CN102058504A - Anti-saccharification agent - Google Patents

Abstract

The invention provides the application of extracts of buddleja blades, and the extracts of buddleja blades are used to produce anti-saccharification agents, anti-aging agents, skin collagen damage inhibitors, or agents for inhibiting, preventing or improving the decrease in skin firmness or elasticity or skin wrinkles.

Description

Anti-gfycation agent

Technical field

The present invention relates to the damage inhibitor of anti-gfycation agent, age resister, skin collagen as uses such as cosmetic composition or food compositions and skin-tightening degree or elastic force descends or inhibition, prevention or the improving agent of wrinkle of skin and the application that is used to make these materials.

Background technology

Between reducing sugar such as glucose and protein saccharification react (Maillard reaction) taking place, generates the saccharifying product.Proteinic saccharification react also takes place in the organism, but when cause hyperglycemia state to continue because of diabetes etc., when perhaps causing decomposition reaction to be difficult to carry out because of age growth, reaction is tilted to the generation of saccharifying product, thereby cause proteinic function impaired, perhaps the saccharifying product is accumulated.This saccharifying product finally becomes glycation end product in late period (Advanced glycation end products; Below also abbreviate " AGEs " sometimes as), the generation of AGEs is an irreversible reaction.The AGEs that generates excretes by metabolism, but with age, accretion rate is slack-off, accumulates in AGEs each tissue in vivo.

AGEs by accumulate in each tissue in vivo or with the receptors bind of AGEs, can cause various symptoms.For example, if in skin (epidermis, corium), generate and accumulate AGEs, then can become whole old and feeble (one of) the reason for example: skin-tightening degree or elastic force decline, wrinkle, colour of skin variation, transparent feel decline, mottle etc. such as lax, dark yellow of skin.In addition, for diabetics, the AGEs that produces because of hyperglycemia can cause complication such as cataract, arteriosclerosis, renal dysfunction.Therefore, for the AGEs that will generate excretes, it is very important that AGEs is decomposed into the form that excretes easily.

At present, for making the effective ingredient of cosmetic composition or food compositions, the composition that suppresses the AGEs generation, the composition that decomposes AGEs are explored.For example, record in the patent documentation 1: the volatility oily thing of Citrus can suppress the generation of the pentose element (ペ Application ト シ ジ Application) as the part of AGEs structure.In addition, record in the patent documentation 2: the Fructus Canrii Albi extract that utilizes ethanol water to extract has the AGEs decomposition, can suppress gloomy skin.

In addition, noroctopine (CMA) is a kind of of specificity is accumulated in collagen protein AGEs structure, the AGEsization of skin collagen is considered to the main cause of wrinkle, skin aging symptom such as lax, gloomy, record in the patent documentation 3: the CMA formation inhibitor is by suppressing the AGEsization of collagen protein, can suppress the proteic degeneration of organism such as skin and blood vessel, can be effectively as one of index of skin aging.

The prior art document

Patent documentation 1: TOHKEMY 2004-35424 number

Patent documentation 2: TOHKEMY 2001-122758 number

Patent documentation 3: TOHKEMY 2009-96731 number

Summary of the invention

Major subjects of the present invention is, the application that a kind of new anti-gfycation agent is provided and is used to make the special component of anti-gfycation agent.

The inventor has carried out research repeatedly in order to solve above-mentioned problem, obtains following opinion.

(i) Herba Buddlejae Lindleyanae (Buddleja axillaris) leaf extract can effectively suppress by the saccharification react between protein such as collagen protein and the reducing sugar and the generation of the AGEs that causes.Thus, can suppress the damage of skin collagen, and then suppress, prevent or improve skin-tightening degree (Zhang ) or the decline of elastic force or the skin aginges such as wrinkle of skin.

(ii) ultraviolet can promote saccharification react.

(iii) the Herba Buddlejae Lindleyanae leaf extract also can effectively suppress the saccharification react by the ultraviolet promotion.Thus, can suppress the damage of the skin collagen that promotes by ultraviolet, and then suppress the skin aging that skin-tightening degree or the decline of elastic force or the wrinkle of skin etc. are promoted by ultraviolet.

The present invention is based on above-mentioned opinion and further studies repeatedly and finish, and provides the damage inhibitor of following anti-gfycation agent, age resister, skin collagen and skin-tightening degree or elastic force to descend or inhibition, prevention or the improving agent of wrinkle of skin and the application that is used to make these materials.

The 1st. the application of Herba Buddlejae Lindleyanae leaf extract is used to make anti-gfycation agent.

The 2nd. as the 1st described application, wherein, the extract of at least a solvent extraction in the group that the Herba Buddlejae Lindleyanae leaf extract is formed for the polyhydric alcohol that utilizes the monohydric alcohol select Free water, carbon number 1～4 and carbon number 2～6.

The 3rd. as the 1st or the 2nd described application, wherein, anti-gfycation agent is a cosmetic composition.

The 4th. as the 1st or the 2nd described application, wherein, anti-gfycation agent is a food compositions.

The 5th. a kind of application of Herba Buddlejae Lindleyanae leaf extract is used to make age resister.

The 6th. as the 5th described application, wherein, the extract of at least a solvent extraction in the group that the Herba Buddlejae Lindleyanae leaf extract is formed for the polyhydric alcohol that utilizes the monohydric alcohol select Free water, carbon number 1～4 and carbon number 2～6.

The 7th. as the 5th or the 6th described application, wherein, age resister is a cosmetic composition.

The 8th. as the 5th or the 6th described application, wherein, age resister is a food compositions.

The 9th. the application of Herba Buddlejae Lindleyanae leaf extract is used to make the damage inhibitor of skin collagen.

The 10th. as the 9th described application, wherein, the extract of at least a solvent extraction in the group that the Herba Buddlejae Lindleyanae leaf extract is formed for the polyhydric alcohol that utilizes the monohydric alcohol select Free water, carbon number 1～4 and carbon number 2～6.

The 11st. as the 9th or the 10th described application, wherein, the damage inhibitor of skin collagen is a cosmetic composition.

The 12nd. as the 9th or the 10th described application, wherein, the damage inhibitor of skin collagen is a food compositions.

The 13rd. the application of Herba Buddlejae Lindleyanae leaf extract is used to make that skin-tightening degree or elastic force descend or inhibition, prevention or the improving agent of wrinkle of skin.

The 14th. as the 13rd described application, wherein, the extract of at least a solvent extraction in the group that the Herba Buddlejae Lindleyanae leaf extract is formed for the polyhydric alcohol that utilizes the monohydric alcohol select Free water, carbon number 1～4 and carbon number 2～6.

The 15th. as the 13rd or the 14th described application, wherein, skin-tightening degree or elastic force descend or inhibition, prevention or the improving agent of wrinkle of skin are cosmetic composition.

The 16th. as the 13rd or the 14th described application, wherein, skin-tightening degree or elastic force descend or inhibition, prevention or the improving agent of wrinkle of skin are food compositions.

The 17th. a kind of food compositions wherein, comprises the Herba Buddlejae Lindleyanae leaf extract of 0.2～40 weight %.

The 18th. as the 17th described compositions, wherein, the extract of at least a solvent extraction in the group that the Herba Buddlejae Lindleyanae leaf extract is formed for the polyhydric alcohol that utilizes the monohydric alcohol select Free water, carbon number 1～4 and carbon number 2～6.

The invention effect

Of the present invention or as the anti-gfycation agent of the manufacturing object of application of the present invention, by comprising the Herba Buddlejae Lindleyanae leaf extract, can effectively suppress saccharification react, utilize this effect, can suppress skin aging.

Particularly, be coated on the skin or picked-up comprises the food compositions of Herba Buddlejae Lindleyanae leaf extract by the cosmetic composition that will comprise the Herba Buddlejae Lindleyanae leaf extract, can prevent, suppress, improve the generation of the AGEs that the saccharifying because of skin proteins such as collagen protein causes or the skin aging that causes because of accumulating of AGEs or wear out.Thus, the impression of skin integral body is retained youth, obtain young outward appearance.As the aging of skin, for example can enumerate: degradation under the degree of compacting of skin or flexibility decrease, wrinkle, pachylosis, skin texture disorder, gloomy, the transparent feel.

In addition, pass through ultraviolet radiation, can promote the generation of the AGEs that the saccharifying because of skin proteins such as collagen protein causes, thereby promote the aging of skin that the Herba Buddlejae Lindleyanae leaf extract can also suppress the skin aging (photoaging) that causes because of saccharifying that ultraviolet radiation promotes.Like this, the Herba Buddlejae Lindleyanae leaf extract saccharifying that can effectively suppress to cause, aging by ultraviolet radiation.In addition, ultraviolet can cause skin collagen take place to cut off or be crosslinked, and the Herba Buddlejae Lindleyanae leaf extract can effectively suppress the cut-out of this skin collagen that is caused by ultraviolet or crosslinked.

Thus, can to suppress under the skin-tightening degree that caused by ultraviolet radiation or flexibility decrease, wrinkle, pachylosis, skin texture disorder, gloomy, the transparent feel degradation aging for the Herba Buddlejae Lindleyanae leaf extract.

In addition, of the present invention or as the anti-gfycation agent of the manufacturing object of application of the present invention, be hopeful to prevent or improve various diseases (diabetic complication (cataract, arteriosclerosis, renal dysfunction, retinopathy, neurological disorder etc.), arteriosclerosis, malignant tumor, osteopathia, senile dementia, the parkinson etc. that cause by AGEs.

Description of drawings

Fig. 1 is the figure that AGEs that expression is caused by UVA irradiation promotes.

Fig. 2 is that expression Herba Buddlejae Lindleyanae leaf extract suppresses the figure that the AGEs under the UVA irradiation generates.

Fig. 3 is that expression Herba Buddlejae Lindleyanae leaf extract suppresses the figure that the CMA under the UVA irradiation generates.

Fig. 4 is that expression Herba Buddlejae Lindleyanae leaf extract suppresses the figure that the CMA under the UVA irradiation generates.

Fig. 5 is that expression Herba Buddlejae Lindleyanae leaf extract suppresses the figure that the CMA under the UVA irradiation generates.

Fig. 6 is that expression Herba Buddlejae Lindleyanae leaf extract suppresses the figure that the AGEs under the UVA irradiation generates.

Fig. 7 is that expression Herba Buddlejae Lindleyanae leaf extract suppresses the plain figure that generates of pentoside under the UVA irradiation.

The specific embodiment

Below, describe the present invention in detail.

The damage inhibitor of anti-gfycation agent of the present invention, age resister, skin collagen and skin-tightening degree or elastic force descend, inhibition, prevention or the improving agent of wrinkle of skin, comprise the Herba Buddlejae Lindleyanae leaf extract as effective ingredient.In addition, application of the present invention is meant for the damage inhibitor of making anti-gfycation agent, age resister, skin collagen and skin-tightening degree or elastic force descends, inhibition, prevention or the improving agent of wrinkle of skin and use the Herba Buddlejae Lindleyanae leaf extract, preferably uses as effective ingredient.

The Herba Buddlejae Lindleyanae leaf extract

The Herba Buddlejae Lindleyanae leaf extract is also referred to as Herba Buddlejae Lindleyanae (マ Application De レ シ one) extract, Herba Buddlejae Lindleyanae elite (エ キ ス) etc., the Herba Buddlejae Lindleyanae leaf is extracted and obtains with solvent.The Herba Buddlejae Lindleyanae leaf can directly be supplied with extraction, also can cut, broken or pulverize the back and supply with and extract.With regard to extracting method, can distinguish the temperature of setting its solvent arbitrarily, solvent phase weight rate or extraction time for the Herba Buddlejae Lindleyanae leaf.

Extract solvent and can make any of water, organic solvent.As organic solvent, can enumerate: the monohydric alcohol of carbon numbers 1～4 such as methanol, ethanol, normal propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutanol, sec-butyl alcohol, the tert-butyl alcohol; The polyhydric alcohol or derivatives thereof of carbon numbers 2～6 such as ethylene glycol, propylene glycol, 1,3 butylene glycol, hexanediol, glycol monoethyl ether; Esters such as ethyl acetate; Ketone such as acetone, butanone; Nitriles such as acetonitrile; Ethers such as ether, oxolane; The saturated hydrocarbons of carbon numbers 5～7 such as pentane, hexane, heptane, Pentamethylene., cyclohexane extraction; The arene of carbon number such as toluene, benzene 6～8; Halogenated hydrocarbon such as dichloromethane, chloroform; Dimethyl formamide; Dimethyl sulfoxide etc.

Extracting solvent can be used alone or be used in combination two or more.Wherein, the monohydric alcohol of preferred water, carbon number 1～4 and the polyhydric alcohol of carbon number 2～6, more preferably water, ethanol, propylene glycol and butanediol.Be used in combination when two or more, preferably the second alcohol and water mixed and use.At this moment, with respect to the solvent total amount, alcoholic acid usage rate is preferably about 50～90 capacity %, 60～80 capacity % more preferably from about, in Capacity Ratio, and most preferably from about 70: 30 (ethanol: water).

With regard to the temperature of extracting solvent, can use the solvent of room temperature or room temperature, also can use heated solvent or hot solvent (being heated near the solvent of boiling point).Particularly, when the extraction solvent was water, as long as the temperature during extraction was not particularly limited following for the boiling point of solvent, is preferably about 40～100 ℃, more preferably about 60～100 ℃, further more preferably about 80～100 ℃.As long as the temperature when extracting just can fully be extracted the composition with anti-saccharogenic activity in above-mentioned scope.Extraction time is not particularly limited, and can be set at about 30 seconds～4 hours usually, is preferably about 3～50 minutes, more preferably about 4～40 minutes.

In addition, can extract by being stirred under the normal pressure as required.Wherein, extracting method and extraction conditions etc. is not particularly limited, and for example, also can carry out pressurised extraction.By so extracting processing, can obtain aqueous Herba Buddlejae Lindleyanae leaf extract.

In the present invention, this extract directly can be used under previous status, but when comprising organic solvent, preferably utilize distilling under reduced pressure etc. to remove organic solvent.In addition, in the present invention, can use aqueous Herba Buddlejae Lindleyanae leaf extract, also can use and carry out dried such as drying under reduced pressure, lyophilization, spray drying as required to reduce or to remove liquid component and concentrated aqueous, the semi-solid, solid, shaped or the pulverous Herba Buddlejae Lindleyanae leaf extract that obtain.

In addition, the Herba Buddlejae Lindleyanae leaf extract also can be bought commercially available product.

Cosmetic composition

Of the present invention or as the damage inhibitor and the skin-tightening degree of the anti-gfycation agent of the manufacturing object of application of the present invention, age resister, skin collagen or elastic force descends, inhibition, prevention or the improving agent of wrinkle of skin, can be by the Herba Buddlejae Lindleyanae leaf extract be obtained cosmetic composition with being mixed together as the permissible known base of cosmetic composition or carrier.

The form of cosmetic composition is not particularly limited, and for example can enumerate: basic cosmetics such as astringent, emulsion, facial cream, beautifying liquid, Sun block cosmetics, facial film, hand cream, skin cream, emollient cream; Washings such as cleansing milk, makeup removing breast, bath gel, shampoo, hair care breast apply some make up; Cosmetic cosmetics such as vanishing cream, sun screen, lip gloss, lipstick, rouge; Bath shampoo etc.

The content of the Herba Buddlejae Lindleyanae leaf extract in the cosmetic composition is converted into dry weight, for example can be about 0.00001～20 weight %, is preferably about 0.0001～10 weight %, more preferably about 0.001～5 weight %.Damage inhibitory action, skin-tightening degree or the elastic force of sufficient anti-saccharification, aging resistance effect, skin collagen descend or inhibition, prevention or the improvement effect of wrinkle of skin as long as the content of Herba Buddlejae Lindleyanae leaf extract in above-mentioned scope, just can obtain with the common consumption of cosmetics.

As base or carrier, can enumerate: hydrocarbon such as paraffin, liquid paraffin, squalane, white beeswax, gelled hydrocarbon (プ ラ ス チ ベ one ス etc.), ceresine, ceresin(e), vaseline, tristearin, microwax, alpha-olefin low polymers, liquid paraffin,light; Fatty acids such as lauric acid, myristic acid, Palmic acid, stearic acid, behenic acid, isostearic acid; Triglycerides such as three (2 ethyl hexanoic acid) glyceride (tricaprylin), three (caprylic/capric) glyceride; Higher alcohols such as spermol, stearyl alcohol, behenyl alcohol; Methyl polysiloxane, high poly-methyl polysiloxane, dimethyl siloxane-methyl (polyoxyethylene) siloxanes-methyl (polyoxypropylene) silicone copolymers, dimethyl siloxane-methyl (polyoxyethylene) silicone copolymers, dimethyl siloxane-methyl (polyoxypropylene) silicone copolymers, polyoxyethylene-methyl polysiloxane copolymer, poly-(oxygen ethylene-oxypropylene)-methyl polysiloxane copolymer, dimethyl siloxane-methyl spermaceti oxygen radical siloxane copolymer, the stearic oxygen radical siloxane of dimethyl siloxane-methyl copolymer, alkyl acrylate copolymer methyl polysiloxane ester, the cross-linking type methyl polysiloxane, the cross-linking type methyl phenyl silicone, the polyether-modified polysiloxanes of cross-linking type, cross-linking type alkyl, polyether modified polyorganosiloxane, the alkyl-modified polysiloxanes of cross-linking type, decamethylcyclopentaandoxane, the ethyl trisiloxanes, methyl gathers trimethicone, the methylsiloxane network polymers, polyoxyethylene-methyl polysiloxane copolymer, methylhydrogenpolysi,oxane, triethoxysilyl ethyl poly dimethyl siloxy ethylhexyl polydimethylsiloxane, silicone oil such as dimethyl polysiloxane; Ethylene glycol acetate, ethylene acetate, triethylene glycol diacetate esters, hexanediol diacetate esters and 2-methyl-2-propylene-1, ethyl glycol acetates such as 1-glycol diacetate; Triethylene glycol two valerates, 2,2,4-trimethyl-1,3-pentanediol mono isobutyrate, 2,2,4-trimethyl-1, diol esters such as 3-pentanediol diisobutyrate; Glycol diacrylate, diethylene glycol diacrylate, propylene glycol mono acrylic ester, 2, glycol acrylate such as 2-dimethyl-propylene glycol diacrylate and 1,3 butylene glycol diacrylate; Glycol dinitrates such as dinitroglycol, diethylent glycol dinitrate, triethylene glycol dinitrate and propylene glycol dinitrate; 2,2 '-[1,4-benzene dioxy base] diethanol; Cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose; Polyvinyl pyrrolidone; Carrageenin; Poly-vinyl butyrate; Polyethylene Glycol; Dioxane; The butanediol adipate polyester; Esters such as isopropyl myristate, octyldodecanol myristinate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, tetramethylolmethane four (2 ethyl hexanoic acid) ester; Polysaccharide such as dextrin, maltodextrin; Lower alcohol such as ethanol, isopropyl alcohol; Glycol ethers such as glycol monoethyl ether, ethylene glycol monoethyl ether, ethylene glycol ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, Diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, dihydroxypropane single-ether, propylene glycol monopropyl ether, dipropylene glycol list ether, dipropylene glycol list propyl ether; Aqueous bases such as water etc.

Wherein, preferred hydrocarbons (alpha-olefin low polymers particularly, squalane, liquid paraffin,light, liquid paraffin), triglyceride (three (2 ethyl hexanoic acid) glyceride particularly, three (caprylic/capric) glyceride), higher alcohol (spermol particularly, stearyl alcohol behenyl alcohol), silicone oil (methyl polysiloxane particularly, alkyl acrylate copolymer methyl polysiloxane ester, the cross-linking type methyl polysiloxane, decamethylcyclopentaandoxane, the ethyl trisiloxanes, methyl gathers trimethicone, the methylsiloxane network polymers, polyoxyethylene-methyl polysiloxane copolymer, methylhydrogenpolysi,oxane, triethoxysilyl ethyl poly dimethyl siloxy ethylhexyl polydimethylsiloxane, dimethyl polysiloxane), esters (isononyl isononanoate particularly, tetramethylolmethane four (2 ethyl hexanoic acid) ester), polysaccharide (dextrin particularly, maltodextrin), glycol ethers (particularly diethylene glycol monoethyl ether), water.

Base or carrier can be used alone or be used in combination two or more.

In addition, in the cosmetic composition, in the scope of not damaging effect of the present invention, can add addible known additive in the cosmetics, for example surfactant, thickening agent, preservative agent, pH regulator agent, chelating agen, stabilizing agent, counter-stimulus, antiseptic, coloring agent, dispersant, spice, pearling agent etc.Additive can be used alone or be used in combination two or more.

As surfactant, for example can enumerate: sorbitan fatty acid ester classes such as sorbitan list isostearate, Span-20, sorbitan monopalmitate, sorbitan monostearate, sorbitan five (2 ethyl hexanoic acid) two glyceride, sorbitan four (2 ethyl hexanoic acid) two glyceride; Fatty acid glycerine esters such as glyceryl monostearate, monostearate malic acid glyceride; Polyglyceryl fatty acid ester classes such as polyglycereol monostearate, polyglycereol list isostearate, Risorex PGIS 22; Methyl glycol fatty acid ester classes such as propylene glycol monostearate; Polyoxyethylene solidifies Oleum Ricini 40 (HCO-40), polyoxyethylene solidifies Oleum Ricini 50 (HCO-50), polyoxyethylene curing Oleum Ricini 60 (HCO-60), polyoxyethylene curing Oleum Ricini 80 etc. and solidifies castor oil derivative; Polyoxyethylene sorbitan fatty acid ester classes such as polyoxyethylene (20) Span-20 (polysorbate20), polyoxyethylene (20) sorbitan monostearate (polysorbate60), polyoxyethylene (20) sorbitan monooleate (polysorbate80), polyoxyethylene (20) sorbitan isostearate; Polyoxyethylene list coconut oil fat acid glyceride; The glycerol alkyl ether; Alkyl-glucoside; Polyoxyalkylene alkyl such as Polyoxyethylene cetyl ether; Amine such as stearylamine, oleyl amine; Polysiloxane-based surfactants such as polyoxyethylene-methyl polysiloxane copolymer, lauryl PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane, PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane etc.

Wherein, preferred fatty acid glyceride type (particularly glyceryl monostearate), polyglyceryl fatty acid ester class (particularly polyglycereol monostearate), (particularly polyoxyethylene solidifies Oleum Ricini 50 (HCO-50) to solidify castor oil derivative, polyoxyethylene solidifies Oleum Ricini 60 (HCO-60)), polyoxyethylene sorbitan fatty acid ester class (polyoxyethylene (20) sorbitan isostearate particularly, polyoxyethylene (20) sorbitan monostearate (polysorbate60)), polyoxyalkylene alkyl (particularly Polyoxyethylene cetyl ether), polysiloxane-based surfactant (polyoxyethylene-methyl polysiloxane copolymer particularly, lauryl PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane, PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane).

With respect to the total amount of cosmetic composition, the content of surfactant can be set at about 0.001～20 weight %.

As thickening agent, for example can enumerate: guar gum; locust bean gum; carrageenin; xanthan gum; glucosan; methylcellulose; ethyl cellulose; carboxymethyl cellulose; hydroxy methocel; hydroxyethyl-cellulose; hydroxypropyl cellulose; hydroxypropyl emthylcellulose; sodium alginate; propylene glycol alginate; polyvinyl alcohol; polyvinyl pyrrolidone; polyvinyl methyl ether; CVP Carbopol ETD2050; acrylic acid alkyl methacrylate copolymer; sodium polyacrylate; Polyethylene Glycol; bentonite; dextrin fatty acid ester; pectin; (2-(Acryloyloxy)ethanol/acryloyl group dimethyl sodium taurocholate) copolymer; distearyl dimethylammonium Strese Hofmann's hectorite.; (ammonium acryloyldime-thyltaurate// vinyl pyrrolidone) copolymer; polyglycol distearate; ethylene glycol three isostearates; polyoxyethylene (20) methyl glucoside three isostearates etc.

Wherein, preferred xanthan gum, acrylic acid alkyl methacrylate copolymer, hydroxyethyl-cellulose, hydroxypropyl cellulose, hydroxypropyl emthylcellulose, Polyethylene Glycol, CVP Carbopol ETD2050, (2-(Acryloyloxy)ethanol/acryloyl group dimethyl sodium taurocholate) copolymer, distearyl dimethylammonium Strese Hofmann's hectorite., (ammonium acryloyldime-thyltaurate// vinyl pyrrolidone) copolymer, polyglycol distearate, ethylene glycol three isostearates, polyoxyethylene (20) methyl glucoside three isostearates.

With respect to the total amount of cosmetic composition, the content of thickening agent can be set at about 0.001～10 weight %.

As preservative agent, antiseptic, can enumerate benzoic acid, sodium benzoate, dehydroactic acid, dehydro sodium acetate, p-Hydroxybenzoic acid isobutyl ester, p-Hydroxybenzoic acid isopropyl ester, butyl p-hydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, benzyl p-hydroxybenzoate, methyl parahydroxybenzoate, phenyl phenol etc.Wherein, preferred methyl parahydroxybenzoate, propyl p-hydroxybenzoate, phenyl phenol.

With respect to the total amount of cosmetic composition, the content of preservative agent, antiseptic can be set at about 0.001～5 weight %.

As the pH regulator agent, can enumerate: mineral acid (hydrochloric acid, sulphuric acid, phosphoric acid, polyphosphoric acid, boric acid etc.), organic acid (lactic acid, acetic acid, citric acid, sodium citrate, tartaric acid, malic acid, succinic acid, sodium succinate, oxalic acid, gluconic acid, fumaric acid, propanoic acid, acetic acid, aspartic acid, episilon amino caproic acid, glutamic acid, taurine etc.), gluconic acid lactone, ammonium acetate, inorganic base (sodium bicarbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, calcium hydroxide, magnesium hydroxide etc.), organic base (monoethanolamine, triethanolamine, diisopropanolamine (DIPA), triisopropanolamine, lysine etc.) etc.Wherein, preferred succinic acid, sodium succinate, citric acid, sodium citrate, triethanolamine, potassium hydroxide, sodium hydroxide.

With respect to the total amount of cosmetic composition, the content of pH regulator agent can be set at about 0.0001～5 weight %.

As chelating agen, can enumerate: ethylenediaminetetraacetic acid (edetic acid), edetate (sodium salt (edetate sodium: Japanese Pharmacopoeia, EDTA-2Na etc.), potassium salt etc.), phytic acid, gluconic acid, polyphosphoric acid, Metaphosphoric acid etc.Wherein, preferred edetate sodium.With respect to the total amount of cosmetic composition, the content of chelating agen can be set at about 0.0001～5 weight %.

As stabilizing agent, can enumerate sodium polyacrylate, dibenzylatiooluene, Butylated hydroxyanisole etc.With respect to the total amount of cosmetic composition, the content of stabilizing agent can be set about 0.0001～5 weight %.

As counter-stimulus, can enumerate Radix Glycyrrhizae extract, sodium alginate etc.With respect to the total amount of cosmetic composition, the content of counter-stimulus can be set at about 0.001～10 weight %.

As coloring agent, can enumerate inorganic pigment, natural pigment etc.With respect to the total amount of cosmetic composition, the content of coloring agent can be set at about 0.00001～10 weight %.

As pearling agent, can enumerate glycol distearate, ethylene glycol monostearate, triethylene glycol distearate etc.Wherein, preferred glycol distearate.With respect to the total amount of cosmetic composition, the content of pearling agent can be set at about 0.0001～10 weight %.

In addition, in the cosmetic composition,, can cooperate addible known anti-saccharifying composition in the cosmetics for further strengthening the effect of the present invention of improving, suppressing, prevent in skin, to accumulate the skin aging that causes because of AGEs.Known anti-saccharifying composition can be used alone or be used in combination two or more.

As known anti-saccharifying composition, for example can enumerate: the fruit of Radix Oenotherae erythrosepalae oil or Radix Oenotherae erythrosepalae extract, Fructus Phyllanthi, fruit juice or their extract (TOHKEMY 2006-028090, TOHKEMY 2006-62989 number etc.); L-arginine, L-lysine, caseinhydrolysate (above) referring to TOHKEMY 2001-039816; Water-disintegrable tannin (Japanese kokai publication hei 9-40519 number); Carnosine, alpha-lipoic acid (above) referring to " the disconnected マ ニ ユ ア Le of the up-to-date skin Skin of beauty treatment め ?" (" the up-to-date skin diagnosis handbook that is used to improve looks), Off レ グ ラ Application ス ジ ヤ one Na Le society (fragrance periodical publisher), distribution on August 15th, 2006; The flower of the flower of the flower of Rosa centifolia L, ovary, hybridization Flos Rosae Rugosae, ovary, calyx, leaf, stem, Fructus rosae multiflorae, grape leaf, Folium Kaki, Folium Mali pumilae, Flos Inulae, the extract of YULAN leaf (above) referring to TOHKEMY 2006-273811 number; The Paeonia plant extract, the Scutellaria plant extract, the Herba Melissae officinalis genus plants extract, the Helianthus plant extract, the aloe plant extract, Rhizoma Polygonati (ア マ De コ ロ) genus plants extract, the linum extract, the gul extract, the tilia genus plants extract, the asarum plant extract, the Herba Houttuyniae genus plants extract, the tussilago farfara genus plant extract, the burnet plant extract, the mint extract, Sambucus plant extract (above) referring to TOHKEMY 2003-212749 number; The extract of Rhizoma Alpiniae Galangae (TOHKEMY 2006-62987 number); The extract (above) of Thujopsis dolabrata, Uncaria gambier Roxb., Rhizoma Polygoni Cuspidati, pyrola japonicaKlenze ex Alef, Fructus Pruni, Flos Celosiae Cristatae, Mucuna birdwoodiana, Betula platyphylla Suk., Crataegus Oxyacantha, Europe Millefolium, Cortex Ilicis Rotundae (タ ラ ヨ ウ), Herba Houttuyniae, Herba Potentillae Chinensis, Radix Ophiopogonis, Thujopsis dolabrata (ヒ バ), Fructus Vitis viniferae, Herba Polygoni Avicularis, Fructus Sapindi Mukouossi, Fructus Chaenomelis, Fructus Litchi, Flos Chrysanthemi referring to TOHKEMY 2003-212770 number; Hamamelis virginiana, Fructus Pruni, pyrola japonicaKlenze ex Alef, Folium Vaccinii vitis-idaeae, Coptis japonica, Flos Caryophylli Lagerstroemia indica L., Uncaria gambier Roxb., geranium thunbergii, nuphar root grass, Punica granatum L., Radix Paeoniae, revolve the extract (above) of fruit palmate meadowsweet, Radix Et Rhizoma Rhei, Camellia sinensis, Caryophyllus, narrow leaf Senna fruit, Folium hydrangeae strigosae, Fructus Rubi, Herba Potentillae Chinensis, Flos Rosae Multiflorae, Paeonia suffruticosa, Sage, Japanese alder (ヤ シ ヤ Block シ), Fructus Myricae rubrae, Eucalyptus globulus Labill, logwood, Radix Sanguisorbae referring to TOHKEMY 2002-241299 number; The extract of Caulis Akebiae, Aloe, Fructus Pruni, birch (カ バ), Radix Platycodonis, Fructus Schisandrae Chinensis, Radix Notoginseng, Herba Bidentis Tripartitae, Rhizoma Polygonati, Herba stellariae mediae, Herba tetragoniae, Poria, Fructus Citri grandis (above) referring to TOHKEMY 2002-241293 number; The extract (above) of Calyx Hibisci Sabdariffae, Hibiscus rosasinensis (Ha イ PVC ス カ ス), Semen Plantaginis, Semen Persicae, Aesculus chinensis Bunge, Ramulus Cinnamomi, Fructus Schisandrae Chinensis, Radix Arnebiae (Radix Lithospermi), Folium Sennae (セ Application Na), Semen Cuscutae, the Pseudobulbus Bletillae (Rhizoma Bletillae) referring to Japanese kokai publication hei 11-106336 number; The fruit of Semen Ziziphi Spinosae, Semen Sterculiae Lychnophorae, Semen Cucurbitae, Folium Eucommiae, Salacia prinoides (Willd.) DC. root, umbrella shape are liked the extract (above referring to TOHKEMY 2007-254345 number) of eastern blade of grass; The extract (above) of silk ball (ア マ チ ヤ), Herba Cytisi sciparii, Herba Saussureae Involueratae, devil claw root, Radix Et Caulis Acanthopanacis Senticosi, Radix Rhodiolae (ロ ゼ ア), false Radix Gentianae (エ Le カ Application プ one レ) referring to TOHKEMY 2007-254344 number; The extract of Fructus Caricae (TOHKEMY 2006-298812 number); The false fluffy extract (TOHKEMY 2006-219447 number) of the chrysanthemum of seemingly wadding a quilt with cotton; The extract of Vaccinium plant (TOHKEMY 2006-117700 number); Agrimony (ア グ リ モ ニ one), the blue or green gallbladder (ア シ ユ ワ ガ Application ダ) of lobus cardiacus cattle, Fructus Anisi Stellati (ア ニ ス), Herb Gynostemmae Pentaphylli, the sweetleaf Fructus Rubi corchorifolii Immaturus, Semen Ginkgo, Fructus Foeniculi, Radix Hamamelidis Mollis, Rhizoma Curcumae Longae, Echinacea, Radix Et Caulis Acanthopanacis Senticosi, Ramulus Sambuci Williamsii, Ilex paraguarensis (エ Le バ マ テ), Herba Plantaginis, Fructus Canarii albi, Adeps Bovis seu Bubali, Fructus Citri sinensis, Fructus Kaki, Herba Glechomae, Flos Matricariae chamomillae, the fragrant cocoa of Brazil, Herba Mimosae Pudicae, Flos Chrysanthemi, Largeleaf Gymnema, uncaria tomentosa, Herba Schizonepetae, キ ラ ウ エ イ, Flos Lonicerae, Fructus psidii guajavae immaturus, Fructus Lycii, Vickers Bears bamboo, Herba clerodendranthi spicati, Semen sojae atricolor, mulberry, Cortex Cinnamomi, Semen Cassiae, Fructus Momordicae charantiae, cola, Cortex Acanthopancis, Herba Centellae, Herba Coriandri, Radix Arnebiae (Radix Lithospermi), Heritiera littoralis Ait, Flos Carthami, salacia reticulata (サ ラ シ ア オ Block ロ Application ガ), Fructus Crataegi, Radix Notoginseng, Folium Perillae, Herba Houttuyniae, gin, Rhizoma Zingiberis Recens, Cortex Cryptomeriae Fortunei Radicis, Herba Equiseti Arvinsis, Flos Chrysanthemi, Mentha viridis L, Salvia japonica Thunb., savoury, Crataegus Oxyacantha, Fructus Pyri Pashiae, Herba thymi vulgaris, brown roble (タ ヒ ボ), Herba Taraxaci, tuberous chervil, Camellia sinensis, Herba Passiflorae Caeruleae, Flos Caryophylli, Bellis perennis, Fructus anethi, the Cortex Eucommiae, Semen Myristicae, Rhizoma Alpiniae Officinarum, Herba Urticae Cannabinae, Hibiscus rosasinensis, soil three-coloured amaranth (white pig Muqiu), Herba Hedyotidis Diffusae, high mountain Millefolium (Ha go ロ モ ソ ウ), Herba Ocimi (Herba Ocimi Pilosi), Flos Nelumbinis, Herba Scutellariae Barbatae, Photiniaserrulata, peach, hyssop (ヒ ソ Star プ), Folium Eriobotryae, chryanthemum parthenium, luxuriant and rich with fragrance island good fortune wood, Caulis wisteriae sinensis, before the rickshaw, blue berry, violet, Mentha pulegium Linn., Stigma Croci, Mentha arvensis L. syn.M.haplocalyxBrig, Flos lupuli (Flos Humuli Lupuli), the borage, slick and sly Sirikaya, Althaea officinalis L., the Origanum majorana L. grass, Herba Tagetis Patulae, Herba Verbasci Thapsi, dawrf mallow (マ ロ ウ ス モ one Le), Radix Malvae sylvestris (マ ロ ウ Block Le one), sea Fructus Mangifera Indicae, Silybum marianum Gaertn, the comospore maple, メ デ ウ ス イ one ト, Fructus Chaenomelis, beach wood crust halberd, Centaurea cyanus, milfoil, Eucalyptus, Semen Coicis, Radix Artemisia ordosicae, Fructus Rubi, lavandula angustifolia, bodhi tree, the askew bean in South Africa, NINGMENGXIANG Rhizoma Imperatae, lemon thyme, Herba Verbenae, lemon mint, Rosehips, moss rose (ロ one ズ ピ Application Network バ ッ Star), Herba Rosmarini Officinalis, red rose, cassia tree, Herba Apocyni veneti, the extract of wild strawberry (above) referring to TOHKEMY 2004-250445 number; The extract of Cortex malloti japonici, persimmon, mulberry, Herba Hyperici perforati, Herba Centellae, Galega officinalis L, gum-bush, Rosehips (above) referring to TOHKEMY 2004-189663 number; The extract (above) of oriental cherry, Radix Rhodiolae, blue berry, Folium Vaccinii vitis-idaeae, candleberry (シ ロ ヤ マ モ モ), Herba stellariae mediae, caraway (ヒ メ ウ イ キ ヨ ウ), Flos Impatientis, three tingia shrubs referring to TOHKEMY 2001-316221 number; The extract (above) of Taxus leaf, Flos Sophorae, Cortex erythrinae (カ イ ト ウ ヒ), Fructus Rosae Laevigatae, bay tree, Folium seu Semen Daphniphylli macropodi, stone Chang root, Fructus Xanthii, Bulbus Fritillariae Uninbracteatae, Ramulus et Folium Actinidiae Polygamae referring to Japanese kokai publication hei 8-259431 number; The extract of Folium Dauci Sativae (TOHKEMY 2004-51580 number); The extract of Uncaria gambier Roxb., Betula platyphylla Suk., haw berry, Camellia sinensis, Caryophyllus, Herba Houttuyniae, Herba Potentillae Chinensis, Flos Rosae Multiflorae, Fructus Vitis viniferae, Aesculus chinensis Bunge, Anthemis nobilis (above) referring to TOHKEMY 2005-35911 number; Aminoguanidine or its salt (up-to-date medical science, No. 2,49 volumes, the 78th～83 page, 1994); Semen sojae atricolor kind skin, Ilex paraguarensis leaf (green), Flos tiliae miquelianae, Folium Salicis Babylonicae oak leaf (ウ ラ ジ ロ ガ シ Leaf), the fructus zizaniae caduciflorae seed, salicis, sprouting, the Herba Euphrasiae Regelii aerial parts, the Radix vernoniae asperae root, Hylocereus undatus, globe artichoke leaf, Semen Litchi, the Ka Tuba bark, the Herba bromi japonici aerial parts, the Herba Passiflorae Caeruleae leaf, Folium Salicis Babylonicae rag wood (チ ヤ デ Block グ レ) leaf, buckwheat leaf, the Herba Silybi mariani achene, Folium Angelicae, harpagophythi radix, heavy ant ebon skin, the Agaricus blazei filament, Brazil's Radix Ginseng (パ Off イ ア) root, the Brazilian Acai fruit, Nemacystus decipiens (Sur.) Kuck herb and root stock, the machining object of leaf (above) referring to TOHKEMY 2008-088102; The Melia azedarach L. extract; A Lisiding; Glycosamine etc.Wherein, preferably derive from the composition (particularly Radix Oenotherae erythrosepalae oil or Radix Oenotherae erythrosepalae extract, Fructus Phyllanthi extract, Semen Litchi extract, Flos Rosae Multiflorae petal extract, Aesculus chinensis Bunge extract, Herba Silybi mariani extract, Melia azedarach L. extract) of plants such as Radix Oenotherae erythrosepalae, Fructus Phyllanthi, Fructus Litchi, Flos Rosae Multiflorae, Aesculus chinensis Bunge, Herba Silybi mariani, Melia azedarach L.; Water-disintegrable tannin (particularly deriving from the water-disintegrable tannin of Semen Castaneae endothelium); L-arginine or its salt; Lysine or its salt; Carnosine; Alpha-lipoic acid; Aminoguanidine or its salt; A Lisiding; Glycosamine.

Consumption when using known anti-saccharifying composition is converted into dry weight, with respect to the total amount of cosmetic composition, can be set at for example about 0.00001～10 weight %.

In addition, in the cosmetic composition, in the scope that does not hinder effect of the present invention, can cooperate antioxidant content, aging resistance composition, anti-inflammatory component, whitening composition, cutin softening composition, cell-activating composition, vitamins, blood circulation promoting composition, the composition of preserving moisture, to DNA damage have prevention and/or repair composition, ultra-violet absorption composition, ultraviolet scattering composition, cleaning ingredients, antimicrobial component, converge other active component that can add in the cosmetics that grade.Other active component can be used alone or be used in combination two or more.

As antioxidant content, can enumerate: derive from plant () composition for example: Fructus Vitis viniferae, Radix Ginseng, Radix Arnebiae (Radix Lithospermi) etc.; Procyanidin, tocopherol and derivant thereof, ascorbic acid and derivant thereof, Hesperidin, glucityl Hesperidin, ergothioneine, sodium sulfite, arabo-ascorbic acid and salt thereof, flavonoid, glutathion, glutathion peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiolaurine, hypotaurine etc.Wherein, preferred Semen Vitis viniferae extract, extract of red vine leaves, Radix Ginseng extract, Folium Radix Arnebiae (Folium Radix Lithospermi) extract, procyanidin, tocopherol and derivant (particularly Delta-Tocopherol, alpha-tocopherol), ascorbic acid and derivant thereof (particularly ascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, Ascorbyl Tetraisopalmitate (ascorbic acid four (2-hexyldecanoic acid) ester)), Hesperidin, glucityl Hesperidin, ergothioneine.

With respect to the total amount of cosmetic composition, the content of antioxidant can be set at about 0.00001～10 weight %.

As the aging resistance composition, can enumerate: hydrolyzed soybean protein, retinoid (retinol and derivant thereof, tretinoin, retinal etc.), pangamic acid, kinetins, ursolic acid, Rhizoma Curcumae Longae extract, sphingol derivant, silicon, silicic acid, N-methyl-L-serine, mevalonolactone etc.Wherein, preferred artemia extract, hydrolyzed soybean protein, retinol, retinyl acetate, retinol cetylate.

With respect to the total amount of cosmetic composition, the content of aging resistance composition can be set at about 0.0001～10 weight %.

As anti-inflammatory component, can enumerate: the composition that derives from plant (for example Radix Arnebiae (Radix Lithospermi)); Allantoin, Calamina, glycyrrhizic acid or derivatives thereof, enoxolone or derivatives thereof, zinc oxide, Kessazulen (グ ア イ ア ズ レ Application), pyridoxine hydrochloride, menthol, Camphora, Oleum Terebinthinae, indomethacin, salicylic acid or derivatives thereof etc.Wherein, preferred Folium Radix Arnebiae (Folium Radix Lithospermi) extract, allantoin, glycyrrhizic acid dipotassium, enoxolone stearyl ester.

With respect to the total amount of cosmetic composition, the content of anti-inflammatory component can be set at about 0.0001～10 weight %.

As whitening composition, for example can enumerate: arbutin; Hydroquinone; Kojic acid; Ellagic acid; Phytic acid; Resveratrol (Le シ ノ one Le); Flos Matricariae chamomillae ET; The ascorbic acid or derivatives thereof; The vitamin E or derivatives thereof; The pantothenic acid or derivatives thereof; The plant component of tranamic acid etc. or Pear Power effect (for example plant extract or quintessence oil).Wherein, preferred arbutin, hydroquinone, kojic acid, ascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, Ascorbyl Tetraisopalmitate (ascorbic acid four (2-hexyldecanoic acid) ester), tranamic acid.

With respect to the total amount of cosmetic composition, the content of whitening composition can be set at about 0.0001～30 weight %.

As the cutin softening composition, can enumerate: lanoline, carbamide, phytic acid, lactic acid, lactate, glycolic, salicylic acid, malic acid, citric acid etc.Wherein, preferred lactic acid, sodium lactate, glycolic, salicylic acid, phytic acid.

With respect to the total amount of cosmetic composition, the content of cutin softening composition can be set at about 0.0001～50 weight %.

As the cell-activating composition, can enumerate: the composition that derives from plant (for example Pericarpium Citri tangerinae); Amino acids such as γ-An Jidingsuan, episilon amino caproic acid; Vitaminss such as retinol and derivant thereof, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acid class; Alpha-hydroxy such as glycolic, lactic acid acids; Plain No. 301 of tannin, flavonoid, saponin, allantoin, sensitization etc.Wherein, preferred Folium Vaccinii vitis-idaeae extract, retinol, retinyl acetate, retinol cetylate.

With respect to the total amount of cosmetic composition, the content of cell-activating composition can be set at about 0.0001～10 weight %.

As vitamins, can enumerate: retinoids such as retinol derivatives such as retinol, retinyl acetate, retinol cetylate, retinal, tretinoin, tretinoin methyl ester, tretinoin ethyl ester, retinol retinoic acid ester, d-Delta-Tocopherol retinoic acid ester, alpha-tocopherol retinoic acid ester, betatocopherol retinoic acid ester; Provitamin A classes such as beta-carotene, alpha-carotene, gamma carotene, δ-carotene, lycopene, cryptoxanthin, kryptoxanthin, echinenone; Vitamin E classes such as Delta-Tocopherol, alpha-tocopherol, betatocopherol, dl-alpha-tocofecol succinic acid ester, dl-alpha-tocofecol succinic acid calcium, Delta-Tocopherol, tocopheryl nicotinate; Vitamin B2 classes such as riboflavin, flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD), Riboflavine Tertrabutyrate, Riboflavin Tetrabutyrate, riboflavin-5 '-phosphate ester sodium, riboflavin four nicotinates; Nicotinic acid classes such as methyl nicotinate, nicotinic acid, nicotiamide; Vitamin c class such as ascorbyl stearate, L-Vitamin C dipalmitate, Ascorbyl Tetraisopalmitate (ascorbic acid four (2-hexyldecanoic acid ester)), ascorbic acid, sodium ascorbate, hydroascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, ascorbate glucoside; Vitamin D classes such as hesperidin methyl, vitamin D2, gallbladder calcium ostelin; Vitamin K such as phylloquinone, farnoquinone class; The dibenzoylthiamine element, dibenzoyl thiamine, the thiamine salt hydrochlorate, thiamine cetyl hydrochlorate, the thiamine rhodanate, thiamine lauryl hydrochlorate, thiamine nitrate, the thiamine monophosphate, the thiamine lysinate, the thiamine triphosphate, thiamine phosplate phosphate, the thiamine phosplate, the thiamine bisphosphate, thiamine bisphosphate hydrochlorate, the thiamine triguaiacyl phosphate, vitamin B1 classes such as thiamine triguaiacyl phosphate monophosphate; Vitamin B12 classes such as vitamin B6 classes such as pyridoxine hydrochloride, acetic acid Benadon, pyridoxal hydrochloride, 5 '-pyridoxal 5-phosphate, hydrochloric acid pyridoxamine, cobalamin, hydroxocobalamin, deoxyadenosine cobalt amine; Folic acid such as folic acid, pteroylglutamic acid class; Pantothenic acid classes such as pantothenic acid, calcium pantothenate, pantothenylol (panthenol), D-pantetheine, D-pantethine, coenzyme A, pantothenylol ether; Biotin such as biotin, biotin complex of yeast. class; Also have the vitaminoid action factors such as carnitine, ferulic acid, alpha-lipoic acid, orotic acid, γ-Hi-Z etc. in addition.

Wherein, preferred: retinoids such as retinol, retinyl acetate, retinol cetylate; Ascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, Ascorbyl Tetraisopalmitate vitamin c class such as (ascorbic acid four (2-hexyldecanoic acid esters)); Vitamin E such as Delta-Tocopherol, tocopheryl nicotinate class; Nicotinic acid classes such as nicotiamide.

With respect to the total amount of cosmetic composition, the content of vitamins can be set at about 0.001～30 weight %.

As the blood circulation promoting action component, can enumerate: derive from plant (Radix Ginseng for example, angelica keiskei koidzumi, arnica montana, Semen Ginkgo, Fructus Foeniculi, Rabdosia japonica (エ Application メ イ ソ ウ), オ ラ Application ダ カ シ, Flos Matricariae chamomillae, Anthemis nobilis, Radix Dauci Sativae, Radix Gentianae, Fructus Arctii, rice, Fructus Crataegi, Lentinus Edodes, Crataegus Oxyacantha, Juniperus communis L., Rhizoma Chuanxiong, Japan's Herba Swertiae bimaculatae, Herba thymi vulgaris, Flos Caryophylli, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Semen Persicae, Pericarpium Citri tangerinae, Radix Dauci Sativae, Bulbus Allii, butchers broom, Fructus Vitis viniferae, Paeonia suffruticosa, Aesculus chinensis Bunge, Herba Melissae officinalis, Fructus Citri grandis, Semen Coicis, Herba Rosmarini Officinalis, Rosehips, Pericarpium Citri Reticulatae, Radix Angelicae Sinensis, Pericarpium Citri tangerinae, peach, Fructus Pruni, Semen Juglandis, corn) composition; Tocopheryl nicotinate, glucityl Hesperidin, Hesperidin.Wherein, preferably ginseng's extract, tocopheryl nicotinate, glucityl Hesperidin, Hesperidin.

With respect to the total amount of cosmetic composition, the content of blood circulation promoting composition can be set at about 0.00001～10 weight %.

As the composition of preserving moisture, can enumerate: the composition that derives from plant (for example Herba Imperatae); Aminoacid and derivants thereof such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glycosamine, theanine; Protein such as collagen protein, gelatin, elastin laminin or peptide, its hydrolysate; Polyhydric alcohol such as glycerol, 1,3 butylene glycol, propylene glycol, Polyethylene Glycol, dipropylene glycol, diglycerol; Sugar alcohols such as Sorbitol; Phospholipid such as lecithin, hydrolecithin; Mucopolysaccharides such as hyaluronic acid, hyaluronate sodium, hyaluronan, hyaluronan sodium, heparin, chrondroitin; Lactic acid, pyrrolidone sodium carboxylate, carbamide etc. derive from the composition of NMF; Polyglutamic acid; MPC polymer (for example LIPIDURE (registered trade mark) etc.) etc. has the polymer of phospholipid polar group; The methyl glucoside polyethenoxy ether; Trimethyl glycine (betanin); The ethoxy urea; Acrylic acid-acrylamide-dimethyl diallyl ammonium chloride copolymer; Sorbitol etc.Wherein, preferred Rhizoma Imperatae extract, hydrolytic collagen, elastin hydrolysis, MPC polymer glycerol, 1,3 butylene glycol, Polyethylene Glycol, dipropylene glycol, diglycerol, methyl glucoside polyethenoxy ether, trimethyl glycine (betanin), ethoxy urea, acrylic acid-acrylamide-dimethyl diallyl ammonium chloride copolymer, hydrolecithin, hyaluronic acid, hyaluronate sodium, hyaluronan, hyaluronan sodium, Sorbitol.

With respect to the total amount of cosmetic composition, the content of the composition of preserving moisture can be set at about 0.001～10 weight %.

As the composition that DNA damage is had prevention and/or repair, can enumerate: the composition that derives from animal (for example artemia); Derive from the composition of plant (for example uncaria tomentosa); Nucleic acid compositions such as DNA, DNA salt, RNA, RNA salt.Wherein, preferred artemia extract, DNA-Na.

With respect to the total amount of cosmetic composition, the content that DNA damage is had the composition of prevention and/or repair can be set at about 0.00001～0.1 weight %.

As the ultra-violet absorption composition; can enumerate: p-methoxycinnamic acid 2-Octyl Nitrite, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, 2; 4; 6-three [4-(the own oxygen carbonyl of 2-ethyl) anilino-]-1; 3,5-triazine, dimethoxybenzylidenegroup group oxo-imidazole alkane propanoic acid 2-Octyl Nitrite, 2, two [{ 4-(2-ethyl hexyl oxy)-2-hydroxyl }-phenyl]-6-(4-methoxyphenyl)-1 of 4-; 3,5-triazine etc.Wherein, preferred p-methoxycinnamic acid 2-Octyl Nitrite, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, 2,4,6-three [4-(the own oxygen carbonyl of 2-ethyl) anilino-]-1,3,5-triazines.

With respect to the total amount of cosmetic composition, the content of ultra-violet absorption composition can be set at about 0.01～20 weight %.

As ultraviolet scattering composition, can enumerate: inorganic compound such as zinc oxide, titanium oxide, ferrum oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, anhydrous silicic acid, silicic acid cerium, moisture silicic acid; The material that these inorganic compound is coated with inorganic particles such as moisture silicic acid, aluminium hydroxide, Muscovitum or Talcums or obtain and handle and the material that obtains etc. with silicone oil or fatty acid aluminium salt etc. with resin-oatmeal bluk recombination such as polyamide, polyethylene, polyester, polystyrene, nylon.Wherein, inorganic compound such as preferred zinc oxide, titanium oxide, ferrum oxide or material that these inorganic compound are obtained with inorganic particle such as aluminium hydroxide, moisture silicic acid, Muscovitum or Talcum or silicone oil coating.

With respect to the total amount of cosmetic composition, the content of ultraviolet scattering composition can be set at about 0.001～35 weight %.

As cleaning ingredients, can enumerate: anion surfactants such as polyoxyalkylene alkyl (or thiazolinyl) ether sulfate, alkyl (or thiazolinyl) sulfate, higher fatty acid salt, ether carboxylate, amide ether carboxylate, alkyl phosphate salt, N-acyl amino hydrochlorate, polyoxyalkylene fatty acid amide ether sulfate, acyl group isethionate, acyl group taurine ester; Amine oxide, fatty acid glyceride, sorbitan fatty acid ester, alkyl polyglucoside (ア Le キ Le サ Star カ ラ イ De), polyoxyalkylene alkyl, fatty acid alkanol amides, polyoxyalkylene solidify Semen Ricini wet goods non-ionic surface active agent; But addition has the cationic surfactants such as one or two long chain alkyl ammonium salts of chain alkyl alkylene oxide, that have straight or branched; Carboxylation betanin, sulfonation betanin, imidazoles

Amphoteric surfactant such as betanin, amide betaine.

Wherein, preferred anionic surfactant, non-ionic surface active agent, amphoteric surfactant.In the anion surfactant, preferred higher fatty acid salt (the particularly salt of senior fatty acids such as Palmic acid, lauric acid, myristic acid, stearic acid), N-acyl amino hydrochlorate (particularly N-lauroyl NaAsp, potassium hydroxide/N-fatty acid distribution of coconut oil acyl glutamic acid potassium, fatty acid distribution of coconut oil acylglycine sodium, myristoyl sodium glutamate).In the non-ionic surface active agent, preferred fatty acid alkanolamide (particularly fatty acid distribution of coconut oil diglycollic amide, fatty acid distribution of coconut oil single ethanol amide), amine oxide (particularly cocos nucifera oil alkyl dimethyl amine oxide, lauryl dimethyl amine oxide).In the amphoteric surfactant, preferred imidazoles

Betanin (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole particularly

Betanin, N-fatty acid distribution of coconut oil acyl group-N-carboxyl methoxy ethyl-N-carboxymethyl ethylenediamine disodium).

With respect to the total amount of cosmetic composition, the content of cleaning ingredients can be set at about 0.01～80 weight %.

As antimicrobial component, can enumerate: chlorhexidine, salicylic acid, benzalkonium chloride, ethacridine lactate, ethanol, benzethonium chloride, cresol, gluconic acid and derivant thereof, povidone iodine, potassium iodide, iodine, isopropyl methyl phenol, triclocarban, triclosan, plain No. 101 of sensitization, plain No. 201 of sensitization, p-Hydroxybenzoate, phenyl phenol, 1,2-pentanediol, salt dialkylaminobenzoic acid diaminourea glycine etc.Wherein, preferred benzalkonium chloride, benzethonium chloride, gluconic acid and derivant thereof, isopropyl methyl phenol, triclocarban, triclosan, plain No. 101 of sensitization, plain No. 201 of sensitization, p-Hydroxybenzoate, phenyl phenol, 1,2-pentanediol, salt dialkylaminobenzoic acid diaminourea glycine, more preferably benzalkonium chloride, gluconic acid and derivant thereof, benzethonium chloride, isopropyl methyl phenol.

With respect to the total amount of cosmetic composition, the content of antimicrobial component can be set at about 0.0003～10 weight %.

As astringent component, can enumerate: slaines such as Alumen, polymeric aluminum chloride, aluminum chloride, aldioxa salt, zinc sulfate, aluminium potassium sulfate; Organic acid such as tannin, citric acid, lactic acid, succinic acid.Wherein, preferred Alumen, polymeric aluminum chloride, aluminum chloride, aldioxa salt, aluminium potassium sulfate, tannin.

With respect to the total amount of cosmetic composition, the content of astringent component can be set at about 0.0003～10 weight %.

Above-mentioned cosmetic composition can prepare by each composition is mixed to stir according to conventional method.For example, can in the cosmetics base, be pre-mixed stir insoluble composition and oiliness composition after, cooperate water composition, mix stirring once more.For insoluble composition is dispersed in the base easily, can use blenders such as intimate mixing machine.

The preferred compositions of composition

As the preferred compositions of Herba Buddlejae Lindleyanae leaf extract and other active component, can enumerate following combination.

Under the situation that contains known anti-saccharifying composition, can enumerate: with the combination of Radix Oenotherae erythrosepalae oil or Radix Oenotherae erythrosepalae extract, Fructus Phyllanthi extract, Semen Litchi extract, Flos Rosae Multiflorae petal extract, Aesculus chinensis Bunge extract, Herba Silybi mariani extract, Melia azedarach L. extract, water-disintegrable tannin, L-arginine or its salt, lysine or its salt, carnosine, alpha-lipoic acid, aminoguanidine or its salt, A Lisiding or glycosamine;

Containing under the situation of antioxidant content, can enumerate: with the combination of Semen Vitis viniferae extract, extract of red vine leaves, Radix Ginseng extract, Folium Radix Arnebiae (Folium Radix Lithospermi) extract, procyanidin, tocopherol or derivatives thereof (Delta-Tocopherol, alpha-tocopherol), ascorbic acid or derivatives thereof (ascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, Ascorbyl Tetraisopalmitate (ascorbic acid four (2-hexyldecanoic acid) ester)), Hesperidin, glucityl Hesperidin or ergothioneine;

Under the situation that contains the aging resistance composition, can enumerate: with the combination of hydrolyzed soybean protein, retinol, retinyl acetate or retinol cetylate;

Containing under the situation of anti-inflammatory component, can enumerate: with the combination of Folium Radix Arnebiae (Folium Radix Lithospermi) extract, allantoin, glycyrrhizic acid dipotassium or enoxolone stearyl ester;

Containing under the situation of whitening composition, can enumerate: with the combination of arbutin, hydroquinone, kojic acid, ascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, Ascorbyl Tetraisopalmitate (ascorbic acid four (2-hexyldecanoic acid) ester) or tranamic acid;

Under the situation that contains the cutin softening composition, can enumerate: with the combination of lactic acid, sodium lactate, glycolic, salicylic acid or phytic acid;

Under the situation that contains the cell-activating composition, can enumerate: with the combination of Folium Vaccinii vitis-idaeae extract, retinol, retinyl acetate or retinol cetylate;

Containing under the situation of vitamins, can enumerate: with the combination of retinoid (retinol, retinyl acetate, retinol cetylate), vitamin c class (ascorbic acid, ascorbic acid phosphoric acid esters sodium, magnesium L-ascorbyl-2-phosphate, Ascorbyl Tetraisopalmitate (ascorbic acid four (2-hexyldecanoic acid) ester)), vitamin E class (Delta-Tocopherol, tocopheryl nicotinate), nicotinic acid class (nicotiamide);

Under the situation that contains the blood circulation promoting action component, can enumerate: with the combination of Radix Ginseng extract, tocopheryl nicotinate, glucityl Hesperidin or Hesperidin;

Under the situation that contains the composition of preserving moisture, can enumerate: with the combination of Rhizoma Imperatae extract, hydrolytic collagen, elastin hydrolysis, MPC polymer glycerol, 1,3 butylene glycol, Polyethylene Glycol, dipropylene glycol, diglycerol, methyl glucoside polyethenoxy ether, trimethyl glycine (betanin), ethoxy urea, acrylic acid-acrylamide-dimethyl diallyl ammonium chloride copolymer, hydrolecithin, hyaluronic acid, hyaluronate sodium, hyaluronan, hyaluronan sodium or Sorbitol;

Under the situation that contains the composition that DNA damage is had prevention and/or repair, can enumerate: with the combination of artemia extract or DNA-Na;

Under the situation that contains ultra-violet absorption composition or ultraviolet scattering composition, can enumerate: with p-methoxycinnamic acid 2-Octyl Nitrite, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate or 2,4,6-three [4-(the own oxygen carbonyl of 2-ethyl) anilino-]-1,3,5-triazine, zinc oxide, titanium oxide, ferrum oxide, these inorganic compound are coated with inorganic particle (aluminium hydroxide, moisture silicic acid, Muscovitum or Talcum) or silicone oil and the combination of the material that obtains;

Containing under the situation of cleaning ingredients, can enumerate: with higher fatty acid salt (Palmic acid particularly; lauric acid; myristic acid; the salt of senior fatty acid such as stearic acid); N-acyl amino hydrochlorate (N-lauroyl NaAsp particularly; potassium hydroxide/N-fatty acid distribution of coconut oil acyl glutamic acid potassium; fatty acid distribution of coconut oil acylglycine sodium; the myristoyl sodium glutamate); fatty acid alkanol amides (fatty acid distribution of coconut oil diglycollic amide particularly; the fatty acid distribution of coconut oil single ethanol amide); amine oxide (cocos nucifera oil alkyl dimethyl amine oxide particularly; lauryl dimethyl amine oxide); imidazoles

Betanin (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole particularly

Betanin, N-fatty acid distribution of coconut oil acyl group-N-carboxyl methoxy ethyl-N-carboxymethyl ethylenediamine disodium) combination;

Containing under the situation of antimicrobial component, can enumerate: with the combination of benzalkonium chloride, gluconic acid and derivant thereof, benzethonium chloride or isopropyl methyl phenol;

Containing under the situation of astringent component, can enumerate: with the combination of Alumen, polymeric aluminum chloride, aluminum chloride, aldioxa salt, aluminium potassium sulfate or tannin.

Wherein, the known anti-saccharifying composition of preferred compositions, antioxidant content, aging resistance composition, anti-inflammatory component, cutin softening composition, cell-activating composition, vitamins, blood circulation promoting action component, the composition of preserving moisture, DNA damage had composition, ultra-violet absorption or the scattering composition and the cleaning ingredients of prevention and/or repair.Wherein, more preferably make up known anti-saccharifying composition, aging resistance composition, DNA damage had composition, vitamins and the antioxidant content of prevention and/or repair.

Have the concrete example of preferred compositions of composition, vitamins and the antioxidant content of prevention and/or repair as Herba Buddlejae Lindleyanae leaf extract and known anti-saccharifying composition, aging resistance composition, to DNA damage, can enumerate following combination.

[table 1]

Food compositions

Of the present invention or as the damage inhibitor and the skin-tightening degree of the anti-gfycation agent of the manufacturing object of application of the present invention, age resister, skin collagen or elastic force descends or inhibition, prevention or the improving agent of wrinkle of skin, can the food prepared therefrom compositions.

This food compositions can be suitable as health food, dietary supplement (comprising balanced nutritious food, supplies etc.).In addition, also be suitable as health functional food (comprising special food for health care (comprising reduction disease risks, the specification standards type indicated), the food special for health care of tape spare, trophic function food).

Dosage form is not particularly limited, and makes dosage forms such as tablet, pill, granule, powder, powder, capsule (comprising soft capsule), water preparation, Emulsion, liquor, extractum or elixir after can using known method that the Herba Buddlejae Lindleyanae leaf extract is cooperated directly or therein the excipient that is generally used for food or additive.Wherein, consider from the aspect of taking easily and carrying, preferred: beverage; Powder drink; Preparations such as mucilage, tablet, powder agent, granule, capsule, drop.As required, being mixed together, carrying out preparation with food additive such as oils and fats, stabilizing agent, emulsifying agent, dispersant, suspending agent, spice, thickening agent, sweeting agent, coloring agent, spice, antiseptic, antioxidant, organic acid gets final product.

As oils and fats, can enumerate: the solidified oil of Oleum Arachidis hypogaeae semen, cocoa butter, rice germ oil, perilla oil, Semen Lini wet goods crude vegetal etc. or these crude vegetals, the glyceride of fatty acid (comprising medium-chain fatty acid) (glyceride, two glyceride, triglyceride etc.), Cera Flava etc.Wherein, preferred Cera Flava.With respect to the total amount of food compositions, content of oil and grease can be set at about 0.001～10 weight %.

As emulsifying agent, dispersant, suspending agent or stabilizing agent, can enumerate: polyhydric alcohol such as Polyethylene Glycol, propylene glycol, glycerol, Sorbitol; Fatty acid glyceride; Sodium carboxymethyl cellulose etc.Wherein, preferably glycerine, fatty acid glyceride, sodium carboxymethyl cellulose.With respect to the total amount of food compositions, the content of emulsifying agent, dispersant, suspending agent or stabilizing agent can be set at about 0.0001～10 weight %.

As thickening agent, can enumerate: locust bean gum, guar gum, xanthan gum, tamarind gum, pectin, carrageenin etc.Wherein, preferred xanthan gum.With respect to the total amount of food compositions, the content of thickening agent can be set at about 0.001～10 weight %.

As sweeting agent, can enumerate: sucrose, fructose, maltose, erythritol, trehalose, maltose alcohol, Radix Glycyrrhizae extract, Flos Chrysanthemi processing sweeting agent, aspartame, acesulfame potassium, Sorbitol, xylitol etc.With respect to the total amount of food compositions, the content of sweeting agent can be set at about 0.0001～50 weight %.

As antiseptic, can enumerate: benzoic acid or its salt, sorbic acid or its salt, butyl p-hydroxybenzoate, p-Hydroxybenzoic acid isobutyl ester, p-Hydroxybenzoic acid isopropyl ester, ethylparaben etc.With respect to the total amount of food compositions, the content of antiseptic can be set at about 0.001～10 weight %.

As antioxidant, can enumerate: ascorbic acid, sodium ascorbate, ascorbyl stearate, ascorbic acid sodium stearate, ascorbyl palmitate, bisulfites, sodium dithionite, sulfur dioxide, EDTA calcium disodium, arabo-ascorbic acid, sodium erythorbate, tocopherol etc.Wherein, preferred ascorbic acid, ascorbyl palmitate, tocopherol.With respect to the total amount of food compositions, the content of antioxidant can be set at about 0.001～10 weight %.

As organic acid, can enumerate: citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid, maleic acid etc.With respect to the total amount of food compositions, organic acid content can be set at about 0.001～10 weight %.

Food additive can be used alone or be used in combination two or more.

In the preparation, can add other active component.

In the food compositions,,, can cooperate addible known anti-saccharifying composition in the food for further strengthening effects of the present invention such as anti-saccharifying, aging resistance, the damage of inhibition skin collagen as other active component.Known anti-saccharifying composition can be used alone or be used in combination two or more.

As known anti-saccharifying composition, also can in food compositions, use at the described anti-saccharifying composition of cosmetic composition part.Also the situation with cosmetic composition is identical for preferred known anti-saccharifying composition.

As the active component beyond the known anti-saccharifying composition, can enumerate: vitaminss such as retinoid, vitamin(e) B group, vitamin c class, vitamin E class, vitamin D class, vitamin K class; Aminoacid such as threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, agedoite, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine; Taurine; collagen protein; glycosamine; acetylglucosamine; hyaluronic acid; isoflavone; polyphenyl phenol (for example derives from the endothelium of Semen Castaneae; the polyphenyl phenol of plants such as Semen Vitis viniferae); biotin; whey peptide; soybean peptide; Lac regis apis; γ-Hi-Z; orotic acid; rutin; Hesperidin; carnitine; carnitine hydrochloride; collagen peptide; the elastin laminin peptide; ceramide; lycopene; astaxanthin; lactobacillus extract (for example LFK); glutathion; rutin; (for example: uncaria tomentosa derive from plant; Fructus Vitis viniferae; Rhizoma Zingiberis Recens; Flos Nelumbinis; Fructus Vitis viniferae; Fructus Melo; Haematocoocus Pluvialls; Semen Litchi; the Flos Rosae Multiflorae petal; Fructus Phyllanthi extract) composition; ubiquinone derivative (for example coenzyme Q10); Nidus collocaliae etc.

At this, as retinoid, can the illustration retinal, retinol, tretinoin, carotene, dehydroretinal, lycopene etc.; As vitamin(e) B group, can the illustration thiamine disulfide, thiamine disulphide, thiamine double hexadecyl sulfuric acid, benfotiamine, prosulthiamine, fursultiamine, bisbentiamine, cycotiamine, octotiamine, allithiamine, dithiopropylthiamine, fursultiamine, ground match thiamine, sulbutiamine, thiamine phosplate disulphide, thiamine pyrophosphate, cycotiamine, thiamine ethyl disulphide, thiamine propyl disulfide thing, riboflavin, flavin adenine dinucleotide (FAD), Benadon, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine., hydroxocobalamin, cobalamin, mecobalamin, deoxyadenosine cobalt amine, folic acid, tetrahydrofolic acid, dihydrofoilic acid, nicotinic acid, nicotiamide, nicotinyl alcohol, pantothenic acid, pantothenylol, biotin, choline, inositol etc.; As vitamin c class, can the illustration ascorbic acid, sodium ascorbate, ascorbyl stearate, ascorbic acid sodium stearate, ascorbyl palmitate, arabo-ascorbic acid etc.; As the vitamin D class, can the illustration vitamin D2, gallbladder calcium ostelin, hydroxyl gallbladder calcium ostelin, dihydroxy gallbladder calcium ostelin, dihydrotachysterol etc.; As the vitamin E class, can the illustration tocopherol and derivant etc.

In other active component, preferred polyphenyl phenol (for example, derive from the Semen Castaneae endothelium, the polyphenyl phenol of plants such as Semen Vitis viniferae), soybean peptide, hyaluronic acid, collagen peptide, the elastin laminin peptide, ceramide, lycopene, coenzyme Q10, astaxanthin, the Fructus Melo extract, lactobacillus extract (for example LFK), glutathion, rutin, the uncaria tomentosa extract, the Radix seu Herba Tetrastigmatis Hypoglauci leaf extract, the Haematocoocus Pluvialls extract, Rhizoma Zingiberis Recens extract, the Flos Nelumbinis embryo extract, ascorbic acid, tocopherol, Fructus Phyllanthi extract, the Flos Rosae Multiflorae petal extract, Semen Litchi extract, more preferably Fructus Phyllanthi extract, Flos Rosae Rugosae petal extract, the Fructus Melo extract, lactobacillus extract (for example LFK), Semen Litchi extract, polyphenyl phenol, Rhizoma Zingiberis Recens extract, ceramide, hyaluronic acid, lycopene, uncaria tomentosa extract or astaxanthin.

Other active component can be used alone or be used in combination two or more.

The preferred compositions of composition

As the preferred compositions of Herba Buddlejae Lindleyanae leaf extract and other composition, can enumerate following combination.

Containing under the greasy situation, can enumerate and mellisic combination;

Under the situation that contains emulsifying agent, dispersant, suspending agent or stabilizing agent, can enumerate combination with glycerol, fatty acid glyceride or sodium carboxymethyl cellulose;

Containing under the situation of thickening agent, can enumerate combination with xanthan gum;

Containing under the situation of sweeting agent, can enumerate: with the combination of sucrose, fructose, maltose, erythritol, trehalose, maltose alcohol, Radix Glycyrrhizae extract, Flos Chrysanthemi processing sweeting agent, aspartame, acesulfame potassium, Sorbitol or xylitol;

Containing under the situation of antiseptic, can enumerate: with the combination of benzoic acid or its salt, sorbic acid or its salt, butyl p-hydroxybenzoate, p-Hydroxybenzoic acid isobutyl ester, p-Hydroxybenzoic acid isopropyl ester or ethylparaben;

Containing under the situation of antioxidant, can enumerate combination with ascorbic acid, ascorbyl palmitate or tocopherol;

Containing under the organic acid situation, can enumerate: with the combination of citric acid, succinic acid, tartaric acid, aspartic acid, lactic acid, malic acid, malonic acid, fumaric acid or maleic acid;

Under the situation that contains known anti-saccharifying composition, can enumerate: with the combination of Fructus Phyllanthi extract, Semen Litchi extract, Flos Rosae Multiflorae petal extract, Aesculus chinensis Bunge extract, Herba Silybi mariani extract, Melia azedarach L. extract, water-disintegrable tannin, L-arginine or its salt, lysine or its salt, carnosine, alpha-lipoic acid, aminoguanidine or its salt, A Lisiding, glycosamine;

Containing under the situation of other active component, can enumerate: with the combination of Fructus Phyllanthi extract, Flos Rosae Multiflorae petal extract, Fructus Melo extract, lactobacillus extract (for example LFK), Semen Litchi extract, polyphenyl phenol, Rhizoma Zingiberis Recens extract, ceramide, hyaluronic acid, lycopene, uncaria tomentosa extract or astaxanthin.

Wherein, preferably Herba Buddlejae Lindleyanae leaf extract and Fructus Phyllanthi extract, Flos Rosae Multiflorae petal extract, Fructus Melo extract, lactobacillus extract (for example LFK), Semen Litchi extract, polyphenyl phenols, Rhizoma Zingiberis Recens extract, ceramide, hyaluronic acid, lycopene, uncaria tomentosa extract or astaxanthin are made up.

When food compositions is the food compositions of preparationizations such as supplies of above-mentioned explanation, the content of Herba Buddlejae Lindleyanae leaf extract, total amount with respect to food compositions, be converted into dry weight, be preferably about 0.0001 weight % above, more preferably about 0.001 weight % above, more preferably about 0.01 weight % above, more preferably about 0.1 weight % above, further more than more preferably about 0.2 weight %.And, be preferably about 70 weight % following, more preferably about 50 weight % following, further more preferably about 40 weight % following, further more preferably about 20 weight % following, further more preferably about 10 weight % following, further below more preferably about 5 weight %.As long as the content of Herba Buddlejae Lindleyanae leaf extract is in above-mentioned scope, then in the food compositions of the amount that can absorb naturally, will contain the Herba Buddlejae Lindleyanae leaf extract of inhibition, prevention or the improvement effect of damage inhibitory action, skin-tightening degree or the elastic force decline or the wrinkle of skin that can obtain sufficient anti-saccharification, aging resistance effect, skin collagen just.

＜normal food compositions 〉

In addition, this food compositions can prepare by add the Herba Buddlejae Lindleyanae leaf extract in bread and cheese.As food, for example can enumerate: beverages such as milk, milk beverage, lactobacillus beverage, fruit juice refreshment drink, soda pop, juice beverage, tea beverage, fruit drink, ion beverage, sports drink, functional drinks, vitamin supply beverage, the balanced beverage of nutrient, gel beverage, alcoholic beverage, soup class; Egg milk pudding, milk pudding, cloth class Ds such as fruit juice pudding, jellies, the tartar sauce class, milk oils isogel shape cake, chewing gum, chewing gum classes such as bubble gum (strip chewing gum, sugar-coat granular chewing gum etc.), chocolate-like (plain chocolate, coating chocolate or Fructus Fragariae Ananssae chocolate, the blue berry chocolate, Fructus Melo chocolate etc. has added the chocolate of local flavor etc.), soft sweet (comprises caramel, nougat, chewing gum, cotton candy etc.), caramel classes such as taffy, Biscuits (hard cookies, soft cookies, muffin, crispbread, half perishable cookies etc.), cake classes such as cake; Cold drink classes such as ice cream, ice milk, milk flavor ice-cream, sherbert (シ ヤ one ベ Star ト), popsicle; Bread and Pastries; Such as noodles; Pet food etc.

Food compositions is during for the food compositions that adds effective ingredient obtain in bread and cheese, the content of Herba Buddlejae Lindleyanae leaf extract, total amount with respect to food compositions, be converted into dry weight, be preferably about 0.0001 weight % above, more preferably about 0.001 weight % above, more preferably about 0.01 weight % above, more preferably about 0.1 weight % above, further more than more preferably about 0.2 weight %.And, be preferably about 40 weight % following, more preferably about 20 weight % following, further more preferably about 10 weight % following, further below more preferably about 5 weight %.As long as the content of Herba Buddlejae Lindleyanae leaf extract is in above-mentioned scope, then in the food compositions of the amount that can absorb naturally, will contain the Herba Buddlejae Lindleyanae leaf extract of inhibition, prevention or the improvement effect of damage inhibitory action, skin-tightening degree or the elastic force decline or the wrinkle of skin that can obtain sufficient anti-saccharification, aging resistance effect, skin collagen just.

The form of food compositions, even from considering for being bad at or being difficult to swallow the aspect that also can absorb simply and swallow easily for the consumer of (swallowing) tablet, granule, capsule etc., preferred drink (particularly lactobacillus beverage, fruit juice refreshment drink, functional drinks), jellies, gel cake, more preferably lactobacillus beverage, functional drinks.

The using method of compositions

Cosmetic composition is smeared with common using method, the access times of cosmetics and is got final product.

In addition, food compositions gets final product for for example amount picked-up of about 0.01～20000mg, preferred about 0.1～10000mg, further preferred about 50～1000mg with 1 daily intake of the Herba Buddlejae Lindleyanae leaf extract that is converted into dry weight.

People as the object of the preparation of the manufacturing object of of the present invention or application of the present invention, be not particularly limited, with regard to cosmetic composition, the old man, can find out because of AGEs and generate or accumulate the people that causes skin aging (degradation under degree of compacting or flexibility decrease, wrinkle, pachylosis, skin texture disorder, gloomy, the transparent feel), particularly can find out that because of UV-induced AGEs generates or accumulates the people that causes skin aging etc. be the object that is fit to.

In addition, with regard to food compositions, except above-mentioned people, diabetics (particularly having caused the patient of complication such as cataract, arteriosclerosis, renal dysfunction, retinopathy, neurological disorder), arteriosclerosis patient, malignant tumor patient, osteopathia patient, patients of senile dementia, parkinsonian etc. also are the objects that is fit to.

In addition, no matter be cosmetic composition or food compositions, can thus, can prevent the AGEs generation that causes because of age growth or ultraviolet etc. or accumulate to cause skin aging or slow down aging speed with the artificial object of health.

Container

Of the present invention or as the compositions of the preparation of the manufacturing object of application of the present invention, can be accommodated in the container of the shape suitably selected according to application target, purposes, material and use.As container shapes, can illustration: bottle type, cast, jar type, dropper type, allotter (デ イ ス ペ Application サ one) type, excellent type, pouch, the convenient bag of aluminium foil etc.In addition, as material, can illustration: polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE etc.), ABS resin, ethylene-vinyl alcohol resin, polystyrene, glass, metal (aluminum etc.) etc.In addition, these materials are considered from the aspects such as stability of intensity, flexibility, weatherability, composition, can carry out various coatings and handle, and perhaps these materials are made up by for example mixing to wait, and perhaps carry out lamination, use as container material.

Embodiment

Below, enumerate embodiment and illustrate in greater detail the present invention, but the present invention is not limited to these embodiment.

Reference example 1 (promotion that UV-induced AGEs generates)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.Then, with this collagen gel make D-ribose (Aldrich company) be dissolved in the ribose solution that the ultimate density that obtains among the PBS is 50mM, 37 ℃ of following two weeks of incubation, carry out saccharification react thus.During this incubation, be 5J/cm with the exposure rate ²Condition irradiation UVA.

Then, make collagen protein-gel dissolving, use lysate, utilize ELISA to measure the growing amount of AGEs by the collagenase processing.Use AGEs antibody (anti-AGEs monoclonal antibody, clone 6D12, peroxidase labelling, Transgenic company) in the mensuration, make its colour developing with TMB reagent (manufacturing of Dako company).

In addition, in said method, except not carrying out the UVA irradiation, carry out same operation, in contrast with it.Carry out 4 AGEs reactions of formation.

The result as shown in Figure 1.The longitudinal axis of Fig. 1 is represented the relative value that the AGEs growing amount that will contrast was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 1.As shown in Figure 1, shine the generation that can significantly promote AGEs by UVA.

Test example 1 (inhibition that the AGEs that the UVA irradiation causes generates)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.When making the collagen solution gelation, it is 0.01w/v% or 0.001w/v% that interpolation Herba Buddlejae Lindleyanae leaf extract (ethanol extraction) makes its ultimate density.Need to prove that the Herba Buddlejae Lindleyanae leaf extract is a powder.Then, this collagen gel in 50mM ribose solution, 37 ℃ of following two weeks of incubation, is carried out saccharification react thus.During this incubation, be 5J/cm with the exposure rate ²Condition irradiation UVA.

Implement to measure according to the method for reference example 1.

In addition, except not adding the Herba Buddlejae Lindleyanae leaf extract, carry out and above-mentioned same operation, in contrast it.Carry out 4 AGEs reactions of formation.

The result as shown in Figure 2.The longitudinal axis of Fig. 2 is represented the relative value that the AGEs growing amount when not adding the Herba Buddlejae Lindleyanae leaf extract was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 2.As shown in Figure 2, the Herba Buddlejae Lindleyanae leaf extract can be significantly and is suppressed the generation of the AGEs under the UVA irradiation relatively with consumption.

Reference example 2 (promotion that UV-induced CMA generates)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.Then, with this collagen gel make D-ribose (Aldrich company) be dissolved in the ribose solution that the ultimate density that obtains among the PBS is 50mM, 37 ℃ of following two weeks of incubation, carry out saccharification react thus.During this incubation, be 5J/cm with the exposure rate ²Condition irradiation UVA.

Then, make collagen protein-gel dissolving, use lysate, utilize the growing amount of ELISA mensuration as a kind of noroctopine (CMA) of AGEs by the collagenase processing.Antibody use AGEs antibody (monoclonal anti CMA antibody (3F5), by Japan Women's University forever the well lecturer grant), secondary antibodies uses anti-mouse immuning ball protein/HRP (manufacturing of Dako company), makes its colour developing with TMB reagent (manufacturing of Dako company).

In addition, in said method, except not carrying out the UVA irradiation, carry out same operation, in contrast with it.Carry out 4 CMA reactions of formation.

The result as shown in Figure 3.The longitudinal axis of Fig. 3 is represented the relative value that the CMA growing amount that will contrast was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 3.As shown in Figure 3, shine the generation that can significantly promote CMA by UVA.

Test example 2 (inhibition that the CMA that the UVA irradiation causes generates)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.When making the collagen solution gelation, it is 0.01w/v% or 0.001w/v% that interpolation Herba Buddlejae Lindleyanae leaf extract (ethanol extraction) makes its ultimate density.Then, with this collagen gel make D-ribose (Aldrich company) be dissolved in the ribose solution that the ultimate density that obtains among the PBS is 50mM, 37 ℃ of following two weeks of incubation, carry out saccharification react thus.During this incubation, be 5J/cm with the exposure rate ²Condition irradiation UVA.

Implement to measure according to the method for reference example 2.

In addition, except not adding the Herba Buddlejae Lindleyanae leaf extract, carry out and above-mentioned same operation, in contrast it.Carry out 4 CMA reactions of formation.

The result as shown in Figure 4.The longitudinal axis of Fig. 4 is represented the relative value that the CMA growing amount when not adding the Herba Buddlejae Lindleyanae leaf extract was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 4.As shown in Figure 4, the Herba Buddlejae Lindleyanae leaf extract can be significantly and is suppressed the generation of the CMA under the UVA irradiation relatively with consumption.

Test example 3 (inhibition that CMA generates)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.When making the collagen solution gelation, adding Herba Buddlejae Lindleyanae leaf extract (ethanol extraction), to make its ultimate density be 0.01w/v%, or adding aminoguanidine (AG), to make its ultimate density be 0.1w/v%.

Then, with this collagen gel make D-ribose (Aldrich company) be dissolved in the ribose solution that the ultimate density that obtains among the PBS is 50mM, 37 ℃ of following two weeks of incubation, carry out saccharification react thus.

Implement to measure according to the method for reference example 2.

In addition, except not adding beyond Herba Buddlejae Lindleyanae leaf extract or the aminoguanidine, carry out and above-mentioned same operation, in contrast it.Carry out 4 CMA reactions of formation.

The result as shown in Figure 5.The longitudinal axis of Fig. 5 is represented the relative value that the CMA growing amount with do not add Herba Buddlejae Lindleyanae leaf extract or aminoguanidine the time was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 5.As shown in Figure 5, the Herba Buddlejae Lindleyanae leaf extract can significantly suppress the generation of the CMA under the UVA irradiation.In addition, its inhibition degree has various AGEs structures to generate inhibiting aminoguanidine also strong than known.

Test example 4 (inhibition that AGEs generates)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.Adding Herba Buddlejae Lindleyanae leaf extract (ethanol extraction) in collagen protein-gel in preparation, to make its ultimate density be 0.1w/v% or 0.01w/v%, and perhaps adding aminoguanidine (AG), to make its ultimate density be 0.1w/v%.Then, with this collagen gel make D-ribose (Aldrich company) be dissolved in the ribose solution that the ultimate density that obtains among the PBS is 50mM, 37 ℃ of following two weeks of incubation, carry out saccharification react thus.

Implement to measure according to the method for reference example 1.

In addition, except not adding beyond Herba Buddlejae Lindleyanae leaf extract or the aminoguanidine, carry out and above-mentioned same operation, in contrast it.Carry out 4 AGEs reactions of formation.

The result as shown in Figure 6.The longitudinal axis of Fig. 6 is represented the relative value that the AGEs growing amount with do not add Herba Buddlejae Lindleyanae leaf extract or aminoguanidine the time was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 6.As shown in Figure 6, the Herba Buddlejae Lindleyanae leaf extract can be significantly and is suppressed the generation of the AGEs under the UVA irradiation relatively with consumption.In addition, its inhibition degree has various AGEs structures to generate inhibiting aminoguanidine also strong than known.

Test example 5 (the plain inhibition that generates of pentoside)

Use collagen protein-gel to cultivate test kit (trade name: Cellmatrix, the new field gelatin company of Japan make) preparation collagen protein-gel.Adding Herba Buddlejae Lindleyanae leaf extract (ethanol extraction) in collagen protein-gel in preparation, to make its ultimate density be 0.1w/v% or 0.01w/v%, and perhaps adding aminoguanidine (AG), to make its ultimate density be 0.1w/v%.Then, with this collagen gel make D-ribose (Aldrich company) be dissolved in the ribose solution that the ultimate density that obtains among the PBS is 50mM, 37 ℃ of following two weeks of incubation, carry out saccharification react thus.Then, make collagen protein-gel dissolving by the collagenase processing, and utilize ELISA to measure the growing amount of the pentoside element of lysate.One time antibody uses AGEs antibody (the plain monoclonal antibody of anti-pentoside, clone PEN-12, peroxidase labelling, Transgenic company), makes its colour developing with TMB reagent (manufacturing of Dako company).

In addition, except not adding beyond Herba Buddlejae Lindleyanae leaf extract or the aminoguanidine, carry out and above-mentioned same operation.Carry out 4 plain reactions of formation of pentoside.

The result as shown in Figure 7.The longitudinal axis of Fig. 7 is represented the relative value that the plain growing amount of the pentoside with do not add Herba Buddlejae Lindleyanae leaf extract or aminoguanidine the time was made as at 100 o'clock.In addition, be meansigma methods ± standard deviation shown in Fig. 7.As shown in Figure 7, the Herba Buddlejae Lindleyanae leaf extract can be significantly and is suppressed the generation of pentoside element relatively with consumption.In addition, its inhibition degree has various AGEs structures to generate inhibiting aminoguanidine also strong than known.

Can generate with the pentoside element during known collagen protein saccharifying is the AGEs structure of representative, wherein, and known CMA as collagen protein specificity saccharification react product.Collagen protein mainly is present in corium, and UVA can arrive corium, therefore, by the foregoing description as can be known, the Herba Buddlejae Lindleyanae leaf extract can effectively suppress the saccharifying of the collagen protein that is promoted by ultraviolet in the saccharifying of the collagen protein in the corium and the corium, and then effectively suppresses by the proteic damage of UV-induced dermal collagen.

Test example 6 (service test)

[table 2]

Embodiment 1

The Herba Buddlejae Lindleyanae leaf extract	0.001w/v％
		1,3 butylene glycol	6w/v％
Glycerol	4w/v％
		Antiseptic (methyl parahydroxybenzoate, propyl p-hydroxybenzoate)	In right amount
The pH regulator agent	In right amount
		Water	In right amount

The cosmetics that prepare the embodiment 1 that forms shown in the above-mentioned table 2 allow the male of one's late 30s and women (3) every day twice (sooner or later) use an amount of these two weeks of cosmetics, and the result can find out the tendency that skin texture improves.

Embodiment

(1) cosmetic composition

The unit of the numerical value among the embodiment of following cosmetic composition is " weight % ".In addition, the weight of Herba Buddlejae Lindleyanae leaf extract is dry weight.

In all prescriptions of cosmetic composition, as the Herba Buddlejae Lindleyanae leaf extract, the preferred alcohol extract.

The prescription example

(1) cosmetic composition

The unit of the numerical value in the prescription example of following cosmetic composition is " weight % ".

Embodiment 2 transparent skin moistening liquid

Herba Buddlejae Lindleyanae leaf extract 0.1

Limnanthes Alba Seed Oil 0.1

Fructus Phyllanthi extract 0.01

Lysine 1

Hydrolyzed soybean protein 0.5

Procyanidin 0.0005

MPC polymer 0.01

Glycerol 4

1,3 butylene glycol 6

Polyoxyethylene solidifies Oleum Ricini 0.5

Antiseptic (methyl parahydroxybenzoate, propyl p-hydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 3 transparent skin moistening liquid

Herba Buddlejae Lindleyanae leaf extract 0.01

Semen Vitis viniferae extract 0.001

Alpha-tocopherol 0.1

Ascorbic acid 0.5

Folium Radix Arnebiae (Folium Radix Lithospermi) extract 0.001

Dipropylene glycol 15

Polyoxyethylene sorbitol acid anhydride isostearate (20EO) 0.5

Hydroxyethyl-cellulose 0.01

Antiseptic (methyl parahydroxybenzoate, phenyl phenol) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 4 emulsifying skin lotions

Herba Buddlejae Lindleyanae leaf extract 1

Brazil's Butyrospermum fruit oil 0.1

Arginine 0.5

Carnosine 0.01

Retinyl acetate 0.01

Semen Vitis viniferae extract 0.01

Methyl glucoside polyethenoxy ether 1

Hyaluronic acid 0.05

1,3 butylene glycol 13

Polyoxyethylene solidifies Oleum Ricini 0.5

Three (caprylic/capric) glyceride 0.2

Three (2 ethyl hexanoic acid) glyceride 0.2

Xanthan gum 0.1

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 5 emulsifying skin lotions

Herba Buddlejae Lindleyanae leaf extract 1

Limnanthes Alba Seed Oil 0.3

Gamma-Linolenic acid 0.05

Arginine 0.7

Arginine monohydrochloride 0.3

Hydrolyzed soybean protein 0.2

Semen Vitis viniferae extract 0.1

Magnesium ascorbyl phosphate 0.01

MPC polymer 0.1

Dipropylene glycol 8

Glycerol 1

1,3 butylene glycol 0.5

Polyoxyethylene solidifies Oleum Ricini 0.5

Tetramethylolmethane four (2 ethyl hexanoic acid) ester 0.5

Acrylic acid-alkyl methacrylate copolymer 0.25

Hydroxyethyl-cellulose 0.01

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 6 emulsifying skin lotions

Herba Buddlejae Lindleyanae leaf extract 1

Radix Oenotherae erythrosepalae oil 0.05

Linoleic acid 0.01

Semen Litchi extract 0.001

Flos Rosae Multiflorae petal extract 0.001

Hydrolyzed soy egg 0.001

D-Delta-Tocopherol 0.01

Procyanidin 0.001

Sodium ascorbyl phosphate 0.1

1,3 butylene glycol 7

Diglycerol 3

Polyoxyethylene sorbitol acid anhydride isostearate (20EO) 0.5

Three (2 ethyl hexanoic acid) glyceride 1

Hydroxyethyl-cellulose 0.05

CVP Carbopol ETD2050 0.1

Chelating agen is an amount of

Antiseptic (propyl p-hydroxybenzoate, phenyl phenol) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 7 emulsions

Herba Buddlejae Lindleyanae leaf extract 0.001

Radix Oenotherae erythrosepalae oil 0.4

Semen Litchi extract 0.2

Carnosine 0.1

Hydrolyzed soybean protein 0.5

D-Delta-Tocopherol 0.01

Nicotiamide 1.5

Hydrolytic collagen 0.05

Folium Radix Arnebiae (Folium Radix Lithospermi) extract 0.1

Folium Vaccinii vitis-idaeae extract 0.0001

Dipropylene glycol 3

1,3 butylene glycol 10

POE sorbitan monostearate (polysorbate60) 0.8

Tetramethylolmethane four (2 ethyl hexanoic acid) ester 5

Three (2 ethyl hexanoic acid) glyceride 2

Squalane 1

Methyl gathers trimethicone 0.1

Decamethylcyclopentaandoxane 0.2

Behenyl alcohol 0.4

Acrylic acid-alkyl methacrylate copolymer 0.1

Xanthan gum 0.1

(2-(Acryloyloxy)ethanol/acryloyl group dimethyl sodium taurocholate) copolymer 0.8

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate, propyl p-hydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 8 emulsions

Herba Buddlejae Lindleyanae leaf extract 0.3

Brazil's Butyrospermum fruit oil 0.05

Limnanthes Alba Seed Oil 0.8

Semen Litchi extract 0.2

Lysine 0.5

Hydrolyzed soybean protein 1

D-Delta-Tocopherol 0.1

Alpha-tocopherol 0.9

Rhizoma Imperatae extract 0.5

Methyl glucoside polyethenoxy ether 0.1

Allantoin 0.005

Lactic acid 0.5

Dipropylene glycol 1

Glycerol 4

1,3 butylene glycol 10

Glyceryl monostearate 0.2

Polyoxyethylene cetyl ether 0.8

Tetramethylolmethane four (2 ethyl hexanoic acid) ester 3

Methyl polysiloxane 0.5

Ethyl trisiloxanes 3

Acrylic acid-alkyl methacrylate copolymer 0.75

CVP Carbopol ETD2050 0.001

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 9 facial creams

Herba Buddlejae Lindleyanae leaf extract 0.001

Radix Oenotherae erythrosepalae oil 1

Butyrospermum parkii 0.3

Retinol cetylate 0.5

D-Delta-Tocopherol 0.005

Alpha-tocopherol 0.005

Fructus Phyllanthi extract 1

Nicotiamide 0.5

Hydrolytic collagen 0.01

Elastin hydrolysis 0.01

Hydrogenated soya phosphatide 0.3

Hyaluronic acid 0.1

Glycerol 2

1,3 butylene glycol 5

Polyoxyethylene solidifies Oleum Ricini 3

Three (caprylic/capric) glyceride 2

Tetramethylolmethane four (2 ethyl hexanoic acid) ester 3

Squalane 7

Spermol 1

Stearyl alcohol 0.5

Acrylic acid-alkyl methacrylate copolymer 0.3

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate, propyl p-hydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 10 facial creams

Herba Buddlejae Lindleyanae leaf extract 0.5

Butyrospermum parkii 5

Gamma-Linolenic acid 0.5

Linoleic acid 0.3

Flos Rosae Multiflorae petal extract 0.5

Hydrolyzed soybean protein 0.8

Semen Vitis viniferae extract 0.1

Tocopheryl nicotinate 0.3

Methyl glucoside polyethenoxy ether 3

Radix Ginseng extract 0.1

Folium Vaccinii vitis-idaeae extract 0.1

Dipropylene glycol 1.5

Glycerol 2

1,3 butylene glycol 3.5

Polyethylene Glycol 0.01

Polyoxyethylene solidifies Oleum Ricini 2

Glyceryl monostearate 1

Three (caprylic/capric) glyceride 5

Squalane 2

Liquid paraffin 1

Methyl polysiloxane 0.1

Cyclomethicone 0.1

Spermol 2

CVP Carbopol ETD2050 0.4

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate, phenyl phenol) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 11 facial creams

Herba Buddlejae Lindleyanae leaf extract 1

Limnanthes Alba Seed Oil 0.2

Butyrospermum parkii 1.5

Fructus Phyllanthi extract 0.01

Arginine 0.01

Retinol 0.1

Alpha-tocopherol 0.5

Ascorbyl Tetraisopalmitate 0.5

Artemia extract 0.001

DNA-Na 0.05

P-methoxycinnamic acid 2-Octyl Nitrite 8

Diethylamino-hydroxybenzoyl-hexyl-benzoate 2

Polysiloxanes coating zinc oxide 0.1

Polysiloxanes coats titanium oxide 10

1,3 butylene glycol 8

Polyethylene Glycol 0.03

Lauryl PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane 3

PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane 1.5

Three (caprylic/capric) glyceride 4

Methyl gathers trimethicone 35

Methylsiloxane network polymers 3

Cross-linking type methyl polysiloxane 0.5

Acrylic acid-alkyl methacrylate copolymer 0.2

CVP Carbopol ETD2050 0.05

Distearyl dimethylammonium Strese Hofmann's hectorite. 1.5

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 12 facial creams

Herba Buddlejae Lindleyanae leaf extract 0.005

Radix Oenotherae erythrosepalae oil 3

Semen Litchi extract 0.1

Alpha-lipoic acid 0.01

Hydrolyzed soybean protein 0.1

Semen Vitis viniferae extract 0.005

Rhizoma Imperatae extract 0.001

Artemia extract 0.5

P-methoxycinnamic acid 2-Octyl Nitrite 10

Diethylamino-hydroxybenzoyl-hexyl-benzoate 5

2,4,6-three [4-(the own oxygen carbonyl of 2-ethyl) anilino-] 1,3,5-triazines 3

Polysiloxanes coating zinc oxide 5

Polysiloxanes coats titanium oxide 1

Inorganic compound coating zinc oxide 0.05

Glycerol 5

1,3 butylene glycol 2

Lauryl PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane 1

PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane 1

Three (2 ethyl hexanoic acid) glyceride 1.5

Methyl polysiloxane 3

Decamethylcyclopentaandoxane 30

Methylsiloxane network polymers 5

Alkyl acrylate copolymer methyl polysiloxane ester 0.1

Acrylic acid-alkyl methacrylate copolymer 0.05

Muscovitum 2

Chelating agen is an amount of

Antiseptic (propyl p-hydroxybenzoate, phenyl phenol) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 13 cleansing cream

Herba Buddlejae Lindleyanae leaf extract 0.02

Radix Oenotherae erythrosepalae oil 0.01

Semen Litchi extract 0.005

Arginine 0.1

Hydrolyzed soybean protein 0.5

D-Delta-Tocopherol 0.01

Folium Radix Arnebiae (Folium Radix Lithospermi) extract 0.001

Glycyrrhizic acid dipotassium 0.1

Glycerol 0.01

1,3 butylene glycol 1

Diglycerol 5

Glyceryl monostearate 0.5

Monostearate polyglycerin ester 2

Three (caprylic/capric) glyceride 10

Liquid paraffin 3

Liquid paraffin,light 10

Ethyl trisiloxanes 0.5

Stearyl alcohol 3

CVP Carbopol ETD2050 0.5

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate, phenyl phenol) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 14 cleansing cream

Herba Buddlejae Lindleyanae leaf extract 0.5

Gamma-Linolenic acid 1

Fructus Phyllanthi extract 0.01

Semen Vitis viniferae extract 0.01

Radix Ginseng extract 0.1

Allantoin 0.0001

Dipropylene glycol 7

1,3 butylene glycol 0.01

Glyceryl monostearate 1

POE sorbitan monostearate 2

Tetramethylolmethane four (2 ethyl hexanoic acid) ester 8

Three (2 ethyl hexanoic acid) glyceride 8

Squalane 1

Liquid paraffin 7

Methyl polysiloxane 2

Behenyl alcohol 1

CVP Carbopol ETD2050 0.5

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate, propyl p-hydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 15 cleansing milk

Herba Buddlejae Lindleyanae leaf extract 0.01

Brazil's Butyrospermum fruit oil 0.1

Butyrospermum parkii 0.1

Fructus Phyllanthi extract 1

Lysine 0.01

Semen Vitis viniferae extract 0.005

MPC polymer 0.5

Acrylic acid-acrylamide-dimethyl diallyl ammonium chloride copolymer 3

Allantoin 0.001

1,3 butylene glycol 2

Fatty acid distribution of coconut oil acylglycine sodium 5

Potassium hydroxide/N-fatty acid distribution of coconut oil acyl glutamic acid potassium 15

N-fatty acid distribution of coconut oil acyl group-N-carboxyl methoxy ethyl-N-carboxymethyl ethylenediamine disodium 4

Cocos nucifera oil alkyl dimethyl amine oxide 1

Polyglycol distearate 1

Polyoxyethylene methyl glucoside three isostearates 3

Pearling agent 2

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 16 cleansing milk

Herba Buddlejae Lindleyanae leaf extract 0.5

Limnanthes Alba Seed Oil 0.1

Gamma-Linolenic acid 0.3

Linoleic acid 0.2

Flos Rosae Multiflorae extract 0.1

Arginine 0.01

Hydrolyzed soybean protein 0.01

Alpha-tocopherol 0.1

Methyl glucoside polyethenoxy ether 3

Sorbitol 1

Hyaluronic acid 0.1

Radix Ginseng extract 0.0001

Folium Radix Arnebiae (Folium Radix Lithospermi) extract 0.1

Dipropylene glycol 1

Lauroyl NaAsp 10

Fatty acid distribution of coconut oil single ethanol amide 7

Myristoyl sodium glutamate 5

2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazole

Betanin 3.5

Polyglycol distearate 4

Pearling agent 1

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

The pH regulator agent is an amount of

Spice is an amount of

The water remainder

Add up to 100

Embodiment 17 gels

Herba Buddlejae Lindleyanae leaf extract 0.003

Delta-Tocopherol 0.05

Magnesium ascorbyl phosphate 3.0

Allantoin 0.1

1,3 butylene glycol 5.0

POE-solidifies Oleum Ricini 60 2.0

Macadimia nut oil 1.5

Three (2 ethyl hexanoic acid) glyceride 1.5

Glyceryl monostearate 0.5

Methyl phenyl silicone 0.5

CVP Carbopol ETD2050 0.4

Dextrin cetylate 0.3

Hydroxypropyl emthylcellulose 0.2

Hydrogenated soya phosphatide 0.05

Sodium polyacrylate 0.01

The pH regulator agent is an amount of

Chelating agen is an amount of

The pure water remainder

100

Embodiment 18 facial films

Herba Buddlejae Lindleyanae leaf extract 1

Delta-Tocopherol 1.0

Polyvinyl alcohol 10.0

Ethanol 8.0

Glycerol 3.0

Polyethylene Glycol 0.4

Spice is an amount of

Antiseptic is an amount of

The pure water remainder

100

Embodiment 19 facial creams

Herba Buddlejae Lindleyanae leaf extract 0.005

Delta-Tocopherol 4.0

Gamma-Tocopherol 1.0

Pyridoxine hydrochloride 0.1

Retinol 0.01

White vaseline 25.0

Stearyl alcohol 10.0

Propylene glycol 5.0

Behenyl alcohol 5.0

POE-solidifies Oleum Ricini 60 4.0

Glyceryl monostearate 1.0

Dibenzylatiooluene 0.01

Antiseptic is an amount of

The pure water remainder

100

Embodiment 20 emulsions

Herba Buddlejae Lindleyanae leaf extract 0.01

Artemia extract 0.0004

Erythritol 0.02

1-methyl-2-pyridinium carboxylate HCl 0.002

P-methoxycinnamic acid 2-Octyl Nitrite 10

Polysiloxanes is handled zinc oxide 5

Three (2 ethyl hexanoic acid) glyceride 4

Diethylamino-hydroxybenzoyl-hexyl-benzoate 1

Alkyl acrylate copolymer methyl polysiloxane ester 0.2

Acrylic acid-alkyl methacrylate copolymer 0.05

Decamethylcyclopentaandoxane 16

Methyl gathers trimethicone 3

Lauryl PEG-9 poly dimethyl siloxy ethyl polydimethylsiloxane 2.6

Dibenzylatiooluene 0.02

Chelating agen is an amount of

Antiseptic (methyl parahydroxybenzoate) is an amount of

Spice is an amount of

The water remainder

100

(2) food compositions

In the prescription example of following food compositions, the weight of Herba Buddlejae Lindleyanae leaf (extract) is dry weight.

In all prescriptions of food compositions, as the Herba Buddlejae Lindleyanae leaf extract, the preferred alcohol extract.

Embodiment 21 beverages

Herba Buddlejae Lindleyanae extract 0.10g

Fructose Glucose Liquid 1.00g

Ascorbic acid 0.05g

Malic acid 0.05g

Spice 0.1g

Pure water 48.79g

Add up to 50.00g (1 bottle)

This beverage meal every days 3 respectively absorbs 1 bottle.

Embodiment 22 tablets

Herba Buddlejae Lindleyanae extract 100mg

Crystalline cellulose 113.5mg

Sucrose fatty acid ester 5mg

Maltose alcohol 30mg

Sodium citrate 50mg

Vitamin B1 1mg

Vitamin B2 0.5mg

Add up to 300mg (1)

This tablet meal every days 3 respectively absorbs 3.

Embodiment 23 powder drinks

Herba Buddlejae Lindleyanae extract 0.30g

Agar 1.50g

Lactose 2.70g

Citric acid 0.50g

Reduction maltose 0.495g

Matcha spice 0.005g

Add up to 5.5g (1 bag)

This powder drink is soluble in water, and every days 3, meal respectively absorbed 1 bag.

Embodiment 24 granules

Herba Buddlejae Lindleyanae extract 200mg

Lactulose 500mg

Oligomeric xylose 200mg

Citric acid 100mg

Add up to 1000mg

With the mode subpackage of per 1 bag 300mg, take 3 bags as 1 feed ration.

Embodiment 25 mucilages

Herba Buddlejae Lindleyanae extract 500mg

Lactulose 200mg

Fructus Citri sinensis concentrated fruit juice 1500mg

Marine collagen protein peptide 2000mg

Sodium citrate 500mg

Citric acid 420mg

L-tartaric acid 210mg

DL-malic acid 70mg

Gelating agent (サ Application カ ラ) 480mg

Guar gum 60mg

Calcium lactate 200mg

Sucralose 6mg

Spice 100mg

Add up to 6246mg

For comprising above-mentioned use level as 1 feed ration, be dissolved in mentioned component among the eliminating cold for resuscitation water 120ml after, add agar, make in the mode of each about 21g, obtain mucilage.Said preparation is taken 6 as adult's 1 feed ration.

Embodiment 26 soft capsules

Capsule 's content

Herba Buddlejae Lindleyanae extract 120mg

Water-disintegrable tannin 20mg

Hydrolyzed soybean protein 20mg

Flos Nelumbinis embryo extract 5mg

Ceramide 3 mg

Hyaluronic acid 0.5mg

CoQ10 2mg

Haematocoocus Pluvialls pigment extract (containing astaxanthin) 4mg

Vitamin C 1mg

Fatty glyceride 10mg

Cera Flava 5mg

The capsule tunicle

Gelatin 92mg

Pulullan polysaccharide 3mg

Glycerol 35mg

Colouring matter 3mg

Add up to 323.5mg (1 capsules)

This soft capsule meal every days 3 respectively absorbs 2.

Industrial applicability

The Lindley Butterflybush Herb leaf extract can suppress the generation of AGEs and the generation of being shone the AGEs that causes by ultraviolet ray. Therefore, the cosmetic composition take the Lindley Butterflybush Herb leaf extract as active ingredient or food compositions can be suitable for suppressing to accumulate the skin aging that causes by AGEs.

Claims (8)

1. the application of Herba Buddlejae Lindleyanae (Buddleja Axillaris) leaf extract is used to make anti-gfycation agent.

2. application as claimed in claim 1, wherein, the extract of at least a solvent extraction in the group that the Herba Buddlejae Lindleyanae leaf extract is formed for the polyhydric alcohol that utilizes the monohydric alcohol select Free water, carbon number 1～4 and carbon number 2～6.

3. application as claimed in claim 1 or 2, wherein, anti-gfycation agent is a cosmetic composition.

4. application as claimed in claim 1 or 2, wherein, anti-gfycation agent is a food compositions.

5. the application of Herba Buddlejae Lindleyanae leaf extract is used to make age resister.

6. the application of Herba Buddlejae Lindleyanae leaf extract is used to make the damage inhibitor of skin collagen.

7. the application of Herba Buddlejae Lindleyanae leaf extract is used to make the skin-tightening degree or elastic force descends or inhibition, prevention or the improving agent of wrinkle of skin.

8. a food compositions wherein, comprises the Herba Buddlejae Lindleyanae leaf extract of 0.2～40 weight %.

Images