such as the choosing of raw material, buying, preparations, operate according to the relevant regulations of health food fully, guaranteed the advanced and stable of product, adopt modern preparation process, cooperate the strict quality method, make the present invention accomplish safety, effective, stable, quality controllable.Through toxicological security test and function assessment verification experimental verification, the present invention has good enhancing immunity and improves the health care of skin moisture, and without any side effects and bad reaction, is desirable health food.Therefore say that this product has stronger market competitive power.
Below in conjunction with accompanying drawing to the specific embodiments of the invention book that elaborates
Description of drawings
Fig. 1 is the chewable tablet preparation technology flow chart of health food of the present invention;
Fig. 2 is the tablet producing technology flow chart of swallowing of health food of the present invention;
Fig. 3 is the pulvis preparation technology flow chart of health food of the present invention;
Fig. 4 is the granule preparation technology flow chart of health food of the present invention;
Fig. 5 is the hard capsule preparation technology flow chart of health food of the present invention;
Fig. 6 is the soft capsule preparation technology flow chart of health food of the present invention;
Fig. 7 is the oral liquid preparation technology flow chart of health food of the present invention.
The specific embodiment
Embodiment one: the preparation of collagen peptide powder
With the fish scale is raw material, through decalcification, clean, extract dry back, uses pure water under 95-100 ℃ heating condition, extracted 2-6 hour, filter through mesh screen, extract and residue fish scale are separated, get the collagen extract, in the collagen extract, add papain and carry out enzymolysis, treat to add after enzymolysis is finished active carbon to the enzymolysis liquid processing of decolouring, remove by filter active carbon and other impurity, remove the heavy metal plasma through resin, reach refining purpose, adopt vacuum concentration process that enzymolysis liquid is concentrated, through 110 ℃, the high-temperature short-time sterilization of 20-30 second, last spray-drying promptly obtains described collagen peptide powder.
Embodiment two: the preparation of collagen peptide powder
Fish-skin raw material from freezer takes out thawed under natural environment 10-24 hour, and the warm water profit that adds about 40 ℃ rises, and makes it soft, is easy to processing.Use the fish-skin after disintegrating machine rises to profit to carry out fragmentation, the pure water that adds simultaneously about 50 ℃ is sized mixing.Slurries are transferred in the enzymatic vessel, and constant volume heats and adds ethanol, removes foreign protein.Again constant volume after the removal of impurities is regulated PH=7.0-8.5, adds chymotrypsin and papain, 40-55 ℃ of enzymolysis 3.5 hours, during do not stop to stir.Enzyme goes out after reaction is finished.Enzymolysis liquid carries out centrifugation, removes residue, and clear liquid is behind membrane filtration, and low temperature concentrates, uses activated carbon decolorizing, sterilization, and spray-drying promptly obtains described collagen peptide powder.
Embodiment three: the preparation of Glucosamine
Glucosamine can be made by the form of various salt, and the example hydrochloric acid Glucosamine is made by following method: with about 8% salt acid treatment 24 hours, to ash content≤10%, cleaning to pH value was more than 6 with shrimp, crab shell.It is below 8 to pH value that above-mentioned clean shrimp and crab shells is handled 3 hours afterwash with 5% sodium hydroxide solution at 100 ℃.Above-mentioned cleaned product is dried moisture≤below 15%, be the chitin finished product under 90 ℃-100 ℃ temperature.Under 90 ℃ of conditions with chitin with hydrolysis 5h under 〉=31% hydrochloric acid solution.Said hydrolyzed liquid is precipitated at normal temperatures, get the aminoglucose hydrochloride crude product after filtering.The aminoglucose hydrochloride crude product is dissolved again, and use activated carbon decolorizing.With the transparent liquid of aminoglucose hydrochloride Concentrated and crystallized in vacuum 8h under≤60 ℃ temperature.Above-mentioned crystallization product with 〉=95% edible alcohol wash cleaning solution transparent till.Moisture≤0.1% is arrived in the vacuum drying under 80 ℃ of temperature of the aminoglucose hydrochloride of top washes clean.Carry out powder essence, screening, weighing, packing at last, promptly obtain described aminoglucose hydrochloride.
Embodiment four: the preparation of aloe extract
Select full more than 3 years, the ripe aloe leaf of growth cycle for use, soak, clean up with clear water, sterilization, acceptable material is chosen in go-no-go, removes epidermis, the peeling aloe of gained is squeezed the juice, obtain the thick juice of aloe, the thick juice of aloe under 50 ℃～55 ℃ conditions, is used pectinase enzymatic hydrolysis 20min-60min, decolouring with active carbon in the intact back of enzymolysis, gets enzymolysis liquid with concentration after filtration; Subsequently the gained enzymolysis liquid is carried out low-temperature quick-freezing (quick freezing temperature for-20 ℃ to-40 ℃), and be 8% in drying (temperature of charge is controlled at below 60 ℃) to water content under the vacuum of 13～130Pa; Pulverize at last, sieve, packing promptly obtains described aloe extract.
Embodiment five: the preparation of vitamin C (ascorbic acid)
Vitamin C (ascorbic acid) is selected from synthetic vitamin C and various vitamin C salt, coated vitamin C or natural complex C (acerola concentrate powder) and contains the ascorbic Fruit powder of high level, as one or more the mixing in sea-buckthorn powder, Brazilian large cherry powder, Kiwi berry, bright jujube, strawberry, loquat, orange, tangerine, the persimmon etc.
Embodiment six: the preparation of the chewable tablet of described health food
Collagen peptide powder 20.0%; Glucosamine 3.0%; Aloe extract 0.5%;
Acerola concentrate powder 10.0%; D-sorbite 62.5%; Honey peach essence 0.5%;
Flavoring apple essence 0.5%; Malic acid 1.0%; Citric acid 1.0%;
Dolomol 0.6%; Silica 0.4%.
Earlier with collagen peptide powder, Glucosamine, aloe extract, acerola concentrate powder, D-sorbite, citric acid, malic acid, honey peach essence, flavoring apple essence is pulverized or sieve; Taking by weighing the less aloe extract of formula ratio, citric acid, malic acid, honey peach essence, flavoring apple essence mixes; Again load weighted former protein peptide powder, Glucosamine, acerola concentrate powder, D-sorbite, dolomol, silica being dropped into mixer carries out always mixing with the unclassified stores that has mixed; The material that always is mixed after sparing is carried out compressing tablet by tablet press machine; Last packing promptly makes the chewable tablet of health food of the present invention.
The chewable tablets sample that makes according to embodiment six, carry out toxicological test according to " health food check and assessment technique standard " (version in 2003) regulation, the result is as follows: 1, acute oral toxicity test result: the maximum tolerated dose (MTD) of female, male Kunming mouse all greater than 20.0g/kgbw, is belonged to nontoxic level.2, three genetic toxicity test results: Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity result of the test are all negative.3,30 days feeding trial results: give rat oral gavage 30 days with 2.5g/kgbw, 5.0g/kgbw, 10.0g/kgbw dosage, experimental session, animal growth is good, each dosage group body weight, weightening finish, food utilization, routine blood test index, blood biochemistry index, organ weights and internal organs/body weight ratio and control group compare, there was no significant difference (P＞0.05).Gross anatomy is not seen the abnormal change relevant with sample with tissue pathology checking.Point out to feed in 30 days rat is not seen obvious toxic-side effects.According to " health food check and assessment technique standard " (version in 2003) regulation, animal function and human feeding trial have been carried out, the result is as follows: 1) per os gives mouse 0.5g/kgbw, 1.0g/kgbw, 3.0g/kgbw dosage 30 days, 1.0g/kgbw, 3.0g/kgbw dosage can strengthen the mouse delayed allergy, improve mouse the antibody-producting cell number, strengthen the NK cells in mice activity, 3.0g/kgbw dosage can increase ability and mice serum HD50 value that mouse monokaryon-the macrophage charcoal is cleaned up, compare P＜0.05 or P＜0.01 with control group.Mouse lymphocyte conversion capability and the huge ability of biting chicken red blood cell of mouse that weight of mice, spleen/body weight ratio, ConA induce there is not obvious influence.Point out this sample to have the function that strengthens immunity.2) volunteer is divided into test-meal group and control group at random by the skin moisture situation, edible respectively sample and placebo, the test back is the result show: test-meal group skin moisture obviously improves after test-meal, with comparing difference before the test-meal conspicuousness (P＜0.05) is arranged, with the control group comparing difference conspicuousness (P＜0.05) is arranged also, point out this sample to have the function of the skin moisture of improvement.Before and after the test-meal sample, every detection indexs such as routine blood test, blood biochemistry show no obvious abnormalities variation, also do not observe allergy and other bad reactions.
Embodiment seven: the preparation of the tablet of swallowing of described health food
Collagen peptide powder 15.0%; Glucosamine 3.0%; Aloe extract 0.5%;
Vitamin C sodium salt 1.5%; Isomalt 45.0%; Dextrin 10.0%;
Starch 20.0%; PVP 3.0%; Dolomol 0.6%;
Silica 0.4%; Dressing material 1.0%.
Elder generation pulverizes collagen peptide powder, Glucosamine, aloe extract, vitamin C, isomalt, dextrin, starch, PVP or sieves; By formula ratio take by weighing pulverizing successively, material after sieving; Load weighted material is dropped into mixer, mix; Add an amount of alcohol, granulate by granulator; The particle that makes is carried out drying with drying equipment, carry out whole grain by pelletizing machine subsequently; Adding dolomol, silica carry out always mixing, and the material that always is mixed after sparing is carried out compressing tablet by tablet press machine, and plain sheet is temporary, and is standby; The dressing material is added in the suitable quantity of water, stir, be mixed with the coating solution that concentration is 5.0%-15.0%, the plain sheet that presses is carried out Cotton seeds by the dressing machine; Last packing promptly makes the tablet of swallowing of health food of the present invention.
Execute example eight: the preparation of the pulvis of described health food
Collagen peptide powder 20.0%; Glucosamine 4.0%; Aloe extract 1.0%;
Vitamin C 1.5%; Antierythrite 45.0%; Fructose 15.0%;
Sucralose 0.2%; Lemon powder 9.0%; Lemon extract 2.0%;
Malic acid 1.5%; Citric acid 0.8%; Carragheen 1.0%.
Earlier above-mentioned each material is sieved; Take by weighing material after sieving successively by formula ratio; Load weighted material is dropped into mixer, mix; After the packing, promptly make the pulvis of health food of the present invention.
Embodiment nine: the preparation of the granule of described health food
Collagen peptide powder 15.0%; Glucosamine 3.0%; Aloe extract 1.0%;
Vitamin C 1.5%; Sucrose 25.0%; Isomalt 31.9%;
Dextrin 10.0%; PVP 3.0%; AK sugar 0.1%;
Orange essence 2.5%; Orange powder 5.0%; Malic acid 1.5%;
Citric acid 0.5%.
Earlier above-mentioned each material is pulverized, sieved; By formula ratio take by weighing pulverizing successively, material after sieving; Load weighted material is dropped into mixer, mix; Add an amount of alcohol, granulate by granulator; The particle that makes is carried out drying with drying equipment, carry out whole grain by pelletizing machine subsequently; Last packing promptly makes the granule of health food of the present invention.
Embodiment ten: the preparation of the hard capsule of described health food
Collagen peptide powder 50.0%; Glucosamine 10.0%; Aloe extract 2.0%;
Coated vitamin C 5.0%; Microcrystalline cellulose 32.0%; Dolomol 0.6%;
Silica 0.4%.
Earlier above-mentioned each material is pulverized, sieved; By formula ratio take by weighing pulverizing successively, material after sieving; Load weighted material is dropped into mixer, mix; By capsule filler capsule is filled then; Last packing promptly makes the hard capsule of health food of the present invention.
Embodiment 11: the preparation of the soft capsule of described health food
The prescription of soft capsule peel is as follows:
Gelatin 3 6.0%; Glycerine 18.0%;
Methyl p-hydroxybenzoate 0.06%; Water 45.94%.
After taking by weighing above-mentioned rubber raw material by formula ratio, change glue in the inputization glue jar; The rubber solution of gained is transferred in the bucket of band attemperator after by colloid mill, is connected on the soft capsule pellet press, be used to prepare soft capsule peel.
The prescription of health food of the present invention is as follows:
Collagen peptide powder 10.0%; Glucosamine 2.0%; Aloe extract 0.5%;
Vitamin C 0.8%; Soybean oil 73.8%; Beeswax 2.0%;
Ditert-butylhydro quinone 0.2%.
Earlier collagen peptide powder, Glucosamine, aloe extract, vitamin C are pulverized, sieved; Material after sieving by the formula ratio weighing, standby; Take by weighing soybean oil, beeswax and ditert-butylhydro quinone by formula ratio, be heated dissolving, drop in the above-mentioned standby material, stir, make its emulsification; Obtain uniform and stable emulsion by colloid mill then.Above-mentioned emulsion is put into reservoir, be injected in the soft capsule peel, suppress by the soft capsule pellet press; The soft capsule that presses is cleaned, and be cured by drying equipment; Last packing promptly makes the soft capsule of health food of the present invention.
Embodiment 12: the preparation of the oral liquid of described health food
Collagen peptide powder 25.0%; Glucosamine 4.0%; Aloe extract 1.0%;
Vitamin C sodium salt 1.5%; Sucrose 41.0%; Fructose 15.0%;
Sucralose 0.2%; Strawberry powder 9.0%; Strawberry essence 1.0%;
Malic acid 1.5%; Citric acid 0.8%.
Take by weighing above-mentioned each material by formula ratio, drop in the water, fully dissolving; Then gained solution is transferred in the oral liquid bottle placer, injects in the container; Sterilize, promptly make the oral liquid of health food of the present invention.
The raw material of above-mentioned various exact efficacy is carried out scientific composition, thereby guarantee the effect of product.In the present invention, the collagen peptide powder is owing to belong to peptide matters, utilization easily is absorbed by the body, the needed important composition collagen of preserving moisture of synthesized human skin, collagen is the main component in the skin, account for more than 71% of protein content in the skin cell, the network structure that it constitutes in the skin can effectively keep moisture in the skin.And the Glucosamine utilization that is absorbed by the body forms high molecular glucide in skin, can firmly pin the moisture in the skin, and moisture in the skin can be effectively pinned in the two collocation.Studies show that simultaneously collagen peptide and Glucosamine also have the function that improves body immunity.Contain a large amount of polysaccharide and the various composition of preserving moisture in the aloe extract, can effectively strengthen body immunity and improve moisture of skin.Vitamin C can effectively promote the synthetic of collagen in vivo, is a kind of important vitamin substances of needed by human body.Various active ingredients are reasonably combined, can give full play to health care of the present invention.
The former protein peptide powder of collagen peptide arogel of the present invention is a kind of hmw protein, and thread collagen fabric can make skin keep solid and flexible.Collagen is the main component in the skin, accounts for more than 71% of protein content in the skin cell.The growth of skin, reparation and nutrition all be unable to do without collagen.Collagen makes cell become plentiful, thereby makes skin full, keeps skin elasticity with moist.Therefore, it is particularly important that additional skin collagen just seems, motherland's medical science recognizes for a long time, with tortoise-shell glue, deer horn glue, donkey-hide gelatin etc. as invigorant, can play anti-aging, the effect of beautifying face and moistering lotion.These all contain a large amount of collagens.In addition, also contain a large amount of amino acid in the collagen, its main component is a free amino acid such as glycine, hydroxyproline, alanine, asparatate, serine, and amino acid content accounts for about 40%, and they all are the NMF compositions.In addition, a large amount of existence of tropocollagen molecule outside hydrophilic radical carboxyl and hydroxyl etc. make tropocollagen molecule very easily form hydrogen bond with water, so collagen and polypeptide have good water conservation moisture-keeping functions.Collagen contains a kind of amino acid of uniqueness---need a large amount of HYP when hydroxyproline (HYP), synthetic new collagen.And skin moistened is relevant with institute's water content in the epidermis with elasticity.There are some researches show that the nutrition of collagen peptide and physiological function mainly contain following several respects: protect gastric mucosa and antiulcer action, the effect of inhibition increased blood pressure, promote bone formation effect, promote the skin collagen metabolism, collagen diseases such as arthritis are had excellent prevention and therapeutic action.Therefore, collagen peptide has very big DEVELOPMENT PROSPECT at food and medicine and other fields.In addition, collagen peptide has the effect that strengthens immunity.Collagen peptide and fiber adhesion albumen have very high compatibility, so collagen peptide has very dark influence to the cancer metastasis process.Discover in addition with enzyme handle the black carp collagen can obtain having suppress blood platelet condense, antitumor, improve multiple biologically active peptide such as immunocompetence.By having studied rosy clouds jellyfish collagen protein active peptide effect of immunologic function is shown that rosy clouds jellyfish collagen protein active peptide has certain immunological enhancement.Moreover collagen peptide powder of the present invention is a kind of peptide matters that makes through enzymolysis, has characteristics such as easy digestion, easy absorption.
Glucosamine has the important physical effect to human body.Glucosamine is as the final catabolite of chitin, the synthetic isoreactivity that not only has treatment of arthritis, anti-inflammatory, SP polysaccharide, and can activate NK, LAK cell, has immunoregulation effect, and participate in structure tissue and cell membrane, be the intermediate material of the big molecule synthesis of proteoglycan.Because this compounds has physiologically active, therefore to use comparatively extensively at medicine, biological field, the research of association area also is subjected to increasing attention.There are some researches show that Glucosamine can induce white blood corpuscle K562 also can suppress the growth of tumour cell to the macrophage differentiation.Simultaneously Glucosamine can obviously suppress the growth of SGC27901 cell, to the inhibitory action of HepG22, the growth of LS2174 cell a little less than.Glucosamine also has the effect of mitosis former state, can induction of lymphocyte propagation and secretion IL22.Show that Glucosamine has certain antitumor action and immunological enhancement.Glucosamine increases the expression of calcineurin, the Ca of activated lymphocyte by improving calcium ion concentration in the lymph simultaneously
2+Signal path, induction of lymphocyte propagation.Studies show that Glucosamine concentration 200,100mgL
-1The time, can significantly promote the mouse boosting cell propagation that ConA induces, performance strengthens immunity.
Aloe Liliaceae perennial herb, evergreen, meat herbaceous plant, the present invention has added aloe extract.As a kind of natural plant crude drugs, in " Chinese Compendium of Materia Medica " just relevant for the record of aspects such as aloe proterties, function.Polysaccharide is the main active in the aloe.Research in decades is verified, and aloe polysaccharide has been brought into play certain effect at aspects such as regulating immunity of organism, antitumor, radioresistance.The aloe polysaccharide extract can promote the growth of mouse immune organ spleen, thymus gland, and it is obviously relevant with dosage that its weight increases trend, has the effect that promotes to strengthen immunologic function.Research and inquirement under acute low pressure severe hypoxia and the tired stressed condition aloe to the influence of mouse immune cytokine, the result shows: anoxia condition down and fatigue stress be regulated down serum interleukin 1,6, the normal control group of 8 content obviously descends, and serum interleukin 1,6,8 content of bright aloe, compound Chinese aloe group then do not reduce substantially.Show that aloe stress have certain immunoregulation effect by mouse to anoxic fatigue.There are some researches show that also the aloe barbadensis Miller polysaccharide can significantly improve S
180Mouse red blood cell C
3bAcceptor garland promotion rate reduces its inhibiting rate, thereby from the erythrocyte immune angle, discloses aloe polysaccharide and have function antitumor and the raising immunity of organism.By aloe gel juice and polysaccharide thereof the mouse of feeding, measure spleen and thymic weight, macrophage phagocytic function and lymphocyte quantity and the function of respectively organizing mouse.The result compares aloe gel juice and polysaccharide solution thereof with control group all makes mouse immune organ spleen, thymic weight that increase is in various degree arranged; The percentage of engulfing of Turnover of Mouse Peritoneal Macrophages rises to 53.17% and 38.57% from 17.33% respectively, and phagocytic index rises to 1.23 and 0.69 from 0.28 respectively; T lymphocyte quantity and the function compared with control group in the mouse peripheral blood also have remarkable increase.Both all have certain humidification to the body's immunity of mouse preliminary explanation, and effect the former be better than the latter.Aloe contains abundant B family vitamin and vitamin C, provitamin A, vitamin E.Face and hand mainly take place in dry skin, one of them reason is be deficient in vitamin in the meals A and B family vitamin, and the skin cause of being exposed to the weather, the amino acid that contains in the aloe, organic acid, polysaccharide and trace element, all be the composition in the skin NMF (NMF), so aloe has the effect that improves skin moisture.
Vitamin C (ascorbic acid) has synthetic, the prevention scurvy that promotes collagen, treatment gingival atrophy, hemorrhage, prevention of arterial sclerosis, antioxidant, treatment anaemia, anti-cancer, protection cell, detoxifcation, the protection liver, improves the immunity of human body, the effect that improves the emergency capability of body.The synthetic vitamin C that needs of collagen is participated in, so hypovitaminosis C, collagen can not normally synthesize, and causes the cell asynthesis.Therefore, the collocation of vitamin C and collagen peptide powder has synergy among the present invention.In addition, vitamin C is a kind of powerful antioxidant, and itself is oxidized, and makes oxidized form of glutathione be reduced to reduced glutathione, thus the performance antioxidation.As long as vitamin C abundance; then vitamin C, glutathione ,-SH forms strong anti-oxidant set boxing, removes free radical, stops the toxic action of lipid peroxidation and some chemical substance; the eubolism of liver-protective detoxification ability and cell, the performance beautification function.Human leukocytes contains abundant vitamin C equally, and intraleukocytic vitamin C can sharply reduce when organism infection.And replenishing vitamins C can strengthen the chemotaxis and the deformability of neutrophil leucocyte, improve sterilizing ability, promote lymphoblastic generation, improve body to the identification of external and malignant cell with kill, participate in the synthetic of immunoglobulin (Ig), improve CI complement esterase active, increase the generation of complement CI, promote the generation of interferon, viral interference mRNA transcribes, the hyperplasia that suppresses virus, thus performance strengthens the health care of immunity.
Claims (11)
1. one kind has the health food that improves moisture of skin and strengthen immunity function, comprises following component by weight percentage:
Collagen peptide powder 1.0%～80.0%; Glucosamine 0.1%～40.0%;
Aloe extract 0.1%～30.0%; Vitamin C (ascorbic acid) 0.1%～50.0%;
Auxiliary material 0.0%～90.0%.
2. health food according to claim 1, it is characterized in that, described collagen peptide powder is made by following method: be raw material with the fish scale, through decalcification, clean, extract dry back,, extracted 2-6 hour under 95-100 ℃ heating condition with pure water, filter through mesh screen, extract and residue fish scale are separated, get the collagen extract, in the collagen extract, add papain and carry out enzymolysis, treat to add after enzymolysis is finished active carbon to the enzymolysis liquid processing of decolouring, remove by filter active carbon and other impurity, remove the heavy metal plasma, reach refining purpose through resin, adopt vacuum concentration process that enzymolysis liquid is concentrated, through 110 ℃, the high-temperature short-time sterilization of 20-30 second, last spray-drying makes this product.
3. health food according to claim 1 is characterized in that, described collagen peptide powder is made by following method: from the fish-skin raw material of freezer taking-up, thawed under natural environment 10-24 hour, the warm water profit that adds about 40 ℃ rises, and makes it soft, be easy to processing, use the fish-skin after disintegrating machine rises to profit to carry out fragmentation, the pure water that adds simultaneously about 50 ℃ is sized mixing, and slurries are transferred in the enzymatic vessel, constant volume, heating also adds ethanol, removes foreign protein, constant volume again after the removal of impurities, regulate PH=7.0-8.5, add chymotrypsin and papain, 40-55 ℃ of enzymolysis 3.5 hours, during do not stop to stir, enzyme goes out after reaction is finished, enzymolysis liquid carries out centrifugation, removes residue, and clear liquid is behind membrane filtration, low temperature concentrates, use activated carbon decolorizing, sterilization, spray-drying obtains finished product.
4. health food according to claim 1 is characterized in that: in the described collagen peptide powder, and protein content 〉=70%, the above peptide molecular weight in peptide content 〉=60%, 70%≤5000 dalton.
5. health food according to claim 1, it is characterized in that, described Glucosamine can be made by the form of various salt, the example hydrochloric acid Glucosamine is made by following method: with shrimp, the crab shell was with about 8% salt acid treatment 24 hours, to ash content≤10%, cleaning to pH value is more than 6, it is below 8 to pH value that above-mentioned clean shrimp and crab shells is handled 3 hours afterwash with 5% sodium hydroxide solution at 100 ℃, above-mentioned cleaned product is dried moisture≤below 15% under 90 ℃-100 ℃ temperature, be the chitin finished product, under 90 ℃ of conditions with chitin with hydrolysis 5h under 〉=31% hydrochloric acid solution, said hydrolyzed liquid is precipitated at normal temperatures, get the aminoglucose hydrochloride crude product after filtering, the aminoglucose hydrochloride crude product is dissolved again, and use activated carbon decolorizing, with the transparent liquid of aminoglucose hydrochloride Concentrated and crystallized in vacuum 8h under≤60 ℃ temperature, above-mentioned crystallization product with 〉=95% edible alcohol wash cleaning solution transparent till, the vacuum drying under 80 ℃ of temperature of the aminoglucose hydrochloride of top washes clean is carried out powder essence at last to moisture≤0.1%, screening, weighing, packing is finished product.
6. health food according to claim 1, it is characterized in that, described aloe extract is made by following method: select full more than 3 years, the ripe aloe leaf of growth cycle for use, soak, clean up with clear water, sterilization, acceptable material is chosen in go-no-go, remove epidermis, the peeling aloe of gained is squeezed the juice, obtain the thick juice of aloe, the thick juice of aloe under 50 ℃～55 ℃ conditions, is used pectinase enzymatic hydrolysis 20min-60min, decolouring with active carbon in the intact back of enzymolysis, gets enzymolysis liquid with concentration after filtration; Subsequently the gained enzymolysis liquid is carried out low-temperature quick-freezing (quick freezing temperature for-20 ℃ to-40 ℃), and be 8% in drying (temperature of charge is controlled at below 60 ℃) to water content under the vacuum of 13～130Pa; Pulverize at last, sieve, packing gets product.
7. health food according to claim 1, it is characterized in that: described vitamin C (ascorbic acid) is selected from synthetic vitamin C and various vitamin C salt, coated vitamin C or natural complex C (acerola concentrate powder) and contains the ascorbic Fruit powder of high level, as one or more the mixing in sea-buckthorn powder, Brazilian large cherry powder, Kiwi berry, bright jujube, strawberry, loquat, orange, tangerine, the persimmon etc.
8. health food according to claim 1 is characterized in that, described auxiliary material comprises following component by weight percentage:
Fruit powder 0.0%～40.0%; Flavoring essence 0.0%～20.0%;
Sweetener 0.0%～80.0%; Acid 0.0%～30.0%;
Adhesive 0.0%～20.0%; Filler 0.0%～80.0%;
Lubricant 0.0%～5.0%; Diluent 0.0%～95.0%;
Dressing material 0.0%～10.0%; Local flavor conditioning agent 0.0%～5.0%;
Suspending agent 0.0%～5.0%; Anticorrisive agent 0.0%～5.0%.
9. health food according to claim 7 is characterized in that: described Fruit powder is selected from one or more the mixing in sea-buckthorn powder, orange powder, lemon powder, cherry powder, apple powder, strawberry powder, milk powder and the coconut palm powder; Described flavoring essence is selected from one or more the mixing in corn essence, grapefruit essence, orange essence, lemon extract, cherry essence, flavoring apple essence, strawberry essence, milk flavour and the cocoanut flavour; Described sweetener is selected from that Sucralose, steviol glycoside, AK sugar, Aspartame, mogroside, knob are sweet, one or more the mixing in D-sorbite, isomalt, sweet mellow wine, maltitol, lactose and other sugar alcohols; Described acid is selected from one or more the mixing in citric acid, malic acid, lactic acid, tartaric acid and the fumaric acid; Described adhesive is selected from one or more the mixing in HPMC, methylcellulose, PVP, starch slurry, dextrin, Icing Sugar, syrup, rubber cement, gelatin and the microcrystalline cellulose; Described filler is selected from one or more the mixing in fructose, sucrose, starch, dextrin, microcrystalline cellulose, D-sorbite, isomalt, sweet mellow wine, maltitol, lactose and other sugar alcohols; Described lubricant is selected from one or more the mixing in talcum powder, dolomol, silica and the stearic acid; Described diluent is selected from one or more the mixing in alcohol, glycerine, propane diols, polyoxyethylene sorbitan monoleate, water and the edible oil; Described dressing material is selected from HPMC, talcum powder, polyvinyl alcohol, polyethylene glycol, Tween 80, PVP, hydroxyethylcellulose and colouring agent, cover one or more the mixing in the photo etching; Described local flavor conditioning agent is selected from one or more the mixing in malt extract, lipid end and the salt; Described suspending agent is selected from one or more the mixing in carragheen, xanthans, konjac glucomannan, beeswax, sapn, tween and the polyethylene glycol; Described anticorrisive agent is selected from one or more the mixing in parabens, sorbic acid salt and the ditert-butylhydro quinone.
10. health food according to claim 1 is characterized in that: described product is prepared to oral formulations.
11. health food according to claim 10 is characterized in that: described oral formulations comprises tablet, pulvis, granule, hard capsule, soft capsule and oral liquid.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002125638A (en) * | 2000-10-19 | 2002-05-08 | Nippon Meat Packers Inc | Joint strengthening beverage |
| CN1698626A (en) * | 2005-05-31 | 2005-11-23 | 中国海洋大学 | Skin beautifying agent and food with heath caring and beautifying function |
| CN1986828A (en) * | 2005-12-22 | 2007-06-27 | 法玛智财科技顾问股份有限公司 | Fish scale collagen and its production process |
| CN101828661A (en) * | 2010-05-13 | 2010-09-15 | 山东森健生物科技发展有限公司 | Health-care food for improving moisture of skin and removing wrinkle |
-
2011
- 2011-02-01 CN CN 201110034094 patent/CN102106502B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002125638A (en) * | 2000-10-19 | 2002-05-08 | Nippon Meat Packers Inc | Joint strengthening beverage |
| CN1698626A (en) * | 2005-05-31 | 2005-11-23 | 中国海洋大学 | Skin beautifying agent and food with heath caring and beautifying function |
| CN1986828A (en) * | 2005-12-22 | 2007-06-27 | 法玛智财科技顾问股份有限公司 | Fish scale collagen and its production process |
| CN101828661A (en) * | 2010-05-13 | 2010-09-15 | 山东森健生物科技发展有限公司 | Health-care food for improving moisture of skin and removing wrinkle |
Non-Patent Citations (3)
| Title |
|---|
| 《安徽医药》 20070131 李金林等 D-氨基葡萄糖盐酸盐的制备优化研究 第11-12页 1-11 第11卷, 第1期 * |
| 《广东化工》 20091231 周治德等 芦荟冻干粉生产概述 第61-62页 1-11 第36卷, 第11期 * |
| 《营养学报》 20070228 付辰炜等 氨基葡萄糖对小鼠免疫功能的影响 第51-54页 1-11 第29卷, 第1期 * |
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